Background:Dermatomyositis-associated interstitial lung disease(DM-ILD)represents a severe and insidious complication of dermatomyositis(DM).The study aimed to investigate the association between DM-ILD and arterial b...Background:Dermatomyositis-associated interstitial lung disease(DM-ILD)represents a severe and insidious complication of dermatomyositis(DM).The study aimed to investigate the association between DM-ILD and arterial blood gas indices,serum ion levels,and the timing of interstitial lung disease onset,with the goal of identifying potential predictors for DM-ILD.Methods:The investigation involved the collection of basic data from 89 patients with DM hospitalized at the Chinese PLA General Hospital between January 2019 and April 2022,and 43 normal control patients hospitalized for physical examinations during the same period.Analyses were conducted to explore the relationship between DM-ILD,arterial blood gas indices,disease duration,and serum ions.A regression model to predict DM-ILD was developed using these indices,and a receiver operating characteristic curve was generated.Results:Significant differences were observed in pH and PaO2 between the control group and the disease group(p<0.05).The DM group exhibited higher levels of pH,actual bicarbonate,and base excess(BE)compared with the control group.In contrast,pH and BE levels were lower in the DM-ILD group than in the DM group,with these differences being statistically significant(p<0.05).Interstitial lung disease was correlated with the duration of the disease and pH levels(p<0.05).The cutoff values for age,disease duration,pH,and Cl^(-)were 55.5 years,5.5 years,7.432,and 101.5 mmol/L,respectively.The model demonstrated a prediction sensitivity and specificity for DM-ILD of 0.809 and 0.722,respectively,with an area under the curve of 0.809.Conclusion:Arterial blood gas analysis and serum Cl^(-)levels may assist in predicting DM-ILD.A combined monitoring approach involving arterial blood gas pH,disease duration,age,and serum Cl^(-)levels could enhance the accuracy of DM-ILD predictions and hold significant clinical evaluation potential.展开更多
目的评估Apgar评分及脐带血pH值对足月新生儿窒息的预测价值,探讨Apgar评分及脐带血pH值与足月新生儿窒息严重程度的相关性。方法选取窒息足月新生儿46例作为窒息组,健康足月新生儿49例作为健康组,比较两组出生1、5 min Apgar评分和脐带...目的评估Apgar评分及脐带血pH值对足月新生儿窒息的预测价值,探讨Apgar评分及脐带血pH值与足月新生儿窒息严重程度的相关性。方法选取窒息足月新生儿46例作为窒息组,健康足月新生儿49例作为健康组,比较两组出生1、5 min Apgar评分和脐带血pH值;采用受试者工作特征(receiver operating characteristic curve,ROC)曲线分析出生1、5 min Apgar评分,脐带血pH值和三者联合检测对足月新生儿窒息的预测价值;采用Spearman等级相关性分析探讨1、5 min Apgar评分和脐带血pH值与足月新生儿窒息严重程度的相关性。结果窒息组出生1、5 min Apgar评分和脐带血pH值显著低于健康组,差异有统计学意义(P<0.01);ROC曲线分析结果显示,出生1、5 min Apgar评分+脐带血pH值联合检测对足月新生儿窒息的预测价值最高。轻度窒息亚组出生1、5 min Apgar评分和脐带血pH值均显著高于重度窒息亚组,差异有统计学意义(P<0.05或P<0.01);Spearman等级相关性分析结果显示,出生1、5 min Apgar评分和脐带血pH值与足月新生儿窒息严重程度均呈负相关(P<0.05或P<0.01)。结论出生1、5 min Apgar评分+脐带血pH值联合检测对足月新生儿窒息具有较好的预测价值,且Apgar评分及脐带血pH值与足月新生儿窒息严重程度具有相关性。展开更多
目的:探讨脐动脉血血气分析在新生儿窒息诊断中的应用价值。方法:选取2019年5月—2022年5月于夷陵区妇幼保健院分娩的窒息新生儿100例作为研究对象,根据新生儿5 min Apgar评分分为轻度窒息组(62例)与重度窒息组(38例),另选取同期正常新...目的:探讨脐动脉血血气分析在新生儿窒息诊断中的应用价值。方法:选取2019年5月—2022年5月于夷陵区妇幼保健院分娩的窒息新生儿100例作为研究对象,根据新生儿5 min Apgar评分分为轻度窒息组(62例)与重度窒息组(38例),另选取同期正常新生儿50例作为对照组。三组新生儿均行脐动脉血血气分析,比较三组血气指标水平、pH值分布情况。结果:轻度窒息组与重度窒息组血液碱剩余(BE)绝对值、乳酸、动脉血二氧化碳分压(PaCO_(2))水平高于对照组,酸碱度(pH)、碳酸氢根(HCO_(3)^(-))水平低于对照组,差异有统计学意义(P<0.05);重度窒息组BE绝对值、乳酸、PaCO_(2)水平高于轻度窒息组,pH值、HCO_(3)^(-)低于轻度窒息组,差异有统计学意义(P<0.05)。轻度窒息组与重度窒息组pH值>7.25、pH值7.21~7.25占比低于对照组,pH值≤7.20占比高于对照组,差异有统计学意义(P<0.05);重度窒息组pH值>7.25占比低于轻度窒息组,pH值7.21~7.25、pH值≤7.20占比高于轻度窒息组,差异有统计学意义(P<0.05)。结论:脐动脉血血气分析应用于新生儿窒息诊断中,能够提高诊断准确性,可为改善新生儿预后提供可靠依据,具有较高的临床应用价值。展开更多
目的探讨动脉血气分析指标(arterial blood gas analysis,ABGA)在急性呼吸困难患者中的诊断和预后价值。方法对采用动脉血气分析的265例急性呼吸困难患者进行回顾性分析,以探讨ABGA指标在急性呼吸困难患者的诊断和预后价值。结果ABGA指...目的探讨动脉血气分析指标(arterial blood gas analysis,ABGA)在急性呼吸困难患者中的诊断和预后价值。方法对采用动脉血气分析的265例急性呼吸困难患者进行回顾性分析,以探讨ABGA指标在急性呼吸困难患者的诊断和预后价值。结果ABGA指标不能用于区分肺源性与其他原因所致的急性呼吸困难患者,也不能用于确认呼吸困难的病因。只有在焦虑导致的过度换气患者中,pH值和低氧血症具有准确诊断价值,ROC曲线下面积为0.87。pH值很低的患者住院率高,进入重症监护室几率高,30 d内死亡率达到16.1%。根据pH值将患者分为3组:pH≤7.39组,pH 7.40~7.44组,pH≥7.45组。随访12个月,pH≤7.39组患者死亡率为35.6%,pH 7.40~7.44组患者死亡率为27.9%,pH≥7.45组患者的死亡率为21.7%。多变量Cox比例风险分析表明,肺源性和非肺源性患者初发时pH值是12个月时死亡率的独立预测因子。结论ABGA指标对急性呼吸困难的诊断价值有限,但pH值是患者12个月死亡率的独立预测因子。展开更多
文摘Background:Dermatomyositis-associated interstitial lung disease(DM-ILD)represents a severe and insidious complication of dermatomyositis(DM).The study aimed to investigate the association between DM-ILD and arterial blood gas indices,serum ion levels,and the timing of interstitial lung disease onset,with the goal of identifying potential predictors for DM-ILD.Methods:The investigation involved the collection of basic data from 89 patients with DM hospitalized at the Chinese PLA General Hospital between January 2019 and April 2022,and 43 normal control patients hospitalized for physical examinations during the same period.Analyses were conducted to explore the relationship between DM-ILD,arterial blood gas indices,disease duration,and serum ions.A regression model to predict DM-ILD was developed using these indices,and a receiver operating characteristic curve was generated.Results:Significant differences were observed in pH and PaO2 between the control group and the disease group(p<0.05).The DM group exhibited higher levels of pH,actual bicarbonate,and base excess(BE)compared with the control group.In contrast,pH and BE levels were lower in the DM-ILD group than in the DM group,with these differences being statistically significant(p<0.05).Interstitial lung disease was correlated with the duration of the disease and pH levels(p<0.05).The cutoff values for age,disease duration,pH,and Cl^(-)were 55.5 years,5.5 years,7.432,and 101.5 mmol/L,respectively.The model demonstrated a prediction sensitivity and specificity for DM-ILD of 0.809 and 0.722,respectively,with an area under the curve of 0.809.Conclusion:Arterial blood gas analysis and serum Cl^(-)levels may assist in predicting DM-ILD.A combined monitoring approach involving arterial blood gas pH,disease duration,age,and serum Cl^(-)levels could enhance the accuracy of DM-ILD predictions and hold significant clinical evaluation potential.
文摘目的评估Apgar评分及脐带血pH值对足月新生儿窒息的预测价值,探讨Apgar评分及脐带血pH值与足月新生儿窒息严重程度的相关性。方法选取窒息足月新生儿46例作为窒息组,健康足月新生儿49例作为健康组,比较两组出生1、5 min Apgar评分和脐带血pH值;采用受试者工作特征(receiver operating characteristic curve,ROC)曲线分析出生1、5 min Apgar评分,脐带血pH值和三者联合检测对足月新生儿窒息的预测价值;采用Spearman等级相关性分析探讨1、5 min Apgar评分和脐带血pH值与足月新生儿窒息严重程度的相关性。结果窒息组出生1、5 min Apgar评分和脐带血pH值显著低于健康组,差异有统计学意义(P<0.01);ROC曲线分析结果显示,出生1、5 min Apgar评分+脐带血pH值联合检测对足月新生儿窒息的预测价值最高。轻度窒息亚组出生1、5 min Apgar评分和脐带血pH值均显著高于重度窒息亚组,差异有统计学意义(P<0.05或P<0.01);Spearman等级相关性分析结果显示,出生1、5 min Apgar评分和脐带血pH值与足月新生儿窒息严重程度均呈负相关(P<0.05或P<0.01)。结论出生1、5 min Apgar评分+脐带血pH值联合检测对足月新生儿窒息具有较好的预测价值,且Apgar评分及脐带血pH值与足月新生儿窒息严重程度具有相关性。
文摘目的:探讨脐动脉血血气分析在新生儿窒息诊断中的应用价值。方法:选取2019年5月—2022年5月于夷陵区妇幼保健院分娩的窒息新生儿100例作为研究对象,根据新生儿5 min Apgar评分分为轻度窒息组(62例)与重度窒息组(38例),另选取同期正常新生儿50例作为对照组。三组新生儿均行脐动脉血血气分析,比较三组血气指标水平、pH值分布情况。结果:轻度窒息组与重度窒息组血液碱剩余(BE)绝对值、乳酸、动脉血二氧化碳分压(PaCO_(2))水平高于对照组,酸碱度(pH)、碳酸氢根(HCO_(3)^(-))水平低于对照组,差异有统计学意义(P<0.05);重度窒息组BE绝对值、乳酸、PaCO_(2)水平高于轻度窒息组,pH值、HCO_(3)^(-)低于轻度窒息组,差异有统计学意义(P<0.05)。轻度窒息组与重度窒息组pH值>7.25、pH值7.21~7.25占比低于对照组,pH值≤7.20占比高于对照组,差异有统计学意义(P<0.05);重度窒息组pH值>7.25占比低于轻度窒息组,pH值7.21~7.25、pH值≤7.20占比高于轻度窒息组,差异有统计学意义(P<0.05)。结论:脐动脉血血气分析应用于新生儿窒息诊断中,能够提高诊断准确性,可为改善新生儿预后提供可靠依据,具有较高的临床应用价值。
