Supported by the National Natural Science Foundation of China,the research group led by Prof.Ye Lilin(叶丽林)and Prof.Wu Yuzhang at the Third Military Medical University,Prof.Qi Hai at Tsinghua University and Prof.Xu ...Supported by the National Natural Science Foundation of China,the research group led by Prof.Ye Lilin(叶丽林)and Prof.Wu Yuzhang at the Third Military Medical University,Prof.Qi Hai at Tsinghua University and Prof.Xu Jianqing at Fudan University recently reported a novel subset of effect or CD8 T cells.They demonstrated that this subset of cells plays a critical role in viral control during chronic infec-展开更多
The SoxC transcription factors （Sox4, Sox11, and Sox12） play important roles in the development of the vertebrate eye and retina. However, their expression and function during retinal and optic nerve regeneration re...The SoxC transcription factors （Sox4, Sox11, and Sox12） play important roles in the development of the vertebrate eye and retina. However, their expression and function during retinal and optic nerve regeneration remain elusive. In this study, we investigated the expression and possible functions of the SoxC genes after retinal and optic nerve injury in adult zebrafish. We found that among the five SoxC members, Soxllb was strongly induced in BrdU-positive cells in the inner nuclear layer （INL） after retinal injury, and morpholino-mediated Soxllb-knockdown significantly reduced the number of proliferating cells in the INL at 4 days post-injury. After optic nerve lesion, both Soxl la and Soxl lb were strongly expressed in retinal ganglion cells （RGCs）, and knockdown of both Soxl la and Soxllb inhibited RGC axon regrowth in retinal explants. Our study thus uncovered a novel expression pattern of SoxC family genes after retinal and optic nerve injury, and suggests that they have important functions during retinal and optic nerve regeneration.展开更多
Let W be the Weyl group of type F4. We explicitly describe a finite set of basic braid I＊-transformations and show that any two reduced I＊-expressions for a given involution in W can be transformed into each other t...Let W be the Weyl group of type F4. We explicitly describe a finite set of basic braid I＊-transformations and show that any two reduced I＊-expressions for a given involution in W can be transformed into each other through a series of basic braid/,-transformations. Our main result extends the earlier work on the Weyl groups of classical types （i.e., An, Bn, and Dn）.展开更多
文摘Supported by the National Natural Science Foundation of China,the research group led by Prof.Ye Lilin(叶丽林)and Prof.Wu Yuzhang at the Third Military Medical University,Prof.Qi Hai at Tsinghua University and Prof.Xu Jianqing at Fudan University recently reported a novel subset of effect or CD8 T cells.They demonstrated that this subset of cells plays a critical role in viral control during chronic infec-
基金supported by grants from National Natural Science Foundation of China(31401234)Natural Science Foundation of Jiangsu Province,China(BK20140428)+1 种基金the Basic Research Program of Education Department of Jiangsu Province,China(14KJB180019)the Science and Technology Project of Nantong Municipality,Jiangsu Province,China(MS22015002)
文摘The SoxC transcription factors （Sox4, Sox11, and Sox12） play important roles in the development of the vertebrate eye and retina. However, their expression and function during retinal and optic nerve regeneration remain elusive. In this study, we investigated the expression and possible functions of the SoxC genes after retinal and optic nerve injury in adult zebrafish. We found that among the five SoxC members, Soxllb was strongly induced in BrdU-positive cells in the inner nuclear layer （INL） after retinal injury, and morpholino-mediated Soxllb-knockdown significantly reduced the number of proliferating cells in the INL at 4 days post-injury. After optic nerve lesion, both Soxl la and Soxl lb were strongly expressed in retinal ganglion cells （RGCs）, and knockdown of both Soxl la and Soxllb inhibited RGC axon regrowth in retinal explants. Our study thus uncovered a novel expression pattern of SoxC family genes after retinal and optic nerve injury, and suggests that they have important functions during retinal and optic nerve regeneration.
文摘Let W be the Weyl group of type F4. We explicitly describe a finite set of basic braid I＊-transformations and show that any two reduced I＊-expressions for a given involution in W can be transformed into each other through a series of basic braid/,-transformations. Our main result extends the earlier work on the Weyl groups of classical types （i.e., An, Bn, and Dn）.
