p53 gene plays an important role in apoptosis, which is necessary for successful invasion of trophoblast cells. The change from an arginine(Arg) to a proline(Pro) at codon 72 can influence the biological activity ...p53 gene plays an important role in apoptosis, which is necessary for successful invasion of trophoblast cells. The change from an arginine(Arg) to a proline(Pro) at codon 72 can influence the biological activity of p53, which predisposes to an increased risk of recurrent spontaneous abortion(RSA). In order to investigate the association between p53 polymorphism at codon 72 and RSA, we conducted this meta-analysis. Pubmed, Embase and Web of science were used to identify the eligible studies. Odds ratio(OR) with 95% confidence interval(CI) was used to evaluate the strength of the association. Six studies containing 937 cases of RSA and 830 controls were included, and there was one study deviated from Hardy-Weinberg equilibrium(HWE). There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model(Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14–2.24) and co-dominant model(Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02–2.12) whether the study that was deviated from HWE was eliminated or not. A significant association was observed in allelic model(Pro vs. Arg; OR=1.28, 95% CI: 1.04–1.57) after exclusion of the study that was deviated from HWE. No association was noted in recessive model(Pro/Pro+Pro/Arg vs. Arg/Arg; OR=1.05, 95% CI: 0.86–1.30) and co-dominant model(Pro/Arg vs. Arg/Arg; OR=0.96, 95% CI: 0.77–1.19). Subgroup analysis by ethnicity also indicated a significant association between p53 polymorphism at codon 72 and RSA in Caucasian group. No heterogeneity and publication bias were found. Our meta-analysis implied that p53 polymorphism at codon 72 carries high maternal risk of RSA.展开更多
Aim: To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk. We focus on allele variants of low-penetrance genes associated with cell control, ...Aim: To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk. We focus on allele variants of low-penetrance genes associated with cell control, the detoxification processes and smoking. Methods: In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk. Results: The joint risk for smokers carrying Pro^* and MI^*, Pro^* and GSTM1null or GSTM1 null and CYP1A1 MI^* variants was significantly higher (odds ratio [OR]: 13.13, 95% confidence interval [CI]: 2.41-71.36; OR: 3.97, 95% CI: 1.13-13.95 and OR: 6.87, 95% CI: 1.68-27.97, respectively) compared with that for the reference group, and for non-smokers was not significant. OR for combinations among p53cd72, GSTM1 and CYP1A1 M1 in smokers were positively and significantly associated with prostate cancer risk compared with non-smokers and compared with the putative lowest risk group (OR: 8.87, 95% CI: 1.25-62.71). Conclusion: Our results suggest that a combination of p53cd72, CYP1A1, GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population, which means that smokers carrying susceptible genotypes might have a significantly higher risk than those carrying non-susceptible genotypes.展开更多
Aim:To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk.We focus on allele variants of low-penetrance genes associated with cell control,the ...Aim:To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk.We focus on allele variants of low-penetrance genes associated with cell control,the detoxifica- tion processes and smoking.Methods:In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk.Results:The joint risk for smokers carrying Pro* and Ml*,Pro* and GSTMlnull or GSTM1 null and CYP1A1 Ml* variants was significantly higher (odds ratio [OR]:13.13.95% confidence interval [CI]:2.41-71.36;OR:3.97,95% CI:1.13-13.95 and OR:6.87. 95% CI:1.68-27.97,respectively)compared with that for the reference group,and for non-smokers was not significant. OR for combinations among p53cd72,GSTM1 and CYP1A1 M1 in smokers were positively and significantly associated with prostate cancer risk compared with non-smokers and compared with the putative lowest risk group(OR:8.87,95% CI:1.25-62.71).Conclusion:Our results suggest that a combination of p53cd72,CYP1A1,GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population,which means that smokers carrying susceptible genotypes might have a significantly higher risk than those carrying non-susceptible genotypes.展开更多
基金supported by The National Science and Technology Pillar of China program during the Twelfth Five-Year Plan Period(No.2014BAI 05B05)
文摘p53 gene plays an important role in apoptosis, which is necessary for successful invasion of trophoblast cells. The change from an arginine(Arg) to a proline(Pro) at codon 72 can influence the biological activity of p53, which predisposes to an increased risk of recurrent spontaneous abortion(RSA). In order to investigate the association between p53 polymorphism at codon 72 and RSA, we conducted this meta-analysis. Pubmed, Embase and Web of science were used to identify the eligible studies. Odds ratio(OR) with 95% confidence interval(CI) was used to evaluate the strength of the association. Six studies containing 937 cases of RSA and 830 controls were included, and there was one study deviated from Hardy-Weinberg equilibrium(HWE). There was a significant association between p53 polymorphism at codon 72 and RSA in recessive model(Pro/Pro vs. Pro/Arg+Arg/Arg; OR=1.60, 95% CI: 1.14–2.24) and co-dominant model(Pro/Pro vs. Arg/Arg; OR=1.47, 95% CI: 1.02–2.12) whether the study that was deviated from HWE was eliminated or not. A significant association was observed in allelic model(Pro vs. Arg; OR=1.28, 95% CI: 1.04–1.57) after exclusion of the study that was deviated from HWE. No association was noted in recessive model(Pro/Pro+Pro/Arg vs. Arg/Arg; OR=1.05, 95% CI: 0.86–1.30) and co-dominant model(Pro/Arg vs. Arg/Arg; OR=0.96, 95% CI: 0.77–1.19). Subgroup analysis by ethnicity also indicated a significant association between p53 polymorphism at codon 72 and RSA in Caucasian group. No heterogeneity and publication bias were found. Our meta-analysis implied that p53 polymorphism at codon 72 carries high maternal risk of RSA.
文摘Aim: To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk. We focus on allele variants of low-penetrance genes associated with cell control, the detoxification processes and smoking. Methods: In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk. Results: The joint risk for smokers carrying Pro^* and MI^*, Pro^* and GSTM1null or GSTM1 null and CYP1A1 MI^* variants was significantly higher (odds ratio [OR]: 13.13, 95% confidence interval [CI]: 2.41-71.36; OR: 3.97, 95% CI: 1.13-13.95 and OR: 6.87, 95% CI: 1.68-27.97, respectively) compared with that for the reference group, and for non-smokers was not significant. OR for combinations among p53cd72, GSTM1 and CYP1A1 M1 in smokers were positively and significantly associated with prostate cancer risk compared with non-smokers and compared with the putative lowest risk group (OR: 8.87, 95% CI: 1.25-62.71). Conclusion: Our results suggest that a combination of p53cd72, CYP1A1, GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population, which means that smokers carrying susceptible genotypes might have a significantly higher risk than those carrying non-susceptible genotypes.
文摘Aim:To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk.We focus on allele variants of low-penetrance genes associated with cell control,the detoxifica- tion processes and smoking.Methods:In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk.Results:The joint risk for smokers carrying Pro* and Ml*,Pro* and GSTMlnull or GSTM1 null and CYP1A1 Ml* variants was significantly higher (odds ratio [OR]:13.13.95% confidence interval [CI]:2.41-71.36;OR:3.97,95% CI:1.13-13.95 and OR:6.87. 95% CI:1.68-27.97,respectively)compared with that for the reference group,and for non-smokers was not significant. OR for combinations among p53cd72,GSTM1 and CYP1A1 M1 in smokers were positively and significantly associated with prostate cancer risk compared with non-smokers and compared with the putative lowest risk group(OR:8.87,95% CI:1.25-62.71).Conclusion:Our results suggest that a combination of p53cd72,CYP1A1,GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population,which means that smokers carrying susceptible genotypes might have a significantly higher risk than those carrying non-susceptible genotypes.