VOLUMETRIC-SWEPT DISPLAY SYSTEM BASED ON HELIX ROTATING SCREEN AND DMD

Based on the helix rotating screen and the digital micro-mirror device （DMD）, the former proto of volumetric-swept display system is improved. The 3-D display system adopting a helix rotating screen to construct an imaging space meliorate the defects, such as the smaller image space, the fewer voxels and the severer voxel overlap dead zone caused by planar rotating screen. DMD with spatial light modular （SLM） technology increases the transmission bandwidth of 3-D data in the voxel activation subsystem and activate multi-voxel once time. The volumetric-swept system based on helix rotating screen and DMD is developed. The experimental results show that the image space, the vision dead zone, the voxels on slice, and the voxel activation capacity of the designed proto are superior to the plane rotating screen system.

Construction of a Multipurpose M13KE Phage Display System

In this study, a multipurpose M13KE phage display vector was constructed from wild-type M13KE phage for long peptide or protein display libraries without helper phage to expand the scope of targeted high-throughput screening. Based on the relationship between the structure and function of minor coat protein of wild-type MI3KE （wt-plII）, a truncated gene III （tglll） encoding minor coat protein from M13KE phage was cloned. A fusion gene fragment harboring a hw/tac promoter, signal peptide and C-terminal region sequence of gill was assembled with SOEing-PCR （splice-overlapping-extension polymerase chain reaction） method and inserted into M13KE vector. SDS-PAGE and Western blot analysis with anti-M13 pIII moneclonal antibody were employed to detect the expression of re- combinant protein, c-Myc and HA tag sequences were fused into the recombinant protein. The results showed that tglll was inserted into an unessential region of M13KE. According to the results of SDS-PAGE and Western blot with anti-M13 pIII antibody, pIII was expressed by wt-gIII and tgIII, glII harboring two tags ex- pressed both c-Myc and HA peptides using SDS-PAGE and Western blot with the corresponding monoclonal antibodies. In this study, a multipurpose M13KE phage display system was successfully constructed, which could express both short and long peptide libraries without helper phage. In future, the obtained M13KE phage display system may be used for targeted high-throughput screening of long peptide libraries without helper phage.

Liquid crystal Fresnel lens display

A novel see-through display with a liquid crystal lens array was proposed.A liquid crystal Fresnel lens display（LCFLD） with a holographic screen was demonstrated.The proposed display system has high efficiency,simple fabrication,and low manufacturing cost due to the absence of a polarizer and color filter.

Information Visualization Theorem for Battlefield Screen

Designing military screen (display) is not complicated in the past, the design should contains easiness of using, visibility and functionality. And it is important that contains all of the information what the system could be gotten. Today military display design can be valued by consideration of human’s cognition model. A few information, which operators of military display could easily miss, could bring critical loss. So the military display needs the ability to help operator decide the military decision with sufficient consideration of battlefield information in a short time. The information is considerably complicated because it has many military entities and many attributes for each entities. For this reason this research contains the methodology of information organization especially for visual information. When the operator use military display, the required information should be recognized at a glance and located where the operator can place his eye easily. Therefore, the display screen should efficiently organize and effectively transfer the information. This paper specifically proposes design methodology to effectively organize and visualize the information in the display screen. The theory of information visualization in a variety of fields already exist, but it has no established theory for the origin of the display screen design. Since the theory was selected to organize the military display interface design for the display screen of the battlefield situation existing information visualization theory.

User Centered Design for Battlefield Screen

This thesis paper is a brief summary of user centered design, (particularly in the situation of under the battlefield), which incorporates the related information after reviewing many other papers. A display screen user requires an ability to provide proper information while considering a variety of information in a short period. While operating the display screen, the user is heavily pressed for time as the missions are allocated through many different steps of orders. In addition, since a failure would cause fatal damage or cause further defeat, this increases the pressure of time. The right environment for operating a display screen is most useful when the user is in the most vulnerable time period or long-term continuous operation of the display screen. In that kind of sterile environment, the operating display screen is there to help the user’s decisions for the matter at hand, in this it should follow the user centered design and improve the user’s handiness and use. Furthermore, the information should be provided in accordance with the user's informational and perceptional process, and the capacity of the information process should be improved with the movement through each process and step. This thesis paper can be used as a reference material when designing the display screen in order to apply a user’s experiences.

Encoding and display technologies for combinatorial libraries in drug discovery:The coming of age from biology to therapy

Drug discovery is a sophisticated process that incorporates scientific innovations and cuttingedge technologies.Compared to traditional bioactivity-based screening methods,encoding and display technologies for combinatorial libraries have recently advanced from proof-of-principle experiments to promising tools for pharmaceutical hit discovery due to their high screening efficiency,throughput,and resource minimization.This review systematically summarizes the development history,typology,and prospective applications of encoding and displayed technologies,including phage display,ribosomal display,mRNA display,yeast cell display,one-bead one-compound,DNA-encoded,peptide nucleic acidencoded,and new peptide-encoded technologies,and examples of preclinical and clinical translation.We discuss the progress of novel targeted therapeutic agents,covering a spectrum from small-molecule inhibitors and nonpeptidic macrocycles to linear,monocyclic,and bicyclic peptides,in addition to antibodies.We also address the pending challenges and future prospects of drug discovery,including the size of screening libraries,advantages and disadvantages of the technology,clinical translational potential,and market space.This review is intended to establish a comprehensive high-throughput drug discovery strategy for scientific researchers and clinical drug developers.

数字视频ASIC中OSD系统的实现

介绍1款视频处理ASIC芯片中OSD系统的设计方案,先读取OSD内部SRAM中的属性和字符内容,然后控制电路根据属性将字符内容以RGB的形式表现出来,最后将OSD信息与视频内容进行α混合,从而可以在屏幕上得到OSD信息。该OSD系统用户自定义性强,使用改进的内部SRAM中1/2/4像素深度(BPP,Bits Per Pixel)字符或图形点阵的存储结构以提高字符或图形存储量,其具有闪烁、阴影、透明、单个字符宽高加倍、非线性放大、可编程的行列数和颜色等诸多功能。芯片在UMC0.18μm CMOS工艺下流片,其OSD系统的工作频率可达170 MHz。

Immersive autostereoscopic display based on curved screen and parallax barrier

In this Letter,we present a display system based on a curved screen and parallax barrier,which provides stereo images with a horizontal field of view of 360°without wearing any eyewear,to achieve an immersive autostereoscopic effect.The display principle and characteristics of this display system are studied theoretically in detail.Three consecutive pixels on a curved screen and parallax barrier form a display unit,which can generate separate viewing zones for the left and right eyes,respectively.Simulation and experimental results show that the non-crosstalk effect can be obtained in the viewing zones,which proves the effectiveness of this display system.This study provides some new ideas for the improvement of the autostereoscopic display and to enable envisioned applications in virtual reality technology.

360° light field 3D display system based on a triplet lenses array and holographic functional screen

A 360° light field 3D display system is presented, which consists of a liquid crystal display, a novel triplet lenses array, and a holographic functional screen （HFS）. The mapping relationship among pixels, 3D objects, and view- ing positions are investigated. The aberration analysis of the single lens is carried out both in the simulation and the experiment, which shows that it cannot provide an excellent 3D image to the viewers. In order to suppress the aberrations, ＂the primary aberration theory＂ and ＂the damped least-squares method＂ are used for optical analysis and lens design. A 3D image with aberration correction can be viewed around the proposed display system.

Development of novel-nanobody-based lateral-flow immunochromatographic strip test for rapid detection of recombinant human interferon a2b

Recombinant human interferon a2b(rhIFNa2b)is widely used as an antiviral therapy agent for the treatment of hepatitis B and hepatitis C.The current identification test for rhIFNa2b is complex.In this study,an anti-rhIFNa2b nanobody was discovered and used for the development of a rapid lateral flow strip for the identification of rhIFNa2b.RhIFNa2b was used to immunize an alpaca,which established a phage nanobody library.After five steps of enrichment,the nanobody I22,which specifically bound rhIFNa2b,was isolated and inserted into the prokaryotic expression vector pET28a.After subsequent purification,the physicochemical properties of the nanobody were determined.A semiquantitative detection and rapid identification assay of rhIFNa2b was developed using this novel nanobody.To develop a rapid test,the nanobody I22 was coupled with a colloidal gold to produce lateral-flow test strips.The developed rhIFNa2b detection assay had a limit of detection of 1 mg/mL.The isolation of I22 and successful construction of a lateral-flow immunochromatographic test strip demonstrated the feasibility of performing ligand-binding assays on a lateral-flow test strip using recombinant protein products.The principle of this novel assay is generally applicable for the rapid testing of other commercial products,with a great potential for routine use in detecting counterfeit recombinant protein products.

从IGAS 2018展望印刷业的智能化未来

在云计算的发展潜力、最大限度地提高效率、不断减少劳动力等因素的驱使下,包括小森(Komori)、好利用(Horizon)、利优比新菱(RMGT)、富士胶片(Fujifilm)、惠普(HP)、网屏(Screen)在内的很多公司,都在展会上宣传了智能工厂的概念。智能工厂的概念最早是从智慧工厂(英文直译为“黑暗工厂”)演化而来,意思是在工厂里根本没有工人。事实证明,如今智能印刷并非仅仅停留在概念上,近期澳大利亚有两家主要的印刷商安装了机器人在他们的工厂。例如,Southern Colour公司现在已经实现了没有操作人员制版;Active Display集团正在使用机器人为他们两款新的Onset宽幅平板打印机提供输送印刷材料和搬走印刷成品的工作。

Pre-process algorithm for satellite laser ranging data based on curve recognition from points cloud

The satellite laser ranging （SLR） data quality from the COMPASS was analyzed, and the difference between curve recognition in computer vision and pre-process of SLR data finally proposed a new algorithm for SLR was discussed data based on curve recognition from points cloud is proposed. The results obtained by the new algorithm are 85 % （or even higher） consistent with that of the screen displaying method, furthermore, the new method can process SLR data automatically, which makes it possible to be used in the development of the COMPASS navigation system.

Identification of HBsAg-specific antibodies from a mammalian cell displayed full-length human antibody library of healthy immunized donor

Hepatitis B immunoglobulin （HBIG） is important in the management of hepatitis B virus （HBV） infection. Aiming to develop recombinant monoclona# antibodies as an alternative to HBIG, we report the successful identification of HBV surface antigen （HBsAg）-specific antibodies from a full-length human antibody library displayed on mammalian cell surface. Using total RNA of peripheral blood mononuclear cells of a natively immunized donor as template, the antibody repertoire was amplified. Combining four-way ligation and the FIp recombinase-mediated integration （FIp-ln） system, we constructed a mammalian cell-based, fully human, full-length antibody display library in which each cell displayed only one kind of antibody molecule. By screening the cell library using fluorescence-activated cell sorting （FACS）, eight cell clones that displayed HBsAg-specific antibodies on cell surfaces were identified. DNA sequence analysis of the antibody genes revealed three unique antibodies. FACS data indicated that fluorescent strength of expression （FSE）, fluorescent strength of binding （FSB） and relative binding ability （RBA） were all different among them. These results demonstrated that by using our antibody mammalian display and screening platform, we can successfully identify antigen-specific antibodies from an immunized full-length antibody library. Therefore, this platform is very useful for the development of therapeutic antibodies.

Resolving display shape dependence issues on tabletops

Advances in display technologies are transforming the capabilities—and potential applications—of system interfaces. Previously, the overwhelming majority of systems have utilised rectangular displays;this may soon change with digital devices increasingly designed to be ubiquitous and pervasive, to facilitate frictionless human interaction. At present, software is invariably designed assuming it will be used with a display of a specific shape; however, there is an emerging demand for systems built around interacting with tabletop interfaces to be capable of handling a wide range of potential display shapes. In this paper,the design of software for use on a range of differently shaped tabletop displays is considered, proposing a novel but extensible technique that can be used to minimise the influence of the issues of using different display shapes. Furthermore, we present a study that applies the technique to adapt several software applications to several different display shapes.

Javelin:an access and manipulation interface for large displays

We describe a user interface and interaction technique,named'Javelin',designed for large display environments.It provides quick access to random screen regions and manipulation methods for screen widgets which are difficult or impossible to reach.It consists of a dynamic global thumbnail,a touchpad widget that drives the screen cursor,and a teleport widget in which interactions are transferred to its target screen region.Javelin can be easily integrated into many programs to optimize their interaction performance in large screens.The experiment and user study show that Javelin can extend user access field and enhance widget manipulation in large displays.