Synthesis of Glucoside Compounds of Ferrocenyl Phenols and Their Antianemic Activity

Six glucoside compounds have been synthesized by means of phase-transfer catalytic method and deacetylation from the starting material ferrocene. Their structures have been confirmed by elementary analysis, IR,1HNMR and MS. The antianemic activities of some compounds have also been tested. Results indicate that these glucoside compounds possess the antianemic activities and therefore, the further study is well worth making.

Low eradication rate of Helicobacterpyloriwith triple 7-14 days and quadriple therapy in Turkey

AIM:The eradication rate of Helicobacter pylori (H pylori) shows variation among countries and regimens of treatment. We aimed to study the eradication rates of different regimens in our region and some factors affecting the rate of eradication. METHODS:One hundred and sixty-four H pylori positive patients (68 males,96 females;mean age:48±12 years) with duodenal or gastric ulcer without a smoking history were included in the study.The patients were divided into three groups according to the treatment regimens.Omeprazole 20mg,clarithromycin 500mg,amoxicillin 1g were given twice daily for 1 week (Group Ⅰ) and 2 weeks (Group Ⅱ). Patients in Group Ⅲ received bismuth subsitrate 300mg, tetracyline 500mg and metronidazole 500mg four times daily in addition to Omeprazole 20mg twice daily.Two biopsies each before and after treatment were obtained from antrum and corpus,and histopathologically evaluated. Eradication was assumed to be successful if no H pylorus was detected from four biopsy specimens taken after treatment.The effects of factors like age,sex,H pylori density on antrum and corpus before treatment,the total H pylori density,and the inflammation scores on the rate of H pylori eradication were evaluated. RESULTS:The overall eradication rate was 42%.The rates in groups Ⅱ and Ⅲ were statistically higher than that in group Ⅰ (P<0.05).The rates of eradication were 24.5%, 40.7% and 61.5% in groups Ⅰ,Ⅱ and Ⅲ,respectively.The eradication rate was negatively related to either corpus H pylori density or total H pylori density (P<0.05).The median age was older in the group in which the eradication failed in comparison to that with successful eradication (55 yr vs 39 yr,P<0.001).No correlation between sex and H pylori eradication was found. CONCLUSION:Our rates of eradication were significantly lower when compared to those reported in literature.We believe that advanced age and high H pylori density are negative predictive factors for the rate of H pylori eradication.

STUDY ON THE SURFACE OF TITANIUM CARBIDE PARTICLE PACKAGED NICKEL

Two kinds of packaged processes by nickel on the surface of titanium carbide particle are studied in this work. One is the chemical nickel-plating, the other is the organometallic compound decomposition. The composition, structure and morphology of the packaged powder were analyzed with XRD, DAT/TGA, SEM, EPMA etc. It has been shown that nickel was even dispersed on the surface of titanium carbide particle by the. two kinds of processes, deposited nickel exists as spherical particles of about 0.1 μm in diameter. The merits and demerits of the two kinds of processes have been compared, the organometallic copmound decomposition among them is a kind of hopeful method, which is not used by other researchers.

Two-Dimensional Infrared Spectroscopy of the Photoproduct of π-Cyclopentadienyliron Dicarbonyl Dimer

Equilibrium photoproduct of 7r-cyclopentadienyliron dicarbonyl dimer [CpFe（CO）2]2 in non- polar solvent carbon tetrachloride （CC14） is investigated using time-resolved 2D IR spec- troscopy. One of the several possible visible-light-driven photoreaction pathways is confirmed and the product is found to contain a di-carbonyl group that exhibits quantum beating be- tween two equivalent transitions in time-resolved 2D IR spectra, which turns out to be the anti-symmetric and symmetric stretching of the terminal carbonyl stretching modes of CpFe（CO）2C1. This is the main product and its reaction pathway involves radical formation, followed by chloride addition. Quantum-chemistry computations support these experimental results. Our results indicate that 2D IR method can be used to identify in situ structures and dynamics of chemical species involved in condensed-phase chemical reactions.

Coordination chemistry of organometallic polydentate ligand Reactive chemistry of the tridentate ligand trans-Fe(Ph_2PQu-P)_2- (CO)_3 [Ph_2PQu=2-diphenyl-phosphino-4-methylquinoline] and molecular structure of [Fe(CO)_3(μ-Ph_2PQu)_2HgI]^+[HgI_3]

Reaction of a new type of bidentate ligand PhPQu [ PhPQu = 2-diphenylphosphino-4-methylquinoline] with Fe(CO)5 in bu-tanol gave trans-Fe(PhPQu-P)(CO)3 (1).Compound 1,which can act as a neutral tridentate organometallic ligand,was reacted with I B,II B metal compounds and a rhodium complex to give six binuclear complexes with Fe-M bonds,Fe(CO)3(u-Ph2PQu)MXn(2-7) [M=Zn(Ⅰ),Cd(Ⅱ),Hg(Ⅱ),Cu(Ⅰ),Ag(Ⅰ),Rh(Ⅰ)],and an ion-pair complex [Fe(CO)3(n-Ph2PQu)2HgI][HgI3]- (8).The structure of 8 was determined by X-ray crystallography.Complex 8 crystallizes in the space group P-1 with a=1.0758(3),b= 1.6210(4),c = 1.7155(4) nm; a = 75.60(2)β=71.81(2),Y = 81.78(2) and Z = 2 and its structure was refined to give agreement factors of R =0.050 and Rw = 0.057.The Fe-Hg bond distance is 0.2536 nm.

Samarium-153-EDTMP bone uptake rate and its relation to therapeutic effect

OBJECTIVE: To evaluate the measurement of Samarium-153 ethylenediaminetetramethylene phosphonic acid ((153)Sm-EDTMP) bone uptake rate using whole-body scintigraphy and analyze the relationship between bone uptake rate and therapeutic effect. METHODS: Sixty-six patients with painful bony metastases from prostate (n = 15), lung (n = 20), breast (n= 18), nasopharyngeal carcinoma (NPC) (n=5), colon (n=2), kidney (n=2) and unknown cause (n=4) carcinoma were examined with whole-body scintigraphy 10 min and 5 h post administration of (153)Sm-EDTMP. Bone uptake rate was then calculated. (1 ) Complete response (CR): disappearance of > 2 metastases, Karnofsky Performance Score (KPS) increase > 20, moderate or complete remission of bone pain 7 d post injection of (153)Sm-EDTMP. (2) Partial response (PR): disappearance of 1-2 metastases, KPS increase 10-20, moderate remission of bone pain in 3 wk. (3) Non-response (NR): no disappearance or shrinkage of metastases, KPS increase

Comparative analysis of patients not responding to a single dose of ^(153)Sm-EDTMP palliative treatment for painful skeletal metastases

Objective A certain fraction of patients failed palliative treatment of 153Sm-ethylenediaminetetramethy lenephosphate ( 153Sm-EDTMP) for painful skeletal metastases were reviewd. A comparative analysis was designed to identify the factors related to therapeutic response. Methods From a 3-year multi-center clinical trial, 51 cases were collected who did not respond to an intravenous injection of 153Sm-EDTMP at a dosage of 0.5-1.5 mCi/kg. The therapeutic efficacy was evaluated via changes of symptoms, general condition, consumption of analgesics, sum of effect product, and Karnofsky scores. The age, sex, history of treatment, tumor type, location of bony involvement, uptake ratio and number of metastases, and doses used by the patients were compared to those of the responders. Results In 51 non-responders, 43 were male, 34 suffered from lung cancer, 41 had bone lesions in the vertebrae, 39 in the pelvis, and 24 had metastases in the lower extremities. Sex distribution, tumor type and location of the lesion differed significantly between responders and non-responders. No other factor showed differences between the two groups. Though patients of younger age, and lesions with lower uptake of radiopharmaceutical seemed to fail the treatment more easily as observed clinically, this was not confirmed by statistical analysis. Conclusion The sex of the patients, certain types of primary tumors and metastases to lower parts of the body were found to influence the patients’ response to a single dose of 153Sm-EDTMP palliation. Further exploration of a better way to determine dosage and predict response for each individual case is needed.

Synthesis and electroluminescence characterization of a new aluminum complex, [8- hydroxyquinoline] bis [2, 2＇bipyridine] aluminum Al(Bpy)2q

We have synthesized and characterized a new electroluminescent material, [8-hydroxyquinoline] bis[2,2＇bipyridine] aluminum. A solution of this material Al（Bpy）2q in toluene showed absorption maxima at 380 nm,which was attributed to the moderate energy（ π–π＊） transitions of the aromatic rings. The photoluminescence spectrum of Al（Bpy）_2q in the toluene solution showed a peak at 518 nm. This material shows thermal stability up to300 ℃. The structure of the device is ITO/F4-TCNQ（1 nm）/α-NPD（35 nm）/Al（Bpy）2q（35 nm）/ BCP（6 nm）/Alq3（28 nm）/Li F（1 nm）/Al（150 nm）. This device exhibited a luminescence peak at 515 nm（CIE coordinates, xD0.32,yD0.49）. The maximum luminescence of the device was 214 cd/m^2 at 21 V. The maximum current efficiency of OLED was 0.12 cd/A at 13 V and the maximum power efficiency was 0.03 lm/W at 10 V.

Synthesis and electroluminescence properties of tris-[5-choloro-8-hydroxyquinoline]aluminum Al(5-Clq)_3

A new electroluminescent material tris- [5-choloro-8-hydroxyquinoline] aluminum has been synthesized and characterized. Solution of this material AI（5-Clq）3 in toluene showed absorption maxima at 385 nm which was attributed to the moderate energy （π-π＊） transitions of the aromatic rings. The photoluminescence spectrum of AI（5-Clq）3 in toluene solution showed a peak at 522 nm. This material shows thermal stability up to 400 ℃. The structure of the device is ITO/0.4 wt%F4-TCNQ doped α-NPD （35 nm） / AI（5-Clq）3 （30 nm） / BCP （6 nm）/ Alq3 （30 nm） / LiF （1 nm） / A1 （150 nm）. This device exhibited a luminescence peak at 585 nm （CIE coordinates, x = 0.39, y = 0.50）. The maximum luminescence of the device was 920 Cd/m2 at 25 V. The maximum current efficiency of OLED was 0.27 Cd/A at 20 V and maximum power efficiency was 0.04 lm/W at 18 V.

Synthesis and fluorescent properties of bis-salicyloyl hydrazide metal complexes of some group Ⅳ ions

Four novel organometallic compounds containing tin(Ⅳ),titanium(Ⅳ) and zirco-nium(Ⅳ) ions were synthesized and strong fluorescent emission was observed from two tin(Ⅳ) complexes.