SET8 (SET (lysine methyltransferase) domain containing 8) is a member of the SET domain-containing methyltransferasefamily that specifically targets H4K20 for monomethylation. It has been implicated in a diverse array...SET8 (SET (lysine methyltransferase) domain containing 8) is a member of the SET domain-containing methyltransferasefamily that specifically targets H4K20 for monomethylation. It has been implicated in a diverse arrayof biological processes, including controlling gene transcription[1;2], maintaining genome integrity[3;4], regulating cellcycle progression[5;6], and mediating DNA damage and repair[7;8]. In addition to targeting H4K20, SET8 is alsoreported in methylating the tumor suppressor p53 at lysine residue 382 (p53K382me1) and repressing p53-mediatedtranscriptional activation of target genes. In response to ionizing radiation, p53 regulates the transcription of genesin a diverse set of pathways including DNA repair, cell cycle arrest, and apoptosis[9]. Thus, we hypothesis thatSET8 may affect the cellular response to ionizing radiation by interacting with p53.展开更多
A novel dual-band ISGW cavity filter with enhanced frequency selectivity is proposed in this paper by utilizing a multi-mode coupling topology.Its cavity is designed to control the number of modes,and then the ports a...A novel dual-band ISGW cavity filter with enhanced frequency selectivity is proposed in this paper by utilizing a multi-mode coupling topology.Its cavity is designed to control the number of modes,and then the ports are determined by analyzing the coupling relationship between these selected modes.By synthesizing the coupling matrix of the filter,a nonresonating node(NRN)structure is introduced to flexibly tune the frequency of modes,which gets a dualband and quad-band filtering response from a tri-band filter no the NRN.Furthermore,a frequency selective surface(FSS)has been newly designed as the upper surface of the cavity,which significantly improves the bad out-of-band suppression and frequency selectivity that often exists in most traditional cavity filter designs and measurements.The results show that its two center frequencies are f01=27.50 GHz and f02=32.92GHz,respectively.Compared with the dual-band filter that there is no the FSS metasurface,the out-of-band suppression level is improved from measured 5 dB to18 dB,and its finite transmission zero(FTZ)numbers is increased from measured 1 to 4 between the two designed bands.Compared with the tri-band and quadband filter,its passband bandwidth is expanded from measured 1.17%,1.14%,and 1.13% or 1.31%,1.50%,0.56%,and 0.57% to 1.71% and 1.87%.In addition,the filter has compact,small,and lightweight characteristics.展开更多
文摘SET8 (SET (lysine methyltransferase) domain containing 8) is a member of the SET domain-containing methyltransferasefamily that specifically targets H4K20 for monomethylation. It has been implicated in a diverse arrayof biological processes, including controlling gene transcription[1;2], maintaining genome integrity[3;4], regulating cellcycle progression[5;6], and mediating DNA damage and repair[7;8]. In addition to targeting H4K20, SET8 is alsoreported in methylating the tumor suppressor p53 at lysine residue 382 (p53K382me1) and repressing p53-mediatedtranscriptional activation of target genes. In response to ionizing radiation, p53 regulates the transcription of genesin a diverse set of pathways including DNA repair, cell cycle arrest, and apoptosis[9]. Thus, we hypothesis thatSET8 may affect the cellular response to ionizing radiation by interacting with p53.
基金supported by the National key research and development program of China(No.2021YFB2900401)by the National Natural Science Foundation of China(No.61861046)+1 种基金the key Natural Science Foundation of shenzhen(No.JCYJ20220818102209020)the key research and development program of shenzhen(No.ZDSYS20210623091807023)。
文摘A novel dual-band ISGW cavity filter with enhanced frequency selectivity is proposed in this paper by utilizing a multi-mode coupling topology.Its cavity is designed to control the number of modes,and then the ports are determined by analyzing the coupling relationship between these selected modes.By synthesizing the coupling matrix of the filter,a nonresonating node(NRN)structure is introduced to flexibly tune the frequency of modes,which gets a dualband and quad-band filtering response from a tri-band filter no the NRN.Furthermore,a frequency selective surface(FSS)has been newly designed as the upper surface of the cavity,which significantly improves the bad out-of-band suppression and frequency selectivity that often exists in most traditional cavity filter designs and measurements.The results show that its two center frequencies are f01=27.50 GHz and f02=32.92GHz,respectively.Compared with the dual-band filter that there is no the FSS metasurface,the out-of-band suppression level is improved from measured 5 dB to18 dB,and its finite transmission zero(FTZ)numbers is increased from measured 1 to 4 between the two designed bands.Compared with the tri-band and quadband filter,its passband bandwidth is expanded from measured 1.17%,1.14%,and 1.13% or 1.31%,1.50%,0.56%,and 0.57% to 1.71% and 1.87%.In addition,the filter has compact,small,and lightweight characteristics.
