<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:Verdana;"> Oral potentially malignant disorders, which include oral lichen planus ...<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:Verdana;"> Oral potentially malignant disorders, which include oral lichen planus (OLP), are clinical presentations that carry a risk of development to cancer in the oral cavity. Oral lichenoid lesions (OLLs) are also termed interface/lichenoid mucositis. Malignant transformation of them remains controversial, but distinct clinical and histological criteria for how to differentiate OLP from OLLs have not been developed.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Objectives:</span></b><span style="font-family:Verdana;"> The purpose of this study was to elucidate findings that can allow histopathological differentiation of OLP and OLLs using histomorphological and immunohistochemical analyses.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Materials and Methods:</span></b><span style="font-family:Verdana;"> Analyses were performed in 10 cases diagnosed with OLP and 9 cases diagnosed with OLLs. Cytokeratin 19 (CK19), Ki-67 and CD3 were used as primary antibodies to detect basal cells, proliferative activity and T-cell distribution, respectively</span><span style="font-family:Verdana;">, and</span><span style="font-family:Verdana;"> Perlecan and COX-2 to evaluate epithelial intracellular arrangements and interstitial distributions of proteoglycans and enzymes. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> For CK19, positive cells were significantly found in OLLs at both the prominent area and site adjacent to the lesion comparison with those of OLP’s. The number of COX-2 positive cells was significantly higher in spinous and basal layers in OLLs of the prominent area. Additionally, OLLs showed mild to moderate expression for perlecan in the basal to spinous layers and in subepithelial tissue. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Almost no basal cells were noted in the prominent area in OLP. COX-2 and perlecan were found in the basal to spinous layers in OLLs. Although there are restrictions, these suggested the possibility of helping to distinguish between OLP and OLLs.</span>展开更多
目的系统评价中成药白芍总苷胶囊治疗口腔扁平苔藓的有效性和安全性,为口腔扁平苔藓临床治疗用药提供参考。方法采用计算机检索Cochrane图书馆、Pub Med和Embase外文数据库及中国生物医学文献数据库(CBM)、中国期刊全文数据库、万方数...目的系统评价中成药白芍总苷胶囊治疗口腔扁平苔藓的有效性和安全性,为口腔扁平苔藓临床治疗用药提供参考。方法采用计算机检索Cochrane图书馆、Pub Med和Embase外文数据库及中国生物医学文献数据库(CBM)、中国期刊全文数据库、万方数据库、维普数据库等中文数据库,收集白芍总苷治疗口腔扁平苔藓的临床病例对照研究的文献,通过评价质量并提取数据,再采用Rev Man 5.0统计软件进行Meta分析。结果共纳入9项研究文献,口腔扁平苔藓患者总计784例,其中,治疗组404例,对照组380例。Meta分析结果显示,白芍总苷治疗组的总有效率[OR=4.52,95%CI(3.00~6.81)]及显效率[OR=3.02,95%CI(2.17~4.19)]均明显高于对照组,且差异具有显著统计学意义(P<0.01)。结论从现有的临床证据来看,白芍总苷胶囊治疗口腔扁平苔藓具有比较确切的临床疗效。展开更多
目的:总结表皮特异性转移因子(epidermal transfer factor,ETF)治疗口腔扁平苔藓(oral lichen planus)的治疗效果和体会。方法:设立对照组,对我院66名口腔扁平苔藓患者皮下注射ETF,对照组注射猪脾转移因子,2组进行观察和临床分析。结果...目的:总结表皮特异性转移因子(epidermal transfer factor,ETF)治疗口腔扁平苔藓(oral lichen planus)的治疗效果和体会。方法:设立对照组,对我院66名口腔扁平苔藓患者皮下注射ETF,对照组注射猪脾转移因子,2组进行观察和临床分析。结果:应用ETF的治疗组有效率为93.94%,而对照组药品的有效率为73.17%(P<0.05)。结论:ETF对治疗口腔扁平苔藓有很好的疗效。展开更多
文摘<b><span style="font-family:Verdana;">Background:</span></b><span style="font-family:Verdana;"> Oral potentially malignant disorders, which include oral lichen planus (OLP), are clinical presentations that carry a risk of development to cancer in the oral cavity. Oral lichenoid lesions (OLLs) are also termed interface/lichenoid mucositis. Malignant transformation of them remains controversial, but distinct clinical and histological criteria for how to differentiate OLP from OLLs have not been developed.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Objectives:</span></b><span style="font-family:Verdana;"> The purpose of this study was to elucidate findings that can allow histopathological differentiation of OLP and OLLs using histomorphological and immunohistochemical analyses.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Materials and Methods:</span></b><span style="font-family:Verdana;"> Analyses were performed in 10 cases diagnosed with OLP and 9 cases diagnosed with OLLs. Cytokeratin 19 (CK19), Ki-67 and CD3 were used as primary antibodies to detect basal cells, proliferative activity and T-cell distribution, respectively</span><span style="font-family:Verdana;">, and</span><span style="font-family:Verdana;"> Perlecan and COX-2 to evaluate epithelial intracellular arrangements and interstitial distributions of proteoglycans and enzymes. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> For CK19, positive cells were significantly found in OLLs at both the prominent area and site adjacent to the lesion comparison with those of OLP’s. The number of COX-2 positive cells was significantly higher in spinous and basal layers in OLLs of the prominent area. Additionally, OLLs showed mild to moderate expression for perlecan in the basal to spinous layers and in subepithelial tissue. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> Almost no basal cells were noted in the prominent area in OLP. COX-2 and perlecan were found in the basal to spinous layers in OLLs. Although there are restrictions, these suggested the possibility of helping to distinguish between OLP and OLLs.</span>
文摘目的系统评价中成药白芍总苷胶囊治疗口腔扁平苔藓的有效性和安全性,为口腔扁平苔藓临床治疗用药提供参考。方法采用计算机检索Cochrane图书馆、Pub Med和Embase外文数据库及中国生物医学文献数据库(CBM)、中国期刊全文数据库、万方数据库、维普数据库等中文数据库,收集白芍总苷治疗口腔扁平苔藓的临床病例对照研究的文献,通过评价质量并提取数据,再采用Rev Man 5.0统计软件进行Meta分析。结果共纳入9项研究文献,口腔扁平苔藓患者总计784例,其中,治疗组404例,对照组380例。Meta分析结果显示,白芍总苷治疗组的总有效率[OR=4.52,95%CI(3.00~6.81)]及显效率[OR=3.02,95%CI(2.17~4.19)]均明显高于对照组,且差异具有显著统计学意义(P<0.01)。结论从现有的临床证据来看,白芍总苷胶囊治疗口腔扁平苔藓具有比较确切的临床疗效。
文摘目的:总结表皮特异性转移因子(epidermal transfer factor,ETF)治疗口腔扁平苔藓(oral lichen planus)的治疗效果和体会。方法:设立对照组,对我院66名口腔扁平苔藓患者皮下注射ETF,对照组注射猪脾转移因子,2组进行观察和临床分析。结果:应用ETF的治疗组有效率为93.94%,而对照组药品的有效率为73.17%(P<0.05)。结论:ETF对治疗口腔扁平苔藓有很好的疗效。
