·AIM:To report a successful osteo-odonto keratoprosthesis(OOKP) procedure in a case of end stage of corneal blindness due to Stevens-Johnson syndrome (SJS).·METHODS:An interventional case report.·RESULT...·AIM:To report a successful osteo-odonto keratoprosthesis(OOKP) procedure in a case of end stage of corneal blindness due to Stevens-Johnson syndrome (SJS).·METHODS:An interventional case report.·RESULTS:We describe a 35-year-old Indian woman,a known case of SJS with bilateral dry eyes and corneal blindness (failed corneal graft with vascularised total corneal opacity in the right eye and non-healing corneal ulcer in the left eye).Vision was hand movement only in both eyes.The corneal ulcer healed with medical treatment resulting in vascularised total corneal opacity with no improvement in vision.OOKP was performed in the right eye and the vision was improved from hand movement to 6/6.The same vision was maintained in the right eye at the last follow-up 5 years after surgery.·CONCLUSION:OOKP provides good visual rehabilitation with long-term anatomically stable prosthesis in patients with end-stage of ocular surface disorders and corneal blindness secondary to SJS.·展开更多
目的:初步探讨眼面心牙综合症(oculo-facio-cardio-dentalsyndrome,OFCD)患者牙根过度发育的机制。方法:分别取OFCD患者和正常人根尖牙乳头干细胞,通过MTT法检测增殖能力、碱性磷酸酶(alka line phosphatase,ALP)试剂盒法检测ALP活性、W...目的:初步探讨眼面心牙综合症(oculo-facio-cardio-dentalsyndrome,OFCD)患者牙根过度发育的机制。方法:分别取OFCD患者和正常人根尖牙乳头干细胞,通过MTT法检测增殖能力、碱性磷酸酶(alka line phosphatase,ALP)试剂盒法检测ALP活性、Western Blot检测牙本质涎蛋白(dentin sialoprotein,DSP)和核心结合因子(runt-related transcription factor 2,Runx2)的表达量。结果:OFCD患者根尖牙乳头干细胞的增殖活性、ALP活性、DSP和Runx2蛋白表达量均高于正常人来源的根尖牙乳头干细胞。结论:根尖牙乳头干细胞的增殖及成牙成骨能力增强可能是导致OFCD患者牙根过度发育的原因。展开更多
文摘·AIM:To report a successful osteo-odonto keratoprosthesis(OOKP) procedure in a case of end stage of corneal blindness due to Stevens-Johnson syndrome (SJS).·METHODS:An interventional case report.·RESULTS:We describe a 35-year-old Indian woman,a known case of SJS with bilateral dry eyes and corneal blindness (failed corneal graft with vascularised total corneal opacity in the right eye and non-healing corneal ulcer in the left eye).Vision was hand movement only in both eyes.The corneal ulcer healed with medical treatment resulting in vascularised total corneal opacity with no improvement in vision.OOKP was performed in the right eye and the vision was improved from hand movement to 6/6.The same vision was maintained in the right eye at the last follow-up 5 years after surgery.·CONCLUSION:OOKP provides good visual rehabilitation with long-term anatomically stable prosthesis in patients with end-stage of ocular surface disorders and corneal blindness secondary to SJS.·
