Clinical research progress of oral administration of traditional Chinese medicine in the treatment of dry eyes

Dry eye is a common and frequently occurring ophthalmology disease with complex etiology and easy recurrence.Oral administration of traditional Chinese medicine has the characteristicsof high curative effect and little toxic and side effect in the treatment of dry eye.This paper collates the domestic reported clinical studies on the oral administration of traditional Chinese medicine in the treatment of dry eye,which are discussed from four aspects:special prescription for specific disease,addition and subtraction of main prescription,treatment based on syndrome differentiation and proprietary Chinese medicine.The curative effect and advantages of traditional Chinese medicine in the treatment of dry eye are demonstrated,providing a reference for the treatment of dry eye in the future.

Fifty-six Cases of Stubborn Eczema Treated by Oral Administration and Topical Application of Herbal Medicine

Eczema is a kind of very common dermatopathy. The cases with a long course of illness and hard to be cured are termed as stubborn eczema. We have obtained good results in its treatment since 1995 with the Chu Shi Tang (除湿汤Dampness-Clearing Decoction) for oral intake and the Fu Fang Ku Shen Xi Ye (复方苦参洗液) for topical application. The following is a clinical report for treating 56 patients with stubborn eczema.

Treatment of Irritable Bowel Syndrome by Oral Administration of Chinese Medicines and Retention-Enema——A Report of 50 Cases

Irritable bowel syndrome (IBS), a common disease of intestinal dysfunction, is also called emotional enteritis, mucous enteritis, irritable colon and so on1. It is often lingering with a long disease course and is easy to recur. The author has in recent years treated 50 cases of the disease by oral administration of Chinese medicines and retention-enema, with satisfactory results reported as follows.

Therapeutic Effect of Oral Administration and External Therapy of Traditional Chinese Medicine on Cervical Tuberculous Lymphadenopathy

Objective:To analyze the clinical effect and value of oral administration and external therapy of traditional Chinese medicine for treatment of cervical tuberculous lymphadenopathy.Methods:A total of 56 patients with cervical tuberculous lymphadenopathy admitted to our hospital from January 1 to January 2018 were recruited.By using double-blind method,the patients were divided into control group(n=28)and experimental group(n=28).Control group comprised of patients with conventional anti-tuberculosis treatment,while the experimental group comprised of patients treated with oral administration and external therapy of traditional Chinese medicine.Total effective rate,incidence of complication and level of T lymphocyte subsets were compared between the two groups of cervical tuberculous lymphadenopathy patients.Results:Post-treatment data of total effective rate,complication rate,CD3+,CD4+,CD8+,CD4+/CD8+of the experimental group were compared with the control group.P<0.05;statistical analysis showed statistical significance.Post-treatment data of CD3+,CD4+,CD8+,CD4+/CD8+of both control and experimental groups were compared with pre-treatment data.P<0.05;statistical analysis showed statistical significance.Conclusion:Oral administration and external therapy of traditional Chinese medicine possesses significant effect in treatment of cervical tuberculous lymphadenopathy.

Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines

AIM:To evaluate the anti-Helicobacter pylori (H.pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.METHODS:A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H.pylori Sydney strain 1 was performed with broth dilution method.Anti-H.pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).RESULTS:The water extract from Rhizoma Coptidis,Radix Scutellariae and Radix isatidis could significantly inhibit the H.pylori activity with their MIC less than 7.8 mg/mL,suggesting that traditional Chinese herbal medicines have anti-inflammatory and antibacterial effects and can thus be used in treatment of H.pylori infection.CONCLUSION:Rhizoma Coptidis,Radix Scutellariae and Radix isatidis are the potential sources for the synthesis of new drugs against H.pylori.

Clinical Observation on Treatment of Acquired Paralytic Strabismus by Acupuncture Plus Oral Administration of Chinese Herbs

From June 1996 to June 2002, the author treated 38 cases of acquired paralytic strabismus by acupuncture plus oral administration of Zheng Rong Tang (正容汤), with another 38 cases of acquired paralytic strabismus treated only with oral administration of Chinese herbs as the controls. The results are reported as follows.

Research on the modern clinical herbal administration rules in TCM treatment of ovarian cysts based on data mining

Objective:To explore the recent 20 years' herbal administration rules in TCM treatments of ovarian cysts (OCs) based on data mining.Methods:A prescription database for ovarian cysts was established by ACCESS 2007.Importing the database into SPSS17.0 and SPSS Modeler14.1.SPSS17.0 was used for descriptive and cluster analyses,while SPSS Modeler14.1 was used for association rules analysis.Results:After screening,363 prescriptions were obtained.The 10 most frequently-used Chinese herbal medicines are Zedoaria (Rhizoma Curcumae),Poria cocos (Poria),Common buried rubber (Rhizoma Sparganii),Red peony root (Radix Paeoniae Rubra),Peach seed (Semen Persicae),Danggui (Radix Angelicae Sinensis),Chinese angelica (Ramulus Cinnamomi),Liquorice root (Radix Glycyrrhizae),Pangolin scales (Squama Manis) and Moutan cortex (Cortex Moutan Radicis);the 5 most common syndromes of OCs are qi stagnation and blood stasis,phlegm and blood stasis,uterine blood stasis,stagnation of liver qi and retention of phlegm and dampness,nearly to 54.26%;In association rules analysis,5 sets of two-herbs association rules were obtained,17 sets of three-herbs association rules were obtained,22 sets of four-herbs association rules were obtained and 4 sets of five-herbs association rules were obtained;By clustering,13 sets of core couplet medicinals were obtained.Conclusion:Medicinal herbs for promoting blood circulation to remove blood stasis,resolve hard lumps,for strengthening the spleen,eliminating phlegm,and relieving liver qi stagnation were highly used in the treatment of OCs;Herbs attributed to the Liver Meridian,the Spleen Meridian and the Heart Meridian were highly used in OCs;The compatibility of herbs for promoting blood circulation to remove blood stasis and resolve hard lumps were highly used;Guizhi Fuling Wan (GFW) was often used and combined with other herbs in the treatment of OCs.

A meta-analysis of the efficacy of traditional Chinese medicine alone in the treatment of refractory gastroesophageal reflux disease

Background:To systematically evaluate the efficacy and safety of traditional Chinese medicine in the treatment of refractory gastroesophageal reflux.Methods:PubMed,The Cochrane Library,Embase,Web of Science,China National Knowledge Infrastructure,Wanfang Database,China Science and Technology Journal Database and Chinese BioMedical Literature Database were searched for randomized controlled trials of traditional Chinese medicine in the treatment of refractory gastroesophageal reflux from database establishment time to December 2020.After two researchers independently screened the literature,extracted data and evaluated the bias risk included in the study,RevMan5.3 software was used for meta-analysis.Results:A total of 12 randomized controlled trials,were included,including 893 patients.The results of meta-analysis showed that the total effective rate of the treatment group(relative risk=1.28,95%confidence interval(CI)(1.19,1.38),P<0.00001),RGERDQ(refractory gastroesophageal reflux disease)score(mean difference(MD)=−3.35,95%CI(−4.13,−2.57),P<0.00001],acid reflux(acid in the stomach comes out of the mouth)[MD=−0.30,95%CI(−0.45,−0.15),P<0.00001],heartburn(the feeling that the heart is burned)(MD=−0.44,95%CI(−0.60,−0.29),P<0.00001,and retrosternal pain(MD=−0.27,95%CI(−0.44,−0.10),P<0.00001,belching(MD=−0.40,95%CI(−0.57,−0.24),P<0.00001],endoscopic mucosal score(MD=−0.62,95%CI(−0.78,−0.46),P<0.00001],the differences were statistically significant,and the effective rate of mucosal improvement under endoscopy was P=0.93>0.05,with no statistically significant difference.Conclusion:The current evidence shows that traditional Chinese medicine in the treatment of refractory gastroesophageal reflux disease is better than that of western medicine in the total effective rate,relieving acid reflux,heartburn,retrosternal pain and belching symptoms,but it is impossible to judge the improvement of mucosa under endoscope.Due to the limitations of the quality and quantity of included studies,more high-quality studies are needed to confirm the above conclusions.

托里透毒汤口服联合紫草纱条引流促进肛周脓肿术后创面愈合的研究

目的探讨托里透毒汤方口服联合紫草纱条创面引流促进肛周脓肿患者术后创面愈合和影响炎性因子表达研究。方法选取医院2019年6月—2022年1月收治的174例肛周脓肿术的患者为研究对象,随机分为观察组(58例)、对照组A(58例)和对照组B(58例),术后所有患者给予常规处理,对照组A增加紫草纱条创面引流治疗,对照组B增加凡士林纱条创面引流治疗,观察组增加托里透毒汤方口服与紫草纱条创面引流联合治疗。比较3组患者术后第1、7、14天时疼痛程度、创面症状评分、创面愈合情况、炎性因子水平及治疗效果。结果术后第7、14天观察组血清P物质(Substance P,SP)、五羟色胺(5-Hydroxytryptamine,5-HT)水平均低于对照组A与对照组B(P<0.05),对照组A第7、14天各水平均低于对照组B(P<0.05);术后第7、14天观察组分泌物评分、水肿评分均低于对照组A与对照组B(P<0.05),对照组A7 d、14 d各评分均低于对照组B(P<0.05);观察组第7、14天创面缩小率高于对照组A与对照组B(P<0.05),对照组A第7、14天缩小率均高于对照组B,治疗后观察组创面腐肉全部脱落时间与创面愈合时间均短于对照组A与对照组B(P<0.05),对照组A各时间均低于对照组B(P<0.05);术后第7、14天观察组血清肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)、C反应蛋白(C-reactive Protein,CRP)及白细胞介素-6(Interleukin-6,IL-6)炎性因子水平均低于对照组A与对照组B(P<0.05),对照组A第7天、14天各水平均低于对照组B(P<0.05);治疗后观察组患者总有效58例(100.00%)显著比对照组A患者54例(93.10%)和对照组B患者50例(86.21%)高(P<0.05),对照组A总有效率比对照组B高,但两组比较差异不存在统计学意义(P>0.05)。结论托里透毒汤口服联合紫草纱条创面引流可以促进术后创面愈合,降低炎性因子水平,缩短康复进程,值得推广。

基于中医传承辅助平台的中药内服治疗原发性骨质疏松症组方用药规律研究

目的:基于数据挖掘方法探讨中医药治疗原发性骨质疏松症的组方用药规律。方法:检索中国知网、维普、万方等中文数据库2006—2022年中药内服治疗原发性骨质疏松症的中药方剂,通过中医传承辅助平台系统软件(TCMISS)运用关联规则算法、复杂系统熵聚类方法,统计处方中药物的性味归经、使用频率、药物之间的关联规则、核心药物组合和高频中药组合。结果:纳入文献共计210篇,涉及224首方剂,168味中药。总结高频证候分型,居于前4位的分别是肾虚血瘀证、脾肾亏虚证、肝肾阴虚证、肾虚证。性味归经最多为温性药,五味频次最多为甘味药。药物归经前4位的是肝、肾、脾及心经。单味中药使用频次居于前10位的是熟地黄、淫羊藿、当归、杜仲、黄芪、骨碎补、补骨脂、山茱萸、山药、枸杞子。关联规则分析得到45个药对组合及44条关联规则。聚类分析得到20个药物核心组合,优化出10个新方组合。结论:原发性骨质疏松症病因以肾、脾亏虚为主,兼有血瘀,中医药治疗以补益肝肾、健脾益气、活血补血为主。

中医治疗紧张性头痛的研究进展

紧张性头痛(TTH)又称肌收缩性头痛,属于功能性头痛中最常见的类型之一,其表现为紧束性或压迫性非搏动性头痛,可伴或不伴有头部肌群的挛缩性收缩及压痛,呈发作性或持续性,病程数日至数年不等。随着生活节奏的加快,社会压力的增大,其发病率呈逐渐上升的趋势,好发育中青年,女性略高于男性。中医学将其归于“头痛”“首风”“头风”等范畴,虽然在发病中有多种致病因素在起作用,但是中医学通过四诊合参进行辨证论治,针对每个患者病因病机不同处以方药、针灸、推拿、按摩等中医外治,近年来各项研究数据显示,中医内服用药及外治疗法所达到的成效不容小觑,随着中医学的现代化发展,现代医家汲取古代医家宝贵经验,去粗取精,对于紧张性头痛不断深入研究,在传统治疗的基础上加上现代化仪器等,在治疗方面涌现出了更多的诊治方法,且其临床疗效满意。文章归纳近10年关于中医治疗紧张性头痛的文献,归纳中医治疗方法,以探讨更有效的治疗方案,提高临床疗效。

中药内服法治疗糖尿病视网膜病变研究概况

糖尿病是危害人类生命与健康安全的三大疾病之一,除了疾病本身给患者生活造成不便外,随着病情的进展,其产生的多种并发症对患者的影响也不容小觑。视网膜病变是常见的糖尿病并发症之一,严重影响患者的身心健康。中药内服法治疗糖尿病性视网膜病变具有疗效较好、不良反应小等优势。因此,该文对近些年来医家们对糖尿病视网膜病变病因病机的认识及中药方剂内服法医治糖尿病视网膜病变的疗效和作用机制的相关研究进行综述,为临床使用中药治疗糖尿病视网膜病变提供依据与参考。

中药内服及外洗联合血液灌流治疗维持性血液透析伴皮肤瘙痒患者的效果研究

目的:研究中药内服及外洗联合血液灌流治疗维持性血液透析伴皮肤瘙痒患者的效果。方法:选择2022年7月—2023年7月萍乡矿业集团有限责任公司总医院收治的80例维持性血液透析伴皮肤瘙痒患者为研究对象,按随机数字表法分为治疗组和对照组,各组40例。两组均接受血液透析联合血液灌流治疗,对照组接受皮肤瘙痒非药物治疗,治疗组在对照组基础上接受中药内服及经验方祛风止痒安神汤外洗治疗,两组治疗时间均为4周。比较两组实验室指标、瘙痒情况、睡眠质量、生活质量、不良反应。结果:治疗4周后,治疗组组胺(HIS)、甲状旁腺激素(PTH)、血尿素氮(BUN)、血肌酐(Scr)、β_(2)-微球蛋白(β_(2)-MG)均明显低于对照组,血钙、血磷达标率均明显高于对照组,差异均有统计学意义(P<0.05)。治疗4周后,治疗组瘙痒评分、阿森斯失眠量表(AIS)评分均明显低于对照组,治疗组世界卫生组织生存质量测定量表(WHOQOL-BREF)各维度评分及总分均高于对照组,差异均有统计学意义(P<0.05)。治疗期间两组均未出现严重不良反应。结论:中药内服及外洗联合血液灌流治疗维持性血液透析伴皮肤瘙痒患者的效果明显,有助于维持钙磷代谢平衡,对改善皮肤瘙痒及睡眠质量有积极作用,可提高患者生活质量。

灸八髎穴联合内服益气润肠中药汤剂治疗1例中风后气虚便秘患者的护理体会

本文总结灸八髎穴联合内服益气润肠中药汤剂治疗1例中风后气虚便秘患者的护理体会。在完善护理评估的基础上,遵医嘱给予八髎穴艾灸、针灸等中医外治疗法,以增强肠道蠕动,缓解便秘;给予益气润肠中药汤剂内服,从根本上调理;同时基于子午流注理论,为患者开具饮水处方,以软化粪便,促进胃肠蠕动,利于排便;结合患者的疾病特点予以饮食调护、运动疗法和情志护理。经过10d中医内服外用联合治疗以及辨证施护,患者气虚便秘症状得到有效改善。

基于数据挖掘技术探讨中药治疗急性附睾炎用药规律

目的:基于数据挖掘技术探讨中药治疗急性附睾炎的用药规律。方法:检索中国知网(CNKI)、万方数据知识服务平台(WF)自建库至2023年8月1日公开发表的中药治疗急性附睾炎的相关文献。分别建立内服、外用中药处方数据库,运用中医传承辅助平台V3.5软件统计药物使用频次、功效、四气、五味、归经,以及进行关联规则和聚类分析。结果:筛选后获取文献95篇,其中内服中药文献74篇,外用中药文献21篇。得到102首处方,包括63首内服中药处方和39首外用中药处方。内服中药使用频次排名前5的是甘草、当归、柴胡、泽泻、龙胆草,外用中药使用频次排名前5的是大黄、黄柏、天花粉、甘草、白芷。内服中药功效多见清热、活血化瘀、利水渗湿,外用中药功效多见清热、活血化瘀、泻下。内服、外用中药四气皆以寒性为主,其次为温性;五味皆以苦味为主,其次为甘味或辛味。内服中药排名前3的归经是肝、肺、心经,外用中药排名前3的归经是脾、肝、肺经。通过关联规则分析,内服中药获得30条常用药物组合、8条核心药物关联规则;外用中药获得6条常用药物组合、7条核心药物关联规则。通过聚类分析,内服中药获得4个核心药物组合,外用中药获得3个核心药物组合。结论:中药治疗急性附睾炎无论内服还是外用,都强调清热解毒、活血化瘀,组方皆以苦寒清热药为主。内服中药核心药物组合针对急性附睾炎早期湿热蕴结、热毒壅盛和后期瘀血阻络、瘀毒互结之病机,分别治以清热利湿、活血解毒和活血化瘀、清热解毒、软坚散结之法。外用中药核心药物组合则常以清热利湿药、清热解毒药配以活血化瘀药,以改善局部症状为主。

Oral Chinese Herbal Medicine for Heart Failure with Preserved Ejection Fraction: A Meta-Analysis

Objective: To evaluate the effectiveness and safety of oral Chinese herbal medicine(OCHM) for heart failure with preserved ejection fraction(HFp EF). Methods: Pub Med, Excerpta Medica Database(EMBASE), Cochrane Library, Chinese Biological Medicine Database(CBM), Wanfang Database, Chongqing VIP Information(VIP) and China National Knowledge Infrastructure(CNKI) were searched for appropriate articles from respective inceptions until June 3, 2018. Randomized controlled trials(RCTs) investigating the effectiveness of OCHM for the patients with HFp EF were eligible. Quality assessment was performed by employing the Cochrane Risk of Bias assessment tool. Papers were independently reviewed by two reviewers and analyzed using Cochrane software Revman 5.3. Dichotomous data were analyzed by relative risk(RR) with a 95% confidence interval(CI), while continuous variables were analyzed by using mean difference(MD) with 95% CI for effect size. Results: A total of 16 RCTs involving 1,320 participants were identified. Fourteen of the trials used conventional Western medicine(CWM) as the control, the control of 1 trial was no treatment, and another was placebo. Three of the trials served Chinese patent medicine(CPM) as interventions, and other OCHM were Chinese medicine decoctions(CMDs). Only limited evidence showed experimental group with OCHM may get better effect on brain natriuretic peptide(BNP: MD –37.29, 95% CI –53.08 to –21.50, P<0.00001) or N terminal pro B type natriuretic peptide(NT-pro BNP: MD –236.04, 95% CI –356.83 to –115.25, P=0.0001), Minnesota Living with Heart Failure questionnaire(MLHFQ, MD –9.94, 95% CI –16.77 to –3.11, P=0.004), but the results had high heterogeneities. With concerns on 12 of 16 trials, the meta-analysis found that the adjuvant therapy of OCHM might be more effective in increasing overall response rate(RR 1.17, 95% CI 1.11 to 1.24, P<0.00001), when compared with CWM alone. Subgroup meta-analysis between CPMs and CMDs showed that the two CPMs may have more therapeutic effect on MLHFQ, but not on NT-pro BNP, and CMD came to the opposite conclusion. No significant differences were found between experimental groups and control groups on 6-min walk test(6 MWT). Adverse events, such as more defecation, weakness, cardiopalmus, edema, cough and hypotension, were mild in all groups and disappeared after the easement of pharmacological intervention. Conclusions: Due to the insufficient quality of trials that were analyzed, it is not appropriate to confirm or deny the potency of OCHMs in treating HFp EF at the present time. More rigorously designed RCTs focusing on primary endpoints with long-term followup are warranted to validate the effect of OCHMs for patients with HFp EF.

妇产科实施慢性盆腔炎临床治疗的方法及效果分析

目的:探析慢性盆腔炎(CPID)临床治疗的方法及效果。方法:纳入本院2020年1月至2022年12月收治共计200例CPID患者,采用简单随机化方法将纳入患者均分且设定为对照组、观察组(均n=100),前一组给予常规西医治疗,后一组加施中成药口服+红外线腹部照射+低频脉冲电治疗,比较两组临床效果、症状缓解时间、中医症候积分、血液流变学指标以及炎症因子水平和不良反应发生情况。结果:观察组临床总有效率93.00%较对照组的82.00%居于更高水平(P<0.05)。观察组下腹坠胀、下腹疼痛以及腰骶部酸痛等症状缓解时间均较对照组更短(P<0.05)。治疗前,两组下腹胀痛或刺痛、带下色黄质稠量多、胸闷纳呆、经期长量大色黯红等症候评分均无差异(P>0.05);治疗2周,观察组各项症候评分均较对照组更低(P<0.05)。治疗前,两组ESP、CP、PV、FIB水平均无统计学差异(P>0.05);治疗2周,观察组ESP、CP、PV、FIB水平均较对照组更低(P<0.05)。治疗前,两组IL-8、IL-10、TGF-β1、MCP-1水平均无统计学差异(P>0.05);治疗2周,观察组IL-8、TGF-β1、MCP-1水平均较对照组更低,IL-10水平较对照组更高(P<0.05)。观察组头晕、恶心、皮疹等常见不良反应总发生率4.00%与对照组的6.00%比较无统计学差异(P>0.05)。结论:于CPID患者而言,在常规西医治疗基础上加施中成药口服+红外线腹部照射+低频脉冲电治疗,能够取得理想效果,且安全性较高,值得应用。

228 CASES OF PAINFUL SWELLING OF THE YANG-HEAT TYPE TREATED BY COMPRESS WITH XIAO ZHONG SAN

Painful swelling of the yang-heat type can be seen in many kinds of yang-heat syndromes of surgery, gynecology and pediatrics, and in some complications of internal medicine. Since 1987, we have successfully treated 228 cases of different painful swelling syndromes of the yang-heat type by compress with Xiao Zhong San (消肿散), which was developed through repeated scanning on the basis of an ancient prescription of Tiao Wei Cheng Qi Tang (调胃承气汤) described in Treatise on Febrile Diseases written by Zhang Zhongjing. This is reported as follows.

中药口服联合外用疗法治疗HR-HPV持续性感染的临床有效性及安全性分析

目的 探讨中药口服联合外用疗法治疗HR-HPV持续性感染的临床有效性及安全性。方法 将2021年1月-2022年12月在本院妇产科治疗的120例HR-HPV持续性感染患者随机分为两组,对照组使用保妇康栓治疗,观察组使用中药口服联合外用疗法,对比两组的临床疗效、免疫炎性因子、阴道分泌物指标、安全性。结果 观察组治疗有效率明显高于对照组(P<0.05);观察组治疗后阴道灌洗液中IL-2、IFN-γ水平明显高于对照组,IL-4水平明显低于对照组(P<0.05);观察组治疗后阴道分泌物pH值、Nugent评分明显低于对照组(P<0.05);观察组治疗后WBC、RBC、Hb、AST、ALT、BUN、Scr水平均与对照组相当(P>0.05)。结论 中药口服联合外用疗法治疗HR-HPV持续性感染的临床疗效显著,对HR-HPV的抑制力强,能有效调节宫颈免疫功能,改善阴道内环境,且安全性好。

自拟中药口服联合保留灌肠对大肠息肉内镜下黏膜切除术术后恢复的影响

目的探讨自拟中药口服联合保留灌肠对大肠息肉内镜下黏膜切除术(endoscopic mucosal reaection,EMR)术后恢复的影响。方法将该院2019年3月-2020年11月期间在浙江衢化医院行大肠息肉内镜下黏膜切除术(EMR)的100例患者按照随机数表法分为对照组(48例)和观察组(52例),两组患者均给予常规术后治疗,对照组给予保留灌肠治疗,观察组在上述基础联合自拟中药口服治疗,比较两组患者术前术后临床症状积分、肠道菌群水平,统计术后复发率及并发症发生率。结果术前,两组患者腹痛、腹胀、便秘症状积分比较差异无统计学意义(P>0.05),术后3个月,两组患者上述症状积分均下降,且观察组低于对照组(P<0.05);术前,两组患者乳酸杆菌、双歧杆菌、肠球菌、大肠杆菌水平差异无统计学意义(P>0.05),术后3个月,两组患者乳酸杆菌、双歧杆菌水平升高,肠球菌、大肠杆菌水平下降,且观察组优于对照组(P<0.05);术后3、6个月两组患者复发率比较差异无统计学意义(P>0.05);术后12个月,观察组复发率低于对照组(P<0.05);两组患者术后不良反应发生率均较低,且比较差异无统计学意义(χ^(2)=0.252,P>0.05)。结论大肠息肉EMR术后患者应用自拟中药口服联合保留灌肠治疗,能有效改善患者临床症状及肠道菌群水平,降低术后复发率,从而促进术后恢复,且安全性高。