Objective:Oral squamous-cell carcinoma(OSCC)accounts for >90% of oral cancers affecting adults mostly between the fourth to seventh decades of life.The most common OSCC treatment is concomitant chemoradiotherapy(CC...Objective:Oral squamous-cell carcinoma(OSCC)accounts for >90% of oral cancers affecting adults mostly between the fourth to seventh decades of life.The most common OSCC treatment is concomitant chemoradiotherapy(CCRT)having both locoregional and distant control,but CCRT has acute and chronic toxic effects on adjacent normal tissue.This study aimed to determine the side effects of CCRT on the oral mucosa and to characterize the clinicopathology of oral lesions in patients with OSCC.Methods:This descriptive,cross-sectional study was certified by the Ethical Review Committee(UHS/Education/126-12/2728)of the University of Health Sciences,Lahore,Pakistan.OSSC patients(n=81)with various histological subtypes,grades,and stages were recruited,and findings on their oral examination were recorded.These patients received 70,90,and 119 Gy of radiotherapy dosages in combination with the chemotherapy drugs cisplatin and 5-fluorouracil.Data were analyzed using SPSS 20.0.Results:The most common presentation of OSCC was a nonhealing ulcer(63%) involving tongue(55.6%).Clinical findings included mucositis(92.6%)and xerostomia of mild,moderate,and severe degrees in 11.1%,46.9%,and 35.8% cases,respectively.Ulcers(87.7%),palpable lymph nodes(64.2%),limited mouth opening(64.2%)and fistula(40.7%) were also observed.In females,the association of radiotherapy dosage with limited mouth opening,xerostomia,and histological grading was statistically significant(P<0.05).The association of chemotherapy drugs with xerostomia(P=0.003)was also statistically significant.Conclusions:CCRT induced mucositis,xerostomia,and trismus in patients with OSCC.展开更多
The purpose of this article was to increase the knowledge about oral manifestations and complications associated with diabetes mellitus.An overview was performed on Google,especially in recent reliable papers in relat...The purpose of this article was to increase the knowledge about oral manifestations and complications associated with diabetes mellitus.An overview was performed on Google,especially in recent reliable papers in relation to diabetes mellitus and its oral manifestations(keywords were“diabetes mellitus”,“oral manifestations”,and“oral complications”).Data were collected and the results were declared.Diabetes mellitus is one of the most common chronic disorders characterized by hyperglycemia.This disease can have many complications in various regions of the body,including the oral cavity.The important oral manifestations and complications related to diabetes include xerostomia,dental caries,gingivitis,periodontal disease,increased tendency to oral infections,burning mouth,taste disturbance,and poor wound healing.Oral complications in diabetic patients are considered major complications and can affect patients’quality of life.There is evidence that chronic oral complications in these patients have negative effects on blood glucose control,so prevention and management of the oral complications are important.展开更多
目的检索鼻咽癌患者口咽部症状护理相关指南,并进行质量评价和内容分析,为临床提供参考。方法系统检索指南网、头颈部肿瘤相关学会、数据库等,检索日期为建库至2022年3月1日。采用临床指南研究和评价系统(the appraisal of guidelines f...目的检索鼻咽癌患者口咽部症状护理相关指南,并进行质量评价和内容分析,为临床提供参考。方法系统检索指南网、头颈部肿瘤相关学会、数据库等,检索日期为建库至2022年3月1日。采用临床指南研究和评价系统(the appraisal of guidelines for research evaluation instrument,AGREE II)对指南进行质量评价。结果共纳入4篇指南、3篇专家共识。指南总体质量评价为1篇A级、3篇B级,专家共识真实性较好。提取6个方面内容:放射性口腔干燥症的应对、放射性口腔黏膜炎及感染的管理、放射性龋齿的护理、张口受限的训练、吞咽障碍的干预、随访管理,共23条推荐意见。结论纳入的鼻咽癌口咽部症状护理相关的指南总体质量中等,其指南开发的参与人员、严谨性、应用性和独立性领域均有待提高。目前我国尚缺乏高质量的鼻咽癌患者口咽部症状护理相关实践指南,整合的推荐意见具有较好的实践意义。建议在借鉴国外高质量指南的基础上制定本土化循证指南,以指导临床实践。展开更多
文摘Objective:Oral squamous-cell carcinoma(OSCC)accounts for >90% of oral cancers affecting adults mostly between the fourth to seventh decades of life.The most common OSCC treatment is concomitant chemoradiotherapy(CCRT)having both locoregional and distant control,but CCRT has acute and chronic toxic effects on adjacent normal tissue.This study aimed to determine the side effects of CCRT on the oral mucosa and to characterize the clinicopathology of oral lesions in patients with OSCC.Methods:This descriptive,cross-sectional study was certified by the Ethical Review Committee(UHS/Education/126-12/2728)of the University of Health Sciences,Lahore,Pakistan.OSSC patients(n=81)with various histological subtypes,grades,and stages were recruited,and findings on their oral examination were recorded.These patients received 70,90,and 119 Gy of radiotherapy dosages in combination with the chemotherapy drugs cisplatin and 5-fluorouracil.Data were analyzed using SPSS 20.0.Results:The most common presentation of OSCC was a nonhealing ulcer(63%) involving tongue(55.6%).Clinical findings included mucositis(92.6%)and xerostomia of mild,moderate,and severe degrees in 11.1%,46.9%,and 35.8% cases,respectively.Ulcers(87.7%),palpable lymph nodes(64.2%),limited mouth opening(64.2%)and fistula(40.7%) were also observed.In females,the association of radiotherapy dosage with limited mouth opening,xerostomia,and histological grading was statistically significant(P<0.05).The association of chemotherapy drugs with xerostomia(P=0.003)was also statistically significant.Conclusions:CCRT induced mucositis,xerostomia,and trismus in patients with OSCC.
文摘The purpose of this article was to increase the knowledge about oral manifestations and complications associated with diabetes mellitus.An overview was performed on Google,especially in recent reliable papers in relation to diabetes mellitus and its oral manifestations(keywords were“diabetes mellitus”,“oral manifestations”,and“oral complications”).Data were collected and the results were declared.Diabetes mellitus is one of the most common chronic disorders characterized by hyperglycemia.This disease can have many complications in various regions of the body,including the oral cavity.The important oral manifestations and complications related to diabetes include xerostomia,dental caries,gingivitis,periodontal disease,increased tendency to oral infections,burning mouth,taste disturbance,and poor wound healing.Oral complications in diabetic patients are considered major complications and can affect patients’quality of life.There is evidence that chronic oral complications in these patients have negative effects on blood glucose control,so prevention and management of the oral complications are important.
文摘目的检索鼻咽癌患者口咽部症状护理相关指南,并进行质量评价和内容分析,为临床提供参考。方法系统检索指南网、头颈部肿瘤相关学会、数据库等,检索日期为建库至2022年3月1日。采用临床指南研究和评价系统(the appraisal of guidelines for research evaluation instrument,AGREE II)对指南进行质量评价。结果共纳入4篇指南、3篇专家共识。指南总体质量评价为1篇A级、3篇B级,专家共识真实性较好。提取6个方面内容:放射性口腔干燥症的应对、放射性口腔黏膜炎及感染的管理、放射性龋齿的护理、张口受限的训练、吞咽障碍的干预、随访管理,共23条推荐意见。结论纳入的鼻咽癌口咽部症状护理相关的指南总体质量中等,其指南开发的参与人员、严谨性、应用性和独立性领域均有待提高。目前我国尚缺乏高质量的鼻咽癌患者口咽部症状护理相关实践指南,整合的推荐意见具有较好的实践意义。建议在借鉴国外高质量指南的基础上制定本土化循证指南,以指导临床实践。
