目的探讨P53基因密码子72多态性与大肠癌风险的相关性。方法全面检索Pub Med、Medline、EMbase、CBM、CNKI、万方和维普等数据库。检索时间从建库至2014年2月,收集P53基因密码子72多态性与大肠癌易感性的病例对照研究。采用Rev Man 5.2...目的探讨P53基因密码子72多态性与大肠癌风险的相关性。方法全面检索Pub Med、Medline、EMbase、CBM、CNKI、万方和维普等数据库。检索时间从建库至2014年2月,收集P53基因密码子72多态性与大肠癌易感性的病例对照研究。采用Rev Man 5.2软件计算合并效用量OR及其95%CI。结果共纳入25个研究,其中有6 753例患者,8 562例对照者。Meta分析发现,在各遗传模型中,隐性模型PP vs AP+AA中P53基因密码子72多态性与大肠癌发生风险有明显相关性,其余基因模型中P53基因密码子72多态性与大肠癌发生风险无明显相关性。结论在PP vs AP+AA遗传模型中,P53基因密码子72多态性与大肠癌风险性显著相关。展开更多
目的:运用荟萃分析方法研究肿瘤抑制因子p53基因密码子72位点多态性与口腔癌易感性的发生风险。方法:检索维普(VIP)、中国知网(CNKI)、万方、中国生物医学文献数据库(CBM)、PubMed、Embase、WebofScience中有关p53基因密码子72位点多态...目的:运用荟萃分析方法研究肿瘤抑制因子p53基因密码子72位点多态性与口腔癌易感性的发生风险。方法:检索维普(VIP)、中国知网(CNKI)、万方、中国生物医学文献数据库(CBM)、PubMed、Embase、WebofScience中有关p53基因密码子72位点多态性与口腔癌易感性关联研究的文献,以比值比(odds ratio,OR)和95%CI为效应指标,应用STATA 14软件和RevMan5进行荟萃分析,并对发表偏倚及敏感性分析进行检验。结果:纳入16个病例对照研究,口腔癌病例组共计2317例,正常对照组共计2933例。荟萃分析结果显示:在总人群中,p53基因密码子72位点基因多态性与口腔癌风险之间没有显著关联(Pro vs Arg OR=1.03,95%CI:0.887~1.195;Arg Pro+ProPro vs ArgArg OR=0.957,95%CI:0.847~1.081;ProPro vs ArgArg+ArgPro OR=1.082,95%CI:0.835~1.401;ProProvsArg ArgOR=1.059,95%CI:0.783~1.433;ArgProvsArg ArgOR=0.946,95%CI:0.831~1.076;ArgArg+ProProvsArgProOR=0.943,95%CI:0.842~1.055)。针对种族和对照人群来源设计的亚组分析结果也显示p53基因密码子72多态性与口腔癌风险之间没有显著相关性。结论:p53基因密码子72位点多态性与口腔癌的易感性没有直接关联,p53基因多态性可能不是口腔癌易感性的独立影响因素。展开更多
AIM： To evaluate the potential association between p53 codon 72 polymorphism and sporadic colorectal adenocarcinoma development, and human papillornavirus （HPV） infection. METHODS： One-hundred and nine controls an...AIM： To evaluate the potential association between p53 codon 72 polymorphism and sporadic colorectal adenocarcinoma development, and human papillornavirus （HPV） infection. METHODS： One-hundred and nine controls and 53 patients with colon cancer from the city of La Plata, Argentina were analyzed, p53 codon 72 genotypes and HPV infection were identified using allele-specific polymerase chain reaction and nested polymerase chain reaction, respectively. RESULTS： The differences in the distribution ofp53 codon 72 polymorphisrn between the cases and controls were statistically significant. The arginine allele had a prevalence of 0.65 in controls and 0.77 in cases. The corresponding odds ratio for the homozygous arginine genotype was 2.08 （95% CI, 1.06-4.05; P〈0.05）. Lack of association was found between ,053 polymorphism and HPV infection in the set of adenocarcinomas. CONCLUSION： The findings of the present study indicate that p53 codon 72 arginine homozygous genotype may represent a genetic predisposing factor for colon cancer development. However, further studies are needed in order to elucidate the role of p53 codon 72 polymorphism in colorectal cancer.展开更多
AIM:To evaluate the association between p53 codon 72 polymorphism and liver cancer risk by means of meta-analysis. METHODS:Two investigators independently searched the Medline,Embase and Chinese Biomedicine databases....AIM:To evaluate the association between p53 codon 72 polymorphism and liver cancer risk by means of meta-analysis. METHODS:Two investigators independently searched the Medline,Embase and Chinese Biomedicine databases.Summary odds ratios and 95%CI for p53 codon 72 polymorphism and liver cancer were calculated in fixedeffects model(Mantel-Haenszel method)and randomeffects model(DerSimonian and Laird method)when appropriate. RESULTS:This meta-analysis included 1115 liver cancer cases and 1778 controls.The combined results based on all studies showed that there was a statistically significant link between Pro/Pro genotype and liver cancer,but not between Arg/Arg or Pro/Arg genotype and liver cancer.When stratifying for race,similar results were obtained,i.e.patients with liver cancer had a significantly higher frequency of Pro/Pro genotype than non-cancer patients among Asians.After stratifying thevarious studies by control source,gender,family history of liver cancer and chronic hepatitis virus infection,we found that(1)patients among hospital-based studies had a significantly higher frequency of Pro/Pro and a significantly lower frequency of Arg/Arg genotype than individuals without cancer;(2)female patients with liver cancer had a significantly lower frequency of Arg/Arg and a higher frequency of Pro/Arg+Pro/Pro genotypes than female individuals without cancer;(3)subgroup analyses for family history of liver cancer did not reveal any significant association between p53 codon 72 polymorphism and liver cancer development;and(4) patients with negative hepatitis virus infection had a significantly higher frequency of Pro/Pro and a significantly lower frequency of Arg/Arg genotype than individuals without cancer. CONCLUSION:This meta-analysis suggests that the p53 codon 72 polymorphism may be associated with liver cancer among Asians.展开更多
AIM:To investigate the potential role of p53 codon 72 polymorphism as a risk factor for development of anal cancer. METHODS:Thirty-two patients with invasive anal carcinoma and 103 healthy blood donors were included i...AIM:To investigate the potential role of p53 codon 72 polymorphism as a risk factor for development of anal cancer. METHODS:Thirty-two patients with invasive anal carcinoma and 103 healthy blood donors were included in the study.p53 codon 72 polymorphism was analyzed in blood samples through polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. RESULTS:The relative frequency of each allele was 0.60 for Arg and 0.40 for Pro in patients with anal cancer, and 0.61 for Arg and 0.39 for Pro in normal controls. No significant differences in distribution of the codon 72 genotypes between patients and controls were found. CONCLUSION:These results do not support a role for the p53 codon 72 polymorphism in anal carcinogenesis.展开更多
文摘目的探讨P53基因密码子72多态性与大肠癌风险的相关性。方法全面检索Pub Med、Medline、EMbase、CBM、CNKI、万方和维普等数据库。检索时间从建库至2014年2月,收集P53基因密码子72多态性与大肠癌易感性的病例对照研究。采用Rev Man 5.2软件计算合并效用量OR及其95%CI。结果共纳入25个研究,其中有6 753例患者,8 562例对照者。Meta分析发现,在各遗传模型中,隐性模型PP vs AP+AA中P53基因密码子72多态性与大肠癌发生风险有明显相关性,其余基因模型中P53基因密码子72多态性与大肠癌发生风险无明显相关性。结论在PP vs AP+AA遗传模型中,P53基因密码子72多态性与大肠癌风险性显著相关。
文摘目的:运用荟萃分析方法研究肿瘤抑制因子p53基因密码子72位点多态性与口腔癌易感性的发生风险。方法:检索维普(VIP)、中国知网(CNKI)、万方、中国生物医学文献数据库(CBM)、PubMed、Embase、WebofScience中有关p53基因密码子72位点多态性与口腔癌易感性关联研究的文献,以比值比(odds ratio,OR)和95%CI为效应指标,应用STATA 14软件和RevMan5进行荟萃分析,并对发表偏倚及敏感性分析进行检验。结果:纳入16个病例对照研究,口腔癌病例组共计2317例,正常对照组共计2933例。荟萃分析结果显示:在总人群中,p53基因密码子72位点基因多态性与口腔癌风险之间没有显著关联(Pro vs Arg OR=1.03,95%CI:0.887~1.195;Arg Pro+ProPro vs ArgArg OR=0.957,95%CI:0.847~1.081;ProPro vs ArgArg+ArgPro OR=1.082,95%CI:0.835~1.401;ProProvsArg ArgOR=1.059,95%CI:0.783~1.433;ArgProvsArg ArgOR=0.946,95%CI:0.831~1.076;ArgArg+ProProvsArgProOR=0.943,95%CI:0.842~1.055)。针对种族和对照人群来源设计的亚组分析结果也显示p53基因密码子72多态性与口腔癌风险之间没有显著相关性。结论:p53基因密码子72位点多态性与口腔癌的易感性没有直接关联,p53基因多态性可能不是口腔癌易感性的独立影响因素。
基金Supported by the National University of La Plata (grant v-138), Argentina
文摘AIM： To evaluate the potential association between p53 codon 72 polymorphism and sporadic colorectal adenocarcinoma development, and human papillornavirus （HPV） infection. METHODS： One-hundred and nine controls and 53 patients with colon cancer from the city of La Plata, Argentina were analyzed, p53 codon 72 genotypes and HPV infection were identified using allele-specific polymerase chain reaction and nested polymerase chain reaction, respectively. RESULTS： The differences in the distribution ofp53 codon 72 polymorphisrn between the cases and controls were statistically significant. The arginine allele had a prevalence of 0.65 in controls and 0.77 in cases. The corresponding odds ratio for the homozygous arginine genotype was 2.08 （95% CI, 1.06-4.05; P〈0.05）. Lack of association was found between ,053 polymorphism and HPV infection in the set of adenocarcinomas. CONCLUSION： The findings of the present study indicate that p53 codon 72 arginine homozygous genotype may represent a genetic predisposing factor for colon cancer development. However, further studies are needed in order to elucidate the role of p53 codon 72 polymorphism in colorectal cancer.
文摘AIM:To evaluate the association between p53 codon 72 polymorphism and liver cancer risk by means of meta-analysis. METHODS:Two investigators independently searched the Medline,Embase and Chinese Biomedicine databases.Summary odds ratios and 95%CI for p53 codon 72 polymorphism and liver cancer were calculated in fixedeffects model(Mantel-Haenszel method)and randomeffects model(DerSimonian and Laird method)when appropriate. RESULTS:This meta-analysis included 1115 liver cancer cases and 1778 controls.The combined results based on all studies showed that there was a statistically significant link between Pro/Pro genotype and liver cancer,but not between Arg/Arg or Pro/Arg genotype and liver cancer.When stratifying for race,similar results were obtained,i.e.patients with liver cancer had a significantly higher frequency of Pro/Pro genotype than non-cancer patients among Asians.After stratifying thevarious studies by control source,gender,family history of liver cancer and chronic hepatitis virus infection,we found that(1)patients among hospital-based studies had a significantly higher frequency of Pro/Pro and a significantly lower frequency of Arg/Arg genotype than individuals without cancer;(2)female patients with liver cancer had a significantly lower frequency of Arg/Arg and a higher frequency of Pro/Arg+Pro/Pro genotypes than female individuals without cancer;(3)subgroup analyses for family history of liver cancer did not reveal any significant association between p53 codon 72 polymorphism and liver cancer development;and(4) patients with negative hepatitis virus infection had a significantly higher frequency of Pro/Pro and a significantly lower frequency of Arg/Arg genotype than individuals without cancer. CONCLUSION:This meta-analysis suggests that the p53 codon 72 polymorphism may be associated with liver cancer among Asians.
基金Supported by The National Council for Scientific and Technological Development(CNPq),No.142678/2007-4,Brazilian Government
文摘AIM:To investigate the potential role of p53 codon 72 polymorphism as a risk factor for development of anal cancer. METHODS:Thirty-two patients with invasive anal carcinoma and 103 healthy blood donors were included in the study.p53 codon 72 polymorphism was analyzed in blood samples through polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. RESULTS:The relative frequency of each allele was 0.60 for Arg and 0.40 for Pro in patients with anal cancer, and 0.61 for Arg and 0.39 for Pro in normal controls. No significant differences in distribution of the codon 72 genotypes between patients and controls were found. CONCLUSION:These results do not support a role for the p53 codon 72 polymorphism in anal carcinogenesis.
