Optic radiation injury in patients with aneurismal subarachnoid hemorrhage: a preliminary diffusion tensor imaging report

Visual field defect is one of the various clinical manifestations in patients with subarachnoid hemorrhage（SAH）. Little is known about the pathogenic mechanism of visual field defect in SAH. In the current study,we investigated the diffusion tensor imaging （DTI） finding of the optic radiation in patients with SAH followingrupture of a cerebral artery aneurysm. We recruited 21 patients with aneurismal SAH （12 males, 9 females, mean age, 52.67 years; range, 41–68 years） who showed no definite lesion along the visual pathway.Twenty-one age-and sex-matched normal control subjects were also recruited. DTI data were acquired at an average of 5.9 weeks （range： 3–12 weeks） after onset and reconstruction of the optic radiation was performed using DTI-Studio software. The fractional anisotropy value, apparent diffusion coefficient value,and fiber number of the optic radiation were measured. The fractional anisotropy value of the optic radiation was significantly decreased, and the apparent diffusion coefficient value was significantly increased, in patients with aneurismal SAH than in normal control subjects. However, there was no significant difference in the fiber number of the optic radiation between patients with aneurismal SAH and normal control subjects. The decrement of fractional anisotropy value and increment of apparent diffusion coefficient value of the optic radiation in patients with aneurismal SAH suggest optic radiation injury. Therefore, we recommend a thorough evaluation for optic radiation injury in patient with aneurismal SAH.

Diffusion tensor imaging of optic nerve and optic radiation in primary chronic angle-closure glaucoma using 3T magnetic resonance imaging

AIM: To evaluate the value of quantitative diffusion tensor imaging (DTI) in assessing the axonal and myelin damage of the optic nerves and optic radiations in patients with chronic primary angle -closure glaucoma (PACG) by using high -field magnetic resonance (MR) imaging (3T). METHODS: Twenty patients with bilateral chronic PACG and twenty age - and sex matched disease -free control subjects were enrolled. Conventional MRI and DTI were performed on all subjects using 3T MR scanner. Mean diffusivity (MD), fractional anisotropy (FA), axial diffusivities (AD) and radial diffusivities (RD) of each optic nerve and each optic radiation were measured by using post -processing software of DTI studio 2.3, and then compared between left eyes and right eyes and between patients group and control group. The pairedsample t- test were used. RESULTS: There was no abnormality in the shape and signal intensity of the optic nerves and optic radiations in patients group and control group on the conventional MRI. No significant differences were observed in the FA, MD, AD and RD between the right and left optic nerves and optic radiations within patients group and control group (P>0.05). The optic nerves and optic radiations of patients with chronic PACG, as compared with control subjects, had significantly higher MD, AD, RD and significantly lower FA (P<0.05). CONCLUSION: The diffusivity of optic nerves and optic radiations in chronic PACG group showed abnormal and diffusivity parameters could be used markers of axonal and myelin injury in glaucoma.

Magnetic resonance diffusion tensor imaging of optic nerve and optic radiation in healthy adults at 3T

AIM:To investigate the diffusion characteristics of water of optic nerve and optic radiation in healthy adults and its related factors by diffusion tensor imaging（DTI）at3T.METHODS:A total of 107 healthy volunteers performed head conventional MRI and bilateral optic nerve and optic radiation DTI.The primary data of DTI was processed by post-processing software of DTI studio 2.3,obtaining fractional anisotropy value,mean diffusivity value,principal engine value,orthogonal engine value by measuring,and analyzed by the SPSS13.0 statistical software.RESULTS:The bilateral optic nerve and optic radiation fibers presented green color in directional encoded color（DEC）maps and presented high signal in fractional anisotropy（FA）maps.The FA value of the left optic nerve was 0.598±0.069 and the right was 0.593±0.065;the mean diffusivity（MD）value of the left optic nerve was（1.324±0.349）×10-3mm2/s and the right was（1.312±0.350）x10-3mm2/s;the principal engine value(λ?)of the left optic nerve was（2.297±0.522）×10-4mm2/s and the right was（2.277±0.526）×10-3mm2/s;the orthogonal engine value（λ⊥）of the left optic nerve was（0.838±0.285）×10-3mm2/s and the right was（0.830±0.280）×10-3mm2/s;the FA value of the left optic radiation was 0.636±0.057 and the right was0.628±0.056;the mean diffusivity（MD）value of the left optic radiation was（0.907±0.103）×10-3mm2/s and the right was（0.889±0.125）×10-3mm2/s;the principal eigenvalue(λⅡ)of the left optic radiation was（1.655±0.210）×10-3mm2/s and the right was（1.614±0.171）×10-3mn2/s;the orthogonal enginvalue（λ⊥）of the left optic radiation was（0.531±0.103）×10-3mm2/s and the right was（0.524±0.152）×10-3mm2/s.There was no obvious difference between the FA,MD,λ‖,λ⊥of the bilateral optic radiation and the bilateral optic nerve（P】0.05）and no obvious differencebetween male and female group.The FA,MO,λ‖,λ⊥of the bilateral optic radiation and the bilateral optic nerve had no obvious correlations to the age.CONCLUSION:DTI is sensitive to the optic nerve and radiation and the relevant DTI parameters of the optic nerve and radiation are established preliminarily in this study.

Quantitative volumetric analysis of the optic radiation in the normal human brain using diffusion tensor magnetic resonance imaging-based tractography

To attain the volumetric information of the optic radiation in normal human brains, we per- formed diffusion tensor imaging examination in 13 healthy volunteers. Simultaneously, we used a brain normalization method to reduce individual brain variation and increase the accuracy of volumetric information analysis. In addition, tractography-based group mapping method was also used to investigate the probability and distribution of the optic radiation pathways. Our results showed that the measured optic radiation fiber tract volume was a range of about 0.16% and that the fractional anisotropy value was about 0.53. Moreover, the optic radiation probability fiber pathway that was determined with diffusion tensor tractography-based group mapping was able to detect the location relatively accurately. We believe that our methods and results are help- ful in the study of optic radiation fiber tract information.

Association of Optic Radiation Integrity with Cortical Thickness in Children with Anisometropic Amblyopia

Previous studies have indicated regional abnormalities of both gray and white matter in amblyopia. However, alterations of cortical thickness associated with changes in white matter integrity have rarely been reported. In this study, structural magnetic resonance imaging and diffusion tensor imaging （DTI） data were obtained from 15 children with anisometropic amblyopia and 15 age- and gender-matched children with normal sight. Combining DTI and surface-based morphometry, we examined a potential linkage between disrupted white matter integrity and altered cortical thickness. The fractional anisotropy （FA） values in the optic radiations （ORs） of children with anisometropic amblyopia were lower than in controls （P 〈 0.05）. The cortical thickness in amblyopic children was lower than controls in the following subregions： lin- gual cortex, lateral occipitotemporal gyrus, cuneus, occip- ital lobe, inferior parietal lobe, and temporal lobe （P 〈 0.05, corrected）, but was higher in the calcarine gyrus （P 〈 0.05, corrected）. Node-by-node correlation analysis of changes in cortical thickness revealed a significant association between a lower FA value in the OR and diminished cortical thickness in the following subregions： medial lingual cortex, lateral occipitotemporal gyrus, lat- eral, superior, and medial occipital cortex, and lunate cortex. We also found a relationship between changes of cortical thickness and white matter OR integrity in amblyopia. These findings indicate that developmental changes occur simultaneously in the OR and visual cortex in amblyopia, and provide key information on complex damage of brain networks in anisometropic amblyopia. Our results also support the hypothesis that the pathogenesis of anisometropic amblyopia is neurodevelopmental.

Magnetic resonance diffusion tensor imaging-based evaluation of optic-radiation shape and position in meningioma

Employing magnetic resonance diffusion tensor imaging, three-dimensional white-matter imaging and conventional magnetic resonance imaging can demonstrate the tumor parenchyma, peritumoral edema and compression on surrounding brain tissue. A color-coded tensor map and three-dimensional tracer diagram were applied to clearly display the optic-radiation location, course and damage. Results showed that the altered anisotropy values of meningioma patients corresponded with optic-radiation shape, size and position on both sides. Experimental findings indicate that the magnetic resonance diffusion tensor imaging technique is a means of tracing and clearly visualizing the optic radiation.

Corneal damage effects induced by infrared optical parametric oscillator radiation at 3743 nm

The main aim of this paper is to investigate the corneal damage effects induced by mid-infrared optical parametric oscillator(OPO)radiation.Experiments were performed to determine the corneal damage thresholds of New Zealand white rabbit at the wavelength of 3743 nm for ex-posurédurations of 0.1 s,1.0 s and 10.0 s.Through slit-lamp biomicroscope and histopathology,corneal injury characteristics were revealed.The damage thresholds were 3.73 J/cm^(2),7.91 J/cm^(2)and 31.1 J/cm^(2),respectively,for exposure durations of 0.1 s,1.0 s and 10.0 s.The damage data was correlated by an empirical equation:Radiant exposure at the threshold=9.72×exposure duration,^(0.46)where the units of radiant exposure and exposure duration were J/cm^(2)and second.At near-threshold level,corneal injuries at 1 h post-exposure mainly involved the epithelium,and the epithelium damages repaired at 24-h post-exposure.There are sufficient safety margins be-tween the damage thresholds and the maximum permitted exposures from current international laser safety standard IEC 60825-1.

The Study Internal Structure of the Annual Layers in Lake Sediments Using Synchrotron Radiation with X-ray Focusing Optics

1 Introduction Annually laminated(varve)sedimentary deposits are considered as one of the most important archives,since they offer precise temporal information(years)in combination with high time resolutions.Bottom sediments of the lakes contain detailed geochemical information on

Some features of welding arc radiation

This investigation is an attempt to obtain quantitative knowledge of the radiation from welding arc,which includes intensity distribution,radiant energy transfer and selfabsorption.Particular attention is paid to the meaning of optical thickness of welding arc at different welding current conditions.It may provide an useful basis for practical applications,such as ultraviolet radiation protection,information sensingfrom welding arc light,as well as temperature and density measurement in arc plasmas.

Photosensitivity detection using diffusion tensor imaging in a traumatic brain injury patient

The present study examined a patient with traumatic brain injury who exhibited visual photosensitivity and axonal iniury of the left optic radiation, which was detected by diftusion tensor imaging. The patient was a 41-year-old man. He began to complain of photosensitivity at 4 months after head trauma. Ophthalmic evaluation, including visual-evoked potential and conventional brain magnetic resonance imaging, did not reveal a pathologic basis for photosensitivity. Axonal injury in the left optic radiation was detected via diffusion tensor imaging at 36 months after head trauma. The lesion was almost recovered at 76 months. However, photosensitivity continued. Therefore, the photosensitivity was considered to be a result of axonal injury to the left optic radiation, which could be a symptom of maladaptive plasticity that occurs during recovery of axonal injury of the left optic radiation.

Cerebral corridor creator for resection of trigone ventricular tumors:Two case reports

BACKGROUND Resection of deep intracranial tumors requires significant brain retraction,which frequently causes brain damage.In particular,tumor in the trigone of the lateral ventricular presents a surgical challenge due to its inaccessible location and intricate adjacent relationships with essential structures such as the optic radiation(OR)fibers.New brain retraction systems have been developed to minimize retraction-associated injury.To date,there is little evidence supporting the superiority of any retraction system in preserving the white matter tract integrity.This report illustrates the initial surgical excision in two patients using a new retraction system termed the cerebral corridor creator(CCC)and demonstrates its advantage in protecting OR fibers.CASE SUMMARY We report two patients with nonspecific symptoms,who had trigone ventricular lesions that involved the neighboring OR identified on preoperative diffusion tensor imaging(DTI).Both patients underwent successful surgical excision using the CCC.Total tumor removal was achieved without additional neurological deficit.DTI showed that the OR fibers were preserved along the surgical field.Preoperative symptoms were alleviated immediately after surgery.Clinical outcomes were improved according to the Glasgow-Outcome-Scale and Activity-of-Daily-Living Scale assessments.CONCLUSION In the two cases,the CCC was a safe and useful tool for creating access to the deep trigonal area while preserving the white matter tract integrity.The CCC is thus a promising alternative brain retractor.

Instantaneous electron beam emittance measurement system based on the optical transition radiation principle

One kind of instantaneous electron beam emittance measurement system based on the optical transition radiation principle and double imaging optical method has been set up. It is mainly adopted in the test for the intense electron-beam produced by a linear induction accelerator. The system features two characteristics. The first one concerns the system synchronization signal triggered by the following edge of the main output waveform from a Blumlein switch. The synchronous precision of about 1 ns between the electron beam and the image capture time can be reached in this way so that the electron beam emittance at the desired time point can be obtained. The other advantage of the system is the ability to obtain the beam spot and beam divergence in one measurement so that the calculated result is the true beam emittance at that time, which can explain the electron beam condition. It provides to be a powerful beam diagnostic method for a 2.5 kA, 18.5 MeV, 90 ns （FWHM） electron beam pulse produced by Dragon I. The ability of the instantaneous measurement is about 3 ns and it can measure the beam emittance at any time point during one beam pulse. A series of beam emittances have been obtained for Dragon I. The typical beam spot is 9.0 mm （FWHM） in diameter and the corresponding beam divergence is about 10.5 mrad.

Optomechanical soft metamaterials

We present a new type of optomechanical soft metamaterials, which is different from conventional mechanical metamaterials, in that they are simple isotropic and homogenous materials without resorting to any complex nano/microstructures. This metamaterial is unique in the sense that its responses to uniaxial forcing can be tailored by programmed laser inputs to manifest different nonlinear constitutive behaviors, such as monotonic, S-shape, plateau, and non-monotonic snapping performance. To demonstrate the novel metamaterial, a thin sheet of soft material impinged by two counterpropagating lasers along its thickness direction and stretched by an in-plane tensile mechanical force is considered. A theoretical model is formulated to characterize the resulting optomechanical behavior of the thin sheet by combining the nonlinear elasticity theory of soft materials and the optical radiation stress theory. The optical radiation stresses predicted by the proposed model are validated by simulations based on the method of finite elements. Programmed optomechanical behaviors are subsequently explored using the validated model under different initial sheet thicknesses and different optical inputs, and the first- and second-order tangential stiffness of the metamaterial are used to plot the phase diagram of its nonlinear constitutive behaviors. The proposed optomechanical soft metamaterial shows great potential in biological medicine, microfluidic manipulation, and other fields.

An active reflector antenna using a laser angle metrology system

An active reflector is one of the key technologies for constructing large telescopes, especially for millimeter/sub-millimeter radio telescopes. This article in- troduces a new efficient laser angle metrology system for an active reflector antenna on large radio telescopes. Our experiments concentrate on developing an active reflec- tor for improving the detection precisions and the maintenance of the surface shape in real time on the 65-meter prototype radio telescope constructed by Nanjing Institute of Astronomical Optics and Technology （NIAOT; http：//65rn.shao.cas.cn/）. The test results indicate that the accuracy of the surface shape segmentation and maintenance has the dimensions of microns, and the time-response can be on the order of minutes. Our efforts proved to be workable for sub-millimeter radio telescopes.

Electron Beam Spectrum Diagnostics with Optical Transition Radiation on the Beijing Free-Electron Laser

A measurement system was developed to measure the electron beam spectrum of the Beijing free-electron laser based on the optical transition radiation (OTR). This paper describes the system, which consists of a 32-channel high resolution of 0.02% OTR detector, especially the spectrometer. The OTR an-gular-distribution pattern at the focal plane has two apexes, but the two apexes are smoothed out due to the electron beam energy distribution. The energy spectrum can be measured if the magnet energy resolution is higher than 0.7% to distinguish the electron beam energy distribution.

Observation of optical transition radiation from electron beams generated by laser plasma accelerator

Laser plasma accelerators （LPAs） have made great progress, achieving electron beam with energy up to 1 GeV from a centimeter scale capillary plasma waveguide. Here, we report the measurement of optical transition radiation （OTR） from the capillary-based LPA electron beams. Transition radiation images, produced by electrons passing through two separate foils （located at 2.3 m and 3.8 m away from the exit of the LPA） were recorded with a high resolution imaging system, respectively. Two magnetic quadrupole lenses were placed right after the capillary to focus and collimate the electron beams. Significant localized spikes appeared in the OTR images when the electron beam was focused by the magnetic quadrupole lenses, indicating the coherence of the radiation and the existence of ultrashort longitudinal structures inside the electron beam.

Evaluation of optical propagation and radiation in optical waveguide using a numerical method

We introduce a mathematical model based on a concept of intrinsic mode in order to analyse and synthesise optical wave propagation and radiation occurring in a non-uniform optical waveguide used in integrated optics as optical coupler. The model is based on numerical evaluation of electromagnetic wave by applying an intrinsic field integral to evaluate the field behaviour inside the optical waveguide. To analyse the field distribution inside the non-uniform waveguide and predict the beam propagation of optical energy involved in the propagation process, it is necessary to track the motion of any observation point along the tapered waveguide itself. Physically, the rays of the spectrum undergo reflections on the waveguide boundaries until the cut-off occurs and the phenomena of radiation begin. The numerical results show good agreement with those obtained by classical methods of evaluation used bv other works.

Real-time ultra-wideband video streaming in long-reach passive optical networks with wireless radiation in the 10 and 60 GHz bands

Real-time video streaming using ultra-wideband(UWB) technology is experimentally demonstrated along long-reach passive optical networks(LR-PONs) with different wired and wireless reaches. Experimental tests using external and direct modulation with UWB wireless radiation in the 10- and 60-GHz bands are performed. An ultra-bendable fiber is also considered for a last-mile distribution. The video quality at the output of the optical fiber infrastructure of the LR-PON is assessed using the error vector magnitude(EVM), and the link quality indicator(LQI) is used as a figure of merit after wireless radiation. An EVM below –17 dB is achieved for both externally and directly modulated LR-PONs comprising up to 125 km of optical fiber. EVM improvement is observed for longer LR-PONs when directly modulated lasers(DMLs) are used because of the amplitude gain provided by the combined effect of dispersion and DML's chirp. Compared with optical back-to-back operation, the LQI level degrades to the maximum around 20% for LR-PONs ranging between 75 and 125 km of fiber reach and with a wireless coverage of 2 m in the 10-GHz UWB band. The same level of LQI degradation is observed using the 60-GHz UWB band with a LR-PON integrating 101 km of access network, a last-mile distribution using ultra-bendable fiber, and a 5.2-m wireless link.

Numerical evaluation of radiation and optical coupling occurring in optical coupler

We present in this work a new mathematical model to analyze and evaluate optical phenomena occurring in the nonuniform optical waveguide used in integrated optics as an optical coupler. By introducing some modifications to the intrinsic integral, we perfectly assess the radiation field present in the adjacent medium of the waveguide and, thus, follow the evolution of the optical coupling from the taper thin film to the substrate and cladding until there is a total energy transfer. The new model that is introduced can be used to evaluate electromagnetic field distribution in three mediums that constitute any nonuniform optical couplers presenting great or low wedge angles.

Modeling the rail surface unevenness of a high-precision radio telescope

This study proposed a coarse-fine mixed model for describing the rail surface unevenness of an ultra-large fully steerable radio telescope （Qi Tai Telescope） with a diameter of 110 meters. The rail surface unevenness includes information on error arising from two different scales, i.e., the long-period- short-change and the short-period-long-change. Consequently, in this study an idea of a mixed model was proposed, in which trigonometric and fractal functions were, respectively, used to describe infor- mation on error from two scales. Key parameters were determined by using the least squares method and the wavelet transform method, and finally, a specific mathematical expression of the model was obtained by optimization. To validate the effectiveness of the new modeling method, the mixed model was then used to describe the rails of the Green Bank Telescope, the Large Millimeter Telescope, and a radio telescope in Miyun, Beijing. A comparative study revealed that the maximum error was less than 15 %, thus the result was superior to those of existing modeling methods.