1-H-Pyrrole-2-carboxylic acid [2-（naphthalen-1-ylamino）-ethyl]-amide has been synthesized and characterized. Its crystal is of monoclinic, space group P2 1/n with a = 5.930（6）, b = 12.144（13）, c = 20.10（2） , ...1-H-Pyrrole-2-carboxylic acid [2-（naphthalen-1-ylamino）-ethyl]-amide has been synthesized and characterized. Its crystal is of monoclinic, space group P2 1/n with a = 5.930（6）, b = 12.144（13）, c = 20.10（2） , A, β = 95.709（17）°, V= 1441（3） ,A, Z= 4, C17H17N3O, Mr= 279.34, Dc= 1.288 g/cm^3, F（000） = 592, μ（MoKa） = 0.083 mm^-1, S = 1.019, R = 0.0473 and wR = 0.1181 for 1713 observed reflections with I 〉 2 σ（I）. X-ray diffraction reveals that two molecules of the title compound form a dimer through a pair of N-H…O hydrogen bonds.展开更多
A convenient and easy method is described for the formation of carboxamides from carboxylic acids and primary amines in solventless conditions using infrared (IR) light. Thus, under IR light, cinnamic acid derivatives...A convenient and easy method is described for the formation of carboxamides from carboxylic acids and primary amines in solventless conditions using infrared (IR) light. Thus, under IR light, cinnamic acid derivatives and amines can produce yields ranging from 50% to 85% of the resulting amide.展开更多
We describe an iron-catalyzed amide bond formation from readily available carboxylic acids and isocyanates.This method utilizes an abundant and biocompatible iron catalyst and easily accessible starting materials,gene...We describe an iron-catalyzed amide bond formation from readily available carboxylic acids and isocyanates.This method utilizes an abundant and biocompatible iron catalyst and easily accessible starting materials,generates CO_(2) as the only byproduct,and features broad substrate scopes with good functional group compatibility.Therefore,it provides a cost-effective and practical protocol to access a diverse variety of amides.展开更多
A highly efficient copper-catalyzed approach to form amide bonds from formamides and carboxylic acids was developed. This protocol shows broad substrate scopes and high yields in the presence of 1 mol% catalyst and 4....A highly efficient copper-catalyzed approach to form amide bonds from formamides and carboxylic acids was developed. This protocol shows broad substrate scopes and high yields in the presence of 1 mol% catalyst and 4.0 equiv, formamides.展开更多
An efficient solid phase route for the synthesis of amide derivatives by the reaction of carboxylic acids with urea in the presence of catalytic amount of zirconyl chloride under microwave irradiation conditions was d...An efficient solid phase route for the synthesis of amide derivatives by the reaction of carboxylic acids with urea in the presence of catalytic amount of zirconyl chloride under microwave irradiation conditions was described. In this way, a range of interesting amide derivatives was obtained in good to excellent yields. The catalyst was recycled with fresh reactants and it gave almost similar results without significant loss of activity up to the third run.展开更多
A copper-catalyzed decarboxylative oxidative coupling of α,β-unsaturated carboxylic acids with non-cyclic ethers is developed.This method provides a new approach for C(sp^3)–H bond functionalization of non-cyclic e...A copper-catalyzed decarboxylative oxidative coupling of α,β-unsaturated carboxylic acids with non-cyclic ethers is developed.This method provides a new approach for C(sp^3)–H bond functionalization of non-cyclic ethers. Mechanism study shows the reaction involves a radical process.展开更多
The deoxyfluorination of carboxylic,sulfonic,phosphinic acids and phosphine oxides is a fundamentally important approach to access acyl fluorides,sulfonyl fluorides and phosphoric fluorides,thus the development of ine...The deoxyfluorination of carboxylic,sulfonic,phosphinic acids and phosphine oxides is a fundamentally important approach to access acyl fluorides,sulfonyl fluorides and phosphoric fluorides,thus the development of inexpensive,stable,easy-to-handle,versatile,and efficient deoxyfluorination reagents is highly desired.Herein,we report the use of potassium salts of perfluoroalkyl ether carboxylic acids(PFECA)featuring CF_(2)0 units as deoxyfluorination reagents,which are generated mainly as by-products in the manufacture of hexafluoropropene oxide(HFPO).The synthesis of acyl fluorides,sulfonyl fluorides and phosphoric fluorides can be realized via carbonic difluoride(COF_(2))generated in situ from thermal degradation of the PFECA salt.展开更多
N,N-dibutyldiglycol amic acid （HL1） and N,N-dioctyldiglycol nmic acid （HLu） were synthesized and characterized by conventional spectroscopic methods. These molecules were examined as extractants for extraction-sep...N,N-dibutyldiglycol amic acid （HL1） and N,N-dioctyldiglycol nmic acid （HLu） were synthesized and characterized by conventional spectroscopic methods. These molecules were examined as extractants for extraction-separation of La（Ⅲ）, Eu（Ⅲ） and Er（Ⅲ）, as representative ions of light, middle and heavy rare earths, from aqueous chloride solutions. The analysis of the extraction equilibria revealed that the extracted species of lanthanum and europium ions by both of the extractants had a 1：3 metal to ligand ratio It was suggested that erbium ions were extracted into the organic phase via the formation ofEr（LIor Ⅱ）2Cl complexes. The effect of the organic diluents on the extraction-separation efficiency of the studied rare earths by HLI and HLⅡ was investigated by comparing the results obtained in dichloromethane and carbon tetrachloride. Regardless to the diluent used, the order of selectivity presented by the investigated extractants was Er（Ⅲ）〉Eu（Ⅲ）〉La（Ⅲ）. It is noteworthy that, a significant enhancement in separation of the studied rare earths by the extractants was achieved in their competitive extraction experiments with respect to that obtained in single component extraction experiments. Applicability of the extractants for the removal of rare earth ions from spent Ni-MH batteries was tested by removal ofLa（Ⅲ）, Eu（Ⅲ） and Er（Ⅲ） ions from simulated leach solution of such batteries.展开更多
An oxidative amidation of tertiary amines with carboxylic acids has been developed in the presence of FeC13- 6H20 as catalyst and oxygen as oxidant. A variety of tertiary amides were obtained in good to excellent yiel...An oxidative amidation of tertiary amines with carboxylic acids has been developed in the presence of FeC13- 6H20 as catalyst and oxygen as oxidant. A variety of tertiary amides were obtained in good to excellent yields from inexpensive and readily available reagents. The possible reaction pathways were investigated.展开更多
The phenoxy carboxylic acid derivatives have important bioactivities,extensive application,and the research values in the agriculture,forestry,and environment.It is a very important target to obtain more compounds wit...The phenoxy carboxylic acid derivatives have important bioactivities,extensive application,and the research values in the agriculture,forestry,and environment.It is a very important target to obtain more compounds with higher effect,wider application,better selectivity,and lower toxicity.This article concentrates on the synthesis of the phenoxy carboxylic acid derivatives.The five phenoxy carboxylic acid derivatives herbicides have been designed and synthesized.Three of them were reported for the first time and their structures have been confirmed by^1H NMR,MS and IR.展开更多
基金The program was supported by University Science Foundation of TianjinEducational Committee (20050609) and Tianjin Normal University
文摘1-H-Pyrrole-2-carboxylic acid [2-（naphthalen-1-ylamino）-ethyl]-amide has been synthesized and characterized. Its crystal is of monoclinic, space group P2 1/n with a = 5.930（6）, b = 12.144（13）, c = 20.10（2） , A, β = 95.709（17）°, V= 1441（3） ,A, Z= 4, C17H17N3O, Mr= 279.34, Dc= 1.288 g/cm^3, F（000） = 592, μ（MoKa） = 0.083 mm^-1, S = 1.019, R = 0.0473 and wR = 0.1181 for 1713 observed reflections with I 〉 2 σ（I）. X-ray diffraction reveals that two molecules of the title compound form a dimer through a pair of N-H…O hydrogen bonds.
基金PAPIIT/UNAM Projects No.IN200614 and IT202015 and project PIAPI VC02 for partially supporting this worka part of the Project Catedra:Diseno de Sustancias Bioactivas of FESC-UNAM-2012.
文摘A convenient and easy method is described for the formation of carboxamides from carboxylic acids and primary amines in solventless conditions using infrared (IR) light. Thus, under IR light, cinnamic acid derivatives and amines can produce yields ranging from 50% to 85% of the resulting amide.
基金the National Natural Science Foundation of China(2207118522271224)Wuhan University startup funding for financial support.
文摘We describe an iron-catalyzed amide bond formation from readily available carboxylic acids and isocyanates.This method utilizes an abundant and biocompatible iron catalyst and easily accessible starting materials,generates CO_(2) as the only byproduct,and features broad substrate scopes with good functional group compatibility.Therefore,it provides a cost-effective and practical protocol to access a diverse variety of amides.
基金supported by the National Natural Science Foundation of China(No.21372176)Tongji University 985 Phase Ⅲ funds+1 种基金Pujiang Project of Shanghai Science and Technology Commission(No.11 J1409800)the Program for Professor of Special Appointment(Eastern Scholar) at Shanghai Institutions of Higher Learning
文摘A highly efficient copper-catalyzed approach to form amide bonds from formamides and carboxylic acids was developed. This protocol shows broad substrate scopes and high yields in the presence of 1 mol% catalyst and 4.0 equiv, formamides.
文摘An efficient solid phase route for the synthesis of amide derivatives by the reaction of carboxylic acids with urea in the presence of catalytic amount of zirconyl chloride under microwave irradiation conditions was described. In this way, a range of interesting amide derivatives was obtained in good to excellent yields. The catalyst was recycled with fresh reactants and it gave almost similar results without significant loss of activity up to the third run.
基金supported by the National Natural Science Foundation of China (21572240)
文摘A copper-catalyzed decarboxylative oxidative coupling of α,β-unsaturated carboxylic acids with non-cyclic ethers is developed.This method provides a new approach for C(sp^3)–H bond functionalization of non-cyclic ethers. Mechanism study shows the reaction involves a radical process.
基金the National Natural Science Foundation of China(Nos.21737004,21672239,and 21421002)Chinese Academy of Science(KF-STS-QYZX-068)is gratefully acknowledged.
文摘The deoxyfluorination of carboxylic,sulfonic,phosphinic acids and phosphine oxides is a fundamentally important approach to access acyl fluorides,sulfonyl fluorides and phosphoric fluorides,thus the development of inexpensive,stable,easy-to-handle,versatile,and efficient deoxyfluorination reagents is highly desired.Herein,we report the use of potassium salts of perfluoroalkyl ether carboxylic acids(PFECA)featuring CF_(2)0 units as deoxyfluorination reagents,which are generated mainly as by-products in the manufacture of hexafluoropropene oxide(HFPO).The synthesis of acyl fluorides,sulfonyl fluorides and phosphoric fluorides can be realized via carbonic difluoride(COF_(2))generated in situ from thermal degradation of the PFECA salt.
文摘N,N-dibutyldiglycol amic acid （HL1） and N,N-dioctyldiglycol nmic acid （HLu） were synthesized and characterized by conventional spectroscopic methods. These molecules were examined as extractants for extraction-separation of La（Ⅲ）, Eu（Ⅲ） and Er（Ⅲ）, as representative ions of light, middle and heavy rare earths, from aqueous chloride solutions. The analysis of the extraction equilibria revealed that the extracted species of lanthanum and europium ions by both of the extractants had a 1：3 metal to ligand ratio It was suggested that erbium ions were extracted into the organic phase via the formation ofEr（LIor Ⅱ）2Cl complexes. The effect of the organic diluents on the extraction-separation efficiency of the studied rare earths by HLI and HLⅡ was investigated by comparing the results obtained in dichloromethane and carbon tetrachloride. Regardless to the diluent used, the order of selectivity presented by the investigated extractants was Er（Ⅲ）〉Eu（Ⅲ）〉La（Ⅲ）. It is noteworthy that, a significant enhancement in separation of the studied rare earths by the extractants was achieved in their competitive extraction experiments with respect to that obtained in single component extraction experiments. Applicability of the extractants for the removal of rare earth ions from spent Ni-MH batteries was tested by removal ofLa（Ⅲ）, Eu（Ⅲ） and Er（Ⅲ） ions from simulated leach solution of such batteries.
基金financially supported by the Fundamental Research Funds for the Central Universitiesthe Research Funds of Renmin University of China(10XNL017)
文摘An oxidative amidation of tertiary amines with carboxylic acids has been developed in the presence of FeC13- 6H20 as catalyst and oxygen as oxidant. A variety of tertiary amides were obtained in good to excellent yields from inexpensive and readily available reagents. The possible reaction pathways were investigated.
文摘The phenoxy carboxylic acid derivatives have important bioactivities,extensive application,and the research values in the agriculture,forestry,and environment.It is a very important target to obtain more compounds with higher effect,wider application,better selectivity,and lower toxicity.This article concentrates on the synthesis of the phenoxy carboxylic acid derivatives.The five phenoxy carboxylic acid derivatives herbicides have been designed and synthesized.Three of them were reported for the first time and their structures have been confirmed by^1H NMR,MS and IR.
