以4,4'-二氨基-二苯胺-2-磺酸代替苯胺,与1-羟基-7-氨基-3,6-二萘磺酸、间苯二胺、苯胺等合成无致癌作用的环保型黑色直接染料。探索了合成工艺及反应条件,并对其进行耐酸、耐碱等性能测试,用常规染色工艺对皮革进行染色应用。结果...以4,4'-二氨基-二苯胺-2-磺酸代替苯胺,与1-羟基-7-氨基-3,6-二萘磺酸、间苯二胺、苯胺等合成无致癌作用的环保型黑色直接染料。探索了合成工艺及反应条件,并对其进行耐酸、耐碱等性能测试,用常规染色工艺对皮革进行染色应用。结果表明,染料的上染率较高,染料的耐皂洗牢度和耐日晒牢度与直接黑L-3BG相当。产品中未含有22种致癌芳香胺,染料本身也无致癌作用,在碱性条件下不会分解出致癌芳香胺,是符合ECO-Tex Standard 100要求的新型染料。展开更多
Inflammatory bowel disease(IBD),the most important being Crohn's disease and ulcerative colitis,results from chronic dysregulation of the mucosal immune system in the gastrointestinal tract.Although the pathogenes...Inflammatory bowel disease(IBD),the most important being Crohn's disease and ulcerative colitis,results from chronic dysregulation of the mucosal immune system in the gastrointestinal tract.Although the pathogenesis of IBD remains unclear,it is widely accepted that genetic,environmental,and immunological factors are involved.Recent studies suggest that intestinal epithelial defenses are important to prevent inflammation by protecting against microbial pathogens and oxidative stresses.To investigate the etiology of IBD,animal models of experimental colitis have been developed and are frequently used to evaluate new anti-inflammatory treatments for IBD.Several models of experimental colitis that demonstrate various pathophysiological aspects of the human disease have been described.In this manuscript,we review the characteristic features of IBD through a discussion of the various chemically induced experimental models of colitis(e.g.dextran sodium sulfate-,2,4,6-trinitrobenzene sulfonic acid-,oxazolone-,acetic acid-,and indomethacin-induced models).We also summarize some regulatory and pathogenic factors demonstrated by these models that can,hopefully,be exploited to develop future therapeutic strategies against IBD.展开更多
In the presence of p-toluene sulfonic acid (TSA) as a dopant, polyaniline (PAni) nanofibers, (about 80^-65 nm in diameter) were successfully synthesized with a chemical template-free method. It was found that the form...In the presence of p-toluene sulfonic acid (TSA) as a dopant, polyaniline (PAni) nanofibers, (about 80^-65 nm in diameter) were successfully synthesized with a chemical template-free method. It was found that the formation probability, morphology, and diameter of the resulting PAni-TSA nanofibers were sensitive to the synthetic conditions, such as reaction temperature, the molar ratio of TSA to aniline, and the concentration of TSA in the polymerization media. The molecular structure was characterized by using the FT-IR, Raman spectra and X-ray diffraction, which shows that the main chain structure of PAni-TSA nanofibers was in agreement with that of granular PAni.展开更多
文摘以4,4'-二氨基-二苯胺-2-磺酸代替苯胺,与1-羟基-7-氨基-3,6-二萘磺酸、间苯二胺、苯胺等合成无致癌作用的环保型黑色直接染料。探索了合成工艺及反应条件,并对其进行耐酸、耐碱等性能测试,用常规染色工艺对皮革进行染色应用。结果表明,染料的上染率较高,染料的耐皂洗牢度和耐日晒牢度与直接黑L-3BG相当。产品中未含有22种致癌芳香胺,染料本身也无致癌作用,在碱性条件下不会分解出致癌芳香胺,是符合ECO-Tex Standard 100要求的新型染料。
基金National Institute of Health grants,No. DK64289,DK74454,and DK43351),IBD grants from the Eli and Edythe Broad Medical Foundation
文摘Inflammatory bowel disease(IBD),the most important being Crohn's disease and ulcerative colitis,results from chronic dysregulation of the mucosal immune system in the gastrointestinal tract.Although the pathogenesis of IBD remains unclear,it is widely accepted that genetic,environmental,and immunological factors are involved.Recent studies suggest that intestinal epithelial defenses are important to prevent inflammation by protecting against microbial pathogens and oxidative stresses.To investigate the etiology of IBD,animal models of experimental colitis have been developed and are frequently used to evaluate new anti-inflammatory treatments for IBD.Several models of experimental colitis that demonstrate various pathophysiological aspects of the human disease have been described.In this manuscript,we review the characteristic features of IBD through a discussion of the various chemically induced experimental models of colitis(e.g.dextran sodium sulfate-,2,4,6-trinitrobenzene sulfonic acid-,oxazolone-,acetic acid-,and indomethacin-induced models).We also summarize some regulatory and pathogenic factors demonstrated by these models that can,hopefully,be exploited to develop future therapeutic strategies against IBD.
文摘In the presence of p-toluene sulfonic acid (TSA) as a dopant, polyaniline (PAni) nanofibers, (about 80^-65 nm in diameter) were successfully synthesized with a chemical template-free method. It was found that the formation probability, morphology, and diameter of the resulting PAni-TSA nanofibers were sensitive to the synthetic conditions, such as reaction temperature, the molar ratio of TSA to aniline, and the concentration of TSA in the polymerization media. The molecular structure was characterized by using the FT-IR, Raman spectra and X-ray diffraction, which shows that the main chain structure of PAni-TSA nanofibers was in agreement with that of granular PAni.
