Recent discoveries have revealed a groundbreaking phenomenon where light alone, without any thermal input, can induce water evaporation, termed the “photomolecular effect”. This study explores a novel hypothesis tha...Recent discoveries have revealed a groundbreaking phenomenon where light alone, without any thermal input, can induce water evaporation, termed the “photomolecular effect”. This study explores a novel hypothesis that this effect can be explained by ortho-para magnetic spin interactions in water molecules within the water-air interface layer. Water molecules, consisting of hydrogen and oxygen, exhibit different nuclear spin states: ortho-(triplet) and para-(singlet). The interaction of polarized light with these spin states may induce transitions between the rotational levels of ortho- and para-forms due to catalysts like triplet oxygen (O2) in its inhomogeneous magnetic field. Resonance pumping at 532 nm (~18,797 cm−1) due to the transition v1-v2-v3 ~ 0-8-2 (~18,796 cm−1) results in an increase in molecular energy sufficient to overcome intermolecular forces at the water surface, thereby causing evaporation. The proposed ortho-para conversion mechanism involves spin-orbit coupling and specific resonance conditions. This theory provides a quantum mechanical perspective on the photomolecular effect, potentially offering insights into natural processes such as cloud formation and climate modeling, as well as practical applications in solar desalination and industrial drying. Further experimental validation is required to confirm the role of spin interactions in light-induced water evaporation.展开更多
目的本研究目的在于评估Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性,检验其是否具备解决术前半月板手术方式预测困难的能力。方法纳入本院2019年3月至2019年12月因半月板损伤而接受关节镜下手术者55膝58侧半月板。本研...目的本研究目的在于评估Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性,检验其是否具备解决术前半月板手术方式预测困难的能力。方法纳入本院2019年3月至2019年12月因半月板损伤而接受关节镜下手术者55膝58侧半月板。本研究分为两个部分。第一部分:评分过程由两位医生按Ortho One PROMT评分细则分别对半月板损伤者进行独立评分,并根据得分预测半月板手术术式。第二部分:将两位评分医生预测的半月板手术术式分别与手术医生的实际手术术式进行一致性比较,最终评价Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性、敏感度及特异度。结果评分医生预测半月板修复的平均正确率为86.9%,平均敏感度为86.9%,平均特异度为87.5%,平均阳性预测值92.9%,平均阴性预测值为77.9%;预测半月板切除的平均正确率为87.5%,平均敏感度为87.5%,平均特异度为86.9%,平均阳性预测值为77.9%,平均阴性预测值为92.9%。两位评分医生的预测结果与手术医生的实际术式高度一致(k=0.78,k=0.67)。结论Ortho One PROMT评分预测半月板撕裂可修复性不仅简便、可操作性强,而且具有良好的准确性、敏感度和特异度,能够有效解决当前术前半月板手术方式预测困难的问题,具有一定的临床应用推广价值。展开更多
In dentistry,orthodontic root resorption is a long-lasting issue with no effective treatment strategy,and its mechanisms,especially those related to senescent cells,remain largely unknown.Here,we used an orthodontic i...In dentistry,orthodontic root resorption is a long-lasting issue with no effective treatment strategy,and its mechanisms,especially those related to senescent cells,remain largely unknown.Here,we used an orthodontic intrusion tooth movement model with an L-loop in rats to demonstrate that mechanical stress-induced senescent cells aggravate apical root resorption,which was prevented by administering senolytics(a dasatinib and quercetin cocktail).展开更多
Neimadian-point is a newly-found acupointwith a good analgesic effect. 306 orthopedic op-erations on extremities were underNeimadian-point acupuncture anesthesia withgood results. 198 cases with complete clinicalmate...Neimadian-point is a newly-found acupointwith a good analgesic effect. 306 orthopedic op-erations on extremities were underNeimadian-point acupuncture anesthesia withgood results. 198 cases with complete clinicalmaterials were selected and analyzed in the pa-per.展开更多
The Ortho-SUV frame,a novel external fixator,can effectively treat limb deformities and fractures.Its kinematics is used when it is necessary to achieve bone movements with high precision.In this work,the kinematics m...The Ortho-SUV frame,a novel external fixator,can effectively treat limb deformities and fractures.Its kinematics is used when it is necessary to achieve bone movements with high precision.In this work,the kinematics model of the Ortho-SUV frame is established by six pose parameters,and its forward and inverse solutions are given.There is no need to solve nonlinear high-coupling equations with trigonometric functions in this solution method due to its special structure.By numerical examples and simulated orthopedic experiment of tibial fracture,the correctness and accuracy of the kinematics model and its solutions are verified.Besides,on the basis of kinematics analysis,the position workspace and orientation workspace of the Ortho-SUV frame are simulated in Matlab,which can help surgeons choose suitable device dimensions.The kinematics analysis provides a theoretical basis for the Ortho-SUV frame to be used in orthopedic treatment.展开更多
The mesomorphie properties of title complexes are investigated by means of DSC and polarizing microscopy. The mesophase temperature ranges of complexes are wider than that of corresponding organic ligands. The bridgin...The mesomorphie properties of title complexes are investigated by means of DSC and polarizing microscopy. The mesophase temperature ranges of complexes are wider than that of corresponding organic ligands. The bridging groups of the complexes have profoand effects on the mesomorphic behavior, When the bridging groups are opticallhy active. the compleve show chiral smectic展开更多
A model for the petrogenetic affinity and original geotectonic setting of ortho-amphibolites from the Obudu Plateau was tested using the distribution patterns of trace and rare-earth elements from the geochemical anal...A model for the petrogenetic affinity and original geotectonic setting of ortho-amphibolites from the Obudu Plateau was tested using the distribution patterns of trace and rare-earth elements from the geochemical analyses of twelve representative amphibolite samples. Discrimination plots, normalized patterns of the incompatible trace elements against average MORB, low ratios of Ba/Nb (9–23) and Ba/Ta (130–327) and other geochemical characteristics suggest that the protoliths were dominantly of tholeiitic MORB composition. The values of the ratios of La/Ta (8.13–10.8), Rb/Sr (0.04–0.07), Th/U (mainly 4.43–5.43) and Hf/Ta (2.35–2.88) further indicate that the ortho-amphibolites demonstrate E-type MORB characteristics. These features are related to substantial ocean floor divergent tectonic boundary setting rather than marginal basin tectonic setting. This evolutionary pattern appears to be controlled by limited progressive partial melting and fractional crystallization of a single mantle source region, irrespective, however, of variations due to local source heterogeneities. The tholeiitic magmas were most probably generated by hotspot activities on the constructive plate margins and subsequently modified by subduction-related low-K tholeiitic chemistry due to narrowing of a proto oceanic basin between the West African craton and eastern Sahara plate. A likely model, therefore, is that the amphibolites of the Obudu Plateau represent ophiolitic suites with characteristics of enriched mid-ocean floor tholeiites, which were deformed and metamorphosed during a reversed plate motion involving subduction and collision within the Obudu Plateau in the Pan-African orogenic episode.展开更多
The SnCl2 reduction of 2-nitrocyclododecanone or 2-bromo-12-nitrocyclododecanone gave a colorless compound 2,3,5,6-bis（ortho-1,10-decylidene）dihydropyrazine 1a characterized by IR, NMR and X-ray diffraction analysis...The SnCl2 reduction of 2-nitrocyclododecanone or 2-bromo-12-nitrocyclododecanone gave a colorless compound 2,3,5,6-bis（ortho-1,10-decylidene）dihydropyrazine 1a characterized by IR, NMR and X-ray diffraction analysis. Crystal data for 1a： Mr = 358.60, monoclinic, space group P2 1/n, α = 0.48028（3）, b = 2.8646（4）, c = 0.77097（6） nm, β = 98.432（12）°, V = 1.04924（19） nm^3, Dc = 1.135 g/cm^3, Z = 2, F（000） = 400 and μ（MoKa） = 0.065 mm^-1. All ^1H- and ^13C-NMR resonance lines of 1a were assigned by DEPT, COSY, HMQC and HMBC technology. In the crystal, the dihydropyrazine ring has a planar structure, two twelve-membered tings adopt [lene2333] conformation, their double bonds have cis-configuration, and the whole molecule has a center of symmetry. In solution, the symmetric ^1H- and ^13C-NMR signals suggest that two twelve-membered rings of 1a may adopt enantiomorphous [ lene2333] conformation existing in a dynamic equilibrium.展开更多
TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance(MDR)and as an anticancer agent for synergistic antitumor effects.However,the comparatively high critical micelle concen...TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance(MDR)and as an anticancer agent for synergistic antitumor effects.However,the comparatively high critical micelle concentration(CMC),low drug loading(DL)and poor tumor target limit its further clinical application.To overcome these drawbacks,the pH-sensitive star-shaped TPGS copolymers were successfully constructed via using pentaerythritol as the initial materials,ortho esters as the pH-triggered linkages and TPGS active-ester as the terminated MDR material.The amphiphilic star-shaped TPGS copolymers could self-assemble into free and doxorubicin(DOX)-loaded micelles at neutral aqueous solutions.The micelles exhibited the lower CMC(8.2×10^(−5) mg/ml),higher DL(10.8%)and long-term storage and circulation stability,and showed enhanced cellular uptake,apoptosis,cytotoxicity,and growth inhibition for in vitro MCF-7/ADR and/or MCF-7/ADR multicellular spheroids and in vivo MCF-7/ADR tumors via efficiently targeted drug release at tumoral intracellular pH(5.0),MDR reversal of TPGS,and synergistic effect of DOX and TPGS.Therefore,the pH-sensitive micelles self-assembled from star-shaped TPGS copolymers with ortho ester linkages are potentially useful to clinically transform for enhanced MDR cancer treatment.展开更多
For a given compactly supported scaling fun ct ion supported over [0,3]×[0,3], we present an algorithm to construct compac t ly supported orthogonal wavelets. By this algorithm, the symbol function of the associa...For a given compactly supported scaling fun ct ion supported over [0,3]×[0,3], we present an algorithm to construct compac t ly supported orthogonal wavelets. By this algorithm, the symbol function of the associated wavelets can be constructed explicitly.展开更多
Ointment-like poly(ortho esters) were synthesized from the reaction of 3,9-bis (methylene)-2,4,8,10-tetraoxaspiro[5.5]undecane with PEG-400,N,N-bis(2-hydroxyethyl)-n-hexadecylamine and N,N-bis(2-hydroxyethyl) palmitam...Ointment-like poly(ortho esters) were synthesized from the reaction of 3,9-bis (methylene)-2,4,8,10-tetraoxaspiro[5.5]undecane with PEG-400,N,N-bis(2-hydroxyethyl)-n-hexadecylamine and N,N-bis(2-hydroxyethyl) palmitamide respectively. The influence of the catalyst on the intrinsic viscosity of polymers was also studied.展开更多
目的:探讨ORTHO Auto Vue Innova全自动血型仪在血型检测中的应用效果。方法:选取2020年1月-5月溧阳市人民医院输血科的200例患者血型样本,利用全自动血型仪、玻片法与试管法进行血型正定型检测,比较三种检测方法最终结果,鉴定所用时间...目的:探讨ORTHO Auto Vue Innova全自动血型仪在血型检测中的应用效果。方法:选取2020年1月-5月溧阳市人民医院输血科的200例患者血型样本,利用全自动血型仪、玻片法与试管法进行血型正定型检测,比较三种检测方法最终结果,鉴定所用时间,对仪器检测进行无法正确判读结果分析。结果:对200例血型标本采用三种检测方法,其Kappa=1.0(Kappa>0.75),表明上述检测高度一致;仪器法血型鉴定试验中检测200例样本的共用时间和平均时间少于玻片法和试管法,差异具有统计学意义(P<0.05);200例患者仪器法一次性正确判读率为97.00%(194/200)。结论:ORTHO Auto Vue Innova全自动血型仪检测与传统经典手工检测一致性高,结果准确可靠,且实现了规范化和标准化的实验操作,人为因素影响明显降低,可以长期保存检测结果,有利于后期查询和医疗举证。展开更多
文摘Recent discoveries have revealed a groundbreaking phenomenon where light alone, without any thermal input, can induce water evaporation, termed the “photomolecular effect”. This study explores a novel hypothesis that this effect can be explained by ortho-para magnetic spin interactions in water molecules within the water-air interface layer. Water molecules, consisting of hydrogen and oxygen, exhibit different nuclear spin states: ortho-(triplet) and para-(singlet). The interaction of polarized light with these spin states may induce transitions between the rotational levels of ortho- and para-forms due to catalysts like triplet oxygen (O2) in its inhomogeneous magnetic field. Resonance pumping at 532 nm (~18,797 cm−1) due to the transition v1-v2-v3 ~ 0-8-2 (~18,796 cm−1) results in an increase in molecular energy sufficient to overcome intermolecular forces at the water surface, thereby causing evaporation. The proposed ortho-para conversion mechanism involves spin-orbit coupling and specific resonance conditions. This theory provides a quantum mechanical perspective on the photomolecular effect, potentially offering insights into natural processes such as cloud formation and climate modeling, as well as practical applications in solar desalination and industrial drying. Further experimental validation is required to confirm the role of spin interactions in light-induced water evaporation.
文摘目的本研究目的在于评估Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性,检验其是否具备解决术前半月板手术方式预测困难的能力。方法纳入本院2019年3月至2019年12月因半月板损伤而接受关节镜下手术者55膝58侧半月板。本研究分为两个部分。第一部分:评分过程由两位医生按Ortho One PROMT评分细则分别对半月板损伤者进行独立评分,并根据得分预测半月板手术术式。第二部分:将两位评分医生预测的半月板手术术式分别与手术医生的实际手术术式进行一致性比较,最终评价Ortho One PROMT评分在预测半月板撕裂可修复性方面的准确性、敏感度及特异度。结果评分医生预测半月板修复的平均正确率为86.9%,平均敏感度为86.9%,平均特异度为87.5%,平均阳性预测值92.9%,平均阴性预测值为77.9%;预测半月板切除的平均正确率为87.5%,平均敏感度为87.5%,平均特异度为86.9%,平均阳性预测值为77.9%,平均阴性预测值为92.9%。两位评分医生的预测结果与手术医生的实际术式高度一致(k=0.78,k=0.67)。结论Ortho One PROMT评分预测半月板撕裂可修复性不仅简便、可操作性强,而且具有良好的准确性、敏感度和特异度,能够有效解决当前术前半月板手术方式预测困难的问题,具有一定的临床应用推广价值。
基金supported by JST,CREST Grant Number JPMJCR22L5,Japan。
文摘In dentistry,orthodontic root resorption is a long-lasting issue with no effective treatment strategy,and its mechanisms,especially those related to senescent cells,remain largely unknown.Here,we used an orthodontic intrusion tooth movement model with an L-loop in rats to demonstrate that mechanical stress-induced senescent cells aggravate apical root resorption,which was prevented by administering senolytics(a dasatinib and quercetin cocktail).
文摘Neimadian-point is a newly-found acupointwith a good analgesic effect. 306 orthopedic op-erations on extremities were underNeimadian-point acupuncture anesthesia withgood results. 198 cases with complete clinicalmaterials were selected and analyzed in the pa-per.
基金National Key Research & Development Program of China(No.2017YFB1302901)
文摘The Ortho-SUV frame,a novel external fixator,can effectively treat limb deformities and fractures.Its kinematics is used when it is necessary to achieve bone movements with high precision.In this work,the kinematics model of the Ortho-SUV frame is established by six pose parameters,and its forward and inverse solutions are given.There is no need to solve nonlinear high-coupling equations with trigonometric functions in this solution method due to its special structure.By numerical examples and simulated orthopedic experiment of tibial fracture,the correctness and accuracy of the kinematics model and its solutions are verified.Besides,on the basis of kinematics analysis,the position workspace and orientation workspace of the Ortho-SUV frame are simulated in Matlab,which can help surgeons choose suitable device dimensions.The kinematics analysis provides a theoretical basis for the Ortho-SUV frame to be used in orthopedic treatment.
文摘The mesomorphie properties of title complexes are investigated by means of DSC and polarizing microscopy. The mesophase temperature ranges of complexes are wider than that of corresponding organic ligands. The bridging groups of the complexes have profoand effects on the mesomorphic behavior, When the bridging groups are opticallhy active. the compleve show chiral smectic
文摘A model for the petrogenetic affinity and original geotectonic setting of ortho-amphibolites from the Obudu Plateau was tested using the distribution patterns of trace and rare-earth elements from the geochemical analyses of twelve representative amphibolite samples. Discrimination plots, normalized patterns of the incompatible trace elements against average MORB, low ratios of Ba/Nb (9–23) and Ba/Ta (130–327) and other geochemical characteristics suggest that the protoliths were dominantly of tholeiitic MORB composition. The values of the ratios of La/Ta (8.13–10.8), Rb/Sr (0.04–0.07), Th/U (mainly 4.43–5.43) and Hf/Ta (2.35–2.88) further indicate that the ortho-amphibolites demonstrate E-type MORB characteristics. These features are related to substantial ocean floor divergent tectonic boundary setting rather than marginal basin tectonic setting. This evolutionary pattern appears to be controlled by limited progressive partial melting and fractional crystallization of a single mantle source region, irrespective, however, of variations due to local source heterogeneities. The tholeiitic magmas were most probably generated by hotspot activities on the constructive plate margins and subsequently modified by subduction-related low-K tholeiitic chemistry due to narrowing of a proto oceanic basin between the West African craton and eastern Sahara plate. A likely model, therefore, is that the amphibolites of the Obudu Plateau represent ophiolitic suites with characteristics of enriched mid-ocean floor tholeiites, which were deformed and metamorphosed during a reversed plate motion involving subduction and collision within the Obudu Plateau in the Pan-African orogenic episode.
基金This project was supported by the National Natural Science Foundation of China (No. 20072053)
文摘The SnCl2 reduction of 2-nitrocyclododecanone or 2-bromo-12-nitrocyclododecanone gave a colorless compound 2,3,5,6-bis（ortho-1,10-decylidene）dihydropyrazine 1a characterized by IR, NMR and X-ray diffraction analysis. Crystal data for 1a： Mr = 358.60, monoclinic, space group P2 1/n, α = 0.48028（3）, b = 2.8646（4）, c = 0.77097（6） nm, β = 98.432（12）°, V = 1.04924（19） nm^3, Dc = 1.135 g/cm^3, Z = 2, F（000） = 400 and μ（MoKa） = 0.065 mm^-1. All ^1H- and ^13C-NMR resonance lines of 1a were assigned by DEPT, COSY, HMQC and HMBC technology. In the crystal, the dihydropyrazine ring has a planar structure, two twelve-membered tings adopt [lene2333] conformation, their double bonds have cis-configuration, and the whole molecule has a center of symmetry. In solution, the symmetric ^1H- and ^13C-NMR signals suggest that two twelve-membered rings of 1a may adopt enantiomorphous [ lene2333] conformation existing in a dynamic equilibrium.
基金This work is financially supported by the National Natural Science Foundation of China(No.51803001)the Research Foundation of Education Department of Anhui Province of China(No.KJ2018ZD003 and KJ2018A0006)the Academic and Technology Introduction Project of Anhui University(AU02303203).
文摘TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance(MDR)and as an anticancer agent for synergistic antitumor effects.However,the comparatively high critical micelle concentration(CMC),low drug loading(DL)and poor tumor target limit its further clinical application.To overcome these drawbacks,the pH-sensitive star-shaped TPGS copolymers were successfully constructed via using pentaerythritol as the initial materials,ortho esters as the pH-triggered linkages and TPGS active-ester as the terminated MDR material.The amphiphilic star-shaped TPGS copolymers could self-assemble into free and doxorubicin(DOX)-loaded micelles at neutral aqueous solutions.The micelles exhibited the lower CMC(8.2×10^(−5) mg/ml),higher DL(10.8%)and long-term storage and circulation stability,and showed enhanced cellular uptake,apoptosis,cytotoxicity,and growth inhibition for in vitro MCF-7/ADR and/or MCF-7/ADR multicellular spheroids and in vivo MCF-7/ADR tumors via efficiently targeted drug release at tumoral intracellular pH(5.0),MDR reversal of TPGS,and synergistic effect of DOX and TPGS.Therefore,the pH-sensitive micelles self-assembled from star-shaped TPGS copolymers with ortho ester linkages are potentially useful to clinically transform for enhanced MDR cancer treatment.
文摘For a given compactly supported scaling fun ct ion supported over [0,3]×[0,3], we present an algorithm to construct compac t ly supported orthogonal wavelets. By this algorithm, the symbol function of the associated wavelets can be constructed explicitly.
文摘Ointment-like poly(ortho esters) were synthesized from the reaction of 3,9-bis (methylene)-2,4,8,10-tetraoxaspiro[5.5]undecane with PEG-400,N,N-bis(2-hydroxyethyl)-n-hexadecylamine and N,N-bis(2-hydroxyethyl) palmitamide respectively. The influence of the catalyst on the intrinsic viscosity of polymers was also studied.
文摘目的:探讨ORTHO Auto Vue Innova全自动血型仪在血型检测中的应用效果。方法:选取2020年1月-5月溧阳市人民医院输血科的200例患者血型样本,利用全自动血型仪、玻片法与试管法进行血型正定型检测,比较三种检测方法最终结果,鉴定所用时间,对仪器检测进行无法正确判读结果分析。结果:对200例血型标本采用三种检测方法,其Kappa=1.0(Kappa>0.75),表明上述检测高度一致;仪器法血型鉴定试验中检测200例样本的共用时间和平均时间少于玻片法和试管法,差异具有统计学意义(P<0.05);200例患者仪器法一次性正确判读率为97.00%(194/200)。结论:ORTHO Auto Vue Innova全自动血型仪检测与传统经典手工检测一致性高,结果准确可靠,且实现了规范化和标准化的实验操作,人为因素影响明显降低,可以长期保存检测结果,有利于后期查询和医疗举证。
