Deciphering the Hidden Secrets between the Early Skin Wrinkling & the Metabolic (X) Syndrome with the Possible Reversal of This Process at the Molecular Level

The aging process is a group of degenerative changes that physiologically occur in most of the people in the elderly. This affects one or more of the human body systems. The treatment of diseases related to the aging process has a huge impact on the economy of all nations. Aging of the skin comes on the top and despite that, the results of the already present lines of treatment are not always satisfactory. This acts as a stimulus for us to dig deeper to discover the root causes of the premature aging of the skin. This was simply caused by the accumulation of repeated minute damage to the internal structure skin. In other words, if the degree of minute damage is more than the capacity of the skin to repair, the repeated micro-damage is presented in the long run as a skin wrinkling. Moreover, the skin acts as a mirror that reflects the internal structures of the human body. Thus, the more degenerative changes in the human body systems, the more the skin could become wrinkled. Our strategy to prevent or at least slow down the aging process of the skin depends on 2 main steps;the 1st is to reduce the micro-damage as can as possible, and the 2nd is to enhance the capacity of tissue regeneration to be able to reverse the already present damaged skin. As the 2 processes are synchronized with each other, this strategy would be considered the ideal for prevention of skin wrinkling especially premature ones. This not only reverses premature skin wrinkling but also protects it from future wrinklings. This review sharply pointed out the role of the functional collagen of the dermal layer of the skin in the prevention of skin wrinklings. Therefore, it would be the target to study how collagen works in the complex machinery of the dermal layer of the skin. This concept deeply believes that the recovery of dermal collagen has a much better effect than simply ingesting collagen or receiving a topical collagen booster. .

The contribution of steel wallposts to out-of-plane behavior of non-structural masonry walls

For years,non-structural masonry walls have received little attention by code developers and professional engineers.Recently,significant efforts have been made to shed more light on out-of-plane(OOP)behavior of non-structural masonry walls.In updated provisions of the Iranian seismic code,bed joint reinforcements(BJRs)and steel wallposts have been suggested for use.BJRs are horizontal reinforcements;steel wallposts are vertical truss-like elements intended to provide additional OOP restraints for a wall.The contribution of BJRs has previously been investigated by the authors.This study is devoted to investigating the contribution of steel wallposts to the OOP behavior of non-structural masonry walls.Using pre-validated 3D finite element(FE)models,the OOP behavior of 180 non-structural masonry walls with varying configurations and details are investigated.The OOP pressure-displacement curve,ultimate strength,the response modification factor,and the cracking pattern are among the results presented in this study.It is found that steel wallposts,especially those with higher rigidity,can improve the OOP strength of the walls.The contribution of wallposts in the case of shorter length walls and walls with an opening are more pronounced.Results also indicate that masonry walls with wallpost generally have smaller modification factors compared to similar walls without wallpost.

Wrinkling in graded core/shell systems using symplectic formulation

Wrinkles in flat graded elastic layers have been recently described as a timevarying Hamiltonian system by the energy method.Cylindrical core/shell structures can also undergo surface instabilities under the external pressure.In this study,we show that by treating the radial direction as a pseudo-time variable,the graded core/shell system with radially decaying elastic properties can also be described within the symplectic framework.In combination with the shell buckling equation,the present paper addresses the surface wrinkling of graded core/shell structures subjected to the uniform external pressure by solving a series of ordinary differential equations with varying coefficients.Three representative gradient distributions are showcased,and the predicted critical pressure and critical wave number are verified by finite element simulations.The symplectic framework provides an efficient and accurate approach to understand the surface instability and morphological evolution in curved biological tissues and engineered structures.

Stretchable,Transparent,and Ultra-Broadband Terahertz Shielding Thin Films Based on Wrinkled MXene Architectures

With the increasing demand for terahertz(THz)technology in security inspection,medical imaging,and flexible electronics,there is a significant need for stretchable and transparent THz electromagnetic interference(EMI)shielding materials.Existing EMI shielding materials,like opaque metals and carbon-based films,face challenges in achieving both high transparency and high shielding efficiency(SE).Here,a wrinkled structure strategy was proposed to construct ultra-thin,stretchable,and transparent terahertz shielding MXene films,which possesses both isotropous wrinkles(height about 50 nm)and periodic wrinkles(height about 500 nm).Compared to flat film,the wrinkled MXene film(8 nm)demonstrates a remarkable 36.5%increase in SE within the THz band.The wrinkled MXene film exhibits an EMI SE of 21.1 dB at the thickness of 100 nm,and an average EMI SE/t of 700 dBμm^(−1)over the 0.1-10 THz.Theoretical calculations suggest that the wrinkled structure enhances the film’s conductivity and surface plasmon resonances,resulting in an improved THz wave absorption.Additionally,the wrinkled structure enhances the MXene films’stretchability and stability.After bending and stretching(at 30%strain)cycles,the average THz transmittance of the wrinkled film is only 0.5%and 2.4%,respectively.The outstanding performances of the wrinkled MXene film make it a promising THz electromagnetic shielding materials for future smart windows and wearable electronics.

Highly Thermoconductive,Strong Graphene‑Based Composite Films by Eliminating Nanosheets Wrinkles

Graphene-based thermally conductive composites have been proposed as effective thermal management materials for cooling high-power electronic devices.However,when flexible graphene nanosheets are assembled into macroscopic thermally conductive composites,capillary forces induce shrinkage of graphene nanosheets to form wrinkles during solution-based spontaneous drying,which greatly reduces the thermal conductivity of the composites.Herein,graphene nanosheets/aramid nanofiber(GNS/ANF)composite films with high thermal conductivity were prepared by in-plane stretching of GNS/ANF composite hydrogel networks with hydrogen bonds andπ-πinteractions.The in-plane mechanical stretching eliminates graphene nanosheets wrinkles by suppressing inward shrinkage due to capillary forces during drying and achieves a high in-plane orientation of graphene nanosheets,thereby creating a fast in-plane heat transfer channel.The composite films(GNS/ANF-60 wt%)with eliminated graphene nanosheets wrinkles showed a significant increase in thermal conductivity(146 W m^(−1)K^(−1))and tensile strength(207 MPa).The combination of these excellent properties enables the GNS/ANF composite films to be effectively used for cooling flexible LED chips and smartphones,showing promising applications in the thermal management of high-power electronic devices.

Experiment and evaluation of wrinkling strain in a corner tensioned square membrane

Prediction of wrinkling characteristics is strongly correlated with the strain perpendicular to wrinkling direc- tion. In this paper, the strain field of wrinkled membrane is tested by VIC-3D system based on the digital image correlation technique. Experimental results are validated by the tension wrinkling simulation. The experimental strain perpendicular to wrinkling direction is analyzed in depth. The wrinkling strain of a square wrinkled membrane under corner tension is extracted from experimental strain perpendicular to wrinkling direction. A quantitative characterization format of the experimental wrinkling strain is proposed. A modified prediction method of wrinkling amplitude is presented based on the experimental wrinkling strain. The re- sults show that the precision of modified prediction model has improved 13.2% compared with the classical prediction model. The results reveal that the modified model can give an accurate prediction of the wrinkling amplitude.

Nonlinear analysis of photo-induced wrinkling of glassy twist nematic films on compliant substrates

A kinetics approach is developed for the geometrically nonlinear analysis of photo-induced wrinkling of glassy twist nematic films on soft elastic substrates.In this way,the problem is reduced to finding the steady state of an overdamped evolution system according to a kinetic law,rather than directly solving the coupled nonlinear equations.This enables one to account for the complicated director distribution and obtain the precise wrinkling morphology of the film.Though the approach proposed here is for a twist nematic film,it can be extended to study glassy nematic films with other director distributions.

A study on wrinkling characteristics and dynamic mechanical behavior of membrane

An eigenvalue method considering the membrane vibration of wrinkling out-of-plane deformation is introduced, and the stress distributing rule in membrane wrinkled area is analyzed. A dynamic analytical model of rectangular shear wrinkled membrane and its numerical analysis approach are also developed. Results indicate that the stress in wrinkled area is not uniform, i.e. it is larger in wrinkling wave peaks along wrinkles and two ends of wrinkle in vertical direction. Vibration modes of wrinkled membrane are strongly correlated with the wrinkling configurations. The rigidity is larger due to the heavier stress in the part of wrinkling wave peaks. Therefore, wave peaks are always located at the node lines of vibration mode. The vibration frequency obviously increases with the vibration of wave peaks.

Analysis on membrane wrinkling using stress extremum method

A stress extremum method is developed based on Von Karman equations for analysis of membrane wrinkles in this paper. A mechanical model is also established for analyzing shear membrane wrinkles. Expressions of wrinkling wavelength,amplitude and angle are obtained in terms of the stress extremum method. A numerical analysis approach-directly disturbing method is proposed to analyze the configuration parameters of shear membrane wrinkles by introducing out-of-plane disturbing forces to trigger wrinkle formation,while it timely removes the applied forces in order to eliminate the effect of disturbing forces on analytical results. The simulation results agree well with analytical results,which demonstrate that the proposed approach is capable for analyzing the membrane wrinkles with good accuracy.

Large deformation and wrinkling analyses of bimodular structures and membranes based on a peridynamic computational framework

In this paper,the quasi-static large deformation,wrinkling and fracture behaviors of bimodular structures and membranes are studied with an implicit bond-based peridynamic computational framework.Firstly,the constant and tangential stiffness matrices of the implicit peridynamic formulations for the nonlinear problems are derived,respectively.The former is con structed from the linearization of the bond strain on the basis of the geometric approximation while the latter is established according to the linearization of the pairwise force by using first-order Taylor’s expansion.Then,a bimodular material model in peridynamics is developed,in which the tensile or compressive behavior of the material at each point is conveniently described by the tensile or compressive states of the bonds in its neighborhood.Moreover,the bimodular material model is extended to deal with the wrinkling and fracture problems of membranes by setting the compressive micro-modulus to be zero.In addition,the incremental-iterative algorithm is adopted to obtain the convergent solutions of the nonlinear problems.Finally,several representative numerical examples are presented and the results demonstrate the accuracy and efficiency of the proposed method for the large deformation,wrinkling and fracture analyses of bimodular structures and membranes.

Bioinspired Multiscale Wrinkling Patterns on Curved Substrates:An Overview

The surface wrinkling of biological tissues is ubiquitous in nature.Accumulating evidence suggests that the mechanical force plays a significant role in shaping the biological morphologies.Controlled wrinkling has been demonstrated to be able to spontaneously form rich multiscale patterns,on either planar or curved surfaces.The surface wrinkling on planar substrates has been investigated thoroughly during the past decades.However,most wrinkling morphologies in nature are based on the curved biological surfaces and the research of controllable patterning on curved substrates still remains weak.The study of wrinkling on curved substrates is critical for understanding the biological growth,developing threedimensional(3D)or four-dimensional(4D)fabrication techniques,and creating novel topographic patterns.In this review,fundamental wrinkling mechanics and recent advances in both fabrications and applications of the wrinkling patterns on curved substrates are summarized.The mechanics behind the wrinkles is compared between the planar and the curved cases.Beyond the film thickness,modulus ratio,and mismatch strain,the substrate curvature is one more significant parameter controlling the surface wrinkling.Curved substrates can be both solid and hollow with various 3D geometries across multiple length scales.Up to date,the wrinkling morphologies on solid/hollow core-shell spheres and cylinders have been simulated and selectively produced.Emerging applications of the curved topographic patterns have been found in smart wetting surfaces,cell culture interfaces,healthcare materials,and actuators,which may accelerate the development of artificial organs,stimuli-responsive devices,and micro/nano fabrications with higher dimensions.

A new model for wrinkling and collapse analysis of membrane inflated beam

A new model is proposed to accurately predict the wrinkling and collapse loads of a membrane inflated beam. In this model, the pressure effects are considered and a modified factor is introduced to obtain an accurate prediction. The former is achieved by modifying the pressure-related structural parameters based on elastic small strain considerations, and the modified factor is determined by our test data. Compared with previous models and our test data, the present model, named as shell-membrane model, can accurately predict the wrinkling and collapse loads of membrane inflated beams.

Progressive Damage Analysis(PDA)of Carbon Fiber Plates with Out-of-Plane Fold under Pressure

The out-of-plane fold is a common defect of composite materials during the manufacturing process and will greatly affect the compressive strength as well as the service life.Making it of great importance to investigate the influence of out-of-plane defects to the compressive strength of laminate plates of composite materials,and to understand the patterns of defect evolution.Therefore,the strip method is applied in this article to create out-of-plane defects with different aspect ratios in laminated plates of composite materials,and a compressive performance test is conducted to quantify the influence of out-of-plane defects.The result shows that the compressive strength becomes weaker with a greater aspect ratio.When the highest aspect ratio is set to 0.12 in the experiment,the compressive strength reduces by 36.1%.Then we establish a 3-D progressive damage model based on continuum mechanics,and write it into the UMAT subroutine together with the 3-D Hashin criteria and the non-linear degradation criteria of materials.3-D solid modeling is performed for the samples with an out-of-plane fold based on ABAQUS,and progressive damage analysis is conducted to acquire the inplane evolution process of initial failure strength with different laminates.The experimental results agree well with the simulation results.

Exact Solutions and Mode Transition for Out-of-Plane Vibrations of Non-uniform Beams with Variable Curvature

The two coupled governing differential equations for the out-of-plane vibrations of non-uniform beams with variable curvature are derived via the Hamilton’s principle.These equations are expressed in terms of flexural and torsional displacements simultaneously.In this study,the analytical method is proposed.Firstly,two physical parameters are introduced to simplify the analysis.One derives the explicit relations between the flexural and the torsional displacements which can also be used to reduce the difficulty in experimental measurements.Based on the relation,the two governing characteristic differential equations with variable coefficients can be uncoupled into a sixth-order ordinary differential equation in terms of the flexural displacement only.When the material and geometric properties of the beam are in arbitrary polynomial forms,the exact solutions with regard to the outof-plane vibrations of non-uniform beams with variable curvature can be obtained by the recurrence formula.In addition,the mode transition mechanism is revealed and the influence of several parameters on the vibration of the non-uniform beam with variable curvature is explored.

Out-of-plane (SH) soil-structure interaction： a shear wall with rigid and flexible ring foundation

Soil-structure interaction （SSI） of a building and shear wall above a foundation in an elastic half-space has long been an important research subject for earthquake engineers and strong-motion seismologists. Numerous papers have been published since the early 1970s; however, very few of these papers have analytic closed-form solu- tions available. The soil-structure interaction problem is one of the most classic problems connecting the two dis- ciplines of earthquake engineering and civil engineering. The interaction effect represents the mechanism of energy transfer and dissipation among the elements of the dynamic system, namely the soil subgrade, foundation, and super- structure. This interaction effect is important across many structure, foundation, and subgrade types but is most pro- nounced when a rigid superstructure is founded on a rela- tively soft lower foundation and subgrade. This effect may only be ignored when the subgrade is much harder than a flexible superstructure： for instance a flexible moment frame superstructure founded on a thin compacted soil layer on top of very stiff bedrock below. This paper will study the interaction effect of the subgrade and the super- structure. The analytical solution of the interaction of a shear wall, flexible-rigid foundation, and an elastic half- space is derived for incident SH waves with various angles of incidence. It found that the flexible ring （soft layer） cannot be used as an isolation mechanism to decouple asuperstructure from its substructure resting on a shaking half-space.

Wrinkling behavior of magnesium alloy tube in warm hydroforming

In tube hydroforming with axial feeding,under the effect of coupled internal pressure and axial stress,wrinkles often occur and affect the forming results.Wrinkling behavior of an AZ31B magnesium alloy tube was experimentally investigated with different loading paths at different temperatures.Features of wrinkles,including shape,radius and width,were acquired from the experiments,as well as the thickness distribution.Numerical simulations were carried out to reveal the stress state during warm hydroforming,and then the strain history of material at the top and bottom of the wrinkles were analyzed according to the stress tracks and yielding ellipse.Finally,effects of loading paths on expansion ratio limit of warm hydroforming were analyzed.It is verified that at a certain temperature,expansion ratio limit can be increased obviously by applying a proper loading path and realizing enough axial feeding.

Controlled wrinkling analysis of thin films on gradient substrates

The paper investigates continuously changing wrinkle patterns of thin films bonded to a gradient substrate. Three types of gradient substrates including exponential, power-law, and symmetry models are considered. The Galerkin method is used to dis- cretize the governing equation of film bonded to gradient substrates. The wavelength and the normalized amplitude of the wrinkles for substrates of various material gradients are obtained. The numerical simulation based on the finite element method （FEM） is used to evolve the wrinkle patterns. The result agrees well with that of the analytical model. It is concluded that localization of wrinkle patterns strongly depends on the material gradient. The critical membrane force depends on both the minimum value of wrinkle stiffness and the gradient of wrinkle stiffness when the wrinkle stiffness is at its minimum. This work provides a better understanding for local wrinkle formation caused by gradient substrates.

Wrinkling analysis of creased rectangular membrane

In this paper,the wrinkle-crease interaction behavior of a rectangular membrane under edge tension is simulated.The creased membrane is modeled by using a Modified Two-Parameter model.In this model,two crease parameters,i.e.the effective modulus of creased membrane and the residual stress from creasing,are computed by using MacNeal's method that was firstly applied directly in a flat membrane with the local crease.We have proposed a method to solve the wrinkling computing issue of the creased membrane by using a Direct Perturb-Force technique in our previous work.Based on our method,the effects of crease location on the wrinkle-crease interaction behavior can be evaluated accurately.These results will be of great benefit to the analysis and the control of the wrinkles in the membrane structures.

Analytical study of wrinkling in thin-film-on-elastomer system with finite substrate thickness

Surface wrinkling, a film bonded on a pre-strained elastomeric substrate can form periodic wrinkling patterns, is a common phenomenon in daily life. In existing theoretical models, the film is much thinner than the substrate so that the substrate can be considered to be elastomeric with infinite thickness. In this paper, the effect of finite substrate thickness is analyzed theoretically for free boundary condition cases. Based on the minimum potential energy principle, a theoretical model is established, and the wave length and amplitude of the wrinkling pattern are obtained. When the thickness of the substrate is more than 200 times larger than the thickness of the film, the results of this study agree well with the results obtained from the previous models for infinite substrate thickness. However, for thin substrates, the effect of finite substrate thickness becomes significant. The model given in this paper accurately describes the effect of finite substrate thickness, providing important design guidelines for future thin-film-on-substrate systems such as stretchable electronic devices.

5-Aminolevulinic Acid Improves Water Content and Reduces Skin Wrinkling

5-Aminolevulinic acid (ALA) is a natural amino acid that is used as a raw material for the biosynthesis of red-blood-cell hemoglobin in humans and animals. ALA is the subject of research in a wide range of human health care fields, including skin care and medicine. This study investigated whether and to what extent cosmetics containing ALA (skin lotions and creams) improved facial-skin condition in women. As such, a double-blind controlled experiment was conducted among 45 women aged 47.0 ± 1.72 years. Participants were divided into two intervention groups, including those who used cosmetics containing ALA (C-ALA, n = 22) and those who used cosmetics without ALA (W-ALA, n = 23). Specifically, participants were instructed to use their assigned cosmetics twice per day (morning and evening) after washing their faces before each application. Inner skin condition and skin-water content were evaluated via VISIA-Evolution and Multi Display Devices at baseline and after four and eight weeks of use. The experiment lasted for a total of eight weeks. A baseline comparison at week four showed that skin moisture content increased significantly for the C-ALA group (p = 0.021). Further, wrinkling significantly decreased at week four among participants in the C-ALA group who were evaluated as having many wrinkles at baseline (p = 0.034). These findings suggest that cosmetics containing ALA have moisturizing effects and reduce wrinkling caused by dryness.