Optical Surface Monitoring系统跟踪运动靶区的位置精度和剂量精度验证

目的:评估Optical Surface Monitoring System(OSMS)测量靶区运动的几何精度和使用OSMS跟踪运动靶区放疗时的剂量精度。方法:①分别使用OSMS与锥形束CT监测腹部模体的位置,通过移动治疗床使模体产生位移和旋转,对比二者对模体位置的测量结果;②用呼吸运动平台搭载MatriXX二维电离室阵列,测量不同跟踪阈值时模体内相对剂量,分别与计划剂量分布对比,分析不同跟踪阈值时计划验证的gamma通过率。结果:OSMS和锥形束CT系统对模体平移和旋转预设偏移的测量结果差异很小,使用OSMS门控技术时OSMS的阈值越小gamma通过率越高,相对剂量分布与计划剂量的一致性也越好。结论:OSMS系统对模体表面位置监测精度高,可以应用到实际放射治疗的辅助摆位。使用OSMS门控技术跟踪运动靶区可以提高靶区的剂量精度,而且对患者不附加任何电离辐射,适合应用于分次间的辅助摆位和分次内的靶区跟踪。

Surface roughness prediction model in ultrasonic vibration assisted grinding of BK7 optical glass

Pre-knowledge of machined surface roughness is the key to improve whole machining efficiency and meanwhile reduce the expenditure in machining optical glass components.In order to predict the surface roughness in ultrasonic vibration assisted grinding of brittle materials,the surface morphologies of grinding wheel were obtained firstly in the present work,the grinding wheel model was developed and the abrasive trajectories in ultrasonic vibration assisted grinding were also investigated,the theoretical model for surface roughness was developed based on the above analysis.The prediction model was developed by using Gaussian processing regression(GPR)due to the influence of brittle fracture on machined surface roughness.In order to validate both the proposed theoretical and GPR models,32sets of experiments of ultrasonic vibration assisted grinding of BK7optical glass were carried out.Experimental results show that the average relative errors of the theoretical model and GPR prediction model are13.11%and8.12%,respectively.The GPR prediction results can match well with the experimental results.

Position-resolved Surface Characterization and Nanofabrication Using an Optical Microscope Combined with a Nanopipette/Quartz Tuning Fork Atomic Force Microscope

In this work, we introduce position-resolved surface characterization and nanofabrication using an optical microscope(OM) combined with a nanopipette-based quartz tuning fork atomic force microscope(nanopipette/QTF-AFM) system. This system is used to accurately determine substrate position and nanoscale phenomena under ambient conditions. Solutions consisting of 5 nm Au nanoparticles, nanowires, and polydimethylsiloxane(PDMS) are deposited onto the substrate through the nano/microaperture of a pulled pipette. Nano/microscale patterning is performed using a nanopipette/QTF-AFM, while position is resolved by monitoring the substrate with a custom OM. With this tool, one can perform surface characterization(force spectroscopy/microscopy) using the quartz tuning fork(QTF) sensor. Nanofabrication is achieved by accurately positioning target materials on the surface, and on-demand delivery and patterning of various solutions for molecular architecture.

The determination of the thickness and the optical dispersion property of gold film using spectroscopy of a surface plasmon in the frequency domain

We propose to use wavelength modulation approach,i.e.,the spectroscopy of a surface plasmon in the frequency domain,to characterize the optical dispersion property of gold film.Using this method,we determine the dispersion relationship of gold film in a wavelength range from 537.12 nm to 905.52 nm,and our results accord well with the reported results by other authors.This method is particularly suited for studying the optical dispersion properties of thin metal films,because a series of dielectric constants over a wide spectral range can be determined simultaneously via only a single scan of the incident angle,thereby avoiding the repeated measurements required when using the angular modulation approach.

Polar interface and surface optical vibration spectra in multi-layer wurtzite quantum wires： transfer matrix method

The polar interface optical （IO） and surface optical （SO） phonon modes and the corresponding Froehlich electron phonon-interaction Hamiltonian in a freestanding multi-layer wurtzite cylindrical quantum wire （QWR） are derived and studied by employing the transfer matrix method in the dielectric continuum approximation and Loudon＇s uniaxial crystal model. A numerical calculation of a freestanding wurtzite GaN/AlN QWR is performed. The results reveal that for a relatively large azimuthal quantum number m or wave-number kz in the free z-direction, there exist two branches of IO phonon modes localized at the interface, and only one branch of SO mode localized at the surface in the system. The degenerating behaviours of the IO and SO phonon modes in the wurtzite QWR have also been clearly observed for a small kz or m. The limiting frequency properties of the IO and SO modes for large kz and m have been explained reasonably from the mathematical and physical viewpoints. The calculations of electron-phonon coupling functions show that the high-frequency IO phonon branch and SO mode play a more important role in the electron phonon interaction.

Research on automatic inspection system for defects on precise optical surface based on machine vision

In manufacture of precise optical products, it is important to inspect and classify the potential defects existing on the products’ surfaces after precise machining in order to obtain high quality in both functionality and aesthetics. The existing methods for detecting and classifying defects all are low accuracy or efficiency or high cost in inspection process. In this paper, a new inspection system based on machine vision has been introduced, which uses automatic focusing and image mosaic technologies to rapidly acquire distinct surface image, and employs Case-Based Reasoning(CBR)method in defects classification. A modificatory fuzzy similarity algorithm in CBR has been adopted for more quick and robust need of pattern recognition in practice inspection. Experiments show that the system can inspect surface diameter of 500mm in half an hour with resolving power of 0.8μm diameter according to digs or 0.5μm transverse width according to scratches. The proposed inspection principles and methods not only have meet manufacturing requirements of precise optical products, but also have great potential applications in other fields of precise surface inspection.

3D automatic segmentation method for retinal optical coherence tomography volume data using boundary surface enhancement

With the introduction of spectral-domain optical coherence tomography(SD-OCT),much larger image datasets are routinely acquired compared to what was possible using the previous generation of time-domain OCT.Thus,there is a critical need for the development of three-dimensional(3D)segmentation methods for processing these data.We present here a novel 3D automatic segmentation method for retinal OCT volume data.Brie°y,to segment a boundary surface,two OCT volume datasets are obtained by using a 3D smoothingfilter and a 3D differentialfilter.Their linear combination is then calculated to generate new volume data with an enhanced boundary surface,where pixel intensity,boundary position information,and intensity changes on both sides of the boundary surface are used simultaneously.Next,preliminary discrete boundary points are detected from the A-Scans of the volume data.Finally,surface smoothness constraints and a dynamic threshold are applied to obtain a smoothed boundary surface by correcting a small number of error points.Our method can extract retinal layer boundary surfaces sequentially with a decreasing search region of volume data.We performed automatic segmentation on eight human OCT volume datasets acquired from a commercial Spectralis OCT system,where each volume of datasets contains 97 OCT B-Scan images with a resolution of 496
512(each B-Scan comprising 512 A-Scans containing 496 pixels);experimental results show that this method can accurately segment seven layer boundary surfaces in normal as well as some abnormal eyes.

Investigation on the Effect of Film Thickness on the Surface Morphology, Electrical and Optical Properties of E-Beam Deposited Indium Tin Oxide (ITO) Thin Film

The following article has been retracted due to the fact that the authors practise fraud. The scientific community takes a very strong view on this matter, and the Advances in Materials Physics and Chemistry treats all unethical behavior seriously. This paper published in Vol. 4 No. 10 194-202, 2014 has been removed from this site. ? Title: Investigation on the Effect of Film Thickness on the Surface Morphology, Electrical and Optical Properties of E-Beam Deposited Indium Tin Oxide (ITO) Thin Film ? Authors: Golam Saklayen, Shahinul Islam, Ferdous Rahman, Abu Bakar

Impact of Surface Passivation on the Electronic Structure and Optical Properties of the Si1-xGex Nanowires

The electronic structures and optical properties of the [llO]-oriented Sil-xGex nanowires （NWs） passivated with different functional groups （-H, -F and-OH） are investigated by using first-principles calculations. The results show that surface passivation influences the characteristics of electronic band structures significantly： the band gap widths and types （direct or indirect） of the Si1-xGe, NWs with different terminators show complex and robust variations, and the effective masses of the electrons in the NWs can be modulated dramatically by the terminators. The study of optical absorption shows that the main peaks of the parallel polarization component of Si1-x Gex NWs passivated with the functional groups exhibit prominent changes both in height and position, and are red-shifted with respect to those of corresponding pure Si NWs, indicating the importance of both the terminators and Ge concentrations. Our results demonstrate that the electronic and optical properties of Si1-xGex NWs can be tuned by utilizing selected functional groups as well as particular Ge concentrations for customizing purposes.

Optical Surface Tilt Measurement with Sub-Second Accuracy

This paper presents a coherent resolved heterodyne interferometer used for recognition of surfaces of optical systems with resort to a short coherence length light source and a position sensitive detection(PSD), and its special features of surface sensitivity, high resolution and short measuring time.

Band structure,Fermi surface,elastic,thermodynamic,and optical properties of AlZr3,AlCu3,and AlCu2Zr:First-principles study

The electronic properties（Fermi surface,band structure,and density of states（DOS）） of Al-based alloys AlM3（M=Zr and Cu） and AlCu2Zr are investigated using the first-principles pseudopotential plane wave method within the generalized gradient approximation（GGA）.The structural parameters and elastic constants are evaluated and compared with other available data.Also,the pressure dependences of mechanical properties of the compounds are studied.The temperature dependence of adiabatic bulk modulus,Debye temperature,specific heat,thermal expansion coefficient,entropy,and internal energy are all obtained for the first time through quasi-harmonic Debye model with phononic effects for T = 0 K-100 K.The parameters of optical properties（dielectric functions,refractive index,extinction coefficient,absorption spectrum,conductivity,energy-loss spectrum,and reflectivity） of the compounds are calculated and discussed for the first time.The reflectivities of the materials are quite high in the IR-visible-UV region up to ~ 15 eV,showing that they promise to be good coating materials to avoid solar heating.Some of the properties are also compared with those of the Al-based Ni3 Al compound.

Difference scattering field properties between periodic defect particles and three-dimensional slightly rough optical surface

Based on the practical situation of nondestructive examination, the calculation model of the composite scattering is established by using a three-dimensional half-space finite difference time domain, and the Monte Carlo method is used to solve the problem of the optical surface with roughness in the proposed scheme. Moreover, the defect particles are observed as periodic particles for a more complex situation. In order to obtain the scattering contribution of defects inside the optical surface, a difference radar cross section is added into the model to analyze the selected calculations on the effects of numbers, separation distances, different depths and different materials of defects. The effects of different incident angles are also discussed. The numerical results are analyzed in detail to demonstrate the best position to find the defects in the optical surface by detecting in steps of a fixed degree for the incident angle.

Electronic, optical properties, surface energies and work functions of Ag_8SnS_6: First-principles method

Ternary metal chalcogenide semiconductor Ag8 Sn S6, which is an efficient photocatalyst under visible light radiation,is studied by plane-wave pseudopotential density functional theory. After geometry optimization, the electronic and optical properties are studied. A scissor operator value of 0.81 e V is introduced to overcome the underestimation of the calculation band gaps. The contribution of different bands is analyzed by virtue of total and partial density of states. Furthermore, in order to understand the optical properties of Ag8 Sn S6, the dielectric function, absorption coefficient, and refractive index are also performed in the energy range from 0 to 11 e V. The absorption spectrum indicates that Ag8 Sn S6has a good absorbency in visible light area. Surface energies and work functions of（411）,（4 13）,（21 1）, and（112） orientations have been calculated. These results reveal the reason for an outstanding photocatalytic activity of Ag8 Sn S6.

The Diagnosis of Plasma Parameters in Surface Alloying Technique by Optical Emission Spectrometry

Electron density （Ne） in a glow discharge plasma for the surface alloying technique is diagnosed by optical emission spectrometry （OES）. With CH4 as the feeding gas, Ne is obtained by comparing the Hβ spectrum according to the Stark broadening effect. It is noticed that Ne varies with the working pressures （30 Pa to 70 Pa） and cathode voltages （500 V to 1000 V）, respectively. Due to an abnormal glow discharge, Ne is between 1. 71 × 10^15 /cm^3 to 6.64 × 10^15 /cm^3 and increases rapidly with working gas pressures and cathode voltages. The results show that OES is a useful method to measure the plasma parameters in a surface alloying glow discharge plasma.

Surface defect gap solitons in two-dimensional optical lattices

We investigate the existence and stability of surface defect gap solitons at an interface between a defect in a two-dimensional optical lattice and a uniform saturable Kerr nonlinear medium. The surface defect embedded in the two-dimensional optical lattice gives rise to some unique properties. It is interestingly found that for the negative defect, stable surface defect gap solitons can exist both in the semi-infinite gap and in the first gap. The deeper the negative defect, the narrower the stable region in the semi-infinite gap will be. For a positive defect, the surface defect gap solitons exist only in the semi-infinite gap and the stable region localizes in a low power region.

Influence on Multimode Rectangular Optical Waveguide Propagation Loss by Surface Roughness

Optical scattering loss coefficient of muhimode rectangular waveguide is analyzed in this work. First, the effective refrac tive index and the mode field distribution of waveguide modes are obtained using the Marcatili method. The influence on scattering loss coefficient by waveguide surface roughness is then analyzed. Finally, the mode coupling efficiency for the SMFOpticalWaveguide （SOW） structure and MMFOptical Waveguide （MOW） structure are presented. The total scatter ing loss coefficient depends on modes scattering loss coeffi cients and the mode coupling efficiency between fiber and waveguide. The simulation results show that the total scatter ing loss coefficient for the MOW structure is affected more strongly by surface roughness than that for the SOW struc ture. The total scattering loss coefficient of waveguide decreas es from 3.97 x 10^-2 dB/cm to 2.96 x 10^-4 dB/cm for the SOW structure and from 5.24 - 10^-2 dB/cm to 4.7 x 10^-4 dB/ cm for the MOW structure when surface roughness is from 300nm to 20nm and waveguide length is 100cm.

SYNTHESIS， SURFACE POTENTIAL AND NONLINEAR OPTICAL PROPERTIES OF NEW AMPHIPHILIC PORPHYRINS

A new kind of amphiphilic porphyrin containing only one carboxyl on the β point of porphyrin ring was synthesized. The surface potential and SHG (Second Harmonic Generation) efficiency of monolayer were measured and the relationship between the surface potential,SHG and the structure of molecule was discussed.

Volume added surface barrier discharge plasma excited by bipolar nanosecond pulse power in atmospheric air: optical emission spectra influenced by gap distance

In this paper, volume barrier discharge with different gap distances is added on the discharge border of high-voltage electrode of annular surface barrier discharge for generating volume added surface barrier discharge （V-SBD） excited by bipolar nanosecond high-voltage pulse power in atmospheric air. The excited V-SBDs consist of surface barrier discharge （d = 0 mm） and volume added surface barrier discharges （d = 2 mm and 3 mm）. The optical emission spectra are recorded for calculating emission intensities of N2 （C3 ∏u → B3∏g） and N2＋ （B2 ∑u＋ → X2 ∑g＋）, and simulating rotational and vibrational temperatures. The influences of gap distance of V-SBD on emission intensity and plasma temperature are also investigated and analyzed. The results show that d = 0 mm structure can excite the largest emission intensity of N2 （C3 ∏u → B3 ∏g）, while the existence of volume barrier discharge can delay the occurrence of the peak value of the emission intensity ratio of N2 ＋ （B2 ∑u＋ → X2 ∑＋g）/N2 （C3 ∏u → B3 ∏g） during the rising period of the applied voltage pulse and weaken it during the end period. The increasing factor of emission intensity is effected by the pulse repetition rate. The d = 3 mm structure has the highest threshold voltage while it can maintain more emission intensity of N2 （C3 ∏u→ B3∏g） than that of d = 2 mm structure. The structure of d = 2 mm can maintain more increasing factor than that of the d = 3 mm structure with varying pulse repetition rate. Besides, the rotational temperatures of three V-SBD structures are slightly affected when the gap distance and pulse repetition rate vary. The vibrational temperatures have decaying tendencies of all three structures with the increasing pulse repetition rate.

Organization and Ultra-Structural Components of Endothelial Surface Glycocalyx Revealed by Stochastic Optical Reconstruction Microscopy(STORM)

Introduction The endothelial cells(ECs)lining every blood vessel wall constantly expose to the mechanical forces generated by the blood flow.The EC responses to these hemodynamic forces play a critical role in the homeostasis of the circulatory system.In addition to forming a transport barrier between the blood and vessel wall,vascular ECs play important roles in regulating circulation functions.Besides biochemical stimuli,blood flow induced(hemodynamic)mechanical stimuli,such as shear stress,pressure and circumferential stretch,modulate EC morphology and functions by activating mechanosensors,signaling pathways,and gene and protein expressions.The EC responses to the hemodynamic forces(mechano-sensing and transduction)are critical to maintaining normal vascular functions.Failure in the mechano-sensing and transduction leads to serious vascular diseases including hypertension,atherosclerosis,aneurysms and thrombosis,to name a few[1].On the luminal surface of our blood vessels,there is a thin layer called endothelial surface glycocalyx(ESG)which consists of proteoglycans,glycosaminoglycans(GAGs)and glycoproteins.The GAGs in the ESG are heparan sulfate(HS),hyaluronic acid(HA),chondroitin sulfate(CS),and sialic acid(SA)[2].In order to play important roles in vascular functions,such as being a mechanosensor and transducer for the endothelial cells(ECs)to sense the blood flow,a molecular sieve to maintain normal microvessel permeability and a barrier between the circulating cells and endothelial cells forming the vessel wall,the ESG should have an organized structure at the molecular level.Due to the limitations of optical and electron microscopy,the ultra-structure and organization of ESG has not been revealed until recent development of a super high resolution fluorescence optical microscope,STORM(Stochastic Optical Reconstruction Microscopy).The diffraction of a single fluorescence molecule can be described as the point spread function(PSF).When the light of wavelengthλexcites the fluorophore(emitter),the intensity profile of the spot is defined as the PSF with the width^0.6λ/NA,NA is the numerical aperture of the objective.The diffraction-limited image resolution,for a high numerical aperture objective lens,is^200 nm in the lateral direction and^500 nm in the axial direction,for a conventional fluorescence microscope.The key idea of the single-molecule localization microscopy is to light the molecule,in turn,to achieve the nanometer-level accuracy of their position and reconstruction into a super-resolution image,such as STORM.STORM employs photo-switching mechanisms to stochastically activate individual molecules(photo-switchable or photoactivatable fluorophores)within the diffraction-limited region at different times.Then images with sub-diffraction limit resolution are reconstructed from the measured positions of individual fluorophores[3].To trade the super spatial resolution(accuracy),STORM sacrifices its temporal resolution(efficiency)by switching the state and sequentially exciting the emitters at a high density.Rust et al[3]employed organic dyes and fluorescent proteins as photo-switchable emitters to trade temporal resolution for a super spatial resolution(~20 nm lateral and^50 nm axial at present,can go down to a couple of nanometers if using smaller peptides or antibody fragments instead of currently used whole anti-bodies),which is an order of magnitude higher than conventional confocal microscopy.In the current study,we employed STORM to reveal the major ultra-structural components of the ESG,HS and HA,and their organization at the surface of the cultured EC monolayer[4].Materials and methods We used newly acquired Nikon-STORM system to observe the ESG on in vitro EC(bEnd3,mouse brain microvascular endothelial cells)monolayers.After confluency,the bEnd3 cells were immunolabeled with anti-HS,fol-lowed by an ATT0488 conjugated goat anti-mouse IgG,and with biotinylated HA binding protein,followed by an AF647 conjugated anti-biotin.The ESG was then imaged by the STORM with a 100x/1.49 oil immersed lens.Multiple Reporters of ATT0488 and AF647 with alternating illumination were used to acquire the 3D images of HS and HA.The field of 256×256(40×40μm2)of HS and HA at the surface of ECs was obtained based on totally 40,000 of EM-CCD captured images for each reporter at a capturing speed of 19 ms/frame.Results HA is a long molecule weaving into a network which covers the endothelial luminal surface.The diameter of the HA segments is 185.3±44.7 nm,155.5±57.2 nm,and 156.9±56.1 nm,respectively,at the top,middle and bottom regions of the cell luminal surface.In contrast,HS is a shorter molecule,perpendicular to the cell surface.HA and HS are partially overlapped with each other at the endothelial luminal surface.We quantified the length,diameter,orientation,and density of HS at the top,middle and bottom regions of the endothelial surface.The diameter of the observed HS is 191.0±46.0 nm,284.3±71.1 nm,and 184.2±59.6 nm,and the length of the HS is 621.0±75.7 nm,651.0±118.0 nm,and 575.2±105.6 nm,respectively,at the top,middle and bottom regions of the cell luminal surface.For the HS orientation,its angle with the cell surface is 92.9±1.9,88.7±8.2,and 96.2±10.9 degree,respectively,at the top,middle and bottom regions.The angle of 90 degree is perfectly perpendicular to the cell surface.For the HS distribution,the average density is0.398 elements/μm2,0.345 elements/μm2 and 0.665 elements/μm2,respectively,and the distance between the adjacent HS is 1 694.4±628.1 nm,1 844.8±758.5 nm,and 1 221.9±450.7 nm,respectively,at the top,middle and bottom regions.Conclusions Our results suggest that HS plays a major role in mechanosensing and HA plays a major role in the molecular sieve,due to their organization,ultra-structure and distribution.

RESEARCH ON WATER QUALITY TESTS BASED ON OPTICAL WAVEGUIDE SURFACE PLASMON RESONANCE TECHNOLOGY

The water quality testing principle by surface plasmon resonance(SPR)is introduced.Using the scanning mode angular spectral testing and the CCD angular spectral testing,a kind of highresolution,wide-range,and portable optical waveguide SPR angular spectral testing system is studied,the method of improving the testing accuracy is discussed,and a long-life surface plasmon optical waveguide transducer is also proposed.Utilizing the SPR testing system,we contrastively tack some test for several sorts of solution,the results presented that significant differences of SPR peaks observed in different sorts of liquid,which indicated the effectiveness of SPR technology used in water quality testing and analysis.