目的探讨骨质疏松性椎体压缩骨折(osteoporotic vertebral compression fracture,OVCF)患者腰骶区椎旁肌密度与椎体骨密度(vertebral bone mineral density,vBMD)之间的关系。方法回顾性分析了OVCF患者的前瞻性机构数据库(NCT05848167)...目的探讨骨质疏松性椎体压缩骨折(osteoporotic vertebral compression fracture,OVCF)患者腰骶区椎旁肌密度与椎体骨密度(vertebral bone mineral density,vBMD)之间的关系。方法回顾性分析了OVCF患者的前瞻性机构数据库(NCT05848167)。纳入2021年1月至2022年12月共167例患者资料,其中101例定量CT(quantitative computed tomography,QCT)检查资料可用的OVCF患者,女80例,男21例;女性中位年龄73(68.00,82.50)岁,男性中位年龄71(67.00,80.00)岁。在L_(3~5)椎体上终板水平进行椎旁肌密度和面积测量,并使用人工分割和定制编写的程序进行计算。利用QCT Pro软件在L_(1~2)水平进行vBMD测量和计算。按性别、年龄对所有分析进行分层分析。结果本研究发现男性患者的椎旁肌密度与vBMD有统计学相关。在调整年龄和性别后,L_(1~2)vBMD与L_(3)左侧多裂肌、L_(4)左侧竖脊肌、L_(4)右侧多裂肌、L_(5)左右双侧多裂肌密度之间存在统计学意义上的正相关,而在女性患者中未发现显著相关性。结论男性多裂肌密度和vBMD在不同的腰椎水平存在显著的正相关,这与年龄无关。在解释腰椎椎体和椎旁肌关联时,应考虑性别及区域性差异。展开更多
BACKGROUND Osteoporotic vertebral compression fractures(OVCFs)contribute to back pain and functional limitations in older individuals,with percutaneous vertebroplasty(PVP)emerging as a minimally invasive treatment.How...BACKGROUND Osteoporotic vertebral compression fractures(OVCFs)contribute to back pain and functional limitations in older individuals,with percutaneous vertebroplasty(PVP)emerging as a minimally invasive treatment.However,further height loss post-PVP prompts investigation into contributing factors.AIM To investigate the factors associated with further height loss following PVP with cement augmentation in OVCF patients.METHODS A total of 200 OVCF patients who underwent successful PVP between January 2021 and December 2022 were included in this study.“Further height loss”during 1 year of follow-up in OVCF patients with bone edema was defined as a vertical height loss of≥4 mm.The study population was divided into two groups for analysis:The“No Further Height Loss group(n=179)”and the“Further Height Loss group(n=21).”RESULTS In comparing two distinct groups of patients,significant differences existed in bone mineral density(BMD),vertebral compression degree,prevalence of intravertebral cleft(IVF),type of bone cement used,and cement distribution patterns.Results from binary univariate regression analysis revealed that lower BMD,the presence of IVF,cleft distribution of bone cement,and higher vertebral compression degree were all significantly associated with further height loss.Notably,the use of mineralized collagen modified-poly(methyl methacrylate)bone cement was associated with a significant reduction in the risk of further height loss.In multivariate regression analysis,lower BMD and the presence of IVF remained significantly associated with further height loss.CONCLUSION Further height loss following PVP in OVCF patients is influenced by a complex interplay of factors,especially lower BMD and the presence of IVF.These findings underscore the importance of assessing and managing these factors when addressing height loss following PVP in OVCF patients.展开更多
目的:探讨术前预适应训练联合心理干预应用于老年骨质疏松性椎体压缩骨折(Osteoporotic vertebral body compression fractures,OVCF)经皮椎体后凸成形术(Percutaneous vertebral body kyphoplasty,PKP)手术患者的效果。方法:选取2021年...目的:探讨术前预适应训练联合心理干预应用于老年骨质疏松性椎体压缩骨折(Osteoporotic vertebral body compression fractures,OVCF)经皮椎体后凸成形术(Percutaneous vertebral body kyphoplasty,PKP)手术患者的效果。方法:选取2021年8月至2022年8月期间于我院就诊的老年OVCF患者90例,随机分为对照组和观察组,两组各45例。对照组给予常规心理干预,观察组在对照组基础上给予术前预适应训练干预,观察两组术中生命体征变化情况、功能障碍情况及疼痛情况。结果:两组患者心率(Heart rate,HR)、平均动脉压(Mean arterial pressure,MAP)水平均较入室时升高,观察组水平低于对照组(P<0.05);两组患者血氧饱和度(Oxygen saturation of blood,SpO_(2))水平均较入室时降低,观察组水平高于对照组(P<0.05);手术后3d,两组患者Oswestry功能障碍指数(Oswestry dysfunction index,ODI)各维度均较手术前降低,且观察组患者低于对照组(P<0.05);手术后1d,两组患者视觉模拟评分法(Visual analogue scales,VAS)疼痛评分均较手术前降低,且观察组患者低于对照组(P<0.05);两组患者手术后1d椎体高度比较差异无统计学意义。结论:术前预适应训练联合心理干预可以稳定老年OVCF患者PKP术中的生命体征情况,改善术后功能障碍情况,降低疼痛水平,且不会影响手术治疗效果。展开更多
文摘目的探讨骨质疏松性椎体压缩骨折(osteoporotic vertebral compression fracture,OVCF)患者腰骶区椎旁肌密度与椎体骨密度(vertebral bone mineral density,vBMD)之间的关系。方法回顾性分析了OVCF患者的前瞻性机构数据库(NCT05848167)。纳入2021年1月至2022年12月共167例患者资料,其中101例定量CT(quantitative computed tomography,QCT)检查资料可用的OVCF患者,女80例,男21例;女性中位年龄73(68.00,82.50)岁,男性中位年龄71(67.00,80.00)岁。在L_(3~5)椎体上终板水平进行椎旁肌密度和面积测量,并使用人工分割和定制编写的程序进行计算。利用QCT Pro软件在L_(1~2)水平进行vBMD测量和计算。按性别、年龄对所有分析进行分层分析。结果本研究发现男性患者的椎旁肌密度与vBMD有统计学相关。在调整年龄和性别后,L_(1~2)vBMD与L_(3)左侧多裂肌、L_(4)左侧竖脊肌、L_(4)右侧多裂肌、L_(5)左右双侧多裂肌密度之间存在统计学意义上的正相关,而在女性患者中未发现显著相关性。结论男性多裂肌密度和vBMD在不同的腰椎水平存在显著的正相关,这与年龄无关。在解释腰椎椎体和椎旁肌关联时,应考虑性别及区域性差异。
基金the 2022 Panzhihua City Science and Technology Guidance Plan Project,No.2022ZD-S-35.
文摘BACKGROUND Osteoporotic vertebral compression fractures(OVCFs)contribute to back pain and functional limitations in older individuals,with percutaneous vertebroplasty(PVP)emerging as a minimally invasive treatment.However,further height loss post-PVP prompts investigation into contributing factors.AIM To investigate the factors associated with further height loss following PVP with cement augmentation in OVCF patients.METHODS A total of 200 OVCF patients who underwent successful PVP between January 2021 and December 2022 were included in this study.“Further height loss”during 1 year of follow-up in OVCF patients with bone edema was defined as a vertical height loss of≥4 mm.The study population was divided into two groups for analysis:The“No Further Height Loss group(n=179)”and the“Further Height Loss group(n=21).”RESULTS In comparing two distinct groups of patients,significant differences existed in bone mineral density(BMD),vertebral compression degree,prevalence of intravertebral cleft(IVF),type of bone cement used,and cement distribution patterns.Results from binary univariate regression analysis revealed that lower BMD,the presence of IVF,cleft distribution of bone cement,and higher vertebral compression degree were all significantly associated with further height loss.Notably,the use of mineralized collagen modified-poly(methyl methacrylate)bone cement was associated with a significant reduction in the risk of further height loss.In multivariate regression analysis,lower BMD and the presence of IVF remained significantly associated with further height loss.CONCLUSION Further height loss following PVP in OVCF patients is influenced by a complex interplay of factors,especially lower BMD and the presence of IVF.These findings underscore the importance of assessing and managing these factors when addressing height loss following PVP in OVCF patients.
