BACKGROUND Biliary stone disease is a highly prevalent condition and a leading cause of hospitalization worldwide.Hepatolithiasis with associated strictures has high residual and recurrence rates after traditional mul...BACKGROUND Biliary stone disease is a highly prevalent condition and a leading cause of hospitalization worldwide.Hepatolithiasis with associated strictures has high residual and recurrence rates after traditional multisession percutaneous transhepatic cholangioscopic lithotripsy(PTCSL).AIM To study one-step PTCSL using the percutaneous transhepatic one-step biliary fistulation(PTOBF)technique guided by three-dimensional(3D)visualization.METHODS This was a retrospective,single-center study analyzing,140 patients who,between October 2016 and October 2023,underwent one-step PTCSL for hepatolithiasis.The patients were divided into two groups:The 3D-PTOBF group and the PTOBF group.Stone clearance on choledochoscopy,complications,and long-term clearance and recurrence rates were assessed.RESULTS Age,total bilirubin,direct bilirubin,Child-Pugh class,and stone location were similar between the 2 groups,but there was a significant difference in bile duct strictures,with biliary strictures more common in the 3D-PTOBF group(P=0.001).The median follow-up time was 55.0(55.0,512.0)days.The immediate stone clearance ratio(88.6%vs 27.1%,P=0.000)and stricture resolution ratio(97.1%vs 78.6%,P=0.001)in the 3D-PTOBF group were significantly greater than those in the PTOBF group.Postoperative complication(8.6%vs 41.4%,P=0.000)and stone recurrence rates(7.1%vs 38.6%,P=0.000)were significantly lower in the 3D-PTOBF group.CONCLUSION Three-dimensional visualization helps make one-step PTCSL a safe,effective,and promising treatment for patients with complicated primary hepatolithiasis.The perioperative and long-term outcomes are satisfactory for patients with complicated primary hepatolithiasis.This minimally invasive method has the potential to be used as a substitute for hepatobiliary surgery.展开更多
Quantum dialogue(QD)enables two communication parties to directly exchange secret messages simultaneously.In conventional QD protocols,photons need to transmit in the quantum channel for two rounds.In this paper,we pr...Quantum dialogue(QD)enables two communication parties to directly exchange secret messages simultaneously.In conventional QD protocols,photons need to transmit in the quantum channel for two rounds.In this paper,we propose a one-step QD protocol based on the hyperentanglement.With the help of the non-local hyperentanglement-assisted Bell state measurement(BSM),the photons only need to transmit in the quantum channel once.We prove that our one-step QD protocol is secure in theory and numerically simulate its secret message capacity under practical experimental condition.Compared with previous QD protocols,the one-step QD protocol can effectively simplify the experiment operations and reduce the message loss caused by the photon transmission loss.Meanwhile,the non-local hyperentanglement-assisted BSM has a success probability of 100%and is feasible with linear optical elements.Moreover,combined with the hyperentanglement heralded amplification and purification,our protocol is possible to realize long-distance one-step QD.展开更多
This paper studied the effects of different retarders on the performance of the"one-step"alkali-activated composite cementitious material(ACCM)which is composed of ground granulated blast slag(GGBS)and fly a...This paper studied the effects of different retarders on the performance of the"one-step"alkali-activated composite cementitious material(ACCM)which is composed of ground granulated blast slag(GGBS)and fly ash(FA),and analyzed its mechanical properties,hydration mechanism,and retardation mechanism.The effects of retarders on the hydration products,mechanical properties,and hydration kinetics of ACCM were investigated using XRD,SEM,FTIR,EDS,and thermoactive microcalorimetry.The results showed that Na_(2)B_(4)O_(7)·10H_(2)O(B)delayed the exotherm during the alkali activation process and could effectively delay the setting time of ACCM,but the mechanical properties were slightly decreased.The setting time of ACCM increased with the increase in SG content,but the mechanical properties of ACCM decreased with the increase in SG content.C1_(2)H_(22)O_(11)(CHO)could effectively delay the hydration reaction of ACCM and weakly enhanced the compressive strength.H_(3)PO_(4)(HP)at a concentration of 0.05 mol/L had a certain effect on ACCM retardation,but HP at a concentration of 0.07 and 0.09 mol/L had an effect of promoting the setting and hardening time of ACCM.展开更多
In this study,the impact of different reaction times on the preparation of powdered activated carbon(PAC)using a one-step rapid activation method under flue gas atmosphere is investigated,and the underlying reaction m...In this study,the impact of different reaction times on the preparation of powdered activated carbon(PAC)using a one-step rapid activation method under flue gas atmosphere is investigated,and the underlying reaction mechanism is summarized.Results indicate that the reaction process of this method can be divided into three stages:stage I is the rapid release of volatiles and the rapid consumption of O_(2),primarily occurring within a reaction time range of 0-0.5 s;stage II is mainly the continuous release and diffusion of volatiles,which is the carbonization and activation coupling reaction stage,and the carbonization process is the main in this stage.This stage mainly occurs at the reaction time range of 0.5 -2.0 s when SL-coal is used as material,and that is 0.5-3.0 s when JJ-coal is used as material;stage III is mainly the activation stage,during which activated components diffuse to both the surface and interior of particles.This stage mainly involves the reaction stage of CO_(2)and H2O(g)activation,and it mainly occurs at the reaction time range of 2.0-4.0 s when SL-coal is used as material,and that is 3.0-4.0 s when JJ-coal is used as material.Besides,the main function of the first two stages is to provide more diffusion channels and contact surfaces/activation sites for the diffusion and activation of the activated components in the third stage.Mastering the reaction mechanism would serve as a crucial reference and foundation for designing the structure,size of the reactor,and optimal positioning of the activator nozzle in PAC preparation.展开更多
Objective: To evaluate the application value of neutrophils/lymphocytes (NLR), platelets/lymphocytes (PLR), lymphocytes/monocytes (LMR), HEART (history, electrocardiogram, age, risk factors, and troponin) score, and p...Objective: To evaluate the application value of neutrophils/lymphocytes (NLR), platelets/lymphocytes (PLR), lymphocytes/monocytes (LMR), HEART (history, electrocardiogram, age, risk factors, and troponin) score, and point-of- care testing (POCT) in the early warning and precise diagnosis of high-risk chest pain in emergency medicine. Methods: A total of 157 patients with acute chest pain who were admitted to the emergency department and chest pain treatment unit of our hospital between August 2022 and September 2023 were selected. Rapid testing of bedside myocardial markers (ultrasensitive troponin (hs-cTnI), myoglobin (MYO), creatine kinase isoenzyme (CK-MB), D-dimer (D-Dimer), and N-terminal B-type natriuretic peptide precursor (NT-proBNP)) was performed on the patients using a POCT device (ThermoKing BioMQ60proB). A HEART score was used to classify the patients into low (n = 53), intermediate (n = 59), and high-risk (n = 45) groups, and the NLR, PLR, and LMR were calculated. The NLR, PLR, and LMR values were compared among the three groups of patients, and the optimal cutoff values as well as sensitivity and specificity were determined based on receiver operating characteristic (ROC) analysis. Results: The HEART scores of patients in the low-risk, intermediate-risk, and high-risk groups were (2.72 ± 0.24), (4.75 ± 0.56), and (5.32 ± 0.73) respectively, and the differences were statistically significant (P < 0.05). Compared with the low-risk group, the intermediate-risk group and high-risk group had a significantly higher NLR and PLR, and a significantly lower LMR;the high-risk group had higher NLR and PLR and lower values of LMR as compared to the other two groups, and the difference was statistically significant (P < 0.05). The ROC curves suggested that the area under the curve, sensitivity, and specificity of the combined diagnosis of NLR, PLR, LMR, HEART score, and POCT were greater than those of LR, PLR, and LMR with HEART score and POCT alone. Conclusion: The combined application of NLR, PLR, LMR, HEART score, and POCT has significant application value in the early warning and precise diagnosis of emergency high-risk chest pain. It provides a more simple, easy-to-access, and efficient assessment index for the clinical prediction and treatment of emergency high- risk chest pain.展开更多
1POCT概念POCT是Point of Care Testing的缩写,可翻译为“现场快速检测”或“现场即时检测”,是指不需要固定、专用的场所,在最贴近患者/患病动物的地点或采样现场,应用便携式分析仪器及配套试剂进行的一种操作简便、可快速得到结果的...1POCT概念POCT是Point of Care Testing的缩写,可翻译为“现场快速检测”或“现场即时检测”,是指不需要固定、专用的场所,在最贴近患者/患病动物的地点或采样现场,应用便携式分析仪器及配套试剂进行的一种操作简便、可快速得到结果的检测方式。具有即时、便携、简化、快速的特点,世界卫生组织(WHO)对POCT的定位为:经济、灵敏、特异、装置简单、简便易用、快速。展开更多
基金Supported by The Key Medical Specialty Nurturing Program of Foshan During The 14th Five-Year Plan Period,No.FSPY145205The Medical Research Project of Foshan Health Bureau,No.20230814A010024+1 种基金The Guangzhou Science and Technology Plan Project,No.202102010251the Guangdong Science and Technology Program,No.2017ZC0222.
文摘BACKGROUND Biliary stone disease is a highly prevalent condition and a leading cause of hospitalization worldwide.Hepatolithiasis with associated strictures has high residual and recurrence rates after traditional multisession percutaneous transhepatic cholangioscopic lithotripsy(PTCSL).AIM To study one-step PTCSL using the percutaneous transhepatic one-step biliary fistulation(PTOBF)technique guided by three-dimensional(3D)visualization.METHODS This was a retrospective,single-center study analyzing,140 patients who,between October 2016 and October 2023,underwent one-step PTCSL for hepatolithiasis.The patients were divided into two groups:The 3D-PTOBF group and the PTOBF group.Stone clearance on choledochoscopy,complications,and long-term clearance and recurrence rates were assessed.RESULTS Age,total bilirubin,direct bilirubin,Child-Pugh class,and stone location were similar between the 2 groups,but there was a significant difference in bile duct strictures,with biliary strictures more common in the 3D-PTOBF group(P=0.001).The median follow-up time was 55.0(55.0,512.0)days.The immediate stone clearance ratio(88.6%vs 27.1%,P=0.000)and stricture resolution ratio(97.1%vs 78.6%,P=0.001)in the 3D-PTOBF group were significantly greater than those in the PTOBF group.Postoperative complication(8.6%vs 41.4%,P=0.000)and stone recurrence rates(7.1%vs 38.6%,P=0.000)were significantly lower in the 3D-PTOBF group.CONCLUSION Three-dimensional visualization helps make one-step PTCSL a safe,effective,and promising treatment for patients with complicated primary hepatolithiasis.The perioperative and long-term outcomes are satisfactory for patients with complicated primary hepatolithiasis.This minimally invasive method has the potential to be used as a substitute for hepatobiliary surgery.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12175106 and 92365110).
文摘Quantum dialogue(QD)enables two communication parties to directly exchange secret messages simultaneously.In conventional QD protocols,photons need to transmit in the quantum channel for two rounds.In this paper,we propose a one-step QD protocol based on the hyperentanglement.With the help of the non-local hyperentanglement-assisted Bell state measurement(BSM),the photons only need to transmit in the quantum channel once.We prove that our one-step QD protocol is secure in theory and numerically simulate its secret message capacity under practical experimental condition.Compared with previous QD protocols,the one-step QD protocol can effectively simplify the experiment operations and reduce the message loss caused by the photon transmission loss.Meanwhile,the non-local hyperentanglement-assisted BSM has a success probability of 100%and is feasible with linear optical elements.Moreover,combined with the hyperentanglement heralded amplification and purification,our protocol is possible to realize long-distance one-step QD.
基金Funded by Key Laboratory for Comprehensive Energy Saving of Cold Regions Architecture of Ministry of Education(No.JLJZHDKF202204)。
文摘This paper studied the effects of different retarders on the performance of the"one-step"alkali-activated composite cementitious material(ACCM)which is composed of ground granulated blast slag(GGBS)and fly ash(FA),and analyzed its mechanical properties,hydration mechanism,and retardation mechanism.The effects of retarders on the hydration products,mechanical properties,and hydration kinetics of ACCM were investigated using XRD,SEM,FTIR,EDS,and thermoactive microcalorimetry.The results showed that Na_(2)B_(4)O_(7)·10H_(2)O(B)delayed the exotherm during the alkali activation process and could effectively delay the setting time of ACCM,but the mechanical properties were slightly decreased.The setting time of ACCM increased with the increase in SG content,but the mechanical properties of ACCM decreased with the increase in SG content.C1_(2)H_(22)O_(11)(CHO)could effectively delay the hydration reaction of ACCM and weakly enhanced the compressive strength.H_(3)PO_(4)(HP)at a concentration of 0.05 mol/L had a certain effect on ACCM retardation,but HP at a concentration of 0.07 and 0.09 mol/L had an effect of promoting the setting and hardening time of ACCM.
基金supported by the Qingdao Postdoctoral Program Funding(QDBSH20220202045)Shandong provincial Natural Science Foundation(ZR2021ME049,ZR2022ME176)+1 种基金National Natural Science Foundation of China(22078176)Taishan Industrial Experts Program(TSCX202306135).
文摘In this study,the impact of different reaction times on the preparation of powdered activated carbon(PAC)using a one-step rapid activation method under flue gas atmosphere is investigated,and the underlying reaction mechanism is summarized.Results indicate that the reaction process of this method can be divided into three stages:stage I is the rapid release of volatiles and the rapid consumption of O_(2),primarily occurring within a reaction time range of 0-0.5 s;stage II is mainly the continuous release and diffusion of volatiles,which is the carbonization and activation coupling reaction stage,and the carbonization process is the main in this stage.This stage mainly occurs at the reaction time range of 0.5 -2.0 s when SL-coal is used as material,and that is 0.5-3.0 s when JJ-coal is used as material;stage III is mainly the activation stage,during which activated components diffuse to both the surface and interior of particles.This stage mainly involves the reaction stage of CO_(2)and H2O(g)activation,and it mainly occurs at the reaction time range of 2.0-4.0 s when SL-coal is used as material,and that is 3.0-4.0 s when JJ-coal is used as material.Besides,the main function of the first two stages is to provide more diffusion channels and contact surfaces/activation sites for the diffusion and activation of the activated components in the third stage.Mastering the reaction mechanism would serve as a crucial reference and foundation for designing the structure,size of the reactor,and optimal positioning of the activator nozzle in PAC preparation.
文摘Objective: To evaluate the application value of neutrophils/lymphocytes (NLR), platelets/lymphocytes (PLR), lymphocytes/monocytes (LMR), HEART (history, electrocardiogram, age, risk factors, and troponin) score, and point-of- care testing (POCT) in the early warning and precise diagnosis of high-risk chest pain in emergency medicine. Methods: A total of 157 patients with acute chest pain who were admitted to the emergency department and chest pain treatment unit of our hospital between August 2022 and September 2023 were selected. Rapid testing of bedside myocardial markers (ultrasensitive troponin (hs-cTnI), myoglobin (MYO), creatine kinase isoenzyme (CK-MB), D-dimer (D-Dimer), and N-terminal B-type natriuretic peptide precursor (NT-proBNP)) was performed on the patients using a POCT device (ThermoKing BioMQ60proB). A HEART score was used to classify the patients into low (n = 53), intermediate (n = 59), and high-risk (n = 45) groups, and the NLR, PLR, and LMR were calculated. The NLR, PLR, and LMR values were compared among the three groups of patients, and the optimal cutoff values as well as sensitivity and specificity were determined based on receiver operating characteristic (ROC) analysis. Results: The HEART scores of patients in the low-risk, intermediate-risk, and high-risk groups were (2.72 ± 0.24), (4.75 ± 0.56), and (5.32 ± 0.73) respectively, and the differences were statistically significant (P < 0.05). Compared with the low-risk group, the intermediate-risk group and high-risk group had a significantly higher NLR and PLR, and a significantly lower LMR;the high-risk group had higher NLR and PLR and lower values of LMR as compared to the other two groups, and the difference was statistically significant (P < 0.05). The ROC curves suggested that the area under the curve, sensitivity, and specificity of the combined diagnosis of NLR, PLR, LMR, HEART score, and POCT were greater than those of LR, PLR, and LMR with HEART score and POCT alone. Conclusion: The combined application of NLR, PLR, LMR, HEART score, and POCT has significant application value in the early warning and precise diagnosis of emergency high-risk chest pain. It provides a more simple, easy-to-access, and efficient assessment index for the clinical prediction and treatment of emergency high- risk chest pain.
文摘1POCT概念POCT是Point of Care Testing的缩写,可翻译为“现场快速检测”或“现场即时检测”,是指不需要固定、专用的场所,在最贴近患者/患病动物的地点或采样现场,应用便携式分析仪器及配套试剂进行的一种操作简便、可快速得到结果的检测方式。具有即时、便携、简化、快速的特点,世界卫生组织(WHO)对POCT的定位为:经济、灵敏、特异、装置简单、简便易用、快速。