The weapon and equipment operational requirement analysis(WEORA) is a necessary condition to win a future war,among which the acquisition of knowledge about weapons and equipment is a great challenge. The main challen...The weapon and equipment operational requirement analysis(WEORA) is a necessary condition to win a future war,among which the acquisition of knowledge about weapons and equipment is a great challenge. The main challenge is that the existing weapons and equipment data fails to carry out structured knowledge representation, and knowledge navigation based on natural language cannot efficiently support the WEORA. To solve above problem, this research proposes a method based on question answering(QA) of weapons and equipment knowledge graph(WEKG) to construct and navigate the knowledge related to weapons and equipment in the WEORA. This method firstly constructs the WEKG, and builds a neutral network-based QA system over the WEKG by means of semantic parsing for knowledge navigation. Finally, the method is evaluated and a chatbot on the QA system is developed for the WEORA. Our proposed method has good performance in the accuracy and efficiency of searching target knowledge, and can well assist the WEORA.展开更多
A case study of excessive vibration on a motor-compressor system is presented in this paper.After barely two months of operation,the reciprocating compressor motor’s routine monitoring revealed excessive axial vibrat...A case study of excessive vibration on a motor-compressor system is presented in this paper.After barely two months of operation,the reciprocating compressor motor’s routine monitoring revealed excessive axial vibration amplitude.For this reason,the Operational Modal Analysis(OMA)was carried out in order to identify the pri-mary cause.According to the investigation,one of the harmonic components which was 18 times the motor’s running speed matched with a resonance frequency of 112 Hz.According to OMA study,the motor was vibrating in torsional motion because the compressor’s load had stimulated the entire motor-compressor unit at this reso-nance frequency.The analysis also demonstrates the bulging effect of the motor shaft’s axial vibration on the motor’s endplate.展开更多
BACKGROUND Hepatic metastases are common and difficult to treat after colorectal cancer(CRC)surgery.The predictive value of carcinoembryonic antigen(CEA),cancer antigen(CA)125 and CA19-9 combined tests for liver metas...BACKGROUND Hepatic metastases are common and difficult to treat after colorectal cancer(CRC)surgery.The predictive value of carcinoembryonic antigen(CEA),cancer antigen(CA)125 and CA19-9 combined tests for liver metastasis is unclear.AIM To evaluate predictive value of combined tests for CEA,CA125,and CA19-9 levels in patients with liver metastases of CRC.METHODS The retrospective study included patients with CRC alone(50 cases)and patients with CRC combined with liver metastases(50 cases)who were hospitalized between January 2021 and January 2023.Serum CEA,CA125 and CA19-9 levels were compared between the two groups,and binary logistic regression was used to analyze the predictive value of the combination of these tumor markers in liver metastasis.In addition,we performed receiver operating characteristic(ROC)curve analysis to assess its diagnostic accuracy.RESULTS The results showed that the serum CEA,CA125 and CA19-9 levels in the CRC with liver metastasis group were significantly higher than those in the CRC alone group.Specifically,the average serum CEA level in the CRC with liver metastasis group was 162.03±810.01 ng/mL,while that in the CRC alone group was 5.71±9.76 ng/mL;the average serum CA125 levels were 43.47±83.52 U/mL respectively.and 13.5±19.68 U/mL;the average serum CA19-9 levels were 184.46±473.13 U/mL and 26.55±43.96 U/mL respectively.In addition,binary logistic regression analysis showed that CA125 was significant in predicting CRC liver metastasis(P<0.05).ROC curve analysis results showed that the areas under the ROC curves of CEA,CA125 and CA19-9 were 0.607,0.692 and 0.586.CONCLUSION These results suggest that combined detection of these tumor markers may help early detection and intervention of CRC liver metastasis,thereby improving patient prognosis.展开更多
A frequency and spatial domain decomposition method (FSDD) for operational modal analysis (OMA) is presented in this paper, which is an extension of the complex mode indicator function (CMIF) method for experime...A frequency and spatial domain decomposition method (FSDD) for operational modal analysis (OMA) is presented in this paper, which is an extension of the complex mode indicator function (CMIF) method for experimental modal analysis (EMA). The theoretical background of the FSDD method is clarified, Singular value decomposition is adopted to separate the signal space from the noise space. Finally, an enhanced power spectrum density (PSD) is proposed to obtain more accurate modal parameters by curve fitting in the frequency domain. Moreover, a simulation case and an application case are used to validate this method.展开更多
Based on wavelet packet decomposition (WPD) algorithm and Teager energy operator (TEO), a novel gearbox fault detection and diagnosis method is proposed. Its process is expatiated after the principles of WPD and T...Based on wavelet packet decomposition (WPD) algorithm and Teager energy operator (TEO), a novel gearbox fault detection and diagnosis method is proposed. Its process is expatiated after the principles of WPD and TEO modulation are introduced respectively. The preprocessed sigaaal is interpolated with the cubic spline function, then expanded over the selected basis wavelets. Grouping its wavelet packet components of the signal based on the minimum entropy criterion, the interpolated signal can be decomposed into its dominant components with nearly distinct fault frequency contents. To extract the demodulation information of each dominant component, TEO is used. The performance of the proposed method is assessed by means of several tests on vibration signals collected from the gearbox mounted on a heavy truck. It is proved that hybrid WPD-TEO method is effective and robust for detecting and diagnosing localized gearbox faults.展开更多
Aim: To assess that metabolic status of spermatozoa could provide a useful tool for evaluation of semen quality. Methods: The accuracy of the spectrophotometric application of the resazurin reduction assay was asses...Aim: To assess that metabolic status of spermatozoa could provide a useful tool for evaluation of semen quality. Methods: The accuracy of the spectrophotometric application of the resazurin reduction assay was assessed using receiver operating characteristic (ROC) analysis. Results: Areas under ROC curves (AUC) for motile sperm concentration and sperm index (SI) (sperm concentration multiplied by the square root of percentage sperm motility multiplied by the percentage normal sperm morphology) were 0.922. The best discrimination between poor and good semen samples according to the SI was achieved at a cut-off point of A610 = 0.209, where high sensitivity (94.1%) and specificity (91.7%) were calculated. The assay was less accurate when motile sperm concentration was used as the criterion value, yielding sensitivity of 88.2% and specificity of 87.5%, respectively. Likelihood ratios (LR) indicate that absorbances lower than 0.209 were at least 11.3 times as likely to be found in good semen samples than those in poor according to the SI, whereas in the case of motile sperm concentration, the LR was calculated to be 7.06. Conclusion: These results show that the resazurin reduction assay combined with spectrophotometry is an accurate method of assessing the quality of boar semen.展开更多
BACKGROUND Hepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection,which may develop into liver fibrosis,cirrhosis and hepatocellular carcinoma.Detection of early-stage fibrosis ...BACKGROUND Hepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection,which may develop into liver fibrosis,cirrhosis and hepatocellular carcinoma.Detection of early-stage fibrosis related to HBV infection is of great clinical significance to block the progression of liver lesion.Direct liver biopsy is regarded as the gold standard to detect and assess fibrosis;however,this method is invasive and prone to clinical sampling error.In order to address these issues,we attempted to find more convenient and effective serum markers for detecting HBV-induced early-stage liver fibrosis.AIM To investigate serum N-glycan profiling related to HBV-induced liver fibrosis and verify multiparameter diagnostic models related to serum N-glycan changes.METHODS N-glycan profiles from the sera of 432 HBV-infected patients with liver fibrosis were analyzed.Significant changed N-glycan levels (peaks)(P <0.05) in differentfibrosis stages were selected in the modeling group,and multiparameter diagnostic models were established based on changed N-glycan levels by logistic regression analysis.The receiver operating characteristic (ROC) curve analysis was performed to evaluate diagnostic efficacy of N-glycans models.These models were then compared with the aspartate aminotransferase to platelet ratio index (APRI),fibrosis index based on the four factors (FIB-4),glutamyltranspeptidase platelet albumin index (S index),GlycoCirrho-test,and GlycoFibro-test.Furthermore,we combined multiparameter diagnostic models with alanine aminotransferase (ALT) and platelet (PLT) tests and compared their diagnostic power.In addition,the diagnostic accuracy of N-glycan models was also verified in the validation group of patients.RESULTS Multiparameter diagnostic models constructed based on N-glycan peak 1,3,4and 8 could distinguish between different stages of liver fibrosis.The area under ROC curves (AUROCs) of Model A and Model B were 0.890 and 0.752,respectively differentiating fibrosis F0-F1 from F2-F4,and F0-F2 from F3-F4,and surpassing other serum panels.However,AUROC (0.747) in Model C used for the diagnosis of F4 from F0-F3 was lower than AUROC (0.795) in FIB-4.In combination with ALT and PLT,the multiparameter models showed better diagnostic power (AUROC=0.912,0.829,0.885,respectively) when compared with other models.In the validation group,the AUROCs of the three combined models (0.929,0.858,and 0.867,respectively) were still satisfactory.We also applied the combined models to distinguish adjacent fibrosis stages of 432patients (F0-F1/F2/F3/F4),and the AUROCs were 0.917,0.720 and 0.785.CONCLUSION Multiparameter models based on serum N-glycans are effective supplementary markers to distinguish between adjacent fibrosis stages of patients caused by HBV,especially in combination with ALT and PLT.展开更多
Output-only structural identification is developed by a refined Frequency Domain Decomposition(rFDD) approach, towards assessing current modal properties of heavy-damped buildings(in terms of identification challe...Output-only structural identification is developed by a refined Frequency Domain Decomposition(rFDD) approach, towards assessing current modal properties of heavy-damped buildings(in terms of identification challenge), under strong ground motions. Structural responses from earthquake excitations are taken as input signals for the identification algorithm. A new dedicated computational procedure, based on coupled Chebyshev Type Ⅱ bandpass filters, is outlined for the effective estimation of natural frequencies, mode shapes and modal damping ratios. The identification technique is also coupled with a Gabor Wavelet Transform, resulting in an effective and self-contained time-frequency analysis framework. Simulated response signals generated by shear-type frames(with variable structural features) are used as a necessary validation condition. In this context use is made of a complete set of seismic records taken from the FEMA P695 database, i.e. all 44 "Far-Field"(22 NS, 22 WE) earthquake signals. The modal estimates are statistically compared to their target values, proving the accuracy of the developed algorithm in providing prompt and accurate estimates of all current strong ground motion modal parameters. At this stage, such analysis tool may be employed for convenient application in the realm of Earthquake Engineering, towards potential Structural Health Monitoring and damage detection purposes.展开更多
BACKGROUND For lung adenocarcinoma with epidermal growth factor receptor(EGFR)gene mutation,small molecule tyrosine kinase inhibitors are more effective.Some patients could not obtain enough histological specimens for...BACKGROUND For lung adenocarcinoma with epidermal growth factor receptor(EGFR)gene mutation,small molecule tyrosine kinase inhibitors are more effective.Some patients could not obtain enough histological specimens for EGFR gene mutation detection.Specific imaging features can predict EGFR mutation status to a certain extent.AIM To assess the associations of EGFR mutations with high-resolution computerized tomography(HRCT)features in ground-glass nodular lung adenocarcinoma.METHODS This study retrospectively assessed patients with ground-glass nodular lung adenocarcinoma diagnosed between January 2011 and March 2017.EGFR gene mutations in exons 18-21 were detected.The patients were classified into mutant EGFR and wild-type groups,and general data and HRCT image characteristics were assessed.RESULTS Among 98 patients,31(31.6%)and 67(68.4%)had mutated and wild-type EGFR in exons 18-21,respectively.Gender,age,smoking history,location of lesions,morphology,edges,borders,pleural indentations,and associations of nodules with bronchus and blood vessels were comparable in both groups(all P>0.05).Patients with mutant EGFR had larger nodules than those with the wild-type(17.19±6.79 and 14.37±6.30 mm,respectively;P=0.047).Meanwhile,the vacuole/honeycomb sign was more frequent in the mutant EGFR group(P=0.011).The logistic regression prediction model included the combination of nodule size and vacuole/honeycomb sign(OR=1.120,95%CI:1.023-1.227,P=0.014)revealed a sensitivity of 83.9%,a specificity of 52.2%and an AUC of 0.698(95%CI:0.589-0.806;P=0.002).CONCLUSION Nodule size and vacuole/honeycomb features could independently predict EGFR mutation status in ground-glass nodular lung adenocarcinoma.展开更多
Methods for scaling mode shapes determined by operational modal analysis(OMA)have been extensively investigated in the last years.A recent addition to the range of methods for scaling OMA mode shapes is the so-called ...Methods for scaling mode shapes determined by operational modal analysis(OMA)have been extensively investigated in the last years.A recent addition to the range of methods for scaling OMA mode shapes is the so-called OMAH technique,which is based on exciting the structure by harmonic forces applied by an actuator.By applying harmonic forces in at least one degree-of-freedom(DOF),and measuring the response in at least one response DOF,while using at least as many frequencies as the number of mode shapes to be scaled,the mode shape scaling(modal mass)of all modes of interest may be determined.In previous publications on the method the authors have proven that the technique is easy and robust to apply to both small scale and large scale structures.Also,it has been shown that the technique is capable of scaling highly coupled modes by using an extended multiple reference formulation.The present paper summarizes the theory of the OMAH method and gives recommendations of how to implement the method for best results.It is pointed out,as has been shown in previous papers,that the accuracy of the mode scaling is increased by using more than one response DOF,and by selecting DOFs with high mode shape coefficients.To determine the harmonic force and responses,it is recommended to use the three-parameter sine fit method.It is shown that by using this method,the measurement time can be kept short by using high sampling frequency and bandpass filtering whereas spectrum based methods require long measurement times.This means that even for structures with low natural frequencies,the extra measurement time for scaling the mode shapes can be kept relatively short.展开更多
We performed a bioinformatics analysis with validation by multiple databases,aiming to evaluate the diagnostic and prognostic value of Kelch-like ECH-associated protein 1(Keapl)mRNA for lung cancer,and to explore poss...We performed a bioinformatics analysis with validation by multiple databases,aiming to evaluate the diagnostic and prognostic value of Kelch-like ECH-associated protein 1(Keapl)mRNA for lung cancer,and to explore possible mechanisms.Diagnostic performance of Keapl mRNA was determined by receiver operating characteristic(ROC)curve analysis.Prognostic implication of Keapl mRNA was estimated by Kaplan-Meier survival analysis.Co-expressed genes with both Keapl and Nfe2L2 were identified by LinkedOmics.Mechanisms of Keapl-Nfe2L2-co-expressed genes underlying the pathogenesis of lung cancer were explored by function enrichment and pathway analysis.The ROC curve analysis determined a good diagnostic performance of Keapl mRNA for lung squamous cell carcinoma(LUSC),with an area under the ROC curve(AUC)of 0.833,sensitivity of 72.7%,and specificity of 90.6%(P<0.001).Multivariate Cox regression recognized high Keapl mRNA to be an independent risk factor of mortality for overall lung cancer[hazard ratio(HR):11.034,P=0.044],but an independent antagonistic factor for lung adenocarcinoma(LUAD)(HR:0.404,P<0.001).Validation by UALCAN and GEPIA supported Oncomine findings regarding the diagnostic value of Keapl mRNA for LUSC,but denied its prognostic value.After screening,we identified 17 co-expressed genes with both Keapl and Nfe2L2 for LUAD,and 22 for LUSC,mainly enriched in signaling pathway of oxidative stress-induced gene expression via Nrf2.In conclusion,Keapl mRNA has a good diagnostic performance,but controversial prognostic efficacy for LUSC.The pathogenesis of lung cancer is associated with Keapl-Nfe2L2-co-expressed genes by signaling pathway of oxidative stress-induced gene expression via Nrf2.展开更多
In this review article,the past investigations carried out on heritage structures using Ambient Vibration Test(AVT)and Operational Modal Analysis(OMA)for system identification(determination of dynamic properties like ...In this review article,the past investigations carried out on heritage structures using Ambient Vibration Test(AVT)and Operational Modal Analysis(OMA)for system identification(determination of dynamic properties like frequency,mode shape and damping ratios)and associated applications are summarized.A total of 68 major research studies on heritage structures around the world that are available in literature are surveyed for this purpose.At first,field investigations carried out on heritage structures prior to conducting AVT are explained in detail.Next,specifications of accelerometers,location of accelerometers and optimization of accelerometer networks have been elaborated with respect to the geometry of the heritage structures.In addition to this,ambient vibration loads and data acquisition procedures are also discussed.Further,the state of art of performing OMA techniques for heritage structures is explained briefly.Furthermore,various applications of system identification for heritage structures are documented.Finally,conclusions are made towards errorless system identification of heritage structures through AVT and OMA.展开更多
Since the initial international cooperation in the framework of Collaboratory for the Study of Earthquake Predictability(CSEP)in 2007,a lot of forecast models have been developed and served for the earthquake forecast...Since the initial international cooperation in the framework of Collaboratory for the Study of Earthquake Predictability(CSEP)in 2007,a lot of forecast models have been developed and served for the earthquake forecasting experiment in different CSEP testing centers(Schorlemmer et al.,2018).展开更多
A summer-time shipboard meteorological survey is described in the Northwest Indian Ocean. Shipboard observations are used to evaluate a satellite-based sea surface temperature(SST), and then find the main factors th...A summer-time shipboard meteorological survey is described in the Northwest Indian Ocean. Shipboard observations are used to evaluate a satellite-based sea surface temperature(SST), and then find the main factors that are highly correlated with errors. Two satellite data, the first is remote sensing product of a microwave, which is a Tropical Rainfall Measuring Mission Microwave Imager(TMI), and the second is merged data from the microwave and infrared satellite as well as drifter observations, which is Operational Sea Surface Temperature and Sea Ice Analysis(OSTIA). The results reveal that the daily mean SST of merged data has much lower bias and root mean square error as compared with that from microwave products. Therefore the results support the necessary of the merging infrared and drifter SST with a microwave satellite for improving the quality of the SST. Furthermore, the correlation coefficient between an SST error and meteorological parameters, which include a wind speed, an air temperature, a relative humidity, an air pressure, and a visibility. The results show that the wind speed has the largest correlation coefficient with the TMI SST error. However, the air temperature is the most important factor to the OSTIA SST error. Meanwhile,the relative humidity shows the high correlation with the SST error for the OSTIA product.展开更多
In this paper, we show the construction of orthogonal wavelet basis on the interval [0, 1],using compactly supportted Daubechies function. Forwardly, we suggest a kind of method to deal with the differential operator ...In this paper, we show the construction of orthogonal wavelet basis on the interval [0, 1],using compactly supportted Daubechies function. Forwardly, we suggest a kind of method to deal with the differential operator in view of numerical analysis and derive the appoximation algorithm of wavelet ba-sis and differential operator, which affects on the basis, to functions belonging to L2 [0, 1 ]. Numerical computation indicate the stability and effectiveness of the algorithm.展开更多
Cotton Textile:Price Rising in Imp.& Exp.Trade According to State Administration of Statistics,from Jan.to March,3896 statistics-worthy(whose annul output exceeding 20 million yuan)yarn manufacturers produced yarn...Cotton Textile:Price Rising in Imp.& Exp.Trade According to State Administration of Statistics,from Jan.to March,3896 statistics-worthy(whose annul output exceeding 20 million yuan)yarn manufacturers produced yarn 6.18 million tons,rising 12.54% from the展开更多
1.Basic Situation of Copper Rod Production in the First Quarter of 2017In the first quarter of 2017,Antaike researched on 18 domestic copper rod companies and 24production lines involving a total capacity of5.235 mill...1.Basic Situation of Copper Rod Production in the First Quarter of 2017In the first quarter of 2017,Antaike researched on 18 domestic copper rod companies and 24production lines involving a total capacity of5.235 million tons,accounting for around half of national total in-production capacity and over 60%of national total capacity of展开更多
In the present contribution, operational modal analysis in conjunction with bees optimization algorithm are utilized to update the finite element model of a solar power plant structure. The physical parameters which r...In the present contribution, operational modal analysis in conjunction with bees optimization algorithm are utilized to update the finite element model of a solar power plant structure. The physical parameters which required to be updated are uncertain parameters including geometry, material properties and boundary conditions of the aforementioned structure. To determine these uncertain parameters, local and global sensitivity analyses are performed to increase the solution accuracy. An objective function is determined using the sum of the squared errors between the natural frequencies calculated by finite element method and operational modal analysis, which is optimized using bees optimization algorithm. The natural frequencies of the solar power plant structure are estimated by multi-setup stochastic subspace identification method which is considered as a strong and efficient method in operational modal analysis. The proposed algorithm is efficiently implemented on the solar power plant structure located in Shahid Chamran university of Ahvaz, Iran, to update parameters of its finite element model. Moreover, computed natural frequencies by numerical method are compared with those of the operational modal analysis. The results indicate that, bees optimization algorithm leads accurate results with fast convergence.展开更多
Operational Modal Analysis(OMA) refers to the modal analysis of a structure in its operating state. The advantage of OMA is that only the output vibration signal of a system is used in the analysis process. Classic OM...Operational Modal Analysis(OMA) refers to the modal analysis of a structure in its operating state. The advantage of OMA is that only the output vibration signal of a system is used in the analysis process. Classic OMA is based on the white noise excitation assumption and many identification methods have been developed in both time domain and frequency domain. But in reality, many environmental excitations are not compliance with the white noise assumption. In this paper, a method of half power bandwidth analysis is applied to power spectrum analysis to deal with the colored noise and trapezoidal spectral excitation. The modal frequencies and modal damping ratios are derived and the error caused by trapezoidal spectral and colored noise excitation are analyzed. It is proved that the OMA algorithm based on the white noise assumption can be extended to the colored noise environments under certain conditions. Finally, a simulation example with a cantilever beam and a vibration test with four kinds of colored noise and trapezoidal spectrum base excitation are carried out and the results support the proposed method.展开更多
Being able to significantly reduce system installation time and cost,wireless sensing technology has attracted much interest in the structural health monitoring(SHM)community.This paper reports the field application o...Being able to significantly reduce system installation time and cost,wireless sensing technology has attracted much interest in the structural health monitoring(SHM)community.This paper reports the field application of a wireless sensing system on a 4-span highway bridge located in Wayne,New Jersey in the US.Bridge vibration due to traffic and ambient excitation is measured.To enhance the signal-to-noise ratio,a low-noise high-gain signal conditioning module is developed for the wireless sensing system.Nineteen wireless and nineteen cabled accelerometers are first installed along the sidewalk of two neighboring bridge spans.The performance of the wireless sensing system is compared with the high-precision cabled sensing system.In the next series of testing,16 wireless accelerometers are installed under the deck of another bridge span,forming a 4×4 array.Operating deflection analysis is successfully conducted using the wireless measurement of traffic and ambient vibrations.展开更多
文摘The weapon and equipment operational requirement analysis(WEORA) is a necessary condition to win a future war,among which the acquisition of knowledge about weapons and equipment is a great challenge. The main challenge is that the existing weapons and equipment data fails to carry out structured knowledge representation, and knowledge navigation based on natural language cannot efficiently support the WEORA. To solve above problem, this research proposes a method based on question answering(QA) of weapons and equipment knowledge graph(WEKG) to construct and navigate the knowledge related to weapons and equipment in the WEORA. This method firstly constructs the WEKG, and builds a neutral network-based QA system over the WEKG by means of semantic parsing for knowledge navigation. Finally, the method is evaluated and a chatbot on the QA system is developed for the WEORA. Our proposed method has good performance in the accuracy and efficiency of searching target knowledge, and can well assist the WEORA.
文摘A case study of excessive vibration on a motor-compressor system is presented in this paper.After barely two months of operation,the reciprocating compressor motor’s routine monitoring revealed excessive axial vibration amplitude.For this reason,the Operational Modal Analysis(OMA)was carried out in order to identify the pri-mary cause.According to the investigation,one of the harmonic components which was 18 times the motor’s running speed matched with a resonance frequency of 112 Hz.According to OMA study,the motor was vibrating in torsional motion because the compressor’s load had stimulated the entire motor-compressor unit at this reso-nance frequency.The analysis also demonstrates the bulging effect of the motor shaft’s axial vibration on the motor’s endplate.
文摘BACKGROUND Hepatic metastases are common and difficult to treat after colorectal cancer(CRC)surgery.The predictive value of carcinoembryonic antigen(CEA),cancer antigen(CA)125 and CA19-9 combined tests for liver metastasis is unclear.AIM To evaluate predictive value of combined tests for CEA,CA125,and CA19-9 levels in patients with liver metastases of CRC.METHODS The retrospective study included patients with CRC alone(50 cases)and patients with CRC combined with liver metastases(50 cases)who were hospitalized between January 2021 and January 2023.Serum CEA,CA125 and CA19-9 levels were compared between the two groups,and binary logistic regression was used to analyze the predictive value of the combination of these tumor markers in liver metastasis.In addition,we performed receiver operating characteristic(ROC)curve analysis to assess its diagnostic accuracy.RESULTS The results showed that the serum CEA,CA125 and CA19-9 levels in the CRC with liver metastasis group were significantly higher than those in the CRC alone group.Specifically,the average serum CEA level in the CRC with liver metastasis group was 162.03±810.01 ng/mL,while that in the CRC alone group was 5.71±9.76 ng/mL;the average serum CA125 levels were 43.47±83.52 U/mL respectively.and 13.5±19.68 U/mL;the average serum CA19-9 levels were 184.46±473.13 U/mL and 26.55±43.96 U/mL respectively.In addition,binary logistic regression analysis showed that CA125 was significant in predicting CRC liver metastasis(P<0.05).ROC curve analysis results showed that the areas under the ROC curves of CEA,CA125 and CA19-9 were 0.607,0.692 and 0.586.CONCLUSION These results suggest that combined detection of these tumor markers may help early detection and intervention of CRC liver metastasis,thereby improving patient prognosis.
基金China Postdoctoral Science Foundation Under Grant No. 2004035215 Jiangsu Planned Projects for Postdoctoral Research Funds 2004 Aeronautical Science Research Foundation Under Grant No. 04152065
文摘A frequency and spatial domain decomposition method (FSDD) for operational modal analysis (OMA) is presented in this paper, which is an extension of the complex mode indicator function (CMIF) method for experimental modal analysis (EMA). The theoretical background of the FSDD method is clarified, Singular value decomposition is adopted to separate the signal space from the noise space. Finally, an enhanced power spectrum density (PSD) is proposed to obtain more accurate modal parameters by curve fitting in the frequency domain. Moreover, a simulation case and an application case are used to validate this method.
基金This project is supported by National Natural Science Foundation of China (No.50605065)Natural Science Foundation Project of CQ CSTC (No.2007BB2142)
文摘Based on wavelet packet decomposition (WPD) algorithm and Teager energy operator (TEO), a novel gearbox fault detection and diagnosis method is proposed. Its process is expatiated after the principles of WPD and TEO modulation are introduced respectively. The preprocessed sigaaal is interpolated with the cubic spline function, then expanded over the selected basis wavelets. Grouping its wavelet packet components of the signal based on the minimum entropy criterion, the interpolated signal can be decomposed into its dominant components with nearly distinct fault frequency contents. To extract the demodulation information of each dominant component, TEO is used. The performance of the proposed method is assessed by means of several tests on vibration signals collected from the gearbox mounted on a heavy truck. It is proved that hybrid WPD-TEO method is effective and robust for detecting and diagnosing localized gearbox faults.
文摘Aim: To assess that metabolic status of spermatozoa could provide a useful tool for evaluation of semen quality. Methods: The accuracy of the spectrophotometric application of the resazurin reduction assay was assessed using receiver operating characteristic (ROC) analysis. Results: Areas under ROC curves (AUC) for motile sperm concentration and sperm index (SI) (sperm concentration multiplied by the square root of percentage sperm motility multiplied by the percentage normal sperm morphology) were 0.922. The best discrimination between poor and good semen samples according to the SI was achieved at a cut-off point of A610 = 0.209, where high sensitivity (94.1%) and specificity (91.7%) were calculated. The assay was less accurate when motile sperm concentration was used as the criterion value, yielding sensitivity of 88.2% and specificity of 87.5%, respectively. Likelihood ratios (LR) indicate that absorbances lower than 0.209 were at least 11.3 times as likely to be found in good semen samples than those in poor according to the SI, whereas in the case of motile sperm concentration, the LR was calculated to be 7.06. Conclusion: These results show that the resazurin reduction assay combined with spectrophotometry is an accurate method of assessing the quality of boar semen.
基金Supported by Major Science and Technology Special Project of China Thirteenth Five-Year Plan,No.2018ZX10732401-003-015;Guangxi Key Laboratory for the Prevention and Control of Viral Hepatitis,No.GXCDCKL201901
文摘BACKGROUND Hepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection,which may develop into liver fibrosis,cirrhosis and hepatocellular carcinoma.Detection of early-stage fibrosis related to HBV infection is of great clinical significance to block the progression of liver lesion.Direct liver biopsy is regarded as the gold standard to detect and assess fibrosis;however,this method is invasive and prone to clinical sampling error.In order to address these issues,we attempted to find more convenient and effective serum markers for detecting HBV-induced early-stage liver fibrosis.AIM To investigate serum N-glycan profiling related to HBV-induced liver fibrosis and verify multiparameter diagnostic models related to serum N-glycan changes.METHODS N-glycan profiles from the sera of 432 HBV-infected patients with liver fibrosis were analyzed.Significant changed N-glycan levels (peaks)(P <0.05) in differentfibrosis stages were selected in the modeling group,and multiparameter diagnostic models were established based on changed N-glycan levels by logistic regression analysis.The receiver operating characteristic (ROC) curve analysis was performed to evaluate diagnostic efficacy of N-glycans models.These models were then compared with the aspartate aminotransferase to platelet ratio index (APRI),fibrosis index based on the four factors (FIB-4),glutamyltranspeptidase platelet albumin index (S index),GlycoCirrho-test,and GlycoFibro-test.Furthermore,we combined multiparameter diagnostic models with alanine aminotransferase (ALT) and platelet (PLT) tests and compared their diagnostic power.In addition,the diagnostic accuracy of N-glycan models was also verified in the validation group of patients.RESULTS Multiparameter diagnostic models constructed based on N-glycan peak 1,3,4and 8 could distinguish between different stages of liver fibrosis.The area under ROC curves (AUROCs) of Model A and Model B were 0.890 and 0.752,respectively differentiating fibrosis F0-F1 from F2-F4,and F0-F2 from F3-F4,and surpassing other serum panels.However,AUROC (0.747) in Model C used for the diagnosis of F4 from F0-F3 was lower than AUROC (0.795) in FIB-4.In combination with ALT and PLT,the multiparameter models showed better diagnostic power (AUROC=0.912,0.829,0.885,respectively) when compared with other models.In the validation group,the AUROCs of the three combined models (0.929,0.858,and 0.867,respectively) were still satisfactory.We also applied the combined models to distinguish adjacent fibrosis stages of 432patients (F0-F1/F2/F3/F4),and the AUROCs were 0.917,0.720 and 0.785.CONCLUSION Multiparameter models based on serum N-glycans are effective supplementary markers to distinguish between adjacent fibrosis stages of patients caused by HBV,especially in combination with ALT and PLT.
基金Public research funding from“Fondi di Ricerca d’Ateneo ex 60%” and a ministerial doctoral grantfunds at the ISA Doctoral School,University of Bergamo,Department of Engineering and Applied Sciences (Dalmine)
文摘Output-only structural identification is developed by a refined Frequency Domain Decomposition(rFDD) approach, towards assessing current modal properties of heavy-damped buildings(in terms of identification challenge), under strong ground motions. Structural responses from earthquake excitations are taken as input signals for the identification algorithm. A new dedicated computational procedure, based on coupled Chebyshev Type Ⅱ bandpass filters, is outlined for the effective estimation of natural frequencies, mode shapes and modal damping ratios. The identification technique is also coupled with a Gabor Wavelet Transform, resulting in an effective and self-contained time-frequency analysis framework. Simulated response signals generated by shear-type frames(with variable structural features) are used as a necessary validation condition. In this context use is made of a complete set of seismic records taken from the FEMA P695 database, i.e. all 44 "Far-Field"(22 NS, 22 WE) earthquake signals. The modal estimates are statistically compared to their target values, proving the accuracy of the developed algorithm in providing prompt and accurate estimates of all current strong ground motion modal parameters. At this stage, such analysis tool may be employed for convenient application in the realm of Earthquake Engineering, towards potential Structural Health Monitoring and damage detection purposes.
基金by the Zhejiang Province Traditional Chinese Medicine Science and Technology Plan-Zhejiang Province Traditional Chinese Medicine Project for Traditional Chinese Medicine Scientific Research(2020)(Class B),No.2020ZB117。
文摘BACKGROUND For lung adenocarcinoma with epidermal growth factor receptor(EGFR)gene mutation,small molecule tyrosine kinase inhibitors are more effective.Some patients could not obtain enough histological specimens for EGFR gene mutation detection.Specific imaging features can predict EGFR mutation status to a certain extent.AIM To assess the associations of EGFR mutations with high-resolution computerized tomography(HRCT)features in ground-glass nodular lung adenocarcinoma.METHODS This study retrospectively assessed patients with ground-glass nodular lung adenocarcinoma diagnosed between January 2011 and March 2017.EGFR gene mutations in exons 18-21 were detected.The patients were classified into mutant EGFR and wild-type groups,and general data and HRCT image characteristics were assessed.RESULTS Among 98 patients,31(31.6%)and 67(68.4%)had mutated and wild-type EGFR in exons 18-21,respectively.Gender,age,smoking history,location of lesions,morphology,edges,borders,pleural indentations,and associations of nodules with bronchus and blood vessels were comparable in both groups(all P>0.05).Patients with mutant EGFR had larger nodules than those with the wild-type(17.19±6.79 and 14.37±6.30 mm,respectively;P=0.047).Meanwhile,the vacuole/honeycomb sign was more frequent in the mutant EGFR group(P=0.011).The logistic regression prediction model included the combination of nodule size and vacuole/honeycomb sign(OR=1.120,95%CI:1.023-1.227,P=0.014)revealed a sensitivity of 83.9%,a specificity of 52.2%and an AUC of 0.698(95%CI:0.589-0.806;P=0.002).CONCLUSION Nodule size and vacuole/honeycomb features could independently predict EGFR mutation status in ground-glass nodular lung adenocarcinoma.
文摘Methods for scaling mode shapes determined by operational modal analysis(OMA)have been extensively investigated in the last years.A recent addition to the range of methods for scaling OMA mode shapes is the so-called OMAH technique,which is based on exciting the structure by harmonic forces applied by an actuator.By applying harmonic forces in at least one degree-of-freedom(DOF),and measuring the response in at least one response DOF,while using at least as many frequencies as the number of mode shapes to be scaled,the mode shape scaling(modal mass)of all modes of interest may be determined.In previous publications on the method the authors have proven that the technique is easy and robust to apply to both small scale and large scale structures.Also,it has been shown that the technique is capable of scaling highly coupled modes by using an extended multiple reference formulation.The present paper summarizes the theory of the OMAH method and gives recommendations of how to implement the method for best results.It is pointed out,as has been shown in previous papers,that the accuracy of the mode scaling is increased by using more than one response DOF,and by selecting DOFs with high mode shape coefficients.To determine the harmonic force and responses,it is recommended to use the three-parameter sine fit method.It is shown that by using this method,the measurement time can be kept short by using high sampling frequency and bandpass filtering whereas spectrum based methods require long measurement times.This means that even for structures with low natural frequencies,the extra measurement time for scaling the mode shapes can be kept relatively short.
文摘We performed a bioinformatics analysis with validation by multiple databases,aiming to evaluate the diagnostic and prognostic value of Kelch-like ECH-associated protein 1(Keapl)mRNA for lung cancer,and to explore possible mechanisms.Diagnostic performance of Keapl mRNA was determined by receiver operating characteristic(ROC)curve analysis.Prognostic implication of Keapl mRNA was estimated by Kaplan-Meier survival analysis.Co-expressed genes with both Keapl and Nfe2L2 were identified by LinkedOmics.Mechanisms of Keapl-Nfe2L2-co-expressed genes underlying the pathogenesis of lung cancer were explored by function enrichment and pathway analysis.The ROC curve analysis determined a good diagnostic performance of Keapl mRNA for lung squamous cell carcinoma(LUSC),with an area under the ROC curve(AUC)of 0.833,sensitivity of 72.7%,and specificity of 90.6%(P<0.001).Multivariate Cox regression recognized high Keapl mRNA to be an independent risk factor of mortality for overall lung cancer[hazard ratio(HR):11.034,P=0.044],but an independent antagonistic factor for lung adenocarcinoma(LUAD)(HR:0.404,P<0.001).Validation by UALCAN and GEPIA supported Oncomine findings regarding the diagnostic value of Keapl mRNA for LUSC,but denied its prognostic value.After screening,we identified 17 co-expressed genes with both Keapl and Nfe2L2 for LUAD,and 22 for LUSC,mainly enriched in signaling pathway of oxidative stress-induced gene expression via Nrf2.In conclusion,Keapl mRNA has a good diagnostic performance,but controversial prognostic efficacy for LUSC.The pathogenesis of lung cancer is associated with Keapl-Nfe2L2-co-expressed genes by signaling pathway of oxidative stress-induced gene expression via Nrf2.
文摘In this review article,the past investigations carried out on heritage structures using Ambient Vibration Test(AVT)and Operational Modal Analysis(OMA)for system identification(determination of dynamic properties like frequency,mode shape and damping ratios)and associated applications are summarized.A total of 68 major research studies on heritage structures around the world that are available in literature are surveyed for this purpose.At first,field investigations carried out on heritage structures prior to conducting AVT are explained in detail.Next,specifications of accelerometers,location of accelerometers and optimization of accelerometer networks have been elaborated with respect to the geometry of the heritage structures.In addition to this,ambient vibration loads and data acquisition procedures are also discussed.Further,the state of art of performing OMA techniques for heritage structures is explained briefly.Furthermore,various applications of system identification for heritage structures are documented.Finally,conclusions are made towards errorless system identification of heritage structures through AVT and OMA.
基金granted by the National Key Research and Development Program of China(Grant No.2018YFE0109700)National Natural Science Foundation of China(Grant No.42004038)the Special Fund of the Institute of Earthquake Forecasting,China Earthquake Administration(Grant No.2020IEF0501)
文摘Since the initial international cooperation in the framework of Collaboratory for the Study of Earthquake Predictability(CSEP)in 2007,a lot of forecast models have been developed and served for the earthquake forecasting experiment in different CSEP testing centers(Schorlemmer et al.,2018).
基金China Ocean Mineral Resources Research and Development Association Project under contract No.DY125-12-R-03the National Natural Science Foundation of China under contract Nos 41476021 and 41321004the Scientific Research Fund of Second Institute of Oceanography,State Oceanic Administration China under contract No.JT1205
文摘A summer-time shipboard meteorological survey is described in the Northwest Indian Ocean. Shipboard observations are used to evaluate a satellite-based sea surface temperature(SST), and then find the main factors that are highly correlated with errors. Two satellite data, the first is remote sensing product of a microwave, which is a Tropical Rainfall Measuring Mission Microwave Imager(TMI), and the second is merged data from the microwave and infrared satellite as well as drifter observations, which is Operational Sea Surface Temperature and Sea Ice Analysis(OSTIA). The results reveal that the daily mean SST of merged data has much lower bias and root mean square error as compared with that from microwave products. Therefore the results support the necessary of the merging infrared and drifter SST with a microwave satellite for improving the quality of the SST. Furthermore, the correlation coefficient between an SST error and meteorological parameters, which include a wind speed, an air temperature, a relative humidity, an air pressure, and a visibility. The results show that the wind speed has the largest correlation coefficient with the TMI SST error. However, the air temperature is the most important factor to the OSTIA SST error. Meanwhile,the relative humidity shows the high correlation with the SST error for the OSTIA product.
文摘In this paper, we show the construction of orthogonal wavelet basis on the interval [0, 1],using compactly supportted Daubechies function. Forwardly, we suggest a kind of method to deal with the differential operator in view of numerical analysis and derive the appoximation algorithm of wavelet ba-sis and differential operator, which affects on the basis, to functions belonging to L2 [0, 1 ]. Numerical computation indicate the stability and effectiveness of the algorithm.
文摘Cotton Textile:Price Rising in Imp.& Exp.Trade According to State Administration of Statistics,from Jan.to March,3896 statistics-worthy(whose annul output exceeding 20 million yuan)yarn manufacturers produced yarn 6.18 million tons,rising 12.54% from the
文摘1.Basic Situation of Copper Rod Production in the First Quarter of 2017In the first quarter of 2017,Antaike researched on 18 domestic copper rod companies and 24production lines involving a total capacity of5.235 million tons,accounting for around half of national total in-production capacity and over 60%of national total capacity of
文摘In the present contribution, operational modal analysis in conjunction with bees optimization algorithm are utilized to update the finite element model of a solar power plant structure. The physical parameters which required to be updated are uncertain parameters including geometry, material properties and boundary conditions of the aforementioned structure. To determine these uncertain parameters, local and global sensitivity analyses are performed to increase the solution accuracy. An objective function is determined using the sum of the squared errors between the natural frequencies calculated by finite element method and operational modal analysis, which is optimized using bees optimization algorithm. The natural frequencies of the solar power plant structure are estimated by multi-setup stochastic subspace identification method which is considered as a strong and efficient method in operational modal analysis. The proposed algorithm is efficiently implemented on the solar power plant structure located in Shahid Chamran university of Ahvaz, Iran, to update parameters of its finite element model. Moreover, computed natural frequencies by numerical method are compared with those of the operational modal analysis. The results indicate that, bees optimization algorithm leads accurate results with fast convergence.
文摘Operational Modal Analysis(OMA) refers to the modal analysis of a structure in its operating state. The advantage of OMA is that only the output vibration signal of a system is used in the analysis process. Classic OMA is based on the white noise excitation assumption and many identification methods have been developed in both time domain and frequency domain. But in reality, many environmental excitations are not compliance with the white noise assumption. In this paper, a method of half power bandwidth analysis is applied to power spectrum analysis to deal with the colored noise and trapezoidal spectral excitation. The modal frequencies and modal damping ratios are derived and the error caused by trapezoidal spectral and colored noise excitation are analyzed. It is proved that the OMA algorithm based on the white noise assumption can be extended to the colored noise environments under certain conditions. Finally, a simulation example with a cantilever beam and a vibration test with four kinds of colored noise and trapezoidal spectrum base excitation are carried out and the results support the proposed method.
基金This research is partially sponsored by the National Science Foundation,under grant number CMMI-0928095(Program Manager:Dr.Shih-Chi Liu).
文摘Being able to significantly reduce system installation time and cost,wireless sensing technology has attracted much interest in the structural health monitoring(SHM)community.This paper reports the field application of a wireless sensing system on a 4-span highway bridge located in Wayne,New Jersey in the US.Bridge vibration due to traffic and ambient excitation is measured.To enhance the signal-to-noise ratio,a low-noise high-gain signal conditioning module is developed for the wireless sensing system.Nineteen wireless and nineteen cabled accelerometers are first installed along the sidewalk of two neighboring bridge spans.The performance of the wireless sensing system is compared with the high-precision cabled sensing system.In the next series of testing,16 wireless accelerometers are installed under the deck of another bridge span,forming a 4×4 array.Operating deflection analysis is successfully conducted using the wireless measurement of traffic and ambient vibrations.