BACKGROUND Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi(O.tsutsugamushi).Omadacycline,a ...BACKGROUND Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi(O.tsutsugamushi).Omadacycline,a novel tetracycline,exhibits potent antibacterial efficacy against both typical bacteria and atypical pathogens.However,omadacycline application in the treatment of scrub typhus remains limited.CASE SUMMARY In the present work,we report several cases of scrub typhus,with the main clinical symptoms being fever,the formation of eschars or ulcers,local or systemic lymphadenopathy,headache,myalgia and rash.Blood samples were collected before omadacycline was administered,and O.tsutsugamushi infection was confirmed through targeted next-generation sequencing(tNGS).After two days of treatment,the patients’symptoms,including fever,were alleviated,with no adverse drug reactions.CONCLUSION tNGS is an effective method for diagnosing scrub typhus.Omadacycline can be considered an alternative option for antiinfective therapy in patients with O.tsutsugamushi infections.展开更多
四环素类抗生素是20世纪40年代发现的一类新型的抗生素。1948年第一个四环素类抗生素金霉素被应用于临床,随着这类抗生素在临床和非临床上的大量使用,细菌耐药性不断增加、不可避免的不良反应以及其他新型抗生素的诞生,四环素类抗生素...四环素类抗生素是20世纪40年代发现的一类新型的抗生素。1948年第一个四环素类抗生素金霉素被应用于临床,随着这类抗生素在临床和非临床上的大量使用,细菌耐药性不断增加、不可避免的不良反应以及其他新型抗生素的诞生,四环素类抗生素的临床地位逐渐降低。20世纪70年代,第二代四环素类抗生素的米诺环素诞生了,因为其对耐药菌有效而在临床上受到青睐。特别是在2005年,对多种耐药株具有较好活性的第三代四环素类抗生素替加环素被FDA批准上市,之后又经过了13年,2018年FDA(Food and Drug Administration)同时批准了3种新型第三代四环素类抗生素上市,使得四环素类抗生素重新进入了公众的视野。本文主要就第三代四环素类抗生素的抗微生物活性,化学结构特性、作用机制与抗耐药性,以及药物的临床研究等方面进行综述。展开更多
基金Supported by National Natural Science Foundation of China,No.81800721the Postdoctoral Foundation of China,2020M671387.
文摘BACKGROUND Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi(O.tsutsugamushi).Omadacycline,a novel tetracycline,exhibits potent antibacterial efficacy against both typical bacteria and atypical pathogens.However,omadacycline application in the treatment of scrub typhus remains limited.CASE SUMMARY In the present work,we report several cases of scrub typhus,with the main clinical symptoms being fever,the formation of eschars or ulcers,local or systemic lymphadenopathy,headache,myalgia and rash.Blood samples were collected before omadacycline was administered,and O.tsutsugamushi infection was confirmed through targeted next-generation sequencing(tNGS).After two days of treatment,the patients’symptoms,including fever,were alleviated,with no adverse drug reactions.CONCLUSION tNGS is an effective method for diagnosing scrub typhus.Omadacycline can be considered an alternative option for antiinfective therapy in patients with O.tsutsugamushi infections.
文摘四环素类抗生素是20世纪40年代发现的一类新型的抗生素。1948年第一个四环素类抗生素金霉素被应用于临床,随着这类抗生素在临床和非临床上的大量使用,细菌耐药性不断增加、不可避免的不良反应以及其他新型抗生素的诞生,四环素类抗生素的临床地位逐渐降低。20世纪70年代,第二代四环素类抗生素的米诺环素诞生了,因为其对耐药菌有效而在临床上受到青睐。特别是在2005年,对多种耐药株具有较好活性的第三代四环素类抗生素替加环素被FDA批准上市,之后又经过了13年,2018年FDA(Food and Drug Administration)同时批准了3种新型第三代四环素类抗生素上市,使得四环素类抗生素重新进入了公众的视野。本文主要就第三代四环素类抗生素的抗微生物活性,化学结构特性、作用机制与抗耐药性,以及药物的临床研究等方面进行综述。
