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Image Motion Compensation of Off-Axis TMA Three-Line ArrayAerospace Mapping Cameras
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作者 Yongchang Li Pengluo Lu +2 位作者 Longxu Jin Guoning Li Yinan Wu 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2016年第6期80-89,共10页
To enhance the image motion compensation accuracy of off-axis three-mirror anastigmatic( TMA)three-line array aerospace mapping cameras,a new method of image motion velocity field modeling is proposed in this paper. F... To enhance the image motion compensation accuracy of off-axis three-mirror anastigmatic( TMA)three-line array aerospace mapping cameras,a new method of image motion velocity field modeling is proposed in this paper. Firstly,based on the imaging principle of mapping cameras,an analytical expression of image motion velocity of off-axis TMA three-line array aerospace mapping cameras is deduced from different coordinate systems we established and the attitude dynamics principle. Then,the case of a three-line array mapping camera is studied,in which the simulation of the focal plane image motion velocity fields of the forward-view camera,the nadir-view camera and the backward-view camera are carried out,and the optimization schemes for image motion velocity matching and drift angle matching are formulated according the simulation results. Finally,this method is verified with a dynamic imaging experimental system. The results are indicative of that when image motion compensation for nadir-view camera is conducted using the proposed image motion velocity field model,the line pair of target images at Nyquist frequency is clear and distinguishable. Under the constraint that modulation transfer function( MTF) reduces by 5%,when the horizontal frequencies of the forward-view camera and the backward-view camera are adjusted uniformly according to the proposed image motion velocity matching scheme,the time delay integration( TDI) stages reach 6 at most. When the TDI stages are more than 6,the three groups of camera will independently undergo horizontal frequency adjustment. However, when the proposed drift angle matching scheme is adopted for uniform drift angle adjustment,the number of TDI stages will not exceed 81. The experimental results have demonstrated the validity and accuracy of the proposed image motion velocity field model and matching optimization scheme,providing reliable basis for on-orbit image motion compensation of aerospace mapping cameras. 展开更多
关键词 three-line array mapping camera off-axis tma image motion compensation image motion velocity drift angle
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Optimization-based mode selection scheme for OAM millimeter wave system in the off-axis misalignment case
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作者 Haie Dou Lei Wang +1 位作者 Bin Kang Baoyu Zheng 《Digital Communications and Networks》 SCIE CSCD 2024年第1期101-108,共8页
Millimeter-wave transmission combined with Orbital Angular Momentum(OAM)has the advantage of reducing the loss of beam power and increasing the system capacity.However,to fulfill this advantage,the antennas at the tra... Millimeter-wave transmission combined with Orbital Angular Momentum(OAM)has the advantage of reducing the loss of beam power and increasing the system capacity.However,to fulfill this advantage,the antennas at the transmitter and receiver must be parallel and coaxial;otherwise,the accuracy of mode detection at the receiver can be seriously influenced.In this paper,we design an OAM millimeter-wave communication system for overcoming the above limitation.Specifically,the first contribution is that the power distribution between different OAM modes and the capacity of the system with different mode sets are analytically derived for performance analysis.The second contribution lies in that a novel mode selection scheme is proposed to reduce the total interference between different modes.Numerical results show that system performance is less affected by the offset when the mode set with smaller modes or larger intervals is selected. 展开更多
关键词 Orbital angular momentum Millimeter wave off-axis misalignment Mode selection Capacity
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Collision off-axis position dependence of relativistic nonlinear Thomson inverse scattering of an excited electron in a tightly focused circular polarized laser pulse
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作者 王禹博 杨青屿 +2 位作者 常一凡 林宗熠 田友伟 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第1期344-354,共11页
This paper presents a novel view of the impact of electron collision off-axis positions on the dynamic properties and relativistic nonlinear Thomson inverse scattering of excited electrons within tightly focused, circ... This paper presents a novel view of the impact of electron collision off-axis positions on the dynamic properties and relativistic nonlinear Thomson inverse scattering of excited electrons within tightly focused, circularly polarized laser pulses of varying intensities. We examine the effects of the transverse ponderomotive force, specifically how the deviation angle and speed of electron motion are affected by the initial off-axis position of the electron and the peak amplitude of the laser pulse. When the laser pulse intensity is low, an increase in the electron's initial off-axis distance results in reduced spatial radiation power, improved collimation, super-continuum phenomena generation, red-shifting of the spectrum's harmonic peak, and significant symmetry in the radiation radial direction. However, in contradiction to conventional understandings,when the laser pulse intensity is relatively high, the properties of the relativistic nonlinear Thomson inverse scattering of the electron deviate from the central axis, changing direction in opposition to the aforementioned effects. After reaching a peak, these properties then shift again, aligning with the previous direction. The complex interplay of these effects suggests a greater nuance and intricacy in the relationship between laser pulse intensity, electron position, and scattering properties than previously thought. 展开更多
关键词 relativistic nonlinear Thomson inverse scattering off-axis collision radiation angle distribution tightly focused laser pulse
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异氟烷麻醉对小鼠自发肌电及TUS/TMAS诱发肌电的影响
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作者 王茹茹 周晓青 +4 位作者 赵渝卉 刘煦 刘志朋 王欣 殷涛 《中国生物医学工程学报》 CAS CSCD 北大核心 2024年第1期10-17,共8页
经颅超声刺激(TUS)和经颅磁声耦合刺激(TMAS)调控运动皮层效果明显,但受限于清醒状态动物难以束缚,已有研究大多在麻醉状态下进行,对麻醉减弱调控效果的分析集中于中枢神经系统。本研究记录了异氟烷麻醉下24只小鼠的肢体自发肌电和TUS/T... 经颅超声刺激(TUS)和经颅磁声耦合刺激(TMAS)调控运动皮层效果明显,但受限于清醒状态动物难以束缚,已有研究大多在麻醉状态下进行,对麻醉减弱调控效果的分析集中于中枢神经系统。本研究记录了异氟烷麻醉下24只小鼠的肢体自发肌电和TUS/TMAS诱发肌电,定量分析了麻醉对自发肌电和诱发肌电发放率、潜伏期、时长和幅值的影响。结果显示,随着异氟烷输出浓度从0.40%增加至0.75%,每周期内小鼠自发肌电频次减少约50%,肌电发放时长变短,呈抑制状态;TUS/TMAS诱发肌电的成功率分别降低约50%和70%、潜伏期均延长约0.1 s、时长分别缩短约0.3和0.5 s,表明TUS/TMAS对运动皮层的调控效果随麻醉程度的加深而减弱。肢体自发和诱发肌电在发放率和时长上存在关联性特征,提示麻醉状态下小鼠自发肌电抑制状态可能是刺激效果减弱的影响因素之一。 展开更多
关键词 经颅超声刺激(TUS) 经颅磁声耦合刺激(tmaS) 肌电 麻醉
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肠道菌群代谢物TMAO与非酒精性脂肪性肝病的关系
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作者 李媛媛 宋亚贤 +4 位作者 徐玉善 曾晓甫 袁惠 徐兆 江艳 《昆明医科大学学报》 CAS 2024年第2期77-84,共8页
目的检测NAFLD患者血清氧化三甲胺(TMAO)及其前体代谢物水平,及肠道中直肠真杆菌、多形拟杆菌、乳酸杆菌和双歧杆菌的表达量,探讨肠道菌群代谢物TMAO在NAFLD病程进展中的作用。方法随机选取118例受试者,分为NAFLD组86例和健康对照组32例... 目的检测NAFLD患者血清氧化三甲胺(TMAO)及其前体代谢物水平,及肠道中直肠真杆菌、多形拟杆菌、乳酸杆菌和双歧杆菌的表达量,探讨肠道菌群代谢物TMAO在NAFLD病程进展中的作用。方法随机选取118例受试者,分为NAFLD组86例和健康对照组32例,采用高效液相色谱串联质谱法检测受试者血清中TMAO及其前体代谢物的水平,qRT-PCR法检测粪便中目标细菌DNA的表达量。结果NAFLD患者血清TMAO、三甲胺(TMA)及胆碱水平明显升高(P<0.05),肝脏脂肪含量与TMAO的水平具有正相关性(P<0.05);NAFLD患者粪便中乳酸杆菌、直肠真杆菌表达量增加(P<0.05),双歧杆菌、多形拟杆菌表达量减少(P<0.05);血清TMAO水平与粪便中直肠真杆菌的数量呈正相关(r=0.280,P<0.05),与双歧杆菌的数量呈负相关(r=-0.332,P<0.05)。结论血清TMAO水平与NAFLD的严重程度呈正相关,NAFLD患者肠道菌群结构失衡,且与TMAO存在关联,推断肠道菌群可能通过代谢生成TMAO在NAFLD病程进展中起重要作用。 展开更多
关键词 非酒精性脂肪性肝病 氧化三甲胺 三甲胺 肠道菌群
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茱萸丸调控TMA/FMO3/TMAO通路促进胆固醇逆向转运抗动脉粥样硬化
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作者 宋玮 梁清芝 +1 位作者 张钟艺 沈涛 《中华中医药学刊》 CAS 北大核心 2024年第9期124-129,I0020-I0022,共9页
目的旨在研究茱萸丸对动脉粥样硬化(atherosclerosis,AS)形成的影响及其相关机制。方法采用高脂饲料喂养雄性载脂蛋白E基因敲除(ApoE^(-/-))小鼠诱导动脉粥样硬化模型,造模周期为12周。造模成功的47只ApoE^(-/-)小鼠随机分成5组,即模型... 目的旨在研究茱萸丸对动脉粥样硬化(atherosclerosis,AS)形成的影响及其相关机制。方法采用高脂饲料喂养雄性载脂蛋白E基因敲除(ApoE^(-/-))小鼠诱导动脉粥样硬化模型,造模周期为12周。造模成功的47只ApoE^(-/-)小鼠随机分成5组,即模型组10只,茱萸丸低、中、高剂量组各9只,阿托伐他汀钙组10只,以同周龄雄性C57BL/6J小鼠10只作为空白组。空白组与模型组予等体积无菌蒸馏水灌胃,茱萸丸低、中、高剂量组分别给予130.54、261.08、522.16 mg·kg^(-1)灌胃,阿托伐他汀钙组10.40 mg·kg^(-1)灌胃,每日1次,各组小鼠共灌胃12周。给药结束后,采用苏木精-伊红(HE)染色观测主动脉及肝脏病理变化;酶联免疫吸附测定法(ELISA)检测血清中氧化型低密度脂蛋白(ox-LDL)、单核细胞趋化蛋-1(MCP-1)、血管细胞黏附分-1(VCAM-1)、细胞间黏附分子-1(ICAM-1)水平;生化法检测肝脏总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平;超高效液相色谱-质谱联用技术(UHPLC-MS/MS)检测血浆三甲胺(TMA)、氧化三甲胺(TMAO)含量;免疫荧光法检测小鼠肝脏中二甲基苯胺单加氧酶3(FMO3)蛋白的表达水平;实时荧光定量聚合酶链式反应(real-time PCR)检测肝脏FMO3、腺苷三磷酸结合盒转运蛋白A1(ABCA1)、B族Ⅰ型清道夫受体(SR-B1)、ATP结合盒转运子G5抗体(ABCG5)、三磷酸腺苷结合盒转运体G8(ABCG8)和细胞色素P4507A1(CYP7A1)mRNA表达水平。结果与空白组比较,模型组小鼠HE染色可见主动脉内膜大面积增厚,肝脏脂肪变性及炎性浸润严重;血清中ox-LDL、MCP-1、VCAM-1、ICAM-1升高;肝脏TC、TG、LDL-C升高;血浆中TMA、TMAO水平升高;以及肝脏中FMO3 mRNA与蛋白表达水平升高,ABCA1、SR-B1、ABCG5、ABCG8、CYP7A1 mRNA表达水平升高(P<0.01)。与模型组比较,茱萸丸低、中、高剂量组及阿托伐他汀钙组HE染色随着茱萸丸浓度的增加,斑块富集区域逐渐缩小,肝脏脂肪变性及炎性浸润降低;血清中ox-LDL、MCP-1、VCAM-1、ICAM-1降低;肝脏TC、TG、LDL-C降低;血浆中TMA、TMAO水平降低;以及肝脏中FMO3 mRNA与蛋白表达水平降低,ABCA1、SR-B1、ABCG5、ABCG8、CYP7A1 mRNA表达水平降低(P<0.01或P<0.05)。结论茱萸丸对小鼠动脉粥样硬化斑块具有较好的治疗作用,其机制可能与调节TMA/FMO3/TMAO脂代谢通路,促进胆固醇的逆向转运和分解有关。 展开更多
关键词 茱萸丸 动脉粥样硬化 胆固醇逆向转运 tma/FMO3/tmaO脂代谢通路
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Simultaneous detection of CH_(4)and CO_(2)through dual modulation off-axis integrated cavity output spectroscopy
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作者 刘艺璇 王周兵 +3 位作者 韦欣欣 王静静 孟鑫 毛桂林 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第10期468-475,共8页
This study established a novel method for the simultaneous detection of two-component gases.Radio frequency(RF)white noise disturbance laser current and wavelength modulation were simultaneously used to improve the of... This study established a novel method for the simultaneous detection of two-component gases.Radio frequency(RF)white noise disturbance laser current and wavelength modulation were simultaneously used to improve the off-axis integrated cavity output spectroscopy technique,and a high-precision dual modulation OA-ICOS(RF-WM-OA-ICOS)system was established.The two laser beams were coupled into one laser beam that was applied incident to the cavity of RF-WM-OA-ICOS system.The second harmonic signals of CH_(4)and CO_(2)gas simultaneously appeared in the rising or falling edge of a triangular wave.This method was used to measure CH_(4)and CO_(2)with different concentrations.The results indicated that the proposed system has high stability and can accurately and simultaneously measure the concentrations of CH_(4)and CO_(2),with an optimal integration time of 220 s.The minimum detection limit was 10 ppb for CH_(4)and 1.5 ppm for CO_(2).The corresponding noise equivalent absorption sensitivity values were calculated as 2.67×10^(-13)cm^(-1)·Hz^(-1/2)and 5.18×10^(-11)cm^(-1)·Hz^(-1/2),respectively.The proposed dual-component gas simultaneous detection method can also be used for high-precision simultaneous detection of other gases.Therefore,this study may serve as a reference for developing portable multicomponent gas analyzers. 展开更多
关键词 off-axis integrated cavity output spectroscopy wavelength modulation radio frequency(RF)white noise simultaneous detection
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Characteristic Analysis of Off-Axis Meta-Lens
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作者 Jingaowa Hu Yang Liu +4 位作者 Shangnan Zhao Lingjie Wang Haokun Ye Jianping Zhang Xin Zhang 《Optics and Photonics Journal》 2023年第6期87-96,共10页
Meta-lens are a new type of planar optical element that can flexibly manipulate the phase, polarization and amplitude of the beam, and are currently receiving a great deal of attention as they are easier to process an... Meta-lens are a new type of planar optical element that can flexibly manipulate the phase, polarization and amplitude of the beam, and are currently receiving a great deal of attention as they are easier to process and manufacture. Off-axis meta-lens are a special type of meta-lens with a certain degree of dispersion that can be used as a beam-splitting element, providing a unique and feasible way to realize micro-miniature instruments. We analyze the effects of different numerical apertures and off-axis angles on the spectral resolution, focusing efficiency and simulation results of off-axis meta-lens to provide ideas for subsequent research and application of off-axis meta-lens. A number of off-axis meta-lens with parameters NA = 0.408 α = 13°, NA = 0.18 α = 13°<sup></sup> and NA = 0.408 α = 20° were simulated through Lumerical software. The results show that the off-axis angle is related to the resolution;the larger the angle, the better the spectral resolution but the lower the focusing efficiency;when the numerical aperture is smaller, the smaller the coverage of the phase distribution, which will lead to a larger deviation between simulation and theory. The designer needs to balance the numerical aperture, off-axis angle and other parameters reasonably according to the requirements in order to achieve the desired effect. The findings of this study have important reference values for the theoretical analysis of off-axis meta-lens and the design of parameters in practical applications. . 展开更多
关键词 Meta-Lens off-axis Meta-Lens Simulation Analysis
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Propagation of the off-axis superposition of partially coherent beams through atmospheric turbulence 被引量:5
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作者 张恩涛 季小玲 吕百达 《Chinese Physics B》 SCIE EI CAS CSCD 2009年第2期571-580,共10页
The propagation properties of the off-axis superposition of partially coherent beams through atmospheric turbulence and their beam quality in terms of the mean-squared beam width w(z) and the power in the bucket (... The propagation properties of the off-axis superposition of partially coherent beams through atmospheric turbulence and their beam quality in terms of the mean-squared beam width w(z) and the power in the bucket (PIB) are studied in detail, where the effects of partial coherence, off-axis beam superposition and atmospheric turbulence are considered. The analytical expressions for the intensity, the beam width and the PIB are derived, and illustrative examples are given numerically. It is shown that the maximum intensity/max and the PIB decrease and w(z) increases as the refraction index structure constant Cn^2 increases. Therefore, the turbulence results in a degradation of the beam quality. However, the resulting partially coherent beam with a smaller value of spatial correlation parameter γ and larger values of separate distance Xd and beam number M is less affected by the turbulence than that with a larger value of y and smaller values of Xd and M. The main results obtained in this paper are explained physically. 展开更多
关键词 off-axis superposition of partially coherent beams atmospheric turbulence propagation property beam quality
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Off-axis multi-wavelength dispersion controllingmetalens for multi-color imaging 被引量:17
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作者 Kaihua Dou Xin Xie +4 位作者 Mingbo Pu Xiong Li Xiaoliang Ma Changtao Wang Xiangang Luo 《Opto-Electronic Advances》 2020年第4期7-13,共7页
Dispersion control is crucial in optical systems,and chromatic aberration is an important factor affecting imaging quality in imaging systems.Due to the inherent property of materials,dispersion engineering is complex... Dispersion control is crucial in optical systems,and chromatic aberration is an important factor affecting imaging quality in imaging systems.Due to the inherent property of materials,dispersion engineering is complex and needs to trade off other aberration in traditional ways.Although metasurface offers an effective method to overcome these limits and results in well-engineered dispersion,off-axis dispersion control is still a challenging topic.In this paper,we design a single-layer metalens which is capable of focusing at three wavelengths(473 nm,532 nm,and 632 nm)with different incident angles(0°,-17°and 17°)into the same point.We also demonstrate that this metalens can provide an alternative for the bulky color synthetic prism in a 3-chips digital micromirror device(DMD)laser projection system.Through this approach,various off-axis dispersion controlling optical devices could be realized. 展开更多
关键词 off-axis DISPERSION control metalens COLOR imaging
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Far-field vector-diffraction of off-axis parabolic mirror under oblique incidence 被引量:2
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作者 Xia-Hui Zeng Xi-Yao Chen 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第3期190-201,共12页
Based on a full vector-diffraction theory, a detailed theoretical study is carried out, aiming at providing a clear insight into the effects of different focusing and off-axis parabola parameters on far-field vector-d... Based on a full vector-diffraction theory, a detailed theoretical study is carried out, aiming at providing a clear insight into the effects of different focusing and off-axis parabola parameters on far-field vector-diffraction properties of an offaxis parabolic mirror in the presence of misalignments of the incoming beam. The physical origin of these effects is also explored. The results show that the far-field intensity profile is altered by the distortion-, coma-, and astigmatism-like aberrations, which are caused by oblique incidence rather than inherent aberrations for the off-axis configuration. The radius of 90% encircled energy also increases but does not change monotonically with incident beam size increasing, or rather,it first decreases and then increases. The focal shift strongly depends on the effective focal length and oblique incidence angle, but it is almost independent of the beam size, which affects the focusing spot patterns. The intensity distribution produces a higher astigmatic image with off-axis angle increasing. Coma-like aberration starts to become dominant with beam size increasing and results in larger curved propagation trajectory. The incident polarization also affects the intensity distribution. The variation in the Strehl ratio with oblique incidence angle strongly depends on the misalignment direction and beam size as well. In addition, we find that the difference in locus between the catacaustic and the diffraction focus in the meridian is small. But the locus of the sagittal foci is obviously different from the locus of the meridian foci and the catacaustic focus. Moreover, the peak intensity of the sagittal focus is maximum, and the ratio of the peak intensity to that in the meridian plane is approximately 1.5. Understanding these effects is valuable for assessing a practical focused intensity and describing the motion of charged particles under a strong electric field in ultraintense laser–matter interaction. 展开更多
关键词 laser beam focusing off-axis PARABOLIC MIRROR vector-diffraction theory oblique incidence
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Study of structure-property relationship of semiconductor nanomaterials by off-axis electron holography 被引量:1
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作者 Luying Li Yongfa Cheng +5 位作者 Zunyu Liu Shuwen Yan Li Li Jianbo Wang Lei Zhang Yihua Gao 《Journal of Semiconductors》 EI CAS CSCD 2022年第4期36-45,共10页
As the scaling down of semiconductor devices, it would be necessary to discover the structure-property relationship of semiconductor nanomaterials at nanometer scale. In this review, the quantitative characterization ... As the scaling down of semiconductor devices, it would be necessary to discover the structure-property relationship of semiconductor nanomaterials at nanometer scale. In this review, the quantitative characterization technique off-axis electron holography is introduced in details, followed by its applications in various semiconductor nanomaterials including group IV, compound and two-dimensional semiconductor nanostructures in static states as well as under various stimuli. The advantages and disadvantages of off-axis electron holography in material analysis are discussed, the challenges facing in-situ electron holographic study of semiconductor devices at working conditions are presented, and all the possible influencing factors need to be considered to achieve the final goal of fulfilling quantitative characterization of the structure-property relationship of semiconductor devices at their working conditions. 展开更多
关键词 semiconductor nanostructure structure-property relationship off-axis electron holography electrostatic potential charge distribution
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Multiple off-axis acoustic vortices generated by dual coaxial vortex beams 被引量:3
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作者 李雯 戴思捷 +2 位作者 马青玉 郭各朴 丁鹤平 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第2期393-400,共8页
As a kind of special acoustic field, the helical wavefront of an acoustic vortex(AV) beam is demonstrated to have a pressure zero with phase singularity at the center in the transverse plane. The orbital angular mom... As a kind of special acoustic field, the helical wavefront of an acoustic vortex(AV) beam is demonstrated to have a pressure zero with phase singularity at the center in the transverse plane. The orbital angular momentum of AVs can be applied to the field of particle manipulation, which attracts more and more attention in acoustic researches. In this paper,by using the simplified circular array of point sources, dual coaxial AV beams are excited by the even-and odd-numbered sources with the topological charges of l_E and l_O based on the phase-coded approach, and the composite acoustic field with an on-axis center-AV and multiple off-axis sub-AVs can be generated by the superimposition of the AV beams for|l_E| ≠ |l_O|. The generation of edge phase dislocation is theoretically derived and numerically analyzed for l_E=-l_O. The numbers and the topological charges as well as the locations of the center-AV and sub-AVs are demonstrated, which are proved to be determined by the topological charges of the coaxial AV beams. The proposed approach breaks through the limit of only one on-axis AV with a single topological charge along the beam axis, and also provides the feasibility of off-axis particle trapping with multiple AVs in object manipulation. 展开更多
关键词 dual coaxial acoustic vortex(AV) beams multiple off-axis AVs on-axis center-AV topological charge phase-coded approach
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系统性红斑狼疮合并TMA一例 被引量:1
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作者 吴佳瑾 任洁 《海南医学》 CAS 2023年第11期1629-1632,共4页
一例早期确诊为系统性红斑狼疮的青年女性,病程长且反复发作,随着病程进展出现严重的血液系统损害,完善相关检查及肾活检后最终确诊为“狼疮肾炎Ⅳ+Ⅴ型伴TMA肾损伤”。予以激素冲击联合血浆置换、环磷酰胺联合贝利尤单抗免疫抑制治疗,... 一例早期确诊为系统性红斑狼疮的青年女性,病程长且反复发作,随着病程进展出现严重的血液系统损害,完善相关检查及肾活检后最终确诊为“狼疮肾炎Ⅳ+Ⅴ型伴TMA肾损伤”。予以激素冲击联合血浆置换、环磷酰胺联合贝利尤单抗免疫抑制治疗,取得较好效果。本病例警示临床医生对于狼疮肾炎的鉴别诊断,需考虑肾血管病变的存在,并积极治疗。 展开更多
关键词 系统性红斑狼疮 狼疮肾炎 血栓性微血管病变 鉴别诊断
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基于TMA/FMO3/TMAO通路探讨参竹心康方治疗慢性心力衰竭模型大鼠的作用机制 被引量:1
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作者 赵启 赵梦雪 袁清照 《世界中西医结合杂志》 2023年第10期1995-2000,共6页
目的探讨参竹心康方对慢性心力衰竭模型大鼠的治疗作用及机制。方法将50只SPF级雄性SD大鼠按随机数字表法分为对照组,模型组,参竹心康方低、中、高剂量组,每组各10只。慢性心力衰竭大鼠模型的制备选择腹主动脉缩窄法,治疗组予参竹心康... 目的探讨参竹心康方对慢性心力衰竭模型大鼠的治疗作用及机制。方法将50只SPF级雄性SD大鼠按随机数字表法分为对照组,模型组,参竹心康方低、中、高剂量组,每组各10只。慢性心力衰竭大鼠模型的制备选择腹主动脉缩窄法,治疗组予参竹心康方灌胃,余下两组予生理盐水灌胃,此过程持续4周。末次给药后用小动物超声心动图检查大鼠心功能,WB检测肝脏黄素单氧化酶3(Flavin-containing monooxygenase 3,FMO3)表达水平,ELISA法测定血浆B型脑钠肽(Brain Natriuretic Peptide,BNP)、氧化三甲胺(Oxidetrimethylamine,TMAO)及粪便中三甲胺(Trimetlylamine,TMA)的表达,采用16SrDNA高通量测序法检测大鼠结肠内容物的菌群特征。结果与对照组比较,模型组LVESD、LVEDD指标水平明显升高,LVEF水平明显降低,差异有统计学意义(P<0.05);与模型组比较,参竹心康方低、中、高剂量组LVESD、LVEDD指标水平明显降低,LVEF水平明显升高,差异有统计学意义(P<0.05)。与对照组比较,模型组中FMO3的含量明显升高,差异有统计学意义(P<0.05);与模型组比较,参竹心康方低、中、高剂量组中FMO3的含量明显降低差异有统计学意义(P<0.05)。与对照组比较,模型组中TMA的表达量明显升高,差异有统计学意义(P<0.05);与模型组比较,参竹心康方低、中剂量组中TMA含量明显降低,差异有统计学意义(P<0.05)。与对照组比较,模型组大鼠血浆BNP、TMAO含量均明显升高,差异有统计学意义(P<0.05);药物治疗之后,参竹心康方低、中、高剂量组BNP、TMAO含量较模型组均明显降低,差异有统计学意义(P<0.05)。与对照组比较,模型组Shannon、Chao1指数值升高,Simpson指数值下降,差异有统计学意义(P<0.05)。参竹心康中剂量组Shannon、Chao1、Simpson指数值回调与模型组比较,差异有统计学意义(P<0.05)。肠道菌群的Alpha、Beta多样性分析表明,与对照组比较,模型组大鼠菌群丰度及多样性呈下降趋势,而参竹心康方组大鼠肠菌的丰富度及多样性均明显增加。结论参竹心康方对慢性心力衰竭大鼠的保护作用可能与改善肠道菌群紊乱、调控TMA/FMO3/TMAO通路及其相关蛋白的表达相关。 展开更多
关键词 参竹心康方 慢性心力衰竭 肠道菌群 tma/FMO3/tmaO通路
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Optical Design for the Off-axis Reflective Optics with Wide Field
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作者 ZHANGXin CHANGJun +3 位作者 WENGZhi-cheng JIANGHui-lin CONGXiao-jie LUYong-jun 《光学精密工程》 EI CAS CSCD 2001年第5期483-486,共4页
Reflective optics with wide field of view has been applied more and more widely in EUVL or space optics, and also plays an important role in promoting scientific and technological research. Among the reflective optics... Reflective optics with wide field of view has been applied more and more widely in EUVL or space optics, and also plays an important role in promoting scientific and technological research. Among the reflective optics, the off-axis reflective optics is the most hopeful solution to the ever-highest demands of these applications. This paper gives the requirements of both the above mentioned applications and the similarities and differences between these two kinds of optical systems. Finally, a design example of off-axis reflective optics with wide field of view is presented and described. 展开更多
关键词 OPTICAL design off-axis REFLECTIVE OPTICS space OPTICS EUVL
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Derivative Form of Off-axis Aberration Correction Surface and Its Application in Solar Energy Concentration
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作者 LI Li CHEN Ying-Tian HU Sen 《Communications in Theoretical Physics》 SCIE CAS CSCD 2009年第2期315-320,共6页
By using the derivative method, we obtained the same result with that of the previous work of Chen et al. in 2006. Different from the integral form, the derivative form of the surface expression published in this pape... By using the derivative method, we obtained the same result with that of the previous work of Chen et al. in 2006. Different from the integral form, the derivative form of the surface expression published in this paper is derived from differential equation and based on the theory of non-imaging focusing heliostat proposed by Chen et al. in 2001. The comparison of the derivative form of fixed aberration correction surface has been made with that of integral form surface as well as that of spherical surface in concentrating the solar ray. 展开更多
关键词 off-axis aberration correction canting continuous surface asymmetric curvature
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Properties of off-axis hollow Gaussian–Schell model vortex beam propagating in turbulent atmosphere
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作者 Yan-Song Song Ke-Yan Dong +2 位作者 Shuai Chang Yan Dong Lei Zhang 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第6期230-236,共7页
The analytical expression of off-axis hollow Gaussian–Schell model vortex beam(HGSMVB)generated by anisotropic Gaussian–Schell model source is first introduced.The evolution properties of off-axis HGSMVB propagating... The analytical expression of off-axis hollow Gaussian–Schell model vortex beam(HGSMVB)generated by anisotropic Gaussian–Schell model source is first introduced.The evolution properties of off-axis HGSMVB propagating in turbulent atmosphere are analyzed.The results show that the off-axis HGSMVB with smaller coherence length or propagating in stronger turbulent atmosphere will evolve from dark hollow beam into Gaussian-like beam with a larger beam spot faster.The beams with different values of integer order N or the position for hollow and vortex factor R will have almost the same Gaussian-like spot distribution at the longer propagation distance. 展开更多
关键词 vortex beam off-axis beam Gaussian-Schell model sources laser propagation INTENSITY
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Effects of trapped electrons on off-axis lower hybrid current drive in tokamaks
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作者 焦一鸣 龙永兴 +3 位作者 董家齐 高庆弟 王爱科 刘永 《Chinese Physics B》 SCIE EI CAS CSCD 2007年第11期3464-3469,共6页
The effects of trapped electrons on off-axis lower hybrid current drive (LHCD) in tokamaks are studied, A computer code for solving the Fokker-Planck equation in a toroidal geometry is developed and employed. The co... The effects of trapped electrons on off-axis lower hybrid current drive (LHCD) in tokamaks are studied, A computer code for solving the Fokker-Planck equation in a toroidal geometry is developed and employed. The code is suitable for various auxiliary heating and current drive schemes in tokamak plasmas. The influence of the resonance regime on the current drive efficiency as well as the influence of trapped particle fraction on the current drive efficiency are emphasized. It is shown that, as an electrostatic force, the lower hybrid wave causes some of the trapped electrons to be untrapped and lose their energy, which can cut the LHCD efficiency by about 30%. The ITER scaling law is also used to estimate the trapped electron effects. 展开更多
关键词 trapping electron effect off-axis lower hybrid current drive
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Nonparaxial propagation of a vectorial apertured off-axis Lorentz beam
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作者 周国泉 《Chinese Physics B》 SCIE EI CAS CSCD 2009年第5期1853-1860,共8页
Based on the vectorial Ftayleigh-Sommerfeld integral formula and the complex Gaussian expansion of the hardedge aperture function, an analytical propagation expression for a nonparaxial vectorial off-axis Lorentz beam... Based on the vectorial Ftayleigh-Sommerfeld integral formula and the complex Gaussian expansion of the hardedge aperture function, an analytical propagation expression for a nonparaxial vectorial off-axis Lorentz beam passing through a rectangular aperture is derived. The unapertured case, the far field expression and the scalar paraxial result are also presented as special cases of the general formulae, respectively. Some numerical examples are also given to show the propagation characteristics of a nonparaxial vectorial off-axis Lorentz beam through a rectangular aperture. It is indicated that the f parameter, the off-axis displacement and the truncation parameter all play an important role in determining nonparaxial propagation behaviour. 展开更多
关键词 vectorial Rayleigh-Sommerfeld integral nonparaxial vectorial off-axis Lorentz beam rectangular aperture
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