Progress in Traditional Chinese and Weste rn Medicine Treatments and Nursing Care of Knee Osteoarthritis

This paper reviews the causes of knee osteoarthritis, traditional Chinese and Western medicine therapies and nursing research progress and indicates that traditional Chinese and Western medicine have gradually recognized the cause of knee osteoarthritis. Knee osteoarthritis has been treated with various treatments and nursing care planning, and the combination of traditional Chinese and Western medicine has constantly been improved. Nurses should instruct the discharged patient to correctly treat their disease, adopt the health education, and, via the establishment of a healthy lifestyle, insist on a functional exercise to relieve the pain, delay disease progression, and improve quality of life.

CLINICAL APPLICATION OF CHINESE HERBS REMEDIES AS IMMUNOMODULATORS IN THE TREATMENT OF CANCER

IMMUNITY AND TUMOR Immune system has closely relation to the growth and development of tumor. One of its immune functions is to constantly recognize and kill malignant cells which develop from normal cells. The occurance of tumor indicates to some extent the failure of this "immune serveillance" function. Many studies have shown that the tumor cells of body have some tumor interrelative antigen that dose not exist in normal tissues. Tests in vitro

CLINICAL OBSERVATION ON COMBINED TREATMENT OF VASCULAR DEMENTIA WITH ACUPUNCTURE, MOXIBUSTION AND CHINESE MEDICINAL HERBS

In the present study, the clinical effect of acupuncture, moxibustion plus Chinese medicinal herbs for treatment of 30 cases of vascular dementia (VD) was observed and their mechanisms were analyzed by determining the activity of SOD, LPO and GSH-Px. Results showed that after 2 months’combined treatment, of the 30 cases, 12 had marked improvement, 15 had improvement and 3 had not any improvement, with an effective rate of 90%; the activity of SOD and GSH-Px increased considerably while the content of LPO lowered strikingly. There were significant differences between pre-and post-treatment in the activity of SOD and GSH-Px and the content of LPO (P<0. 01). It reveals that this method is capable of improving VD patients’ clinical symptoms and signs such as headache, dizziness, hemi-paralysis or hemianesthesia, forced crying and laughing, etc.and also raising the ability of the body in removing oxygen free radical, and suppressing peroxidization of free radical to reduce its products, thereby alleviating the toxic effect of oxygen free radical on the brain tissues.

Treatment of Retinal Vein Obstruction with Acupuncture and Chinese Medicinal Herbs

We have treated thirty-two cases (52 eyes) of retinal vein obstruction by acupuncture and oral administration of Huo Xue Ming Mu Decoction. The total effective rate of 90.38% demonstrated that the treatment was definitely effective.

Effects of Integrated Chinese Herbs and Western Medicine on Swine Toxoplasmosis

[ Objective] To evaluate the efficacy of integrated Chinese herbs and western medicine on the treatment of swine toxoplasmosis, in order to increase cure rate and lower recurrence rate. [ Method] Pigs artificially infected by Toxoplasma gondii were treated with compound suffonamide and a self-designed Chinese herbs formula, and the quantities of toxoplasma in ascites were determined. Animal regression experiment was per- formed after mice were inoculated with pathological samples of the pigs infected with toxoplasma. After treatment with integrated Chinese herbs and western medicine, the clinical manifestations of pigs were observed and the level of circulating antigen （CAg） in sera was detected. Curative effect indexes of integrated Chinese herbs and western medicine-treated group were compared with that of Chinese herbs-treated group, western medi- cine-treated group and positive control group. [ Result] All the toxoplasma trophozoites were killed by integrated and westem medicine. Regression expedment results showed that toxoplasma appeared only in one mouse that was inoculated with brain of pig. The treated pigs had nonsignificant clinical symptoms; the peak of serum CAg was lower than that of the positive control group and CAg turned negative faster than that of Chinese herbs-treated group, westem medicine-treated group, and positive control group. [ Conclusion] The integrated Chinese herbs and western medicine has good effect on the treatment of swine toxoplasmosis.

China Association of Chinese Medicine Paper notice for seminar on clinical application of TCM classic prescriptions and herbs in the treatment of emotional diseases

Hosted by ChinaAssociation of Chinese Medicine,and organized by World Journal of Integrated traditional and western Medicine,seminar on clinical application of TCM classic prescriptions and herbs in the treatment of emotional diseaseis planned to be held in Yichang,Hubei province from June 22nd to 24th.

Traditional Chinese medicine for prevention and treatment of hepatocarcinoma: From bench to bedside

Traditional Chinese medicine(TCM) has played a positive role in the management of hepatocarcinoma. Hepatocarcinoma patients may present Qi-stagnation, damp-heat, blood stasis, Qi-deficiency, Yin-deficiency and other TCM syndromes(Zheng). Modern treatments such as surgery, transarterial chemoembolization(TACE) and high intensity focus ultrasound treatment would influence the manifestation of TCM syndromes. Herbs with traditional efficacy of tonifying Qi, blood and Yin, soothing liver-Qi stagnation, clearing heat and detoxifying and dissolving stasis, have been demonstrated to be potent to prevent hepatocarcinogenesis. TCM has been widely used in all aspects of integrative therapy in hepatocarcinoma, including surgical resection, liver transplantation, TACE, local ablative therapies and even as monotherapy for middle-advanced stage hepatocarcinoma. Clinical practices have confirmed that TCM is effective to alleviate clinical symptoms, improve quality of life and immune function, prevent recurrence and metastasis, delay tumor progression, and prolong survival time in hepatocarcinoma patients. The effective mechanism of TCM against hepatocarcinoma is related to inducing apoptosis, autophagy, anoikis and cell senescence, arresting cell cycle, regulating immune function, inhibiting metastasis and angiogenesis, reversing drug resistance and enhancing effects of chemotherapy. Along with the progress of research in this field, TCM will contribute more to the prevention and treatment of hepatocarcinoma.

Traditional Chinese Medicinal Syndromes and Treatment in Colorectal Cancer

Colorectal cancer remains the third most common malignancy worldwide. According to the principles of Traditional Chinese Medicine (TCM), colorectal cancer is related to spleen-deficiency, damp-heat, and toxicity accumulation. Traditional Chinese medicine has been confirmed to effectively reduce toxic side effects and enhance curative effects of chemotherapy, palliate clinical syndrome, prevent recurrence and metastasis, improve quality of life and immune function, and prolong survival time in colorectal cancer. However, TCM theoretical and syndrome differentiation study has lagged far behind due to progression of therapy model in colorectal cancer. As a type of drug treatment, there are some common biological basis between chemotherapy, targeted therapy and anti-cancer herb therapy in colorectal cancer, such as apoptosis, cell senescence and autophagy. There are growing needs to explore the effect mechanism and compatibility of anti-cancer herbs, to further enhance the efficacy of TCM treatment in colorectal cancer.

Analysis of Traditional Chinese Medicine Syndromes and Treatment Laws of Diabetic Kidney Disease and the Action Mechanism of High-Frequency Chinese Herbs in the Treatment of Diabetic Kidney Disease Based on Real-World Study

Objective Our objective was to analyze the traditional Chinese medicine(TCM)syndrome and treatment laws of diabetic kidney disease(DKD)and the action mechanism of high-frequency Chinese herbs in the treatment of DKD based on realworldstudy.MethodsThe data of patients with DKD who had been treated in the First Hospital Affiliated to Henan Universityof ChineseMedicine from January1,2014to December 31,2021 were retrospectively analyzed through the hospital information management system.The contents of the cases were statistically analyzed using IBM SPsS Statistics 25 software,and the laws of DKDtreatment were summarized.Network pharmacology and molecular docking were used to analyze the action mechanism of high-frequency Chinese herbs in the treatment of DKD.ResultsThe data of a total of 1,201 patients with DKD were included,involving 72 kinds of TCM syndromes.Nine disease nature elements and six disease location elements were extracted,involving 405 Chinese herbs.The top five high-frequency Chinese herbs were Baizhu(Atractylodis Macrocephalae Rhizoma),Fuling(Poria),Huangqi(Astragali Radix),Chuanxiong(Chuanxiong Rhizoma),and Danshen(Salviae Miltiorrhizae Radix et Rhizoma).Thirty kinds of Chinese herbs with the frequency of≥100 were mainly deficiency-tonifying herbs and blood-activating and stasis-eliminating herbs.The medicinal properties were mainly warm and mild,and the medicinal flavors were sweet and bitter mostly.For the meridian tropism,the main meridian tropism of these herbs is spleen meridian and lung meridian.The clustering method.

Evaluation of the Therapeutic Effect of Contrast-Enhanced Ultrasound on Different Types of Knee Osteoarthritis in the Elderly

Objective: To evaluate the curative effect of the Traditional Chinese Medicine (TCM) external therapy on knee osteoarthritis patients with different TCM constitutions using musculoskeletal ultrasonography and contrast-enhanced ultrasonography, and to explore the application value of contrast-enhanced ultrasonography in knee joint diseases. Methods: A total of 57 patients diagnosed with knee osteoarthritis in Shaanxi University of Traditional Chinese Medicine from December 2019 to May 2021 were collected, and they were divided into qi stagnation and blood stasis type group (23 cases) and cold-dampness obstruction type group (34 cases) according to the traditional Chinese medicine method. All patients were given acupuncture combined with TCM fumigation and washing. All patients underwent musculoskeletal ultrasonography and contrast-enhanced ultrasonography before and after treatment, observed and recorded relevant data, and compared the treatment effects between the two groups. Results: 85.96% (49/57) of knee osteoarthritis (KOA) patients had suprapatellar bursa effusion, 42.1% (24/57) had iliotibial band bursae effusion, some of which had poor sound transmission, and thickened synovium was seen in most effusions, 33.33% (19/57) had osteophyte formation. Compared with before treatment, the depth of suprapatellar sac effusion in the Qi stagnation and blood stasis type group decreased after treatment (P Conclusion: Musculoskeletal contrast-enhanced ultrasonography was used to quantitatively evaluate the efficacy of TCM external therapy on KOA for different TCM constitutions. Dynamic observation of synovial lesions of knee osteoarthritis provides a valuable imaging method for evaluating the efficacy of traditional Chinese medicine.

Pathological Relationship between Intestinal Flora and Osteoarthritis and Intervention Mechanism of Chinese Medicine

Chinese medicine(CM) has a good clinical effect on osteoarthritis(OA), but the mechanism is not very clear. Evidence-based medicine researches have shown that intestinal flora plays a role in the pathogenesis and succession of OA. Intestinal flora affects the efficacy of CM, and CM can affect the balance of intestinal flora. This paper focuses on the relationship between intestinal flora, intestinal microenvironment, brain-gut axis, metabolic immunity and OA, and preliminarily expound the significance of intestinal flora in the pathogenesis of OA and the mechanism of CM intervention. The above discussion will be of great significance in the prevention and treatment of OA by CM from the perspective of intestinal flora.

Patterns of Herbal Combination for the Treatment of Insomnia Commonly Employed by Highly Experienced Chinese Medicine Physicians

Objective：To explore the most effective herbal combinations commonly used by highly experienced Chinese medicine（CM） physicians for the treatment of insomnia.Methods：We collected and analyzed data related to insomnia treatment from the clinics of 7 highly experienced CM physicians in Beijing.The sample included 162 patients and 460 consultations in total.Patient outcomes,such as sleep quality and sleep time per day,were manually collected from the medical records by trained CM clinicians.Three data mining methods,support vector machine（SVM）,logistic regression and decision tree,and multifactor dimensionality reduction（MDR）,were used to determine and confirm the herbal combinations that resulted in positive outcomes in patients suffering from insomnia.Results：Results show that MDR is the most efficient method to predict the effective herbal combinations.Using the MDR model,we identified several combinations of herbs with 100%positive outcomes,such as stir-fried spine date seed,Szechwan lovage rhizome,and prepared thinleaf milkwort root;white peony root,golden thread,and stir-fried spine date seed;and Asiatic cornelian cherry fruit with fresh rehmannia.Conclusions：Results indicate that herbal combinations are effective treatments for patients with insomnia compared with individual herbs.It is also shown that MDR is a potent data mining method to identify the herbal combination with high rates of positive outcome.

Chinese Medicine Involving Triple Rehabilitation Therapy for Knee Osteoarthritis in 696 Outpatients:A Multi-Center,Randomized Controlled Trial

Objective:To determine the effects of Chinese medicine(CM)involving triple rehabilitation therapy on the progression of knee osteoarthritis(KOA).Methods:A total of 722 patients recruited from 38 community health service centers located in China from March 2013 to March 2017 were randomly divided into treatment and control groups equally,using a cluster randomization design.Health education combined with CM involving triple rehabilitation therapy for KOA(electro-acupuncture,Chinese medicinal herb fumigating-washing,and traditional exercises)was administered in the treatment group while conventional rehabilitation therapy(physical factor therapy,joint movement training,and muscle strength training)was administered in the control group.Patients with a visual analog scale(VAS)scores>A were treated with dispersible meloxicam tablets(7.5 mg,once daily).The Lequesne index scores,VAS scores,range of motion(ROM),lower limb muscle strength,knee joint circumference,quantitative scores of KOA symptoms,and the short-form 36 item health survey questionnaire(SF-36)scores were measured for each patient at 5 checkpoints(before treatment,at the 2nd week and the 4th week during the 4-week treatment period,at 1 month and 3 months after end of treatment),and adverse reactions were observed also.Results:A total of 696 patients completed the entire process,with 351 in the treatment group and 345 in the control group.At all treatment checkpoints,the treatment group demonstrated better outcomes than the control group with regard to the total Lequesne index scores,effective rate and improvement rate of the total Lequesne index scores,VAS scores,lower limb muscle strength,knee circumference,quantitative scores of KOA symptoms,and SF-36 scores as well(P<0.05 or P<0.01).No adverse reactions were encountered in this study.Conclusions:CM involving triple rehabilitation therapy can alleviate KOA-related pain and swelling,improve lower limb muscle strength,promote flexion and activity of the knee and improve the quality of life in patients undergoing KOA.It is suitable for patients with early or mid-stage KOA.(Registration No.ChiCTR-TRC-12002538)

Clinical observation on pricking at Sìfèng (四缝 EX-UE 10) combined with Chinese herbs for infantile malnutrition

Objective To explore the best clinical treatment for infantile malnutrition. Methods Three hundred and forty-three patients were randomly divided into a pricking at Sìfèng （四缝 EX-UE 10） group （priking group, n=105）, a Chinese herbs group （n=85） and a pricking and Chinese herbs group （n=153）. The improvements of the clinical symptoms of all three groups were evaluated after the treatment. Results The results of these treatments for all the patients were satisfying. The effective rate of the pricking and Chinese herbs group, which was 98.7 % （151/153）, was superior to that of 94.3 % （99/105） （P0.05） in the pricking group and 91.8% （78/85） in the Chinese herbs group （P0.01）, while no differences in effective rate were found between the pricking group and the Chinese herbs group （P0.05）. Conclusion The pricking at Sìfèng （四缝 EX-UE 10） combined with Chinese herbs is the best treatment for infantile malnutrition.

新型特色水药罐的设计和应用

目的:研制一种新型特色水药罐,以提高水药罐的操作便利性、密封性、保温性及牢固性。方法:新型特色水药罐材质为树脂类,由双层保温罐体、单向排气阀、调节开关、活塞、风琴软管和弹簧组成。其中双层保温罐体的罐壁为内部中空的双层结构;调节开关的中部设有长方形滑动孔;活塞由活塞杆、尾座和活塞头组成;弹簧位于开关底座旁,上端和调节开关连接,下端和双层保温罐体连接。结果:相较于传统特色水药罐,新型特色水药罐用于拔罐所需时间更短,药液洒漏量更少,拔罐前后药液温差更小。结论:新型特色水药罐临床操作简便、密封性强、保温性能良好、不易破碎,是一种适合临床推广使用的拔罐器具。

中药外治组合方案对膝骨关节炎相关炎症因子的影响

目的探究3种中药外治组合疗法对膝骨关节炎(KOA)患者血清中5-HT、IL-6、MMP-13因子的影响。方法选取门诊150例KOA患者,按随机数字表法分为治疗组(A)、对照组1(B)、对照组2(C),各50例。A组予中药涂擦、中药烫熨、五方散贴敷,B组予中药烫熨、五方散贴敷,C组予中药涂擦、五方散贴敷,各组疗程均为1周,分别于治疗前后观察5-HT、IL-6、MMP-13的水平。结果治疗后,3组患者5-HT、IL-6、MMP-13水平较治疗前均降低(P<0.05);A组相关因子水平较B、C组均降低(P<0.05),而B、C组比较,差异无统计学意义(P>0.05)。结论与2种外治法组合疗法比较,3种外治组合疗法治疗KOA有效,可降低KOA患者血清中的炎症因子5-HT、IL-6、MMP-13的水平。

中医外治法治疗膝骨性关节炎研究进展

膝关节骨性关节炎(KOA)是一种以疼痛、肿胀、活动受限和致残性为特征的骨性关节病,是常见的退行性骨科病。膝骨性关节炎常随着患病年限的增加而进展,导致患者生活品质显著降低。目前临床上KOA常用的保守治疗方式主要为中医外治疗法、口服药物治疗以及现代物理疗法。而中医外治法拥有数千年的历史,又可以根据患者的病情特点,辨证施治,以达到最好的治疗效果。在KOA的治疗过程中,中医外治法又因为操作简单,费用低廉,临床疗效好等特点,得到广大患者的支持和认可,有成为KOA主要治疗方式的趋势。随着现代医疗的发展,KOA的中医外治法也有了更深远的创新和发展,通过阅读近年来的文献,更新汇总了最新KOA中医外治法的研究进展,期待能够在KOA患者实际治疗上提供一定的参考与借鉴。

骨关节炎发病机制及治疗研究进展

骨性关节炎(OA)是一种以关节逐渐退变为主要特征的慢性骨性关节疾病,患者症状上多表现为关节疼痛或畸形。临床上最常见的OA为膝骨性关节炎(KOA)。KOA患病率日益升高且中老年人居多,其发病机制尚未完全明确,但越来越多的研究表明多种蛋白酶在微观层面上起着重要作用。由于该疾病导致的关节疼痛与功能障碍,会严重影响着人民健康及生活质量,给患者家庭与社会带来了多重负担,由此可见对KOA治疗方法进行研究显得尤为重要。逐年增加的临床治疗结果表明手术治疗、中医治疗与机器人辅助治疗均可带来良好的治疗效果。现就通过概述KOA患者发病机制、诊治进展,旨在为KOA的临床治疗工作提供参考,为患者的生活质量提供保障。

以“血瘀”理论指导治疗:解读膝骨关节炎“铁超载”的相关机制

背景:膝骨关节炎多发于中老年人,是一类严重影响患者的生活质量甚至有致残风险的疾病。因此,膝骨关节炎的发病机制以及治疗手段已成为研究的焦点。在祖国医学中,膝骨关节炎常以“痹”论治,并与中医“血瘀”理论中血行瘀滞、血脉阻络而致之“痹”紧密相关。铁超载是一类因铁代谢紊乱导致的病理状态,其与中医“血瘀”理论的发病特点、临床表现等高度重合,是促进膝骨关节炎发展的危险因素。目的:基于“血瘀”理论,就铁超载对软骨代谢以及软骨下骨重建的影响展开综述,为中医药治疗膝骨关节炎奠定了全新理论基础,也为探究活血中药干预骨组织后期治疗作用的相关机制提供理论依据。方法:通过检索中国知网、万方数据、PubMed及Web of Science数据库获得文献,中文检索词为“铁死亡,铁,铁超载,骨关节炎,血瘀”以及英文检索词为“ferroptosis,iron,iron overload,osteoarthritis,TCM”,最终纳入文献76篇进行综述分析。结果与结论:①文章针对“血瘀”理论治疗膝骨关节炎的潜力进行发掘,发现“血瘀”是膝骨关节炎进展中至关重要的部分,表明“血瘀”理论是中医治疗膝骨关节炎的关键所在。②“血瘀”与铁超载在致病因素、临床表现、发病特点上有高度的相似性,提示了“血瘀”理论治疗铁超载的可能性,说明铁超载可能是“血瘀”理论治疗膝骨关节炎的重要机制基础,活血类药物的提取物有着缓解铁超载并治疗膝骨关节炎的作用,但具体机制尚不明确。③“血瘀”理论与铁超载的关系及相关机制是未来膝骨关节炎的重要研究方向,可为中医临床开发新药、创新用法等中医现代化手段提供了理论基础,对临床有一定的指导意义。

《清宫医案集成》中熏洗方运用初探

[目的]探究《清宫医案集成》中熏洗方治疗疾病的特殊性和有效性,为现代临床外治法提供参考。[方法]以《清宫医案集成》中117首熏洗方为研究对象,运用Excel软件,对清宫熏洗方的组成、剂量、药性、功效进行整理统计,并结合该书中的相关医案及按语,对熏洗方在清宫中的特色运用进行系统整理。[结果]《清宫医案集成》中的117首宫廷熏洗方在遣方用药上展现出种类繁多、质量上乘,方简药精、效专力宏,随证加减、用药灵活,治病为先、不拘药量,善用风药、不避毒药等多种特色;且另有受众广泛、方式独特、器具考究、药液制备过程细致等其他优势。[结论]《清宫医案集成》中的熏洗方颇具宫廷特色及优势,对其运用展开探索能够获得独特的见解和启示,有助于发扬宫廷用药特色,促进中医药外治疗法的发展,具有较高的研究价值。