This paper presents a novel sequential inverse optimal control(SIOC)method for discrete-time systems,which calculates the unknown weight vectors of the cost function in real time using the input and output of an optim...This paper presents a novel sequential inverse optimal control(SIOC)method for discrete-time systems,which calculates the unknown weight vectors of the cost function in real time using the input and output of an optimally controlled discrete-time system.The proposed method overcomes the limitations of previous approaches by eliminating the need for the invertible Jacobian assumption.It calculates the possible-solution spaces and their intersections sequentially until the dimension of the intersection space decreases to one.The remaining one-dimensional vector of the possible-solution space’s intersection represents the SIOC solution.The paper presents clear conditions for convergence and addresses the issue of noisy data by clarifying the conditions for the singular values of the matrices that relate to the possible-solution space.The effectiveness of the proposed method is demonstrated through simulation results.展开更多
Sequential control applied to the International Thermonuclear Experimental Re- actor (ITER) poloidal field converter system for the purpose of reactive power reduction is the subject of this investigation. Due to th...Sequential control applied to the International Thermonuclear Experimental Re- actor (ITER) poloidal field converter system for the purpose of reactive power reduction is the subject of this investigation. Due to the inherent characteristics of thyristor-based phase-controlled converter, the poloidal field converter system consumes a huge amount of reactive power from the grid, which subsequently results in a voltage drop at the 66 kV busbar if no measure is taken. The installation of a static var compensator rated for 750 MVar at the 66 kV busbax is an essential way to compensate reactive power to the grid, which is the most effective measure to solve the problem. However, sequential control of the multi-series converters provides an additional method to improve the natural power factor and thus alleviate the pressure of reactive power demand of the converter system without any additional cost. In the present paper, by comparing with the symmetrical control technique, the advantage of sequential control in reactive power consumption is highlighted. Simulation results based on SIMULINK are found in agreement with the theoretical analysis.展开更多
With a focus on an industrial multivariable system, two subsystems including the flow and the level outputs are analysed and controlled, which have applicability in both real and academic environments. In such a case,...With a focus on an industrial multivariable system, two subsystems including the flow and the level outputs are analysed and controlled, which have applicability in both real and academic environments. In such a case, at first, each subsystem is distinctively represented by its model, since the outcomes point out that the chosen models have the same behavior as corresponding ones. Then, the industrial multivariable system and its presentation are achieved in line with the integration of these subsystems, since the interaction between them can not actually be ignored. To analyze the interaction presented, the Gershgorin bands need to be acquired, where the results are used to modify the system parameters to appropriate values. Subsequently, in the view of modeling results, the control concept in two different techniques including sequential loop closing control(SLCC) scheme and diagonal dominance control(DDC) schemes is proposed to implement on the system through the Profibus network, as long as the OPC(OLE for process control) server is utilized to communicate between the control schemes presented and the multivariable system. The real test scenarios are carried out and the corresponding outcomes in their present forms are acquired. In the same way, the proposed control schemes results are compared with each other, where the real consequences verify the validity of them in the field of the presented industrial multivariable system control.展开更多
As a method for testing a sequential circuit efficiently, a scan design is usually used. But, since this design has some drawbacks, a non-scan testable design should be discussed. The testable design can be implemente...As a method for testing a sequential circuit efficiently, a scan design is usually used. But, since this design has some drawbacks, a non-scan testable design should be discussed. The testable design can be implemented by enhancing controllability and observability. This paper discusses a non-scan testable design for a sequential circuit by only focusing the improvement of controllability. The proposed design modifies a circuit so that all the FFs can be directly controlled by primary input lines in a test mode. Experimental results show that we can get a good testability using this method.展开更多
A kind of direct methods is presented for the solution of optimal control problems with state constraints. These methods are sequential quadratic programming methods. At every iteration a quadratic programming which i...A kind of direct methods is presented for the solution of optimal control problems with state constraints. These methods are sequential quadratic programming methods. At every iteration a quadratic programming which is obtained by quadratic approximation to Lagrangian function and linear approximations to constraints is solved to get a search direction for a merit function. The merit function is formulated by augmenting the Lagrangian function with a penalty term. A line search is carried out along the search direction to determine a step length such that the merit function is decreased. The methods presented in this paper include continuous sequential quadratic programming methods and discreate sequential quadratic programming methods.展开更多
Sequential chemical extraction procedure has been widely used to partition particulate trace metals into various fractions and to describe the distribution and the statue of trace metals in geo environment. One sequen...Sequential chemical extraction procedure has been widely used to partition particulate trace metals into various fractions and to describe the distribution and the statue of trace metals in geo environment. One sequential chemical extraction procedure was employed here to partition various fractions of Mn in soils. The experiment was designed with quality controlling concept in order to show sampling and analytical error. Experimental results obtained on duplicate analysis of all soil samples demonstrated that the precision was less than 10%(at 95%confidence level). The accuracy was estimated by comparing the accepted total concentration of Mn in standard reference materials (SRMs) with the measured sum of the individual fractions. The recovery of Mn from SRM1 and SRM2 was 94.1%and 98.4%, respectively. The detection limit, accuracy and precision of the sequential chemical extraction procedure were discussed in detailed. All the results suggest that the trueness of the analytical method is satisfactory.展开更多
BACKGROUND:Early withdrawal of invasive mechanical ventilation(IMV) followed by noninvasive MV(NIMV) is a new strategy for changing modes of treatment in patients with acute exacerbations of chronic obstructive pulmon...BACKGROUND:Early withdrawal of invasive mechanical ventilation(IMV) followed by noninvasive MV(NIMV) is a new strategy for changing modes of treatment in patients with acute exacerbations of chronic obstructive pulmonary disease(AECOPD) with acute respiratory failure(ARF).Using pulmonary infection control window(PIC window) as the switch point for transferring from invasive to noninvasive MV,the time for early extubation can be more accurately judged,and therapy efficacy can be improved.This study aimed to prospectively investigate the clinical effectiveness of fiberoptic bronchscopy(FOB) in patients with AECOPD during sequential weaning of invasive-noninvasive MV.METHODS:Since July 2006 to January 2011,106 AECOPD patients with ARF were treated with comprehensive medication and IMV after hospitalization.Patients were randomly divided into two groups according to whether fiberoptic bronchoscope is used(group A,n=54) or not(group B,n=52) during sequential weaning from invasive to noninvasive MV.In group A,for sputum suction and bronchoalveolar lavage(BAL),a fiberoptic bronchoscope was put into the airway from the outside of an endotracheal tube,which was accompanied with uninterrupted use of a ventilator.After achieving PIC window,patients of both groups changed to NIMV mode,and weaned from ventilation.The following listed indices were used to compare between the groups after treatment:1) the occurrence time of PIC,the duration of MV,the length of ICU stay,the success rate of weaning from MV for the first time,the rate of reventilatJon and the occurrence rate of ventilator-associated pneumonia(VAP);2) the convenience and safety of FOB manipulation.The results were compared using Student's f test and the Chi-square test.RESULTS:The occurrence time of PIC was(5.01 ±1.49) d,(5.87±1.87) d in groups A and B,respectively(P<0.05);the duration of MV was(6.98±1.84) d,(8.69±2.41) d in groups A and B,respectively(P<0.01);the length of ICU stay was(9.25±1.84) d,(11.10±2.63) d in groups A and B,respectively(P<0.01);the success rate of weaning for the first time was 96.30%,76.92%in groups A and B,respectively(P<0.01);the rate of reventilation was 5.56%,19.23%in groups A and B,respectively(P<0.05);and the occurrence rate of VAP was 3.70%,23.07%in groups A and B,respectively(P<0.01).Moreover,it was easy and safe to manipulate FOB,and no side effect was observed.CONCLUSIONS:The application of FOB in patients with AECOPD during sequential weaning of invasive-noninvasive MV is effective in ICU.It can decrease the duration of MV and the length of ICU stay,increase the success rate from weaning MV for the first time,reduce the rate of reventilation and the occurrence rate of VAP.In addition,such a method is convenient and safe in patients of this kind.展开更多
The Kuhn-Tucker theorem in nondifferential form is a well-known classical optimality criterion for a convex programming problems which is true for a convex problem in the case when a Kuhn-Tucker vector exists. It is n...The Kuhn-Tucker theorem in nondifferential form is a well-known classical optimality criterion for a convex programming problems which is true for a convex problem in the case when a Kuhn-Tucker vector exists. It is natural to extract two features connected with the classical theorem. The first of them consists in its possible “impracticability” (the Kuhn-Tucker vector does not exist). The second feature is connected with possible “instability” of the classical theorem with respect to the errors in the initial data. The article deals with the so-called regularized Kuhn-Tucker theorem in nondifferential sequential form which contains its classical analogue. A proof of the regularized theorem is based on the dual regularization method. This theorem is an assertion without regularity assumptions in terms of minimizing sequences about possibility of approximation of the solution of the convex programming problem by minimizers of its regular Lagrangian, that are constructively generated by means of the dual regularization method. The major distinctive property of the regularized Kuhn-Tucker theorem consists that it is free from two lacks of its classical analogue specified above. The last circumstance opens possibilities of its application for solving various ill-posed problems of optimization, optimal control, inverse problems.展开更多
[Objectives]To analyze the efficacy of Compound Qingdai Capsule in the treatment of psoriasis and conduct a systematic evaluation.[Methods]The clinical total effective rate,PASI index score,IL-17 level,IL-23 level,TNF...[Objectives]To analyze the efficacy of Compound Qingdai Capsule in the treatment of psoriasis and conduct a systematic evaluation.[Methods]The clinical total effective rate,PASI index score,IL-17 level,IL-23 level,TNF-level,and adverse reactions were analyzed.TSA 0.9 software was used to conduct sequential analysis of the total effective rate,and subgroup analysis was performed according to the average age of the experimental group.[Results]Single application of Compound Qingdai Capsule or in combination with other methods in the treatment of psoriasis was superior to non-Compound Qingdai Capsule group,and the side effects were less than non-Compound Qingdai Capsule group;the n≥40 year-old group had certain heterogeneity,suggesting that the difference was statistically significant,and the effective rate was higher than that of the control group.The funnel plot showed that the graph was asymmetrical,and there may be publication bias or the possibility of low-quality literature.The TSA results indicated that the actual sample size was far lower than the expected sample size,and the cumulative Z value did not reach the TSA cut-off value and more trials need to be included to confirm the efficacy.[Conclusions]Compound Qingdai Capsule has a clear curative effect on psoriasis,and its safety is high.This study can provide relevant evidence for the effectiveness of Chinese patent drugs(CPD)in treating psoriasis.展开更多
Organic optoelectronic materials enable cutting-edge,low-cost organic photodiodes,including organic solar cells(OSCs)for energy conversion and organic photodetectors(OPDs)for image sensors.The bulk heterojunction(BHJ)...Organic optoelectronic materials enable cutting-edge,low-cost organic photodiodes,including organic solar cells(OSCs)for energy conversion and organic photodetectors(OPDs)for image sensors.The bulk heterojunction(BHJ)structure,derived by blending donor and acceptor materials in a single solution,has dominated in the construction of active layer,but its morphological evolution during film formation poses a great challenge for obtaining an ideal nanoscale morphology to maximize exciton dissociation and minimize nongeminate recom-bination.Solution sequential deposition(SSD)can deliver favorable p–i–n vertical component distribution with abundant donor/acceptor interfaces and relatively neat donor and acceptor phases near electrodes,making it highly promising for excellent device performance and long-term stability.Focusing on the p–i–n structure,this review provides a systematic retrospect on regulating this morphology in SSD by summarizing solvent selection and additive strategies.These methods have been successfully implemented to achieve well-defined morphology in ternary OSCs,all-polymer solar cells,and OPDs.To provide a practical perspective,comparative studies of device stability with BHJ and SSD film are also discussed,and we review influential progress in blade-coating techniques and large-area modules to shed light on industrial production.Finally,challenging issues are out-lined for further research toward eventual commercialization.展开更多
文摘This paper presents a novel sequential inverse optimal control(SIOC)method for discrete-time systems,which calculates the unknown weight vectors of the cost function in real time using the input and output of an optimally controlled discrete-time system.The proposed method overcomes the limitations of previous approaches by eliminating the need for the invertible Jacobian assumption.It calculates the possible-solution spaces and their intersections sequentially until the dimension of the intersection space decreases to one.The remaining one-dimensional vector of the possible-solution space’s intersection represents the SIOC solution.The paper presents clear conditions for convergence and addresses the issue of noisy data by clarifying the conditions for the singular values of the matrices that relate to the possible-solution space.The effectiveness of the proposed method is demonstrated through simulation results.
基金supported by International Cooperation Project of Ministry of Science and Technology of China(4.1.P2.CN.01/1A)
文摘Sequential control applied to the International Thermonuclear Experimental Re- actor (ITER) poloidal field converter system for the purpose of reactive power reduction is the subject of this investigation. Due to the inherent characteristics of thyristor-based phase-controlled converter, the poloidal field converter system consumes a huge amount of reactive power from the grid, which subsequently results in a voltage drop at the 66 kV busbar if no measure is taken. The installation of a static var compensator rated for 750 MVar at the 66 kV busbax is an essential way to compensate reactive power to the grid, which is the most effective measure to solve the problem. However, sequential control of the multi-series converters provides an additional method to improve the natural power factor and thus alleviate the pressure of reactive power demand of the converter system without any additional cost. In the present paper, by comparing with the symmetrical control technique, the advantage of sequential control in reactive power consumption is highlighted. Simulation results based on SIMULINK are found in agreement with the theoretical analysis.
文摘With a focus on an industrial multivariable system, two subsystems including the flow and the level outputs are analysed and controlled, which have applicability in both real and academic environments. In such a case, at first, each subsystem is distinctively represented by its model, since the outcomes point out that the chosen models have the same behavior as corresponding ones. Then, the industrial multivariable system and its presentation are achieved in line with the integration of these subsystems, since the interaction between them can not actually be ignored. To analyze the interaction presented, the Gershgorin bands need to be acquired, where the results are used to modify the system parameters to appropriate values. Subsequently, in the view of modeling results, the control concept in two different techniques including sequential loop closing control(SLCC) scheme and diagonal dominance control(DDC) schemes is proposed to implement on the system through the Profibus network, as long as the OPC(OLE for process control) server is utilized to communicate between the control schemes presented and the multivariable system. The real test scenarios are carried out and the corresponding outcomes in their present forms are acquired. In the same way, the proposed control schemes results are compared with each other, where the real consequences verify the validity of them in the field of the presented industrial multivariable system control.
文摘As a method for testing a sequential circuit efficiently, a scan design is usually used. But, since this design has some drawbacks, a non-scan testable design should be discussed. The testable design can be implemented by enhancing controllability and observability. This paper discusses a non-scan testable design for a sequential circuit by only focusing the improvement of controllability. The proposed design modifies a circuit so that all the FFs can be directly controlled by primary input lines in a test mode. Experimental results show that we can get a good testability using this method.
文摘A kind of direct methods is presented for the solution of optimal control problems with state constraints. These methods are sequential quadratic programming methods. At every iteration a quadratic programming which is obtained by quadratic approximation to Lagrangian function and linear approximations to constraints is solved to get a search direction for a merit function. The merit function is formulated by augmenting the Lagrangian function with a penalty term. A line search is carried out along the search direction to determine a step length such that the merit function is decreased. The methods presented in this paper include continuous sequential quadratic programming methods and discreate sequential quadratic programming methods.
文摘Sequential chemical extraction procedure has been widely used to partition particulate trace metals into various fractions and to describe the distribution and the statue of trace metals in geo environment. One sequential chemical extraction procedure was employed here to partition various fractions of Mn in soils. The experiment was designed with quality controlling concept in order to show sampling and analytical error. Experimental results obtained on duplicate analysis of all soil samples demonstrated that the precision was less than 10%(at 95%confidence level). The accuracy was estimated by comparing the accepted total concentration of Mn in standard reference materials (SRMs) with the measured sum of the individual fractions. The recovery of Mn from SRM1 and SRM2 was 94.1%and 98.4%, respectively. The detection limit, accuracy and precision of the sequential chemical extraction procedure were discussed in detailed. All the results suggest that the trueness of the analytical method is satisfactory.
文摘BACKGROUND:Early withdrawal of invasive mechanical ventilation(IMV) followed by noninvasive MV(NIMV) is a new strategy for changing modes of treatment in patients with acute exacerbations of chronic obstructive pulmonary disease(AECOPD) with acute respiratory failure(ARF).Using pulmonary infection control window(PIC window) as the switch point for transferring from invasive to noninvasive MV,the time for early extubation can be more accurately judged,and therapy efficacy can be improved.This study aimed to prospectively investigate the clinical effectiveness of fiberoptic bronchscopy(FOB) in patients with AECOPD during sequential weaning of invasive-noninvasive MV.METHODS:Since July 2006 to January 2011,106 AECOPD patients with ARF were treated with comprehensive medication and IMV after hospitalization.Patients were randomly divided into two groups according to whether fiberoptic bronchoscope is used(group A,n=54) or not(group B,n=52) during sequential weaning from invasive to noninvasive MV.In group A,for sputum suction and bronchoalveolar lavage(BAL),a fiberoptic bronchoscope was put into the airway from the outside of an endotracheal tube,which was accompanied with uninterrupted use of a ventilator.After achieving PIC window,patients of both groups changed to NIMV mode,and weaned from ventilation.The following listed indices were used to compare between the groups after treatment:1) the occurrence time of PIC,the duration of MV,the length of ICU stay,the success rate of weaning from MV for the first time,the rate of reventilatJon and the occurrence rate of ventilator-associated pneumonia(VAP);2) the convenience and safety of FOB manipulation.The results were compared using Student's f test and the Chi-square test.RESULTS:The occurrence time of PIC was(5.01 ±1.49) d,(5.87±1.87) d in groups A and B,respectively(P<0.05);the duration of MV was(6.98±1.84) d,(8.69±2.41) d in groups A and B,respectively(P<0.01);the length of ICU stay was(9.25±1.84) d,(11.10±2.63) d in groups A and B,respectively(P<0.01);the success rate of weaning for the first time was 96.30%,76.92%in groups A and B,respectively(P<0.01);the rate of reventilation was 5.56%,19.23%in groups A and B,respectively(P<0.05);and the occurrence rate of VAP was 3.70%,23.07%in groups A and B,respectively(P<0.01).Moreover,it was easy and safe to manipulate FOB,and no side effect was observed.CONCLUSIONS:The application of FOB in patients with AECOPD during sequential weaning of invasive-noninvasive MV is effective in ICU.It can decrease the duration of MV and the length of ICU stay,increase the success rate from weaning MV for the first time,reduce the rate of reventilation and the occurrence rate of VAP.In addition,such a method is convenient and safe in patients of this kind.
文摘The Kuhn-Tucker theorem in nondifferential form is a well-known classical optimality criterion for a convex programming problems which is true for a convex problem in the case when a Kuhn-Tucker vector exists. It is natural to extract two features connected with the classical theorem. The first of them consists in its possible “impracticability” (the Kuhn-Tucker vector does not exist). The second feature is connected with possible “instability” of the classical theorem with respect to the errors in the initial data. The article deals with the so-called regularized Kuhn-Tucker theorem in nondifferential sequential form which contains its classical analogue. A proof of the regularized theorem is based on the dual regularization method. This theorem is an assertion without regularity assumptions in terms of minimizing sequences about possibility of approximation of the solution of the convex programming problem by minimizers of its regular Lagrangian, that are constructively generated by means of the dual regularization method. The major distinctive property of the regularized Kuhn-Tucker theorem consists that it is free from two lacks of its classical analogue specified above. The last circumstance opens possibilities of its application for solving various ill-posed problems of optimization, optimal control, inverse problems.
基金National Key Research and Development Program"Key Special Project of Traditional Chinese Medicine Modernization Research"(2018YFC1705303)Innovative Talent Promotion Program-Key Technology Innovation Team Program(2017KCT-27)。
文摘[Objectives]To analyze the efficacy of Compound Qingdai Capsule in the treatment of psoriasis and conduct a systematic evaluation.[Methods]The clinical total effective rate,PASI index score,IL-17 level,IL-23 level,TNF-level,and adverse reactions were analyzed.TSA 0.9 software was used to conduct sequential analysis of the total effective rate,and subgroup analysis was performed according to the average age of the experimental group.[Results]Single application of Compound Qingdai Capsule or in combination with other methods in the treatment of psoriasis was superior to non-Compound Qingdai Capsule group,and the side effects were less than non-Compound Qingdai Capsule group;the n≥40 year-old group had certain heterogeneity,suggesting that the difference was statistically significant,and the effective rate was higher than that of the control group.The funnel plot showed that the graph was asymmetrical,and there may be publication bias or the possibility of low-quality literature.The TSA results indicated that the actual sample size was far lower than the expected sample size,and the cumulative Z value did not reach the TSA cut-off value and more trials need to be included to confirm the efficacy.[Conclusions]Compound Qingdai Capsule has a clear curative effect on psoriasis,and its safety is high.This study can provide relevant evidence for the effectiveness of Chinese patent drugs(CPD)in treating psoriasis.
基金supported by the National Key Research and Development Program of China(No.2019YFA0705900)funded by MOST,the Basic and Applied Basic Research Major Program of Guangdong Province(No.2019B030302007)the Natural Science Foundation of China(No.21875073,52122307)the Distinguished Young Scientists Program of Guangdong Province(No.2019B151502021).
文摘Organic optoelectronic materials enable cutting-edge,low-cost organic photodiodes,including organic solar cells(OSCs)for energy conversion and organic photodetectors(OPDs)for image sensors.The bulk heterojunction(BHJ)structure,derived by blending donor and acceptor materials in a single solution,has dominated in the construction of active layer,but its morphological evolution during film formation poses a great challenge for obtaining an ideal nanoscale morphology to maximize exciton dissociation and minimize nongeminate recom-bination.Solution sequential deposition(SSD)can deliver favorable p–i–n vertical component distribution with abundant donor/acceptor interfaces and relatively neat donor and acceptor phases near electrodes,making it highly promising for excellent device performance and long-term stability.Focusing on the p–i–n structure,this review provides a systematic retrospect on regulating this morphology in SSD by summarizing solvent selection and additive strategies.These methods have been successfully implemented to achieve well-defined morphology in ternary OSCs,all-polymer solar cells,and OPDs.To provide a practical perspective,comparative studies of device stability with BHJ and SSD film are also discussed,and we review influential progress in blade-coating techniques and large-area modules to shed light on industrial production.Finally,challenging issues are out-lined for further research toward eventual commercialization.