Liver cancer,one of the most common malignancies worldwide,ranks sixth in incidence and third in mortality.Liver cancer treatment options are diverse,inclu-ding surgical resection,liver transplantation,percutaneous ab...Liver cancer,one of the most common malignancies worldwide,ranks sixth in incidence and third in mortality.Liver cancer treatment options are diverse,inclu-ding surgical resection,liver transplantation,percutaneous ablation,transarterial chemoembolization,radiotherapy,chemotherapy,targeted therapy,immuno-therapy,and traditional Chinese medicine(TCM).A multidisciplinary team(MDT)is essential to customize treatment plans based on tumor staging,liver function,and performance status(PS),ensuring individualized patient care.Treatment decisions require a MDT to tailor strategies based on tumor staging,liver function,and PS,ensuring personalized care.The approval of new first-line and second-line drugs and the establishment of standard treatments based on immune checkpoint inhibitors have significantly expanded treatment options for advanced liver cancer,improving overall prognosis.However,many patients do not respond effectively to these treatments and ultimately succumb to the disease.Modern oncology treatments,while extending patient survival,often come with severe side effects,resistance,and damage to the body,negatively impacting quality of life.Huang et al's study published at World Journal of Gastroenterology rigorously validates the anticancer properties of Calculus bovis,enhancing our understanding of TCM and contributing to new liver cancer treatment strategies.For over 5000 years,TCM has been used in East Asian countries like China to treat various diseases,including liver conditions.Analysis of real-world clinical data suggests that for patients with advanced-stage tumors lacking effective treatments,integrated TCM therapies could provide significant breakthroughs.展开更多
Einstein Probe,an astronomical satellite designed for X-ray observation on astronomical events drastically evolving over time,was successfully sent into preset orbit by a Long March 2C rocket from China’s Xichang Sat...Einstein Probe,an astronomical satellite designed for X-ray observation on astronomical events drastically evolving over time,was successfully sent into preset orbit by a Long March 2C rocket from China’s Xichang Satellite Launch Center located in Sichuan Province at 15:03 GMT+8 on January 9,2024.展开更多
In this paper we propose an absolute error loss EB estimator for parameter of one-side truncation distribution families. Under some conditions we have proved that the convergence rates of its Bayes risk is o, where 0&...In this paper we propose an absolute error loss EB estimator for parameter of one-side truncation distribution families. Under some conditions we have proved that the convergence rates of its Bayes risk is o, where 0<λ,r≤1,Mn≤lnln n (for large n),Mn→∞ as n→∞.展开更多
Heterodera avenae （cereal cyst nematode, CCN） infects many cereal crops and causes serious yield losses worldwide. Interaction studies investigating H. avenae and its hosts are still in their infancy. In this study,...Heterodera avenae （cereal cyst nematode, CCN） infects many cereal crops and causes serious yield losses worldwide. Interaction studies investigating H. avenae and its hosts are still in their infancy. In this study, a barley model plant, the Hordeum vulgare cultivar Golden Promise, was investigated for its potential as a candidate model host to study its inter- action with H. avenae. CCN-infective juveniles were attracted by the root tips and gathered around the root elongation zones of Golden Promise on 0.7% water agar plates. The juveniles invaded the roots and developed successfully until maturation at 40 days after inoculation in sterile sand soil. The cryotomy and syncytium measurements indicated that the syncytia enlarged gradually throughout the development of the nematodes and caused the corresponding root regions to swell obviously. Quantitative real-time PCR analysis showed that the down-regulation of defence-related barley genes and up-regulation Of development-related barley ger^es contribute to the understanding of compatible interaction between H. avenae and Golden Promise. Barley stripe mosaic virus （BSMV） virus-induced gene silencing （VIGS） can be used in the roots of Golden Promise. In conclusion, the Hordeum vulgare cultivar Golden Promise is a suitable candidate model host for interaction studies with Heterodera avenae. The studies presented above document the first CCN host that no.t only has published genome context but also be compatible to BSMV VIGS.展开更多
Despite being the long-time mainstream semiconductor for both logic and power devices, Silicon is now facing its dilemma and limitation of scalability and material potential.Especially for power devices, people are de...Despite being the long-time mainstream semiconductor for both logic and power devices, Silicon is now facing its dilemma and limitation of scalability and material potential.Especially for power devices, people are demanding escalating efficiency with higher blocking voltage while its power consumption and heat generation are less. Constrained by its narrow bandgap of 1.14 eV, Silicon only has a critical breakdown field(E_c) of 0.3 MV/cm, yielding a Baliga figureof-merit(BFOM = ε×μ× E_c^3) of unity when normalized to itself. It is hence required that the dominating factor E_c should be as high as possible such that the BFOM will be hundreds or even thousands of times when compared to Silicon so as to minimize the conduction loss. Beta-Gallium Oxide(β-Ga_2O_3) with decent μ of 250 cm2/Vs, ultra-wide bandgap of4.8 eV and high critical E_c of 8 MV/cm, yielding a superior high BFOM of more than 3000. Therefore, system made withβ-Ga_2O_3 can be thinner, lighter and capable of handling more power than the one with Silicon. In addition, low-cost and large size substrate through melt-grown method endows β-Ga_2O_3 more potentials as cost-effective power devices. After resolving the low thermal conductivity issue,unipolar devices made with ultra-wide bandgap β-Ga_2O_3 are promised to make power transition and our life more efficient.展开更多
In this paper, we devote to constructing the one-sided empirical Bayes(EB) test for the location parameter in the Gamma distribution by nonparametric method. Under some mild conditions, we prove that the EB test is as...In this paper, we devote to constructing the one-sided empirical Bayes(EB) test for the location parameter in the Gamma distribution by nonparametric method. Under some mild conditions, we prove that the EB test is asymptotically optimal with the rate of the order O(n^(-δs/(2s+1))), where 1/2 ≤ δ < 1 and s > 1 is a given natural number. An example is also given to illustrate that the conditions of the main theorems are easily satisfied.展开更多
In this paper,a second-order fnite-diference scheme is investigated for time-dependent space fractional difusion equations with variable coefcients.In the presented scheme,the Crank-Nicolson temporal discretization an...In this paper,a second-order fnite-diference scheme is investigated for time-dependent space fractional difusion equations with variable coefcients.In the presented scheme,the Crank-Nicolson temporal discretization and a second-order weighted-and-shifted Grünwald-Letnikov spatial discretization are employed.Theoretically,the unconditional stability and the second-order convergence in time and space of the proposed scheme are established under some conditions on the variable coefcients.Moreover,a Toeplitz preconditioner is proposed for linear systems arising from the proposed scheme.The condition number of the preconditioned matrix is proven to be bounded by a constant independent of the discretization step-sizes,so that the Krylov subspace solver for the preconditioned linear systems converges linearly.Numerical results are reported to show the convergence rate and the efciency of the proposed scheme.展开更多
The hype was flowing when 5G wireless service began rolling out around 2018(Fig.1).According to the US wireless company Verizon,based in New York City,NY,USA,5G would usher in“a Fourth Industrial Revolution”[1].The ...The hype was flowing when 5G wireless service began rolling out around 2018(Fig.1).According to the US wireless company Verizon,based in New York City,NY,USA,5G would usher in“a Fourth Industrial Revolution”[1].The technology would also allow surgeons to perform operations remotely on patients thousands of kilometers away,permit communications between driverless cars,and offer other life-changing benefits[2,3].展开更多
One day in late 2022 or early 2023,a customer somewhere in the United States will make history by purchasing the first pair of hearing aids sold over the counter(OTC).For more than 40 years,these devices have been ava...One day in late 2022 or early 2023,a customer somewhere in the United States will make history by purchasing the first pair of hearing aids sold over the counter(OTC).For more than 40 years,these devices have been available in the United States and many other countries mainly through audiologists or other hearing professionals.But updated regulations scheduled for enactment later this year by the Food and Drug Administration(FDA),the US agency that oversees drugs and medical devices,will allow retailers to sell hearing aids directly to consumers[1].展开更多
Elaborate proof-of-principle experiments in several laboratories around the world have recently offered glimpses of a future in which high-throughput automatic laboratories guided by artificial intelligence(AI)might e...Elaborate proof-of-principle experiments in several laboratories around the world have recently offered glimpses of a future in which high-throughput automatic laboratories guided by artificial intelligence(AI)might enhance the process for discovery of new materials,such as those for clean energy technologies.And in chemical engineering,using AI to aid in synthesis planning and performance offers the prospect of scientists needing little more than an idea and an internet connection to generate novel molecules in state-of-the-art,remote laboratories.Announced in August 2020,International Business Machine Corporation(IBM)’s RoboRXN for Chemistry provides a high-profile example of the potential for combining AI and laboratory automation[1].The system not only provides chemical recipes to produce organic molecules of interest but can also synthesize those molecules automatically using commercially available hardware—in the case of IBM’s demonstrator,a Flex-category automated-synthesis workstation(Fig.1)manufactured by Chemspeed Technologies(Füllinsdorf,Switzerland).展开更多
Computers already gobble a large share of the world’s electrical power,and their energy demand will likely soar with the deployment of more and more power-hungry artificial intelligence(AI)systems[1].In a step that m...Computers already gobble a large share of the world’s electrical power,and their energy demand will likely soar with the deployment of more and more power-hungry artificial intelligence(AI)systems[1].In a step that might reduce AI’s electricity use and environmental impact,Lightmatter,a startup based in Boston,MA,USA,announced that it has developed a microchip that performs calculations with light and requires about one-sixth the energy of a comparable electronic chip(Fig.1)[2].Other companies are developing similar photon-based chips for AI and for many other uses,including self-driving cars and quantum computing[3,4].展开更多
文摘Liver cancer,one of the most common malignancies worldwide,ranks sixth in incidence and third in mortality.Liver cancer treatment options are diverse,inclu-ding surgical resection,liver transplantation,percutaneous ablation,transarterial chemoembolization,radiotherapy,chemotherapy,targeted therapy,immuno-therapy,and traditional Chinese medicine(TCM).A multidisciplinary team(MDT)is essential to customize treatment plans based on tumor staging,liver function,and performance status(PS),ensuring individualized patient care.Treatment decisions require a MDT to tailor strategies based on tumor staging,liver function,and PS,ensuring personalized care.The approval of new first-line and second-line drugs and the establishment of standard treatments based on immune checkpoint inhibitors have significantly expanded treatment options for advanced liver cancer,improving overall prognosis.However,many patients do not respond effectively to these treatments and ultimately succumb to the disease.Modern oncology treatments,while extending patient survival,often come with severe side effects,resistance,and damage to the body,negatively impacting quality of life.Huang et al's study published at World Journal of Gastroenterology rigorously validates the anticancer properties of Calculus bovis,enhancing our understanding of TCM and contributing to new liver cancer treatment strategies.For over 5000 years,TCM has been used in East Asian countries like China to treat various diseases,including liver conditions.Analysis of real-world clinical data suggests that for patients with advanced-stage tumors lacking effective treatments,integrated TCM therapies could provide significant breakthroughs.
文摘Einstein Probe,an astronomical satellite designed for X-ray observation on astronomical events drastically evolving over time,was successfully sent into preset orbit by a Long March 2C rocket from China’s Xichang Satellite Launch Center located in Sichuan Province at 15:03 GMT+8 on January 9,2024.
文摘In this paper we propose an absolute error loss EB estimator for parameter of one-side truncation distribution families. Under some conditions we have proved that the convergence rates of its Bayes risk is o, where 0<λ,r≤1,Mn≤lnln n (for large n),Mn→∞ as n→∞.
基金supported by the National Natural Science Foundation of China(31571988)the Special Fund for Agro-scientific Research in the Public Interest, China (201503114)the National Key Basic Research Program of China (973 Program, 2013CB127502)
文摘Heterodera avenae （cereal cyst nematode, CCN） infects many cereal crops and causes serious yield losses worldwide. Interaction studies investigating H. avenae and its hosts are still in their infancy. In this study, a barley model plant, the Hordeum vulgare cultivar Golden Promise, was investigated for its potential as a candidate model host to study its inter- action with H. avenae. CCN-infective juveniles were attracted by the root tips and gathered around the root elongation zones of Golden Promise on 0.7% water agar plates. The juveniles invaded the roots and developed successfully until maturation at 40 days after inoculation in sterile sand soil. The cryotomy and syncytium measurements indicated that the syncytia enlarged gradually throughout the development of the nematodes and caused the corresponding root regions to swell obviously. Quantitative real-time PCR analysis showed that the down-regulation of defence-related barley genes and up-regulation Of development-related barley ger^es contribute to the understanding of compatible interaction between H. avenae and Golden Promise. Barley stripe mosaic virus （BSMV） virus-induced gene silencing （VIGS） can be used in the roots of Golden Promise. In conclusion, the Hordeum vulgare cultivar Golden Promise is a suitable candidate model host for interaction studies with Heterodera avenae. The studies presented above document the first CCN host that no.t only has published genome context but also be compatible to BSMV VIGS.
文摘Despite being the long-time mainstream semiconductor for both logic and power devices, Silicon is now facing its dilemma and limitation of scalability and material potential.Especially for power devices, people are demanding escalating efficiency with higher blocking voltage while its power consumption and heat generation are less. Constrained by its narrow bandgap of 1.14 eV, Silicon only has a critical breakdown field(E_c) of 0.3 MV/cm, yielding a Baliga figureof-merit(BFOM = ε×μ× E_c^3) of unity when normalized to itself. It is hence required that the dominating factor E_c should be as high as possible such that the BFOM will be hundreds or even thousands of times when compared to Silicon so as to minimize the conduction loss. Beta-Gallium Oxide(β-Ga_2O_3) with decent μ of 250 cm2/Vs, ultra-wide bandgap of4.8 eV and high critical E_c of 8 MV/cm, yielding a superior high BFOM of more than 3000. Therefore, system made withβ-Ga_2O_3 can be thinner, lighter and capable of handling more power than the one with Silicon. In addition, low-cost and large size substrate through melt-grown method endows β-Ga_2O_3 more potentials as cost-effective power devices. After resolving the low thermal conductivity issue,unipolar devices made with ultra-wide bandgap β-Ga_2O_3 are promised to make power transition and our life more efficient.
基金Supported by the National Natural Science Foundation of China(11671375 and 11471303)Natural Science Foundation of Anhui Provincial Education Department(KJ2017A171)
文摘In this paper, we devote to constructing the one-sided empirical Bayes(EB) test for the location parameter in the Gamma distribution by nonparametric method. Under some mild conditions, we prove that the EB test is asymptotically optimal with the rate of the order O(n^(-δs/(2s+1))), where 1/2 ≤ δ < 1 and s > 1 is a given natural number. An example is also given to illustrate that the conditions of the main theorems are easily satisfied.
基金This research was supported by research Grants,12306616,12200317,12300519,12300218 from HKRGC GRF,11801479 from NSFC,MYRG2018-00015-FST from University of Macao,and 0118/2018/A3 from FDCT of Macao,Macao Science and Technology Development Fund 0005/2019/A,050/2017/Athe Grant MYRG2017-00098-FST and MYRG2018-00047-FST from University of Macao.S。
文摘In this paper,a second-order fnite-diference scheme is investigated for time-dependent space fractional difusion equations with variable coefcients.In the presented scheme,the Crank-Nicolson temporal discretization and a second-order weighted-and-shifted Grünwald-Letnikov spatial discretization are employed.Theoretically,the unconditional stability and the second-order convergence in time and space of the proposed scheme are established under some conditions on the variable coefcients.Moreover,a Toeplitz preconditioner is proposed for linear systems arising from the proposed scheme.The condition number of the preconditioned matrix is proven to be bounded by a constant independent of the discretization step-sizes,so that the Krylov subspace solver for the preconditioned linear systems converges linearly.Numerical results are reported to show the convergence rate and the efciency of the proposed scheme.
文摘The hype was flowing when 5G wireless service began rolling out around 2018(Fig.1).According to the US wireless company Verizon,based in New York City,NY,USA,5G would usher in“a Fourth Industrial Revolution”[1].The technology would also allow surgeons to perform operations remotely on patients thousands of kilometers away,permit communications between driverless cars,and offer other life-changing benefits[2,3].
文摘One day in late 2022 or early 2023,a customer somewhere in the United States will make history by purchasing the first pair of hearing aids sold over the counter(OTC).For more than 40 years,these devices have been available in the United States and many other countries mainly through audiologists or other hearing professionals.But updated regulations scheduled for enactment later this year by the Food and Drug Administration(FDA),the US agency that oversees drugs and medical devices,will allow retailers to sell hearing aids directly to consumers[1].
文摘Elaborate proof-of-principle experiments in several laboratories around the world have recently offered glimpses of a future in which high-throughput automatic laboratories guided by artificial intelligence(AI)might enhance the process for discovery of new materials,such as those for clean energy technologies.And in chemical engineering,using AI to aid in synthesis planning and performance offers the prospect of scientists needing little more than an idea and an internet connection to generate novel molecules in state-of-the-art,remote laboratories.Announced in August 2020,International Business Machine Corporation(IBM)’s RoboRXN for Chemistry provides a high-profile example of the potential for combining AI and laboratory automation[1].The system not only provides chemical recipes to produce organic molecules of interest but can also synthesize those molecules automatically using commercially available hardware—in the case of IBM’s demonstrator,a Flex-category automated-synthesis workstation(Fig.1)manufactured by Chemspeed Technologies(Füllinsdorf,Switzerland).
文摘Computers already gobble a large share of the world’s electrical power,and their energy demand will likely soar with the deployment of more and more power-hungry artificial intelligence(AI)systems[1].In a step that might reduce AI’s electricity use and environmental impact,Lightmatter,a startup based in Boston,MA,USA,announced that it has developed a microchip that performs calculations with light and requires about one-sixth the energy of a comparable electronic chip(Fig.1)[2].Other companies are developing similar photon-based chips for AI and for many other uses,including self-driving cars and quantum computing[3,4].
