目的使用传统指标和FT-IR技术评价乳剂稳定性。方法通过两步乳化法制备O/W乳剂,以平均粒径、离心稳定常数及表面张力3个指标对乳剂进行表征。用浸渍法分别测定水相、油相和乳剂的傅里叶变换红外光谱(FT-IR)图,再用软件origin 7.5对水相...目的使用传统指标和FT-IR技术评价乳剂稳定性。方法通过两步乳化法制备O/W乳剂,以平均粒径、离心稳定常数及表面张力3个指标对乳剂进行表征。用浸渍法分别测定水相、油相和乳剂的傅里叶变换红外光谱(FT-IR)图,再用软件origin 7.5对水相和乳剂的羟基峰进行去卷积,根据最小二乘法拟合出组成羟基峰的高斯曲线。结果 2个乳剂的平均粒径分别为155.9 nm和138.5 nm,离心稳定常数分别为0.377和0.561,表面张力分别为54.22 m N/m和64.80 m N/m;制成乳剂后,FT-IR图中油相的信号峰几乎完全消失,而水相和乳剂的FT-IR图中,羟基峰均由6条高斯曲线组成,乳剂中5条高斯曲线的峰位对比于水相都发生了蓝移。结论定量的传统指标和定性的FT-IR技术相结合,可以更好地评价乳剂的稳定性。展开更多
The transfer phenomena of quinine drug at the aqueous 1,2- dichloroethane (DCE)interface have been studied by the current- scanning polarography. The relationships be-tween the wave height and pH of aqueous phase, con...The transfer phenomena of quinine drug at the aqueous 1,2- dichloroethane (DCE)interface have been studied by the current- scanning polarography. The relationships be-tween the wave height and pH of aqueous phase, concentration of quinine as well as therate of water drop are discussed. The effect of supporting electrolyte, buffer solution andthe nature of organic solvent on the polarographic wave is studied. The transfer char-acteristics of quinine in aqueous phase and in organic phase are compared, The mono- pro-tonated and diprotonated quinines can both transfer at the interface so as to produce twopolarographic waves. The transfer process of quinine at the interface is simultaneouslycontrolled by diffusion and reestablishment of the disturbed protonated equilibrium ofquinine. A further investigation is made by chronopotentiometry. On the basis of thetheoretical analysis, the formulae of the limiting current are derived and discussed. Thetheoretical results are in agreement with the experimental ones. The transfer mechanismof quinine is put forward.展开更多
文摘目的使用传统指标和FT-IR技术评价乳剂稳定性。方法通过两步乳化法制备O/W乳剂,以平均粒径、离心稳定常数及表面张力3个指标对乳剂进行表征。用浸渍法分别测定水相、油相和乳剂的傅里叶变换红外光谱(FT-IR)图,再用软件origin 7.5对水相和乳剂的羟基峰进行去卷积,根据最小二乘法拟合出组成羟基峰的高斯曲线。结果 2个乳剂的平均粒径分别为155.9 nm和138.5 nm,离心稳定常数分别为0.377和0.561,表面张力分别为54.22 m N/m和64.80 m N/m;制成乳剂后,FT-IR图中油相的信号峰几乎完全消失,而水相和乳剂的FT-IR图中,羟基峰均由6条高斯曲线组成,乳剂中5条高斯曲线的峰位对比于水相都发生了蓝移。结论定量的传统指标和定性的FT-IR技术相结合,可以更好地评价乳剂的稳定性。
基金Project supported by the National Natural Science Foundation of China.
文摘The transfer phenomena of quinine drug at the aqueous 1,2- dichloroethane (DCE)interface have been studied by the current- scanning polarography. The relationships be-tween the wave height and pH of aqueous phase, concentration of quinine as well as therate of water drop are discussed. The effect of supporting electrolyte, buffer solution andthe nature of organic solvent on the polarographic wave is studied. The transfer char-acteristics of quinine in aqueous phase and in organic phase are compared, The mono- pro-tonated and diprotonated quinines can both transfer at the interface so as to produce twopolarographic waves. The transfer process of quinine at the interface is simultaneouslycontrolled by diffusion and reestablishment of the disturbed protonated equilibrium ofquinine. A further investigation is made by chronopotentiometry. On the basis of thetheoretical analysis, the formulae of the limiting current are derived and discussed. Thetheoretical results are in agreement with the experimental ones. The transfer mechanismof quinine is put forward.
