直膨式太阳能光伏光热(photovoltaic-thermal,PVT)热泵是一种综合利用太阳能资源的新型高效技术。为探究不同环境条件以及系统配置方式对直膨式太阳能PVT热泵热水系统运行性能的影响,基于能量平衡原理在Matlab平台上建立了系统的仿真模...直膨式太阳能光伏光热(photovoltaic-thermal,PVT)热泵是一种综合利用太阳能资源的新型高效技术。为探究不同环境条件以及系统配置方式对直膨式太阳能PVT热泵热水系统运行性能的影响,基于能量平衡原理在Matlab平台上建立了系统的仿真模型,基于临港地区的环境数据,分析了各季节典型日下不同配置系统的热水供应性能以及发电增益的全年波动情况。结果表明,随压缩机理论输气量的减小,热水系统的性能系数(coefficient of performance,COP)有所提高,但所需的加热时间增加,系统的全年发电增益随理论输气量的减小而减小。展开更多
Research has shown that long-chain noncoding RNAs(lncRNAs) are involved in the regulation of a variety of biological processes, including peripheral nerve regeneration, in part by acting as competing endogenous RNAs. ...Research has shown that long-chain noncoding RNAs(lncRNAs) are involved in the regulation of a variety of biological processes, including peripheral nerve regeneration, in part by acting as competing endogenous RNAs. c-Jun plays a key role in the repair of peripheral nerve injury. However, the precise underlying mechanism of c-Jun remains unclear. In this study, we performed microarray and bioinformatics analysis of mouse crush-injured sciatic nerves and found that the lncRNA Pvt1 was overexpressed in Schwann cells after peripheral nerve injury. Mechanistic studies revealed that Pvt1 increased c-Jun expression through sponging miRNA-214. We overexpressed Pvt1 in Schwann cells cultured in vitro and found that the proliferation and migration of Schwann cells were enhanced, and overexpression of miRNA-214 counteracted the effects of Pvt1 overexpression on Schwann cell proliferation and migration. We conducted in vivo analyses and injected Schwann cells overexpressing Pvt1 into injured sciatic nerves of mice. Schwann cells overexpressing Pvt1 enhanced the regeneration of injured sciatic nerves following peripheral nerve injury and the locomotor function of mice was improved. Our findings reveal the role of lncRNAs in the repair of peripheral nerve injury and highlight lncRNA Pvt1 as a novel potential treatment target for peripheral nerve injury.展开更多
文摘直膨式太阳能光伏光热(photovoltaic-thermal,PVT)热泵是一种综合利用太阳能资源的新型高效技术。为探究不同环境条件以及系统配置方式对直膨式太阳能PVT热泵热水系统运行性能的影响,基于能量平衡原理在Matlab平台上建立了系统的仿真模型,基于临港地区的环境数据,分析了各季节典型日下不同配置系统的热水供应性能以及发电增益的全年波动情况。结果表明,随压缩机理论输气量的减小,热水系统的性能系数(coefficient of performance,COP)有所提高,但所需的加热时间增加,系统的全年发电增益随理论输气量的减小而减小。
基金supported by the National Natural Science Foundation of China,No. 81801213 (to BP)Xuzhou Special Fund for Promoting Scientific and Technological Innovation,Nos. KC21177 (to BP),KC21195 (to HF)Science and Technology Project of Yili Kazak Autonomous Prefecture,No. YZ2019D006 (to HF)。
文摘Research has shown that long-chain noncoding RNAs(lncRNAs) are involved in the regulation of a variety of biological processes, including peripheral nerve regeneration, in part by acting as competing endogenous RNAs. c-Jun plays a key role in the repair of peripheral nerve injury. However, the precise underlying mechanism of c-Jun remains unclear. In this study, we performed microarray and bioinformatics analysis of mouse crush-injured sciatic nerves and found that the lncRNA Pvt1 was overexpressed in Schwann cells after peripheral nerve injury. Mechanistic studies revealed that Pvt1 increased c-Jun expression through sponging miRNA-214. We overexpressed Pvt1 in Schwann cells cultured in vitro and found that the proliferation and migration of Schwann cells were enhanced, and overexpression of miRNA-214 counteracted the effects of Pvt1 overexpression on Schwann cell proliferation and migration. We conducted in vivo analyses and injected Schwann cells overexpressing Pvt1 into injured sciatic nerves of mice. Schwann cells overexpressing Pvt1 enhanced the regeneration of injured sciatic nerves following peripheral nerve injury and the locomotor function of mice was improved. Our findings reveal the role of lncRNAs in the repair of peripheral nerve injury and highlight lncRNA Pvt1 as a novel potential treatment target for peripheral nerve injury.
文摘目的 探讨血D-二聚体(D-dimer,D-D)联合白细胞计数(white blood cell count, WBC)对评估肝硬化Child-Pugh A级患者急性症状性门静脉血栓(portal vein thrombosis, PVT)治疗效果的临床价值。方法 回顾性分析2015年1月至2022年12月在首都医科大学附属北京世纪坛医院干部综合科治疗的128例肝硬化患者的相关临床数据。最终选取18例Child-Pugh A级急性症状性PVT经抗凝治疗后血管再通的患者纳入研究。按抗凝治疗方案的不同,分为低分子肝素组,华法林组和利伐沙班组,比较3组患者PVT抗凝治疗前后的血常规、凝血四项+D-D、肝肾功的结果差异。结果 (1)3组患者的D-D分别在急性症状性PVT时及抗凝治疗血管再通后差异有统计学意义(低分子肝素组:9.01±1.17 vs 1.27±0.65,P<0.001;华法林组:9.28±1.78 vs 1.50±0.31,P<0.001;利伐沙班组:7.04±1.44 vs 1.32±0.32,P<0.01)。(2)3组患者的WBC分别在急性症状性PVT时及抗凝治疗血管再通后差异有统计学意义(低分子肝素组:6.82±0.95 vs 4.50±0.51,P<0.05;华法林组:7.28±0.91 vs 3.99±0.37,P<0.01;利伐沙班组:7.49±1.02 vs 4.43±0.62,P<0.05)。(3)3组患者的其他指标如红细胞计数,血红蛋白等分别在急性症状性PVT时及抗凝治疗血管再通后差异无统计学意义(P>0.05)。(4)PVT时,各组的D-D或者WBC差异无统计学意义;PVT抗凝治疗血管再通后各组的D-D或者WBC差异也无统计学意义(P>0.05)。其他指标如,ALT、AST等差异也无统计学意义(P>0.05)。结论 D-D与WBC分别在肝硬化Child-Pugh A级患者急性症状性PVT时及抗凝治疗血管再通后差异有统计学意义,这两个指标可用于评估PVT抗凝治疗时是否实现血管再通。临床实践中,联合这两个指标可能直接用于评估PVT抗凝治疗后血管是否再通。
