AIM: To investigate the efficacy and safety of n-3 polyunsaturated fatty acids (PUFA) from seal oils for patients with nonalcoholic fatty liver disease (NAFLD) associated with hyperlipidemia. METHODS: One hundred and ...AIM: To investigate the efficacy and safety of n-3 polyunsaturated fatty acids (PUFA) from seal oils for patients with nonalcoholic fatty liver disease (NAFLD) associated with hyperlipidemia. METHODS: One hundred and forty-four patients with NAFLD associated with hyperlipidemia were included in the 24-wk, randomized, controlled trial. The patients were randomized into two groups. Group A (n = 72) received recommended diet and 2 g n-3 PUFA from seal oils, three times a day. Group B (n = 72) received recommended diet and 2 g placebo, three times a day. Primary endpoints were fatty liver assessed by symptom scores, liver alanine aminotransferase (ALT) and serum lipid levels after 8, 12, 16, and 24 wk. Hepatic fat inf iltration was detected by ultrasonography at weeks 12 and 24 after treatment. RESULTS: A total of 134 patients (66 in group A, 68 in group B) were included in the study except for 10 patients who were excluded from the study. After 24 wk of treatment, no change was observed in body weight, fasting blood glucose (FBG), renal function and blood cells of these patients. Total symptom scores, ALT and triglyceride (TG) levels decreased more significantly in group A than in group B (P < 0.05). As expected, there was a tendency toward improvement in aspartate aminotransferase (AST), γ-glutamyltranspeptidase (GGT), and total cholesterol (TCHO) and high- density lipoprotein (HDL) cholesterol levels (P < 0.05) after administration in the two groups. However, no significant differences were found between the two groups. The values of low-density lipoprotein (LDL) were significantly improved in group A (P < 0.05), but no significant change was found in group B at different time points and after a 24-wk treatment. After treatment, complete fatty liver regression was observed in 19.70% (13/66) of the patients, and an overall reduction was found in 53.03% (35/66) of the patients in group A. In contrast, in group B, only f ive patients (7.35%, 5/68) achieved complete fatty liver regression (P = 0.04), whereas 24 patients (35.29%, 24/68) had a certain improvement in fatty liver (P = 0.04). No serious adverse events occurred in all the patients who completed the treatment. CONCLUSION: Our results indicate that n-3 PUFA from seal oils is safe and effi cacious for patients with NAFLD associated with hyperlipidemia and can improve their total symptom scores, ALT, serum lipid levels and normalization of ultrasonographic evidence. Further study is needed to confi rm these results.展开更多
The manufacturing industry today due to worldwide competition is focused on shorter development cycle. In this situation, computer aided education （CAE） technology as a tool for simultaneous achievement of quality, ...The manufacturing industry today due to worldwide competition is focused on shorter development cycle. In this situation, computer aided education （CAE） technology as a tool for simultaneous achievement of quality, cost and delivery （QCD） plays an important role. The hardware-software environment surrounding CAE has evolved. Though technological problems have been understood and general solutions have been derived and reflected in the CAE analysis software, research findings that boost the credibility of CAE have still not been incorporated fully enough into the development of design process. The real technical mechanism issue is not precisely capture. Therefore, it is important to clarify the real cause in CAE results through CAE simulation in order to assure product reliability and assurance. It is the aim of this study to realize the prediction of design analysis process through understanding of unclear technical mechanism in abnormal occurrences with the utilization of CAE simulation. In other words, it is the aim of this study to focus on issue in automotive transaxle oil seal leakage to understand, grasp, and visualize the main cause through usage of CAE analysis process. It is understood that the point of contact and pump volume was related and this could contribute towards seals quality design. Plus, the utilization of CAE analysis in prediction phase to realized design development is also possible展开更多
Experimental investigation has been done to evaluate the leakage performance of labyrinth seal for oil sealing on high-speed sealing test rig at different working and geometric parameters.Typical values of pressure ra...Experimental investigation has been done to evaluate the leakage performance of labyrinth seal for oil sealing on high-speed sealing test rig at different working and geometric parameters.Typical values of pressure ratio ranging from 1.0 to 2.0 were used and the rotating speed varied from 0 to 30,000 tpm.Dimensionless Taylor number was invited to response the effect of rotation.Oil was injected at the rate from 1.2 L/min to 2.8 L/min to check the sealing capacity.Leakage was measured at different seal configurations including sealing clearance,tooth tip thickness,pitch,teeth number,front inclined angle and oil-throwing angle.Different from gas sealing,the application of oil-throwing tooth in oil sealing attracted much interest as an obvious alternative to the conventional labyrinth seal.A blocking ring was captured during testing,which establishes understanding of underlying flow mechanisms in the clearance and plays an important role in oil sealing.There is a critical Taylor number at which the leakage coefficient drops drastically.After the critical Taylor number,a parabola rule appears.An optimal composition of tooth tip thickness,teeth number,oil-throwing angle and front inclined angle exists where the leakage performance behaves better.展开更多
This paper focuses on a strategic improving quality of＂high quality assurance CAE （computer aided engineering） analysis model＂ to be used in development design. The authors present a case oftransaxle oil seal leak...This paper focuses on a strategic improving quality of＂high quality assurance CAE （computer aided engineering） analysis model＂ to be used in development design. The authors present a case oftransaxle oil seal leakage in automotive drive trains, a technical reliability problem that generates bottlenecks for auto manufacturers around the world. The application of this model is used to analyze cavitation caused by the metal particles （foreign matter） generated through transaxle wear. This analyzing method primarily uses numerical simulation （CAE） to clarify the technological mechanism generating oil leaks as a result of foreign metallic substances entering oil seals in the drive train. Quality improvement using this CAE analyzing method was verified by successfully applying it to the technological problem of development design bottlenecks at auto manufacturers.展开更多
基金Supported by Shanghai Natural Science Fund of China, 05ZR14156
文摘AIM: To investigate the efficacy and safety of n-3 polyunsaturated fatty acids (PUFA) from seal oils for patients with nonalcoholic fatty liver disease (NAFLD) associated with hyperlipidemia. METHODS: One hundred and forty-four patients with NAFLD associated with hyperlipidemia were included in the 24-wk, randomized, controlled trial. The patients were randomized into two groups. Group A (n = 72) received recommended diet and 2 g n-3 PUFA from seal oils, three times a day. Group B (n = 72) received recommended diet and 2 g placebo, three times a day. Primary endpoints were fatty liver assessed by symptom scores, liver alanine aminotransferase (ALT) and serum lipid levels after 8, 12, 16, and 24 wk. Hepatic fat inf iltration was detected by ultrasonography at weeks 12 and 24 after treatment. RESULTS: A total of 134 patients (66 in group A, 68 in group B) were included in the study except for 10 patients who were excluded from the study. After 24 wk of treatment, no change was observed in body weight, fasting blood glucose (FBG), renal function and blood cells of these patients. Total symptom scores, ALT and triglyceride (TG) levels decreased more significantly in group A than in group B (P < 0.05). As expected, there was a tendency toward improvement in aspartate aminotransferase (AST), γ-glutamyltranspeptidase (GGT), and total cholesterol (TCHO) and high- density lipoprotein (HDL) cholesterol levels (P < 0.05) after administration in the two groups. However, no significant differences were found between the two groups. The values of low-density lipoprotein (LDL) were significantly improved in group A (P < 0.05), but no significant change was found in group B at different time points and after a 24-wk treatment. After treatment, complete fatty liver regression was observed in 19.70% (13/66) of the patients, and an overall reduction was found in 53.03% (35/66) of the patients in group A. In contrast, in group B, only f ive patients (7.35%, 5/68) achieved complete fatty liver regression (P = 0.04), whereas 24 patients (35.29%, 24/68) had a certain improvement in fatty liver (P = 0.04). No serious adverse events occurred in all the patients who completed the treatment. CONCLUSION: Our results indicate that n-3 PUFA from seal oils is safe and effi cacious for patients with NAFLD associated with hyperlipidemia and can improve their total symptom scores, ALT, serum lipid levels and normalization of ultrasonographic evidence. Further study is needed to confi rm these results.
文摘The manufacturing industry today due to worldwide competition is focused on shorter development cycle. In this situation, computer aided education （CAE） technology as a tool for simultaneous achievement of quality, cost and delivery （QCD） plays an important role. The hardware-software environment surrounding CAE has evolved. Though technological problems have been understood and general solutions have been derived and reflected in the CAE analysis software, research findings that boost the credibility of CAE have still not been incorporated fully enough into the development of design process. The real technical mechanism issue is not precisely capture. Therefore, it is important to clarify the real cause in CAE results through CAE simulation in order to assure product reliability and assurance. It is the aim of this study to realize the prediction of design analysis process through understanding of unclear technical mechanism in abnormal occurrences with the utilization of CAE simulation. In other words, it is the aim of this study to focus on issue in automotive transaxle oil seal leakage to understand, grasp, and visualize the main cause through usage of CAE analysis process. It is understood that the point of contact and pump volume was related and this could contribute towards seals quality design. Plus, the utilization of CAE analysis in prediction phase to realized design development is also possible
基金This work was supported by the National Natural Science Foundation of China(Grant No.51576193 and No.51706223).
文摘Experimental investigation has been done to evaluate the leakage performance of labyrinth seal for oil sealing on high-speed sealing test rig at different working and geometric parameters.Typical values of pressure ratio ranging from 1.0 to 2.0 were used and the rotating speed varied from 0 to 30,000 tpm.Dimensionless Taylor number was invited to response the effect of rotation.Oil was injected at the rate from 1.2 L/min to 2.8 L/min to check the sealing capacity.Leakage was measured at different seal configurations including sealing clearance,tooth tip thickness,pitch,teeth number,front inclined angle and oil-throwing angle.Different from gas sealing,the application of oil-throwing tooth in oil sealing attracted much interest as an obvious alternative to the conventional labyrinth seal.A blocking ring was captured during testing,which establishes understanding of underlying flow mechanisms in the clearance and plays an important role in oil sealing.There is a critical Taylor number at which the leakage coefficient drops drastically.After the critical Taylor number,a parabola rule appears.An optimal composition of tooth tip thickness,teeth number,oil-throwing angle and front inclined angle exists where the leakage performance behaves better.
文摘This paper focuses on a strategic improving quality of＂high quality assurance CAE （computer aided engineering） analysis model＂ to be used in development design. The authors present a case oftransaxle oil seal leakage in automotive drive trains, a technical reliability problem that generates bottlenecks for auto manufacturers around the world. The application of this model is used to analyze cavitation caused by the metal particles （foreign matter） generated through transaxle wear. This analyzing method primarily uses numerical simulation （CAE） to clarify the technological mechanism generating oil leaks as a result of foreign metallic substances entering oil seals in the drive train. Quality improvement using this CAE analyzing method was verified by successfully applying it to the technological problem of development design bottlenecks at auto manufacturers.
