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Tanshinone ⅡA improves Alzheimer’s disease via RNA nuclearenriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis 被引量:1
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作者 Long-Xiu Yang Man Luo Sheng-Yu Li 《World Journal of Psychiatry》 SCIE 2024年第4期563-581,共19页
BACKGROUND Alzheimer’s disease(AD)is a neurodegenerative condition characterized by oxidative stress and neuroinflammation.Tanshinone ⅡA(Tan-ⅡA),a bioactive compound isolated from Salvia miltiorrhiza plants,has sho... BACKGROUND Alzheimer’s disease(AD)is a neurodegenerative condition characterized by oxidative stress and neuroinflammation.Tanshinone ⅡA(Tan-ⅡA),a bioactive compound isolated from Salvia miltiorrhiza plants,has shown potential neuroprotective effects;however,the mechanisms underlying such a function remain unclear.AIM To investigate potential Tan-ⅡA neuroprotective effects in AD and to elucidate their underlying mechanisms.METHODS Hematoxylin and eosin staining was utilized to analyze structural brain tissue morphology.To assess changes in oxidative stress and neuroinflammation,we performed enzyme-linked immunosorbent assay and western blotting.Additionally,the effect of Tan-ⅡA on AD cell models was evaluated in vitro using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.Genetic changes related to the long non-coding RNA(lncRNA)nuclear-enriched abundant transcript 1(NEAT1)/microRNA(miRNA,miR)-291a-3p/member RAS oncogene family Rab22a axis were assessed through reverse transcription quantitative polymerase chain reaction.RESULTS In vivo,Tan-ⅡA treatment improved neuronal morphology and attenuated oxidative stress and neuroinflammation in the brain tissue of AD mice.In vitro experiments showed that Tan-ⅡA dose-dependently ameliorated the amyloid-beta 1-42-induced reduction of neural stem cell viability,apoptosis,oxidative stress,and neuroinflammation.In this process,the lncRNA NEAT1-a potential therapeutic target-is highly expressed in AD mice and downregulated via Tan-ⅡA treatment.Mechanistically,NEAT1 promotes the transcription and translation of Rab22a via miR-291a-3p,which activates nuclear factor kappa-B(NF-κB)signaling,leading to activation of the pro-apoptotic B-cell lymphoma 2-associated X protein and inhibition of the anti-apoptotic B-cell lymphoma 2 protein,which exacerbates AD.Tan-ⅡA intervention effectively blocked this process by inhibiting the NEAT1/miR-291a-3p/Rab22a axis and NF-κB signaling.CONCLUSION This study demonstrates that Tan-ⅡA exerts neuroprotective effects in AD by modulating the NEAT1/miR-291a-3p/Rab22a/NF-κB signaling pathway,serving as a foundation for the development of innovative approaches for AD therapy. 展开更多
关键词 TanshinoneⅡA Alzheimer’s disease Nuclear-enriched abundant transcript 1 Member of RAS oncogene family Rab22a Reactive oxygen species
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Prevalence of Induced Abortion among Female Students in Selected Tertiary Learning Institutions in Gaborone City, Botswana
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作者 Mabole Masweu Isaac Ogweno Owaka Rosebella Kipkalom 《International Journal of Clinical Medicine》 CAS 2024年第3期155-165,共11页
Induced abortion signifies that pregnancy has been tempered with. Abortion is the removal of an embryo or fetus weighing less than 500 grams from its mother. It can either be spontaneous (unprompted) or induced. Abort... Induced abortion signifies that pregnancy has been tempered with. Abortion is the removal of an embryo or fetus weighing less than 500 grams from its mother. It can either be spontaneous (unprompted) or induced. Abortion remains one of the leading causes of maternal deaths in developing countries with induced abortion being the key cause. In 2014 from January to August, 9 abortion related deaths occurred in Botswana. There are several reasons female students in tertiary institutions resort to seeking induced abortion which include the socio-demographics like age and socio-economic factors like financial instability. Parental fears, unintended pregnancy and pressure from the partner also force females to terminate pregnancy. Induced abortion has claimed many women’s lives especially in developing countries with very restrictive abortion laws like Botswana as women do not access safe abortion care services. The study intends to establish the determinants of induced abortion among female students in selected tertiary learning institutions in Gaborone City, Botswana. It concentrated primarily on determining the prevalence of induced abortion. This was a descriptive cross-sectional study using both quantitative and qualitative data collection techniques. Systematic random sampling technique was used to come up with 278 participants. Prior to commencement of data collection, all ethical and logistical prerequisites were satisfied. Informed consent was solicited from all the study participants and the purpose of the study was fully explained. A self-administered questionnaire was used to collect data. Microsoft Excel spread sheet was used to code, clean, and enter the data, which was then exported for analysis to the statistical package for social sciences version 24. Frequency distribution tables, percentages graphs, and pie charts were used to illustrate the descriptive information. The study revealed that prevalence of induced abortion among female students in Gaborone City is 7.9%. They even suggested that induced abortion be liberalized. Age was the only socio-demographic factor associated with induced abortion with p = 0.047 using Chi Square test χ<sup>2</sup> = 7.609, df = 3. The study findings concluded that female students resort to induced abortion as a result of pressure from both parents and male partners especially when the pregnancy is unintended. The study recommends that the abortion law in Botswana be made liberal to ease access to safe abortion care services. It also recommends that contraceptive commodities should consistently be available in public health facilities. 展开更多
关键词 Induced Abortion Prevalence and family Planning
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Microstructure and properties of 35 kg large aluminum alloy flywheel housing components formed by squeeze casting with local pressure compensation
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作者 Ju-fu Jiang Jing Yan +4 位作者 Ying-ze Liu Ning Ge Ying Wang Chang-jie Ding De-chao Zou 《China Foundry》 SCIE EI CAS CSCD 2024年第5期563-576,共14页
The squeeze casting method with local pressure compensation was proposed to form a flywheel housing component with a weight of 35 kg.The numerical simulation,microstructure observation and phase characterization were ... The squeeze casting method with local pressure compensation was proposed to form a flywheel housing component with a weight of 35 kg.The numerical simulation,microstructure observation and phase characterization were performed,and the influence of local pressure compensation on feeding of thick-wall position,microstructure and mechanical properties of the formed components were discussed.Results show that the molten metal keeps a good fluidity and the filling is complete during the filling process.Although the solidification at thick-wall positions of the mounting ports is slow,the local pressure compensation effectively realizes the local forced feeding,significantly eliminating the shrinkage cavity defects.In the microstructure of AlSi9Mg alloy,α-Al primarily consists of fragmented dendrites and rosette grains,while eutectic Si predominantly comprises needles and short rods.The impact of local pressure compensation on strength is relatively minimal,yet its influence on elongation is considerable.Following local pressure compensation,the average elongation at the compensated areas is 9.18%,which represents a 44.90%higher than that before compensation.The average tensile strength is 209.1 MPa,and the average yield strength is 100.6 MPa.The local pressure compensation can significantly reduce or even eliminate the internal defects in the 35 kg large-weight components formed by squeeze casting. 展开更多
关键词 squeeze casting local pressure compensation aluminum alloy microstructure mechanical properties large flywheel housing components
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Bayesian and Non-Bayesian Analysis for the Sine Generalized Linear Exponential Model under Progressively Censored Data
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作者 Naif Alotaibi A.S.Al-Moisheer +2 位作者 Ibrahim Elbatal Mohammed Elgarhy Ehab M.Almetwally 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第9期2795-2823,共29页
This article introduces a novel variant of the generalized linear exponential(GLE)distribution,known as the sine generalized linear exponential(SGLE)distribution.The SGLE distribution utilizes the sine transformation ... This article introduces a novel variant of the generalized linear exponential(GLE)distribution,known as the sine generalized linear exponential(SGLE)distribution.The SGLE distribution utilizes the sine transformation to enhance its capabilities.The updated distribution is very adaptable and may be efficiently used in the modeling of survival data and dependability issues.The suggested model incorporates a hazard rate function(HRF)that may display a rising,J-shaped,or bathtub form,depending on its unique characteristics.This model includes many well-known lifespan distributions as separate sub-models.The suggested model is accompanied with a range of statistical features.The model parameters are examined using the techniques of maximum likelihood and Bayesian estimation using progressively censored data.In order to evaluate the effectiveness of these techniques,we provide a set of simulated data for testing purposes.The relevance of the newly presented model is shown via two real-world dataset applications,highlighting its superiority over other respected similar models. 展开更多
关键词 Sine G family generalized linear failure rate progressively censored data MOMENTS maximum likelihood estimation Bayesian estimation simulation
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Relations Between School and Immigrant Families in Albertan Francophone School: Perspectives of Settlement Workers in Schools - A Secondary Publication
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作者 Marianne Jacquet Gwenaëlle André 《Journal of Contemporary Educational Research》 2024年第3期136-147,共12页
In recent years,Francophone schools in Alberta,a province in western Canada,have seen significant ethnocultural diversification of their school population,thus reflecting recent migratory changes in Canada.The populat... In recent years,Francophone schools in Alberta,a province in western Canada,have seen significant ethnocultural diversification of their school population,thus reflecting recent migratory changes in Canada.The population of a Francophone school board located in an agglomeration of Alberta reflects these new migratory trends.A partial ethnodemographic portrait carried out in 2003 in six of its schools indicates that 50%of the pupils come from an immigrant background and come from 23 different countries;mostly from sub-Saharan African countries.This demographic reality,confirmed more than a decade later,represents a major structural change for Francophone schools.In Alberta,as in other Canadian provinces,inclusion is at the heart of discourse and educational practices.With a transformative aim,it intends to promote ethnocultural diversity in the classroom and equal opportunities through school equity practices.This article focuses on the settlement workers in schools responsible for bridging family,community,and school cultures.The analysis of the interviews of the four workers sheds light on and questions both the institutional practices and the personal strategies put in place to face the challenges encountered in this tripartite collaboration. 展开更多
关键词 Educational inclusion and exclusion Immigration and ethnicity Interculturality and multiculturalism family and education Help for pupils and students Actors in education Canada
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Moving from fear to realization: Family engagement in tuberculosis prevention in children living in tuberculosis Sundanese households in Indonesia
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作者 Windy Rakhmawati Kittikorn Nilmanat Urai Hatthakit 《International Journal of Nursing Sciences》 CSCD 2019年第3期272-277,共6页
Objective: Children living in tuberculosis households need protection.However,families need to be engaged to prevent tuberculosis transmission to children.This study aimed to analyze the details of "moving from f... Objective: Children living in tuberculosis households need protection.However,families need to be engaged to prevent tuberculosis transmission to children.This study aimed to analyze the details of "moving from fear to realization," which is one category of a substantive theory of family engagement in tuberculosis prevention in children.Methods: Fourteen family caregivers participated as key informants after their families met the criteria.The participants were recruited at a lung clinic in West Java,Indonesia and followed up at their homes.The data were gathered using in-depth interviews and analyzed following the coding procedures of the Straussian grounded theory.Findings: "Moving from fear to realization" was the main category that emerged from the experiences of the Sundanese families to begin engaging in tuberculosis prevention in children living in tuberculosis households.It was composed of four sub-categories,namely,fear of tuberculosis,seeking information,following God's will,and awareness of tuberculosis transmission risks.Conclusions: This study showed how a family moves from fear to the realization of tuberculosis transmission risks.Its findings are useful for nurses to provide optimum care in order to prevent tuberculosis transmission to children with household contact by providing both education and counseling for families. 展开更多
关键词 CHILD family Indonesia Qualitative research TUBERCULOSIS
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Two Households——One Family
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作者 遐思 《语言教育》 1990年第3期25-27,共3页
I was nine when my parents told me they were separating.Even my sister Meghan, then seven and my brother Patrick, then foursensed that something was wrong between our parents. At fisrt, Momand Dad tried not to argue i... I was nine when my parents told me they were separating.Even my sister Meghan, then seven and my brother Patrick, then foursensed that something was wrong between our parents. At fisrt, Momand Dad tried not to argue in front of us, but we saw that they hadtalked to each other less-and they got mad ot us for everything. 展开更多
关键词 PARENTS something family everything BROTHER argue TWO households WRONG SISTER tried
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Molecular Composition and Evolution of the Chalcone Synthase (CHS) Gene Family in Five Species of Camellia (Theaceae) 被引量:5
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作者 杨俊波 田欣 +1 位作者 李德铢 郭振华 《Acta Botanica Sinica》 CSCD 2003年第6期659-666,共8页
The molecular composition and evolution of the chalcone synthase (CHS) gene family from five species in Camellia (Theaceae) are explored in this study. Sixteen CHS exon 2 from four Camellia species were amplified from... The molecular composition and evolution of the chalcone synthase (CHS) gene family from five species in Camellia (Theaceae) are explored in this study. Sixteen CHS exon 2 from four Camellia species were amplified from total DNA by PCR method. Three sequences of the fifth species in Camellia and two sequences of Glycine max as the designated outgroups were obtained from GenBank. Our results indicated that CHS gene family in Camellia was differentiated to three subfamilies (A, B, C) during the evolutionary history with six groups (A1, A2, A3, BI, B2, C). Among them, only group A2 was possessed by all five species in this study. However, the other five groups were detected only in some species of the plants studied. All members of CHS gene family in this study had high sequence similarity, more than 90% among the members in the same subfamily and more than 78% among different subfamilies at nucleotide level., According to the estimated components of amino acids, the function of CHS genes in Camellia had been diverged. The nucleotide substitutions of the different groups were not identical. Based on phylogenetic analyse inferred from sequences of CHS genes and their deduced amino acid sequences, we concluded that the CHS genes with new function in this genus were evolved either by mutations on several important sites or by accumulation of the mutations after the gene duplication. A further analysis showed that the diversification of CHS genes in Camellia still occurred recently, and the evolutionary models were different to some extant among different species. So we assumed that the different evolutionary models resulted from the impacts of variable environmental elements after the events of speciation. 展开更多
关键词 CAMELLIA chalcone synthase (CHS) gene family molecular evolution
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Estimation of the Number of Collapsed Houses Damaged by Typhoon Based on Principal Components Analysis and Support Vector Machine 被引量:2
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作者 张新厂 娄伟平 《Meteorological and Environmental Research》 CAS 2010年第4期11-14,共4页
The evaluation model was established to estimate the number of houses collapsed during typhoon disaster for Zhejiang Province.The factor leading to disaster,the environment fostering disaster and the exposure of build... The evaluation model was established to estimate the number of houses collapsed during typhoon disaster for Zhejiang Province.The factor leading to disaster,the environment fostering disaster and the exposure of buildings were processed by Principal Component Analysis.The key factor was extracted to support input of vector machine model and to build an evaluation model;the historical fitting result kept in line with the fact.In the real evaluation of two typhoons landed in Zhejiang Province in 2008 and 2009,the coincidence of evaluating result and actual value proved the feasibility of this model. 展开更多
关键词 TYPHOON The number of collapsed houses Principal Components Analysis Support Vector Machine EVALUATION China
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E-house箱体及吊具的吊装过程受力数值计算
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作者 宋冬冬 乔子明 +2 位作者 赵剑平 张亮 李冬 《机械工程师》 2024年第9期12-15,共4页
预装式变电站(E-house)作为电网重要的电能传输枢纽,已经被广泛应用。在安装施工过程中,箱体质量、吊具结构、吊装速度等因素均会引起箱体形变的发生,导致设备的损坏。为了解决该问题,对所设计的9.8 m×3.2 m尺寸的E-house箱体及吊... 预装式变电站(E-house)作为电网重要的电能传输枢纽,已经被广泛应用。在安装施工过程中,箱体质量、吊具结构、吊装速度等因素均会引起箱体形变的发生,导致设备的损坏。为了解决该问题,对所设计的9.8 m×3.2 m尺寸的E-house箱体及吊具结构进行吊装受力分析,并利用有限元方法分析了吊装结构和箱体的应力变形,确定了吊具和箱体易变形损坏部位。计算结果表明,为减少轴向压力对吊具的影响,钢丝绳安全夹角应控制在60°以内,安全的吊装速度应控制在1 m/s以下。研究结果可以为后续的箱体结构设计与优化提供理论参考。 展开更多
关键词 E-house 吊具 吊装 力学分析 有限元
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Molecular Clone, Expression, and Prediction of Construction and Function to Key Genes of Interleukin Family of Porcine 被引量:4
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作者 JING Zhi-zhong DOU Yong-xi +5 位作者 LUO Qi-hui CHEN Guo-hua MENG Xue-lian ZHENG Ya-dong LUO Xue-nong CAI Xue-peng 《Agricultural Sciences in China》 CAS CSCD 2007年第7期869-876,共8页
This research was to clone, express, and analyze the structure and function of major molecules of porcine interleukin family. Genes of porcine interleukin family were cloned by RT-PCR from stimulated porcine PBMC by L... This research was to clone, express, and analyze the structure and function of major molecules of porcine interleukin family. Genes of porcine interleukin family were cloned by RT-PCR from stimulated porcine PBMC by LPS and PHA, and then expressed in E. coli, and the structure and function of these molecules were predicted by ExPASY. The results showed that genes of IL-4, IL-6, and IL-18 were successfully cloned and expressed. Furthermore, the expression products of recombinant IL-4 and IL-6 both have multiple biological activities. By analyzing these genes with the NCBI/GenBank data, the homologies of the nucleotide acid sequence are 99.25, 99.21, and 100%, respectively, and have great species differences when compared with other animal species. The results of the prediction showed that all these molecules contain several phosphorylation, glycosylation, protein kinase, and signal transduction bonding sites in secondary structure, and all are compact globularity protein in space configuration. These characteristics of structure are the basis for their multiple biological functions. The genes, structure and function of key molecular of porcine interleukin family were successfully cloned, expressed, and analyzed in this paper. 展开更多
关键词 porcine interleukin gene family analysis of homologies prediction of construction
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CHIP regulates bone mass by targeting multiple TRAF family members in bone marrow stromal cells 被引量:5
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作者 Tingyu Wang Shan Li +5 位作者 Dan Yi Guang-Qian Zhou Zhijie Chang Peter X.Ma Guozhi Xiao Di Chen 《Bone Research》 CAS CSCD 2018年第2期145-154,共10页
Carboxyl terminus of Hsp70-interacting protein(CHIP or STUB1) is an E3 ligase and regulates the stability of several proteins which are involved in different cellular functions. Our previous studies demonstrated tha... Carboxyl terminus of Hsp70-interacting protein(CHIP or STUB1) is an E3 ligase and regulates the stability of several proteins which are involved in different cellular functions. Our previous studies demonstrated that Chip deficient mice display bone loss phenotype due to increased osteoclast formation through enhancing TRAF6 activity in osteoclasts. In this study we provide novel evidence about the function of CHIP. We found that osteoblast differentiation and bone formation were also decreased in Chip KO mice. In bone marrow stromal(BMS) cells derived from Chip^-/- mice, expression of a panel of osteoblast marker genes was significantly decreased. ALP activity and mineralized bone matrix formation were also reduced in Chip-deficient BMS cells. We also found that in addition to the regulation of TRAF6, CHIP also inhibits TNFα-induced NF-κB signaling through promoting TRAF2 and TRAF5 degradation. Specific deletion of Chip in BMS cells downregulated expression of osteoblast marker genes which could be reversed by the addition of NF-κB inhibitor. These results demonstrate that the osteopenic phenotype observed in Chip^-/- mice was due to the combination of increased osteoclast formation and decreased osteoblast differentiation. Taken together, our findings indicate a significant role of CHIP in bone remodeling. 展开更多
关键词 CHIP regulates bone mass targeting multiple TRAF family members marrow stromal cells
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Identifying and validating MMP family members(MMP2,MMP9,MMP12,and MMP16)as therapeutic targets and biomarkers in kidney renal clear cell carcinoma(KIRC) 被引量:1
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作者 KUNLUN LI DANDAN LI +7 位作者 BARBOD HAFEZ MOUNIR M.SALEM BEKHIT YOUSEF A.BIN JARDAN FARS KAED ALANAZI EHAB I.TAHA SAYED H.AUDA FAIQAH RAMZAN MUHAMMAD JAMIL 《Oncology Research》 SCIE 2024年第4期737-752,共16页
Kidney Renal Clear Cell Carcinoma(KIRC)is a malignant tumor that carries a substantial risk of morbidity and mortality.The MMP family assumes a crucial role in tumor invasion and metastasis.This study aimed to uncover... Kidney Renal Clear Cell Carcinoma(KIRC)is a malignant tumor that carries a substantial risk of morbidity and mortality.The MMP family assumes a crucial role in tumor invasion and metastasis.This study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma(KIRC)through a comprehensive approach encompassing both computational and molecular analyses.STRING,Cytoscape,UALCAN,GEPIA,OncoDB,HPA,cBioPortal,GSEA,TIMER,ENCORI,DrugBank,targeted bisulfite sequencing(bisulfite-seq),conventional PCR,Sanger sequencing,and RT-qPCR based analyses were used in the present study to analyze MMP gene family members to accurately determine a few hub genes that can be utilized as both therapeutic targets and diagnostic biomarkers for KIRC.By performing STRING and Cytohubba analyses of the 24 MMP gene family members,MMP2(matrix metallopeptidase 2),MMP9(matrix metallopeptidase 9),MMP12(matrix metallopeptidase 12),and MMP16(matrix metallopeptidase 16)genes were denoted as hub genes having highest degree scores.After analyzing MMP2,MMP9,MMP12,and MMP16 via various TCGA databases and RT-qPCR technique across clinical samples and KIRC cell lines,interestingly,all these hub genes were found significantly overexpressed at mRNA and protein levels in KIRC samples relative to controls.The notable effect of the up-regulated MMP2,MMP9,MMP12,and MMP16 was also documented on the overall survival(OS)of the KIRC patients.Moreover,targeted bisulfite-sequencing(bisulfite-seq)analysis revealed that promoter hypomethylation pattern was associated with up-regulation of hub genes(MMP2,MMP9,MMP12,and MMP16).In addition to this,hub genes were involved in various diverse oncogenic pathways.The MMP gene family members(MMP2,MMP9,MMP12,and MMP16)may serve as therapeutic targets and prognostic biomarkers in KIRC. 展开更多
关键词 KIRC MMP gene family CHEMOTHERAPY Overall survival
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A Family of the Exponential Attractors and the Inertial Manifolds for a Class of Generalized Kirchhoff Equations 被引量:4
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作者 Guoguang Lin Lujiao Yang 《Journal of Applied Mathematics and Physics》 2021年第10期2399-2413,共15页
In this paper, we studied a family of the exponential attractors and the inertial manifolds for a class of generalized Kirchhoff-type equations with strong dissipation term. After making appropriate assumptions for Ki... In this paper, we studied a family of the exponential attractors and the inertial manifolds for a class of generalized Kirchhoff-type equations with strong dissipation term. After making appropriate assumptions for Kirchhoff stress term and nonlinear term, the existence of exponential attractor is obtained by proving the discrete squeezing property of the equation, then according to Hadamard’s graph transformation method, the spectral interval condition is proved to be true, therefore, the existence of a family of the inertial manifolds for the equation is obtained. 展开更多
关键词 Kirchhoff-Type Equation Spectral Interval Condition A family of the Exponential Attractors A family of the Inertial Manifolds
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Improving Access to Quality Care in Family Planning:WHO’s Four Cornerstones of Evidence-based Guidance 被引量:1
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作者 Shang-chun WU Yan ZOU +1 位作者 K Church O Meirik 《Journal of Reproduction and Contraception》 CAS 2007年第2期63-71,共9页
The four cornerstones of guidance in technique service of family planning are established by WHO based on high quality evidences. They have been updated according to the appearing new evidences, and the consensuses we... The four cornerstones of guidance in technique service of family planning are established by WHO based on high quality evidences. They have been updated according to the appearing new evidences, and the consensuses were reached by the international experts in this field. The four documents include Medical Eligibility Criteria for Contraceptive Use, Selected Practice Recommendations for Contraceptive Use, Decision-making Tool for Family Planning Clients and Providers and The Global Handbook for Family Planning Providers. The first two documents mainly face to the policymakers and programme managers and were treated as the important references for creating the local guideline. The other two documents were developed for the front-line health-care and family planning providers at different levels, which include plenty of essential technical information to help providers improve their ability in service delivery and counselling. China paid great attention to the introduction and application of WHO guidelines. As soon as the newer editions of these documents were available, the Chinese version would be followed. WHO guidelines have been primarily adapted with the newly issued national guideline, The Clinical Practical Skill Guidelines-Family Planning Part, which was established by China Medical Association. At the same time, the WHO guidelines have been introduced to some of the clinicians and family planning providers at different levels. In the future, more special training courses will be introduced to the township level based on the needs of grass-root providers. 展开更多
关键词 family planning technique service EVIDENCE-BASED GUIDELINE
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Genome wide investigation of Hsf gene family in Phoebe bournei:identification,evolution,and expression after abiotic stresses 被引量:1
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作者 Wenhai Liao Xinghao Tang +6 位作者 Jingshu Li Qiumian Zheng Ting Wang Shengze Cheng Shiping Chen Shijiang Cao Guangqiu Cao 《Journal of Forestry Research》 SCIE EI CAS CSCD 2024年第5期201-215,共15页
Heat shock transcription factors(Hsfs)have important roles during plant growth and development and responses to abiotic stresses.The identification and func-tion of Hsf genes have been thoroughly studied in various he... Heat shock transcription factors(Hsfs)have important roles during plant growth and development and responses to abiotic stresses.The identification and func-tion of Hsf genes have been thoroughly studied in various herbaceous plant species,but not woody species,especially Phoebe bournei,an endangered,unique species in China.In this study,17 members of the Hsf gene family were identi-fied from P.bournei using bioinformatic methods.Phyloge-netic analysis indicated that PbHsf genes were grouped into three subfamilies:A,B,and C.Conserved motifs,three-dimensional structure,and physicochemical properties of the PbHsf proteins were also analyzed.The structure of the PbHsf genes varied in the number of exons and introns.Pre-diction of cis-acting elements in the promoter region indi-cated that PbHsf genes are likely involved in responses to plant hormones and stresses.A collinearity analysis dem-onstrated that expansions of the PbHsf gene family mainly take place via segmental duplication.The expression levels of PbHsf genes varied across different plant tissues.On the basis of the expression profiles of five representative PbHsf genes during heat,cold,salt,and drought stress,PbHsf pro-teins seem to have multiple functions depending on the type of abiotic stress.This systematic,genome-wide investigation of PbHsf genes in P.bournei and their expression patterns provides valuable insights and information for further func-tional dissection of Hsf proteins in this endangered,unique species. 展开更多
关键词 Phoebe bournei Hsf gene family Evolutionary analysis Expression mechanism Abiotic stresses
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CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study 被引量:4
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作者 CHEN Li SUN Ke Xin +13 位作者 JUAN Juan FANG Kai LIU Kuo WANG Xue Yin WANG Ling YANG Chao LIU Xiao Qiang LI Jing TANG Xun WU Yi Qun QIN Xue Ying WU Tao CHEN Da Fang HU Yong Hua 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2017年第1期35-43,共9页
Objective To understand the relationships between CDH13(T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Method... Objective To understand the relationships between CDH13(T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Methods We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight(HMW) adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model. Results In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels(per T: Coef =-0.257, P = 0.001). CDH13 rs7193788 was associated with total adiponectin levels(per A: Coef =-0.221, P = 0.001) and HMW adiponectin levels(per A: Coef =-0.163, P = 0.003). rs7193788 was significantly associated with ischemic stroke(GA/AA vs. GG: OR = 1.55, 95% CI: 1.07 to 2.24, P = 0.020) after Bonferroni correction(α = 0.025). There was an interaction between rs7193788 and diabetes(P = 0.036). Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke(OR = 2.64, 95% CI: 1.58-4.40, P 〈 0.001). Conclusion CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke. 展开更多
关键词 family correction cadherin SNPs genotype transformed preserving false trained burden
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The Family of Exponential Attractors and Inertial Manifolds for a Generalized Nonlinear Kirchhoff Equations 被引量:3
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作者 Guoguang Lin Xiaomei Liu 《Journal of Applied Mathematics and Physics》 2022年第1期172-189,共18页
In this paper, we study the long-time behavior of a class of generalized nonlinear Kichhoff equation under the condition of n dimension. Firstly, the Lipschitz property and squeezing property of the nonlinear semigrou... In this paper, we study the long-time behavior of a class of generalized nonlinear Kichhoff equation under the condition of n dimension. Firstly, the Lipschitz property and squeezing property of the nonlinear semigroup related to the initial-boundary value problem are proved, and then the existence of its exponential attractor is obtained. By extending the space <em>E</em><sub>0</sub> to <em>E<sub>k</sub></em>, a family of the exponential attractors of the initial-boundary value problem is obtained. In the second part, we consider the long-time behavior for a system of generalized Kirchhoff type with strong damping terms. Using the Hadamard graph transformation method, we obtain the existence of a family of the inertial manifolds while such equations satisfy the spectrum interval condition. 展开更多
关键词 A family of the Exponential Attractors Inertial Fractal Set Squeezing Property Spectral Gap Condition A family of the Inertial Manifolds
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Genome-wide identification,characterization and functional prediction of the SRS gene family in sesame(Sesamum indicum L.) 被引量:1
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作者 Farjana Afroz Susmi Tasmina Islam Simi +1 位作者 Md Nahid Hasan Md Abdur Rahim 《Oil Crop Science》 CSCD 2024年第2期69-80,共12页
Sesame(Sesamum indicum L.)is an ancient oilseed crop of the Pedaliaceae family with high oil content and potential health benefits.SHI RELATED SEQUENCE(SRS)proteins are the transcription factors(TFs)specific to plants... Sesame(Sesamum indicum L.)is an ancient oilseed crop of the Pedaliaceae family with high oil content and potential health benefits.SHI RELATED SEQUENCE(SRS)proteins are the transcription factors(TFs)specific to plants that contain RING-like zinc finger domain and are associated with the regulation of several physiological and biochemical processes.They also play vital roles in plant growth and development such as root formation,leaf development,floral development,hormone biosynthesis,signal transduction,and biotic and abiotic stress responses.Nevertheless,the SRS gene family was not reported in sesame yet.In this study,identification,molecular characterization,phylogenetic relationship,cis-acting regulatory elements,protein-protein interaction,syntenic relationship,duplication events and expression pattern of SRS genes were analyzed in S.indicum.We identified total six SiSRS genes on seven different linkage groups in the S.indicum genome by comparing with the other species,including the model plant Arabidopsis thaliana.The SiSRS genes showed variation in their structure like2–5 exons and 1–4 introns.Like other species,SiSRS proteins also contained‘RING-like zinc finger'and‘LRP1'domains.Then,the SiSRS genes were clustered into subclasses via phylogenetic analysis with proteins of S.indicum,A.thaliana,and some other plant species.The cis-acting regulatory elements analysis revealed that the promoter region of SiSRS4(SIN_1011561)showed the highest 13 and 16 elements for light-and phytohormone-responses whereas,SiSRS1(SIN_1015187)showed the highest 15 elements for stress-response.The ABREs,or ABA-responsive elements,were found in a maximum of 8 copies in the SiSRS3(SIN 1009100).Moreover,the available RNA-seq based expression of SiSRS genes revealed variation in expression patterns between stress-treated and non-treated samples,especially in drought and salinity conditions in.S.indicum.Two SiSRS genes like SiSRS1(SIN_1015187)and SiSRS5(SIN_1021065),also exhibited variable expression patterns between control vs PEG-treated sesame root samples and three SiSRS genes,including SiSRS1(SIN_1015187),SiSRS2(SIN_1003328)and SiSRS5(SIN_1021065)were responsive to salinity treatments.The present outcomes will encourage more research into the gene expression and functionality analysis of SiSRS genes in S.indicum and other related species. 展开更多
关键词 SiSRS gene family SHI Transcription factor CHARACTERIZATION Sesamum indicum
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Identification of the lysine and histidine transporter family in Camellia sinensis and the characterizations in nitrogen utilization 被引量:1
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作者 Wei Huang Danni Ma +9 位作者 Fawad Zaman Xulei Hao Li Xia E Zhang Pu Wang Mingle Wang Fei Guo Yu Wang Dejiang Ni Hua Zhao 《Horticultural Plant Journal》 SCIE CAS CSCD 2024年第1期273-287,共15页
In plants,the lysine and histidine transporter(LHT)family represent a class of proteins that mediate the uptake,translocation,and utilization of amino acids.The tea plant(Camellia sinensis)is a perennial evergreen wit... In plants,the lysine and histidine transporter(LHT)family represent a class of proteins that mediate the uptake,translocation,and utilization of amino acids.The tea plant(Camellia sinensis)is a perennial evergreen with a relatively high level of amino acids.However,systematic identification and molecular characterization of the LHT gene family has rarely been reported in tea plants.In this study,22 CsLHTs were identified from the‘Shuchazao’genome and classified into two groups.The modeled three-dimensional structure and the conserved domains presented a high similarity among the LHTs proteins.Moreover,it was predicted that a few genes were conserved through the analysis of the physiochemical characters,structures and cis-elements in promoters.The expression patterns in tea plants revealed that CsLHT7 was mainly expressed in the roots,and CsLHT4 and CsLHT11 exhibited relatively high expression in both the roots and leaves.Moreover,the expression of all three genes could be induced by organic nitrogen.Additionally,heterogeneous expression of CsLHT4,CsLHT7 and CsLHT11 in Arabidopsis thaliana decreased the aerial parts biomass compared with that in WT plants while significantly increased the rosette biomass only for CsLHT11transgenic plants versus WT plants.Overall,our results provide fundamental information about CsLHTs and potential genes in N utilization for further analysis in tea plants. 展开更多
关键词 Camellia sinensis Nitrogen Lysine and histidine transporter(LHT)family
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