我是一名医生。最近在一些国内网站上读到一些鼓励oral sex的文章,文章鼓吹,只要将性器官洗净,口交也很卫生。7月5日晨我在Yahoo!上读到此文,医生的职业道德促使我把此文投稿给贵刊。文章的第一句就提醒我们:the risk of contracting HI...我是一名医生。最近在一些国内网站上读到一些鼓励oral sex的文章,文章鼓吹,只要将性器官洗净,口交也很卫生。7月5日晨我在Yahoo!上读到此文,医生的职业道德促使我把此文投稿给贵刊。文章的第一句就提醒我们:the risk of contracting HIV from oral sex is higher than many people think.展开更多
Objective. This work studied the influencing factors of age, level of education, family planning awareness, relationship with partner, the age at which sexual relationships were initiated, parity, the method of contra...Objective. This work studied the influencing factors of age, level of education, family planning awareness, relationship with partner, the age at which sexual relationships were initiated, parity, the method of contraceptive previously used, the type of contraceptive pill used and the duration of oral hormonal contraception (OC) use in relation to the modification of sexual desire in OC users. Materials and Methods. Prospective study of 760 OC users at the Family Planning Center “Marina Alta” in Alicante (Spain). A logistical regression analysis was carried out to study the relative risk of reduction in libido, taking other risk factors into account. Results. In the simple analysis, women who initiated sexual relationships between 18 and 25 years of age had a lower sexual desire in comparison with women who were sexually active before the age of 18 (OR = 2.11;CI: 1.15 - 3.91). Nulliparous women had a reduced sexual desire compared with those women that had given birth (OR = 2.32;CI: 1.41 - 3.82). An OC use of between 6 months and 1 year reduced sexual desire in comparison with a use of less than 6 months (OR = 0.24;CI: 0.09 - 0.64). In the multivariate analysis, age (OR = 1.12;CI: 1.01 - 1.21) and the use of OC within an initial 6 month to a year period (OR = 0.24;CI: 0.09 - 0.64) presented a statistically significant relationship with the modification of sexual desire. The level of education, family planning awareness, relationship with partner, the method of contraception previously used and the type of contraceptive pill prescribed showed no statistical significance with the modification of sexual desire in OC users. Conclusions. Sexual desire in OC users decreases as a woman’s age increases and in an early stage of use in the first six months after beginning OC treatment.展开更多
Establishment of rational dosage regimens requires the knowledge of pharmacokinetics and pharmacodynamics in the target population. It has been established that side effects produced by drugs are more frequent in wome...Establishment of rational dosage regimens requires the knowledge of pharmacokinetics and pharmacodynamics in the target population. It has been established that side effects produced by drugs are more frequent in women than in men. This may be due to two possibilities, one is that normalized dose received by women is higher than men and the other is that anatomical and physiological characteristics are a quite different. In this review, some aspects that may play a role in the generation of such differences are analyzed, including the impact on absorption, distribution, metabolism and excretion of drugs. Most of the changes can be explained by differences in volume of distribution and systemic clear- ance, however, presystemic clearance also seems to play a role in such dissimilarities. The final result, in general, is that women have higher plasma levels of drugs and usually these differences are reduced or abolished when data are normalized by the body weight, since both, volume of distribution and systemic clearance are influenced by it;however, there are some cases in which differences remain. Further research oriented to establish the role of each of the ana- tomical and physiological differences in the oral pharmacokinetics of drugs is warranted.展开更多
By means of the enzyme linked affinity histothemical method, 45 cases of squamous cell carcinoma(SCC) of the oral mucosa and 15 cases of the approximately normal oral mucosal tissue were detected for estrogen receptor...By means of the enzyme linked affinity histothemical method, 45 cases of squamous cell carcinoma(SCC) of the oral mucosa and 15 cases of the approximately normal oral mucosal tissue were detected for estrogen receptor(ER) and progesterone receptor(PR). The results indicated that In the SCC tissue of the oral mucosa there were 5 cases of ER+ and PR- and 32 cases of both ER+ and PR+. Thirty-seven cases, the summation of the above two items, were considered as receptor(+),therefore the rate of the receptor(+) being 82.22%. ER+ and PR+ were cd related to the sex and age of patients, the neck lymph nodes' metastasizing or not and affected parts of the tumor, while they were related to the differentiation degree of the tumor. The rate of receptor(+) decreased with the decrease of the differentiation degree of the tumor. By X2 test a remarkable difference between grade Ⅰand grade Ⅲ of SCC of the oral mucosa was shown. It is suggested that SCC of the oral mucosa may probobly be hormone dependent tumor. The authors consider that the SCC detection for ER and PR could not only be one of the indices of biologic characteristics for that tumor but also as bases of anti-hormone treatment.展开更多
目的探讨口腔癌患者中性别决定基因盒9(sex-determining region Y box 9,SOX9)、自噬基因(Beclin1)的表达与预后转归的关系.方法选取2017年5月至2018年5月河北省保定市第一中心医院口腔科收治的38例口腔癌患者,取其口腔癌组织标本38份...目的探讨口腔癌患者中性别决定基因盒9(sex-determining region Y box 9,SOX9)、自噬基因(Beclin1)的表达与预后转归的关系.方法选取2017年5月至2018年5月河北省保定市第一中心医院口腔科收治的38例口腔癌患者,取其口腔癌组织标本38份和癌旁组织标本30份,检测患者口腔癌组织中SOX9、Beclin1的表达情况.分析SOX9、Beclin1阳性表达与临床病理因素的关系,采用COX分析影响口腔癌预后转归的危险因素,分析SOX9、Beclin1与预后转归的关系.结果口腔癌组织中SOX9和Beclin1阳性表达率显著高于癌旁正常组织(P<0.05),SOX9、Beclin1阳性表达与年龄、性别无关(P>0.05),与肿瘤分期、分化程度和淋巴转移相关(P<0.05).对口腔癌预后影响因素采取Cox逐步回归分析,结果显示肿瘤分期、淋巴转移、SOX9、Beclin1是影响口腔癌患者预后转归的独立危险因素(P<0.05).SOX9阳性及阴性表达患者无进展生存期分别为10~18月[平均(12.5±2.4)月]、14~23月[平均(17.5±3.1)月];Beclin1阳性及阴性表达患者无进展生存期分别为11~18月[平均(13.7±2.4)月]、13~22月[平均(15.7±3.1)月].SOX9、Beclin1阳性表达患者无进展生存期显著低于阴性表达患者(χ^(2)=7.969、3.315,P<0.05).结论口腔癌患者中SOX9、Beclin1呈阳性表达,其表达与预后转归密切相关,口腔癌患者SOX9、Beclin1表达越高预后转归越差.展开更多
目的研究乳宁口服液对大鼠乳腺增生的治疗作用。方法建立乳腺增生大鼠模型,灌胃给药乳宁口服液,观察低、中、高剂量[0.5,2.5,5.0 m L/(kg·d)]组大鼠的行为学改变、乳房情况,以及血液中激素水平的变化。结果低、中、高剂量乳宁口服...目的研究乳宁口服液对大鼠乳腺增生的治疗作用。方法建立乳腺增生大鼠模型,灌胃给药乳宁口服液,观察低、中、高剂量[0.5,2.5,5.0 m L/(kg·d)]组大鼠的行为学改变、乳房情况,以及血液中激素水平的变化。结果低、中、高剂量乳宁口服液均能显著改善乳腺增生大鼠模型行为学异常、乳房情况,以及血液中雌二醇(E2)、孕酮(P)、催乳素(PRL)水平(P<0.01),且呈一定的量效关系。结论乳宁口服液对乳腺增生有一定治疗作用。展开更多
文摘我是一名医生。最近在一些国内网站上读到一些鼓励oral sex的文章,文章鼓吹,只要将性器官洗净,口交也很卫生。7月5日晨我在Yahoo!上读到此文,医生的职业道德促使我把此文投稿给贵刊。文章的第一句就提醒我们:the risk of contracting HIV from oral sex is higher than many people think.
文摘Objective. This work studied the influencing factors of age, level of education, family planning awareness, relationship with partner, the age at which sexual relationships were initiated, parity, the method of contraceptive previously used, the type of contraceptive pill used and the duration of oral hormonal contraception (OC) use in relation to the modification of sexual desire in OC users. Materials and Methods. Prospective study of 760 OC users at the Family Planning Center “Marina Alta” in Alicante (Spain). A logistical regression analysis was carried out to study the relative risk of reduction in libido, taking other risk factors into account. Results. In the simple analysis, women who initiated sexual relationships between 18 and 25 years of age had a lower sexual desire in comparison with women who were sexually active before the age of 18 (OR = 2.11;CI: 1.15 - 3.91). Nulliparous women had a reduced sexual desire compared with those women that had given birth (OR = 2.32;CI: 1.41 - 3.82). An OC use of between 6 months and 1 year reduced sexual desire in comparison with a use of less than 6 months (OR = 0.24;CI: 0.09 - 0.64). In the multivariate analysis, age (OR = 1.12;CI: 1.01 - 1.21) and the use of OC within an initial 6 month to a year period (OR = 0.24;CI: 0.09 - 0.64) presented a statistically significant relationship with the modification of sexual desire. The level of education, family planning awareness, relationship with partner, the method of contraception previously used and the type of contraceptive pill prescribed showed no statistical significance with the modification of sexual desire in OC users. Conclusions. Sexual desire in OC users decreases as a woman’s age increases and in an early stage of use in the first six months after beginning OC treatment.
文摘Establishment of rational dosage regimens requires the knowledge of pharmacokinetics and pharmacodynamics in the target population. It has been established that side effects produced by drugs are more frequent in women than in men. This may be due to two possibilities, one is that normalized dose received by women is higher than men and the other is that anatomical and physiological characteristics are a quite different. In this review, some aspects that may play a role in the generation of such differences are analyzed, including the impact on absorption, distribution, metabolism and excretion of drugs. Most of the changes can be explained by differences in volume of distribution and systemic clear- ance, however, presystemic clearance also seems to play a role in such dissimilarities. The final result, in general, is that women have higher plasma levels of drugs and usually these differences are reduced or abolished when data are normalized by the body weight, since both, volume of distribution and systemic clearance are influenced by it;however, there are some cases in which differences remain. Further research oriented to establish the role of each of the ana- tomical and physiological differences in the oral pharmacokinetics of drugs is warranted.
文摘By means of the enzyme linked affinity histothemical method, 45 cases of squamous cell carcinoma(SCC) of the oral mucosa and 15 cases of the approximately normal oral mucosal tissue were detected for estrogen receptor(ER) and progesterone receptor(PR). The results indicated that In the SCC tissue of the oral mucosa there were 5 cases of ER+ and PR- and 32 cases of both ER+ and PR+. Thirty-seven cases, the summation of the above two items, were considered as receptor(+),therefore the rate of the receptor(+) being 82.22%. ER+ and PR+ were cd related to the sex and age of patients, the neck lymph nodes' metastasizing or not and affected parts of the tumor, while they were related to the differentiation degree of the tumor. The rate of receptor(+) decreased with the decrease of the differentiation degree of the tumor. By X2 test a remarkable difference between grade Ⅰand grade Ⅲ of SCC of the oral mucosa was shown. It is suggested that SCC of the oral mucosa may probobly be hormone dependent tumor. The authors consider that the SCC detection for ER and PR could not only be one of the indices of biologic characteristics for that tumor but also as bases of anti-hormone treatment.
文摘目的探讨口腔癌患者中性别决定基因盒9(sex-determining region Y box 9,SOX9)、自噬基因(Beclin1)的表达与预后转归的关系.方法选取2017年5月至2018年5月河北省保定市第一中心医院口腔科收治的38例口腔癌患者,取其口腔癌组织标本38份和癌旁组织标本30份,检测患者口腔癌组织中SOX9、Beclin1的表达情况.分析SOX9、Beclin1阳性表达与临床病理因素的关系,采用COX分析影响口腔癌预后转归的危险因素,分析SOX9、Beclin1与预后转归的关系.结果口腔癌组织中SOX9和Beclin1阳性表达率显著高于癌旁正常组织(P<0.05),SOX9、Beclin1阳性表达与年龄、性别无关(P>0.05),与肿瘤分期、分化程度和淋巴转移相关(P<0.05).对口腔癌预后影响因素采取Cox逐步回归分析,结果显示肿瘤分期、淋巴转移、SOX9、Beclin1是影响口腔癌患者预后转归的独立危险因素(P<0.05).SOX9阳性及阴性表达患者无进展生存期分别为10~18月[平均(12.5±2.4)月]、14~23月[平均(17.5±3.1)月];Beclin1阳性及阴性表达患者无进展生存期分别为11~18月[平均(13.7±2.4)月]、13~22月[平均(15.7±3.1)月].SOX9、Beclin1阳性表达患者无进展生存期显著低于阴性表达患者(χ^(2)=7.969、3.315,P<0.05).结论口腔癌患者中SOX9、Beclin1呈阳性表达,其表达与预后转归密切相关,口腔癌患者SOX9、Beclin1表达越高预后转归越差.
文摘目的研究乳宁口服液对大鼠乳腺增生的治疗作用。方法建立乳腺增生大鼠模型,灌胃给药乳宁口服液,观察低、中、高剂量[0.5,2.5,5.0 m L/(kg·d)]组大鼠的行为学改变、乳房情况,以及血液中激素水平的变化。结果低、中、高剂量乳宁口服液均能显著改善乳腺增生大鼠模型行为学异常、乳房情况,以及血液中雌二醇(E2)、孕酮(P)、催乳素(PRL)水平(P<0.01),且呈一定的量效关系。结论乳宁口服液对乳腺增生有一定治疗作用。
