The spatial information of literature refers to the representation of physical or conscious space in literary works,including position,shape,structure,features,and relationships.The spatial information organization an...The spatial information of literature refers to the representation of physical or conscious space in literary works,including position,shape,structure,features,and relationships.The spatial information organization and its method are essential to the whole process of literature production,circulation,acceptance,and reproduction,which is conducive to a deeper exploration of the aesthetic essence of literature in the information era.Taking the organization of spatial information in science fiction as an example,this paper investigates the way of interaction between informatics and literature,explores the function of spatial information in the narrative of science fiction,and discovers digital humanistic laws of literary information organization.This study finds that the spatial information of early science fiction is organized in horizontal,vertical,axial,and causal modes;in the era of digital humanities,influenced by information technology such as the internet,virtual reality,and artificial intelligence,literary space has experienced revolutions characteristic of time-space integration,boundary dissolution,dimensional change,and virtualization;the spatial information organization of contemporary science fiction adopts nested,reticulated,parallel,interactive,and reverse patterns;on the whole,it is featured with fluidity,chaos,correlation,and mutation,creating a unique digital humanistic spectacle.展开更多
In the past 20–30 years,developmental biologists have made tremendous progress in identifying genes required for the specifcation of individual cell types of an organ and in describing how they interact in genetic ne...In the past 20–30 years,developmental biologists have made tremendous progress in identifying genes required for the specifcation of individual cell types of an organ and in describing how they interact in genetic networks.In comparison,very little is known about the mechanisms that regulate tissue polarity and overall organ patterning.Gynoecia and fruits from members of the Brassicaceae family of fowering plants provide excellent model systems to study organ patterning and tissue specifcation because they become partitioned into distinct domains whose formation is determined by polarity establishment both at a cellular and whole tissue level.Interactions among key regulators of Arabidopsis gynoecium and fruit development have revealed a network of upstream transcription factor activities required for such tissue differentiation.Regulation of the plant hormone auxin is emerging as both an immediate downstream output and input of these activities,and here we aim to provide an overview of the current knowledge regarding the link between auxin and female reproductive development in plants.In this review,we will also demonstrate how available data can be exploited in a mathematical modeling approach to reveal and understand the feedback regulatory circuits that underpin the polarity establishment,necessary to guide auxin flows.展开更多
Plant growth and development involve the specification and regeneration of stem cell niches(SCNs).Although plants are exposed to disparate environmental conditions,how environmental cues affect developmental programs ...Plant growth and development involve the specification and regeneration of stem cell niches(SCNs).Although plants are exposed to disparate environmental conditions,how environmental cues affect developmental programs and stem cells is not well understood.Root stem cells are accommodated in meristems in SCNs around the quiescent center(QC),which maintains their activity.Using a combination of genetics and confocal microscopy to trace morphological defects and correlate them with changes in gene expression and protein levels,we show that the cold-induced transcription factor(TF)C-REPEAT BINDING FACTOR 3(CBF3),which has previously been associated with cold acclimation,regulates root development,stem cell activity,and regeneration.CBF3 is integrated into the SHORT-ROOT(SHR)regulatory network,forming a feedback loop that maintains SHR expression.CBF3 is primarily expressed in the root endodermis,whereas the CBF3 protein is localized to other meristematic tissues,including root SCNs.Complementation of cbf3-1 using a wild-type CBF3 gene and a CBF3 fusion with reduced mobility show that CBF3 movement capacity is required for SCN patterning and regulates root growth.Notably,cold induces CBF3,affecting QC activity.Furthermore,exposure to moderate cold around 10℃–12℃promotes root regeneration and QC respecification in a CBF3-dependent manner during the recuperation period.By contrast,CBF3 does not appear to regulate stem cell survival,which has been associated with recuperation from more acute cold(-4℃).We propose a role for CBF3 in mediating the molecular interrelationships among the cold response,stem cell activity,and development.展开更多
文摘The spatial information of literature refers to the representation of physical or conscious space in literary works,including position,shape,structure,features,and relationships.The spatial information organization and its method are essential to the whole process of literature production,circulation,acceptance,and reproduction,which is conducive to a deeper exploration of the aesthetic essence of literature in the information era.Taking the organization of spatial information in science fiction as an example,this paper investigates the way of interaction between informatics and literature,explores the function of spatial information in the narrative of science fiction,and discovers digital humanistic laws of literary information organization.This study finds that the spatial information of early science fiction is organized in horizontal,vertical,axial,and causal modes;in the era of digital humanities,influenced by information technology such as the internet,virtual reality,and artificial intelligence,literary space has experienced revolutions characteristic of time-space integration,boundary dissolution,dimensional change,and virtualization;the spatial information organization of contemporary science fiction adopts nested,reticulated,parallel,interactive,and reverse patterns;on the whole,it is featured with fluidity,chaos,correlation,and mutation,creating a unique digital humanistic spectacle.
基金supported by the UK Biological and Biotechnology Research Council (BBSRC) via grant BB/J004553/1 to the John Innes CentreV. A. G. and L. φ . by BBSRC responsive mode grant BB/K008617/1V. A. G. acknowledges support from the Royal Society Dorothy Hodgkin fellowship
文摘In the past 20–30 years,developmental biologists have made tremendous progress in identifying genes required for the specifcation of individual cell types of an organ and in describing how they interact in genetic networks.In comparison,very little is known about the mechanisms that regulate tissue polarity and overall organ patterning.Gynoecia and fruits from members of the Brassicaceae family of fowering plants provide excellent model systems to study organ patterning and tissue specifcation because they become partitioned into distinct domains whose formation is determined by polarity establishment both at a cellular and whole tissue level.Interactions among key regulators of Arabidopsis gynoecium and fruit development have revealed a network of upstream transcription factor activities required for such tissue differentiation.Regulation of the plant hormone auxin is emerging as both an immediate downstream output and input of these activities,and here we aim to provide an overview of the current knowledge regarding the link between auxin and female reproductive development in plants.In this review,we will also demonstrate how available data can be exploited in a mathematical modeling approach to reveal and understand the feedback regulatory circuits that underpin the polarity establishment,necessary to guide auxin flows.
基金funded by the Ministerio de Ciencia e Innovación(MICIN)of Spain and ERDF(grants PID2019-111523GB-I00 and PID2022-140719NB-I00 to M.A.M.-R.)the"Severo Ochoa Program for Centres of Excellence in R&D"from the Agencia Estatal de Investigación of Spain(AEI)(grant SEV-2016-06722017-2021)+2 种基金MICIN/AEI/10.13039/501100011033(grant CEX2020-000999-S)to M.A.M.-R.,P.P.-G.,M.P.,J.C.d.P.,and K.W.through Centro de Biotecnología y Genómica de Plantassupported by an FPI contract from MICIN(BES-2014-068852),P.P.-G.by a Juan de la Cierva contract from MICIN(FJCI-2015-24905)and Programa Atraccion Talento from Comunidad de Madrid(2017-T2/BIO-3453)J.C.by a Juan de la Cierva contract from AEI(FJCI-2016-28607),K.W.by program PGC2018-093387-A-I00 from MICIN,and O.P.by a postdoctoral contract associated with SEV-2016-0672.
文摘Plant growth and development involve the specification and regeneration of stem cell niches(SCNs).Although plants are exposed to disparate environmental conditions,how environmental cues affect developmental programs and stem cells is not well understood.Root stem cells are accommodated in meristems in SCNs around the quiescent center(QC),which maintains their activity.Using a combination of genetics and confocal microscopy to trace morphological defects and correlate them with changes in gene expression and protein levels,we show that the cold-induced transcription factor(TF)C-REPEAT BINDING FACTOR 3(CBF3),which has previously been associated with cold acclimation,regulates root development,stem cell activity,and regeneration.CBF3 is integrated into the SHORT-ROOT(SHR)regulatory network,forming a feedback loop that maintains SHR expression.CBF3 is primarily expressed in the root endodermis,whereas the CBF3 protein is localized to other meristematic tissues,including root SCNs.Complementation of cbf3-1 using a wild-type CBF3 gene and a CBF3 fusion with reduced mobility show that CBF3 movement capacity is required for SCN patterning and regulates root growth.Notably,cold induces CBF3,affecting QC activity.Furthermore,exposure to moderate cold around 10℃–12℃promotes root regeneration and QC respecification in a CBF3-dependent manner during the recuperation period.By contrast,CBF3 does not appear to regulate stem cell survival,which has been associated with recuperation from more acute cold(-4℃).We propose a role for CBF3 in mediating the molecular interrelationships among the cold response,stem cell activity,and development.