Preparation and Characterization of pH-Responsive Charge Reversal Nanocomposite for miRNA Delivery

pH-responsive charge reversal loaded miRNA nanocomposite was prepared by electrostatic self-assembly.The morphology,particle size and zeta potential of the nanocomposites were analyzed by transmission electron microscopy and dynamic light scattering.The synthesis of the polymer was analyzed by^(1)H-NMR.The zeta-potential changes and cellular uptake effects of the nanocomplexes under different pH environments were investigated.The experimental results show that the surface morphology of the nanocomposite is spherical,and the average particle size is about 135 nm.As the pH value of the solution gradually decreases,the surface charge of the nanocomposite reverses from negative charge to positive charge(from-9.4 to+17.1 mV).Cellular uptake mediated by pH-responsive nanocomposite is selective for tumor cells,and the cellular uptake effect in tumor cells at pH 6.5 was approximately 3 times higher than that at pH 7.4.This pH responsive charge reversal nanocomposite has promising application prospects for gene delivery in the weak acid environment of tumors.

Superparticles Formed by Amphiphilic Tadpole-like Single Chain Polymeric Nanoparticles and Their Application as an Ultrasonic Responsive Drug Carrier

Herein, we report self-assembly of tadpole-like single chain polymeric nanoparticles （TPPs） and the ultrasonic response of the resultant superparticles. The TPPs are with an intramolecularly crosslinked poly（2-（methacryloyloxy）ethyl pent-4-ynoate）-rpoly（hydroxyethyl methacrylate） （PMAEP-r-PHEMA） chain as the ＂head＂ and a poly（2- （dimethylamino）ethyl methacrylate （PDMAEMA） linear chain as the ＂tail＂, and are pre- pared simply and emciently by Glaser-coupling of the pendant alkynes in the PMAEP-r- PHEMA block in the common solvent methanol. The formation of the TPPs was confirmed by gel permeation chromatograph, nuclear magnetic resonance spectroscopy, dynamic light scattering, static dynamic scattering, and transmission electron microscopy. In aqueous solution, the amphiphilic TPPs could self-assemble into regular superparticles, driven by aggregation of the hydrophobic ＂heads＂. Since in the structure there is no chain entanglement and the embedding of PDMAEMA chains disturb close-packing of the ＂heads＂, the superpartieles are responsive to a low-energy ultrasonic vibration, as evidenced by greatly enhanced release of the functional molecules from the superparticles by treatment of a low-energy ultrasound. Therefore, the superparticles should be very promising in the use as the drug carriers that can be manipulated from a long distance, considering that ultrasonic energy can be focused at a small area in a relatively long distance from the ultrasound-radiating source.

Thermoreversible Thickening and Self-assembly Behaviors of pH/Temperature Dually Responsive Microgels with Interpenetrating Polymer Network Structure

The pH /temperature dually responsive microgels of interpenetrating polymer network( IPN) structure composed of poly( N-isopropylacrylamide)( PNIPAM) network and poly( acrylic acid)( PAA) network( PNIPAM /PAA IPN microgels) were synthesized by seed emulsion polymerization. The results obtained by dynamic laser light scattering( DLLS) show that the microgels have good pH /temperature dual sensitivities. The temperature sensitive component and the pH sensitive component inside the microgels have little interference with each other. The rheological properties of the concentrated PNIPAM /PAA IPN microgel dispersions as a function of temperature at pH 4. 0 or 7. 0 were investigated by viscometer,and the results displayed that only at pH 7. 0 the dispersions presented thermoreversible thickening behavior. Then the PNIPAM /PAA fibers were prepared by self-assembly of the PNIPAM /PAA IPN microgels in the ice-crystal templates formed by unidirectional liquid nitrogen freezing method. Field emission scanning electron microscopy( FESEM) images indicate that the PNIPAM /PAA fibers are rounded,randomly orientated and interweaved.

A theoretical model for impact protection of flexible polymer material

The relationship between the protective performance of flexible polymer material and material parameters(elasticmodulus,viscosity coefficient)is explored,an impact collision motion equation between two bodies is establishedfrom the viscoelastic material constitutive,and the relationship between the kinematic response and the materialparameters is obtained.Based on the Kelvin constitutive model,a theoretical model for impact between the pro-tective body and the protected body is established,then the dynamic response is obtained.The feasibility of themodel was verified by drop hammer experiment,and the material parameters(elastic modulus,viscosity coeffi-cient)were obtained by formula.The model is discretized and the relationship between local impact response andmaterial parameters is analyzed.The discussion results on the relationship between the impact response and theprotective material performance indicate that adjusting the elastic modulus,viscosity coefficient,and thicknessof the protective material can effectively improve protective effect.

Multi-objective optimization of the cathode catalyst layer micro-composition of polymer electrolyte membrane fuel cells using a multi-scale,two-phase fuel cell model and data-driven surrogates

Polymer electrolyte membrane fuel cells(PEMFCs)are considered a promising alternative to internal combustion engines in the automotive sector.Their commercialization is mainly hindered due to the cost and effectiveness of using platinum(Pt)in them.The cathode catalyst layer(CL)is considered a core component in PEMFCs,and its composition often considerably affects the cell performance(V_(cell))also PEMFC fabrication and production(C_(stack))costs.In this study,a data-driven multi-objective optimization analysis is conducted to effectively evaluate the effects of various cathode CL compositions on Vcelland Cstack.Four essential cathode CL parameters,i.e.,platinum loading(L_(Pt)),weight ratio of ionomer to carbon(wt_(I/C)),weight ratio of Pt to carbon(wt_(Pt/c)),and porosity of cathode CL(ε_(cCL)),are considered as the design variables.The simulation results of a three-dimensional,multi-scale,two-phase comprehensive PEMFC model are used to train and test two famous surrogates:multi-layer perceptron(MLP)and response surface analysis(RSA).Their accuracies are verified using root mean square error and adjusted R^(2).MLP which outperforms RSA in terms of prediction capability is then linked to a multi-objective non-dominated sorting genetic algorithmⅡ.Compared to a typical PEMFC stack,the results of the optimal study show that the single-cell voltage,Vcellis improved by 28 m V for the same stack price and the stack cost evaluated through the U.S department of energy cost model is reduced by$5.86/k W for the same stack performance.

Multifunctional stimuli responsive polymer-gated iron and gold-embedded silica nano golf balls:Nanoshuttles for targeted on-demand theranostics

Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles （NP）-embedded silica nanoshuttles （MGNSs） with nanopores on their surface. Fluorescently labeled Doxombicin （DOX）, a cancer drug, was loaded in the MGNSs as a payload. DOX loaded MGNSs were encapsulated in heat and pH sensitive polymer P（NIPAM-co- MAA） to enable controlled release of the payload. Magnetically-guided transport of MGNSs was examined in： （a） a glass capillary tube to simulate their delivery via blood vessels; and （b） porous hydrogels to simulate their transport in composite human tissues, including bone, cartilage, tendon, muscles and blood-brain barrier {BBB）. The viscoelastic properties of hydrogels were examined by atomic force microscopy （AFM）. Cellular uptake of DOX- loaded MGNSs and the subsequent pH and temperature-mediated release were demonstrated in differentiated human neurons derived from induced pluripotent stem cells （iPSCs） as well as epithelial HeLa cells. The presence of embedded iron and gold NPs in silica shells and polymer-coating are supported by SEM and TEM. Fluorescence spectroscopy and microscopy documented DOX loading in the MGNSs. Time-dependent transport of MGNSs guided by an external magnetic field was observed in both glass capillary tubes and in the porous hydrogel. AFM results affirmed that the stiffness of the hydrogels model the rigidity range from soft tissues to bone. pH and temperature-dependent drug release analysis showed stimuli responsive and gradual drug release. Cells＇ viability MTT assays showed that MGNSs are non-toxic. The cell death from on-demand DOX release was observed in both neurons and epithelial cells even though the drug release efficiency was higher in neurons. Therefore, development of smart nanoshuttles have significant translational potential for controlled delivery of theranostics＇ payloads and precisely guided transport in specified tissues and organs （for example, bone, cartilage, tendon, bone marrow, heart, lung, liver, kidney, and brain） for highly efficient personalized medicine applications.

Poly (N-Isopropyl Acrylamide-<i>Co</i>-Vanillin Acrylate) Dual Responsive Functional Copolymers for Grafting Biomolecules by Schiff’s Base Click Reaction

This article reports on the synthesis of acrylate monomer from renewable material. Vanillin was selected to be the start material to produce new monomer called vanillin acrylate and abbreviated by (VA). It has been successfully investigated by 1H, 13C NMR, IR and UV and all results were in logic state. The next step was to synthetize three different thermo-responsive functional copolymers by incorporation of three different molar ratios of vanillin acrylate (10, 20, 30 mol%) with N-Isopropylacrylamide via free radical polymerization by AIBN as initiator in solution. All copolymers were deduced by 1NMR and IR and all showed the presence of aldehyde group. The copolymer was used for grafting of tryptophan and β-alanine through the chemical link between amino group and the active aldehyde group by click reactions to form Schiff’s base imine compounds. Moreover, polymers were also elucidated by 1HNMR, IR and UV, Size Exclusion Chromatography (SEC) was used for the molecular weight determination, differential scanning calorimeter (DSC) for glass temperature of solid polymers, XRD for crystallinity. UV-vis Spectroscopy was used for the determination of phase separation or the lower critical solution temperature (Tc) of polymers solution not only in deionized water but in pH5 and pH11. The mount of conversation and linked amino acid was determined by UV-vis Spectroscopy.

Two-Photon Fluorescence Properties and Ultrafast Responses of a Hyperbranched Diketo-Pyrrolo-Pyrrole Polymer with Triphenylamine as the Core

The two-photon fluorescence properties and ultrafast responses of a hyperbranched polyyne （hb-DPP-J2） with triphenylamine as the central core, Diketo-Pyrrolo-Pyrrole as the connecting unit and electron acceptor are studied. The polymer has a D-π-A-π-D conjugated structure along the extended polyyne w-bridge systems, and the effective condugated unit repeats itself in the whole hyperbranehed polymer chain. The polymer exhibits a large two-photon absorption cross section and high fluorescence quantum yields. The ultrafast dynamic results give a deep understanding of the excited energy transfer processes under excitation, and reveal a long relaxation lifetime of the intramolecular charge transfer （ICT） state.

Manipulating the Phase Transition Behavior of Dual Temperature-Responsive Block Copolymers by Adjusting Composition and Sequence

Temperature-responsive polymers have garnered significant attention due to their ability to respond to external stimuli.In this work,dual temperature-responsive block copolymers are synthesized via reversible addition-fragmentation chain transfer polymerization(RAFT)polymerization utilizing zwitterionic monomer methacryloyl ethyl sulfobetaine(SBMA) and N-isopropyl acrylamide(NIPAAm) as monomers.The thermal responsive behaviors can be easily modulated by incorporating additional hydrophobic monomer benzyl acrylate(BN) or hydrophilic monomer acrylic acid(AA),adjusting concentration or pH,or varying the degree of polymerization of the block chain segments.The cloud points of the copolymers are determined by UV-Vis spectrophotometry,and these copolymers exhibit both controlled upper and lower critical solu bility temperatures(LCST and UCST) in aqueous solution.This study analyzes and summarizes the influencing factors of dual temperature responsive block copolymers by exploring the effects of various conditions on the phase transition temperature of temperature-sensitive polymers to explore the relationship between their properties and environment and structure to make them more selective in terms of temperature application range and regulation laws.It is very interesting that the introduction of poly-acrylic acid(PAA) segments in the middle of di-block copolymer PSBMA_(55)-b-PNIPAAm_(80) to form PSBMA_(55)-b-PAA_(x)-b-PNIPAAm_(80) results in a reversal of temperature-responsive behaviors from 'U'(LCST UCST) type,while the copolymer PSBMA_(55)-b-P(NIPAAm_(80)-co-AA_(x)) not.This work provides a clue for tuning the phase transition behavior of polymers for manufacture of extreme smart materials.

Characteristics of resistivity log response of oil layers under polymer flooding

Resistivity log responses are different when the oil layers is filled by a polymer solution or water and it seriously affects the log interpretation of the water flooded layer. In this paper, we first analyze the electrical properties of the polymer solution. Then, according to the different processes for polymer flooding the reservoir, we perform rock resistivity experiments and analyze the rock resistivity variations in different displacement phases. We also compare the resistivity log responses of oil layers filled with the polymer solution to those filled with water. The results show that when displacing the oil-bearing core by different polymers, the resistivity changes monotonously decrease and show either ＂W＂ type or ＂S＂ type. The resistivity log responses are weak when displacing water and there is no flooded show if the oil layer is injected by a fresh water polymer solution. If the oil layer is injected by a sewage polymer solution, the resistivity log response has similar characteristic as a polluted water flooded layer.

A Novel Design Strategy for Temperature-Responsive IPN Hydrogels Based on a Copolymer of Acrylamide and N-(1,1-Dimethyl-3-Oxobutyl)-Acrylamide

A methology is described for the synthesis of novel temperature-responsive interpenetrating polymer network (IPN) hydrogels with poly(2-acrylamido- 2-methylpropane sulfonic acid) (PAMPS) as a tightly crosslinked 1st network, temperature-responsive poly(acrylamide-co-N-(1,1-dimethyl-3-oxobutyl)- acrylamide) (P(AM-co-DAAM)) with low cost as a lossely crosslinked 2nd network. The structure and morphology of the IPN hydrogels were characterized by FTIR, TGA and SEM, and the results indicated that PAMPS network introduced P(AM-co-DAAM) hydrogels have large, thermally stable and interconnected porous network. The properties of the IPN hydrogels, which include: swelling capacity, equilibrium swelling/deswelling ratio, temperature- responsive behavior, and the dwelling kinetics as specific temperature, were investigated carefully. Results showed that the obtained IPN hydrogels displayed a controllable equilibrium swelling/deswelling behavior and possessed remarkable thermosensitivity. In addition, the results also indicate that the incorporation of the hydrophobic groups DAAM has a big effect on the LCST of the IPN hydrogels. Consequently, these novel temperature-responsive IPN hydrogels with low cost and slow-releasing performance would be promising for potential applications, such as environmental catalysis, water treatment, and agriculture.

星点设计-效应面法优化白及多糖pH-离子敏感原位凝胶的处方

目的优化白及多糖pH-离子敏感原位凝胶的处方。方法以去乙酰结冷胶用量、海藻酸钠用量、氯化钙用量、枸橼酸钠与氯化钙的质量比为考察变量,采用单因素实验初步确定各变量的范围。以25℃凝胶前体溶液黏度和37℃胶凝黏度为考察指标,采用星点设计-效应面法优选白及多糖pH-离子敏感原位凝胶的处方工艺,并进行预测分析。结果白及多糖pH敏感原位凝胶的最优处方为:去乙酰结冷胶用量为0.50%,海藻酸钠用量为1.10%,氯化钙用量为0.07%,枸橼酸钠与氯化钙的质量比为4∶1。该处方条件下,25℃前体溶液黏度为(704.00±3.00)mPa·s,37℃胶凝黏度为(12544.70±47.33)mPa·s。结论白及多糖pH-离子敏感原位凝胶稳定性好,前体溶液在25℃流动性良好,凝胶强度良好,可为基于白及多糖原位凝胶的后续研究提供实验基础。

基于2种色素的pH响应型指示膜的制备及性能研究

目的色素是pH响应型指示膜的重要组成,其性质关系着智能指示膜的响应性能,为了探究不同色素对智能指示膜性能的影响。方法以紫草色素(AERE)和紫甘薯色素(ATH)为pH显色剂,以琼脂糖(AG)为成膜基质、甘油为增塑剂,采用流延法制备得到了AG-AERE和AG-ATH 2种体系pH响应型指示膜。采用FT-IR、SEM对指示膜的微观结构进行了表征,对指示膜的力学性能、水溶解性、水溶胀性、水蒸气透过性等进行了测定,同时还考察了其pH响应性、颜色稳定性及体系中染料迁移等性能。结果AG-AERE体系指示膜在4种实验条件下的颜色稳定性均好于AG-ATH体系指示膜,AG-ATH体系指示膜在不同pH区间的颜色响应变化值明显大于AG-AERE体系指示膜。结论AG-ATH体系指示膜对pH变化更为敏感,更适合作为pH响应型新鲜度指示膜,AG-AERE体系指示膜在水性和酸性食品模拟液中染料迁移较低,而AG-ATH体系指示膜在油脂类食品模拟液中几乎无染料迁移,更适合用于油脂类食品的指示包装。

pH/近红外光双响应卡培他滨智能印迹材料的制备及药物释放研究

以广谱抗癌药物卡培他滨(capecitabine,CAP)为模板,上转换纳米粒子为载体,3,5-二羧基-4-甲基丙烯酸酯偶氮苯和丙烯酸官能化明胶为双官能单体,N,N′-亚甲基双丙烯酰胺为交联剂,过硫酸铵为引发剂,采用表面聚合及分子印迹技术制备了具有pH值/近红外光双响应性能的纳米智能药物载体CAP-MIP(capecitabine-imprinted polymers)。实验结果表明,CAP-MIP不仅具有较好的载药活性(吸附容量7.00 mg/g),而且还具有良好的吸附选择性(CAP选择性因子α为2.904)。当介质pH分别为1.2、6.8和8.3时,CAP的最大累积释放率分别为1.71%、41.84%和89.54%,药物释放的平衡时间分别为40 min、180 min和420 min。当介质pH为6.8,且伴有近红外光(λ=980 nm)照射时,目标材料仅180 min就能使CAP达到最大累积释放率96.21%。此外,CAP-MIP还具有良好的稳定性,经过7次吸附-解吸循环后,CAP-MIP载药量损失率仅为8.29%。

pH响应材料及其在智能肥料中的应用

肥料行业的发展正从传统化肥向新型肥料转变。肥料使用在保障粮食安全方面发挥了重大作用,但传统肥料利用率低、养分损失大、环境风险加剧,大多数肥料产品不能按照作物的营养需求规律实现养分精准供应。而智能肥料的研发与创新为解决该问题提供了有效途径,在时空上更精准匹配作物对养分的需求。本文系统综述了pH响应材料的类型、来源及响应机理,探讨pH响应材料的化学结构对pH响应行为的影响,提出pH响应材料促进根肥互馈的观点,剖析pH响应材料在智能肥料中的应用前景,进一步明确pH响应材料在绿色智能肥料创制领域的应用潜力、未来的研究方向及面临的挑战。文章以根肥互馈理念为核心,综合考虑pH响应材料与作物根际酸化效应,设计并利用pH响应材料把根分泌物与智能肥料有机连接,提出开发pH响应肥料的创新思路,指出根肥互馈是协同肥料养分释放和作物养分吸收的关键,提出基于根肥互馈原理匹配作物养分需求规律且具有环境友好性的绿色智能肥料将成为新型肥料的发展趋势。

pH/温度响应型聚合物PMAA-b-PDMAEMA的合成、性能调控及应用

以甲基丙烯酸叔丁酯(tBMA)、甲基丙烯酸N,N-二甲氨基乙酯(DMAEMA)为原料,通过原子转移自由基聚合(ATRP)法合成了两亲性嵌段聚合物聚甲基丙烯酸叔丁酯-b-聚甲基丙烯酸N,N-二甲氨基乙酯(PtBMA-b-PDMAEMA),将其进行水解得到功能可调控的pH/温度双重响应性共聚物PMAA-b-PDMAEMA。采用核磁共振波谱(1H NMR)、傅里叶变换红外光谱(FTIR)、紫外可见分光光度计(UV-Vis)、动态光散射(DLS)及荧光分光光度计等对共聚物的结构及性能进行表征和分析,研究共聚物的嵌段比、分子量及溶液pH对响应性能的调控,并初步考察了共聚物的抗肿瘤潜能。研究结果表明,随着PMAA链段长度增加,等电点向酸性偏移,在等电点时溶液透过率降到最低,表现出良好的pH响应性;温度响应性受溶液pH、分子量及嵌段比的影响,pH越接近等电点、分子量越大,低临界溶液温度(LCST)越低;共聚物与模拟肿瘤细胞膜相互作用后,在pH=5.5酸性微环境下膜中内容物的泄漏率接近100%,实现了对模拟肿瘤细胞的靶向破坏作用,展现了该共聚物良好的环境响应性。

木质素基碳点的制备及其对pH响应分析

以碱木质素为原料,利用对甲苯磺酸进行酸解后再通过水热法制备了S掺杂的木质素基碳点(L-SCDs)。通过透射电镜(TEM)、红外光谱(FT-IR)、X射线光电子能谱(XPS)、紫外-可见吸收光谱(UV-vis)和荧光光谱(FL)对L-SCDs的形貌结构和光学性质进行表征分析,并探究了L-SCDs在不同pH环境下的响应性能。结果表明:L-SCDs主要由类石墨结构的碳核及其表面的发光单元组成,具有很好的分散性,平均粒径为2.19 nm;L-SCDs主要含有碳、氧、硫3种元素,其表面存在羟基、羰基、羧基等官能团,表明碱木质素与对甲苯磺酸发生了反应,S元素成功掺杂到L-SCDs中。L-SCDs在不同pH值下的荧光变化研究发现:L-SCDs在碱性环境下荧光强度显著下降,且pH值越大下降越明显,这主要是因为L-SCDs的发光单元中存在羧基,在碱性环境中形成羧酸盐,发光单元被破坏,荧光强度下降;而在酸性和中性环境下荧光强度无明显变化,表明L-SCDs具有选择性地对pH值响应的特性,可用于荧光探针检测酸碱性。

水合作用与 pH 调控两性离子聚合物刷的相变行为

本文基于Flory-Huggins理论,建立理论模型研究水合作用与pH调控两性离子聚合物(ZP)刷的相变行为.理论模型考虑ZP的水合作用,以及ZP刷体系中的静电作用.研究发现,在不同pH条件下,ZP刷的体积分数随着水合作的减弱而的增加.随着pH的变化,ZP刷构象随着水合性转变行为明显改变,这是由于pH调控ZP链单体带有过多的净电荷(正电荷或负电荷),致使ZP链内出现静电排斥导致ZP刷溶胀.另外,当ZP链单体呈现过多的净电荷,会在很大程度上决定ZP刷体系静电势,影响ZP刷的相变行为.通过考察体系自由能,我们还发现,ZP刷体系自由能呈现了极大值,随着pH值的变化,自由能呈现的极大值随之改变,由此表明了体系的不稳定性,进而导致ZP刷体系发生相变.

pH响应型肉桂醛衍生物的制备及其在香蕉保鲜中的应用

为实现天然植物精油肉桂醛(Cin)的按需释放,解决由于挥发性高、光热敏感等问题导致的应用受限,以壳聚糖(CS)为反应物对肉桂醛进行改性,通过不同摩尔比的氨基和醛基反应制备了对pH敏感的肉桂醛-壳聚糖席夫碱衍生物(Cin-CS)。利用傅里叶红外光谱、扫描电镜表征了样品结构和表面形貌,以不同pH缓冲液和不同体积分数CO_(2)的高湿环境探索了Cin-CS的pH响应行为,研究了Cin-CS对香蕉保鲜效果的影响。结果表明,氨基和醛基摩尔比为4∶1时达到接枝饱和,结构中出现亚胺键,表明接枝成功。随着缓冲液pH的降低、CO_(2)体积分数的升高和反应时间的增加,Cin释放率逐渐增加,达到响应和持续释放的效果。Cin-CS的应用降低了香蕉质量耗损,同时延缓硬度、可溶性固形物等下降,具有一定的保鲜效果。

pH响应型壳聚糖/表面活性剂体系构筑及其提高采收率效果研究

壳聚糖分子本身具有大量的亲水位点(氨基),但仅含有少量的疏水位点(乙酰氨基)。同时,由于疏水基团的随机排布所产生的空间位阻,进一步减弱了其在油水界面吸附的能力。表面活性剂与壳聚糖分子之间能够形成混合吸附层,增大了界面膜强度,减缓液滴之间的聚并,进而协同增强乳状液的稳定性,提高了乳状液的耐温耐盐性能。将阴离子表面活性剂SDS和两性离子表面活性剂BS12与壳聚糖进行复配。通过水溶液分散体系稳定性及油水界面张力等因素对复配比例进行优化筛选,构筑出壳聚糖/表面活性剂的pH响应乳状液增效体系。借助动态光散射(DLS)、静态多重光散射(S-MLS)、界面张力及SEM等表征手段,研究了壳聚糖/表面活性剂复配体系及其形成的乳状液的pH响应行为,进而探明了壳聚糖与表面活性剂分子之间的协同增效作用机理。结果表明:壳聚糖/BS12展示出pH响应性能,兼具良好的提高采收率效果,为刺激响应型驱油体系的开发与应用提供了理论指导。