Twenty-four hour (circadian) rhythmicity is an important component of biological variability associated with studies relating to biomarkers of aging. Chronobiological testing techniques must be utilized because (1) ma...Twenty-four hour (circadian) rhythmicity is an important component of biological variability associated with studies relating to biomarkers of aging. Chronobiological testing techniques must be utilized because (1) many variables that are related to the modulation of metabolic output vary dramatically at different times of the day; (2) various experimental variable and treatment groups must be synchronized with environmental cues that control circadian rhythms; and (3) multiple circadian variables may interact together to modulate the rate of aging. The rhythm for physiological factors such as whole animal metabolic output, body temperature, heart rate, urine flow, potassium, etc. were found to be dissociated or altered by the senescence process; behavioral variables such as spontaneous activity, wheel running, feeding and drinking, verbal performance, as well as sleep-wakefulness rhythms, seem to be accurate predictors of biological age. Circadian rhythms for a variety of enzymes of intermediary metabolism which are directly associated with energy metabolism have been well documented. These well-defined rhythms of enzyme activity have also been shown to degenerate with aging. Rhythms tend to lose amplitude as activity falls with age and as a general loss of regulation (especially time of day where maximal activity might be found) of activity across the 24-h span occurs. As with behavioral variables, changes in enzyme rhythms appear to accurately predict aging. Generally speaking, the loss of temporal organization with age, characterized by decreased circadian amplitude, loose internal synchronization, and poor response to external environmental time queues, is associated with poor health states and decreased longevity. Temporal rhythms for whole animal parameters are highly correlated with molecular events, such as regulation of cellular metabolism. DNA repair, and gene expression. Automated data acquisition and process control systems will be required for future Chronobiological studies to develop biomarkers of aging.展开更多
An S band SLED-type pulse compressor has been manufactured by the Institute of High Energy Physics,Beijing, trying to reach 100 MW maximum input power, which means the output peak power is about 500 MW at the phase re...An S band SLED-type pulse compressor has been manufactured by the Institute of High Energy Physics,Beijing, trying to reach 100 MW maximum input power, which means the output peak power is about 500 MW at the phase reversal time. To improve the reliability at very high power, amplitude modulation and phase modulation with flat-top output are considered, and RF modulation studies on the S-band SLED are presented in this paper.Furthermore, a method is developed using the CST Microwave Studio transient solver to simulate the time response of the pulse compressor, which can verify the modulation theory. In addition, the experimental setup was constructed and the flat-top output obtained in low power tests. Both amplitude modulation and phase modulation methods can give flat-top output, and the average power gain for both methods is almost the same.展开更多
文摘Twenty-four hour (circadian) rhythmicity is an important component of biological variability associated with studies relating to biomarkers of aging. Chronobiological testing techniques must be utilized because (1) many variables that are related to the modulation of metabolic output vary dramatically at different times of the day; (2) various experimental variable and treatment groups must be synchronized with environmental cues that control circadian rhythms; and (3) multiple circadian variables may interact together to modulate the rate of aging. The rhythm for physiological factors such as whole animal metabolic output, body temperature, heart rate, urine flow, potassium, etc. were found to be dissociated or altered by the senescence process; behavioral variables such as spontaneous activity, wheel running, feeding and drinking, verbal performance, as well as sleep-wakefulness rhythms, seem to be accurate predictors of biological age. Circadian rhythms for a variety of enzymes of intermediary metabolism which are directly associated with energy metabolism have been well documented. These well-defined rhythms of enzyme activity have also been shown to degenerate with aging. Rhythms tend to lose amplitude as activity falls with age and as a general loss of regulation (especially time of day where maximal activity might be found) of activity across the 24-h span occurs. As with behavioral variables, changes in enzyme rhythms appear to accurately predict aging. Generally speaking, the loss of temporal organization with age, characterized by decreased circadian amplitude, loose internal synchronization, and poor response to external environmental time queues, is associated with poor health states and decreased longevity. Temporal rhythms for whole animal parameters are highly correlated with molecular events, such as regulation of cellular metabolism. DNA repair, and gene expression. Automated data acquisition and process control systems will be required for future Chronobiological studies to develop biomarkers of aging.
基金Supported by National Natural Science Foundation of China(11475201)
文摘An S band SLED-type pulse compressor has been manufactured by the Institute of High Energy Physics,Beijing, trying to reach 100 MW maximum input power, which means the output peak power is about 500 MW at the phase reversal time. To improve the reliability at very high power, amplitude modulation and phase modulation with flat-top output are considered, and RF modulation studies on the S-band SLED are presented in this paper.Furthermore, a method is developed using the CST Microwave Studio transient solver to simulate the time response of the pulse compressor, which can verify the modulation theory. In addition, the experimental setup was constructed and the flat-top output obtained in low power tests. Both amplitude modulation and phase modulation methods can give flat-top output, and the average power gain for both methods is almost the same.
