目的探讨不同永久起搏电极植入右心室心尖部后损伤电流(current of injury,COI)的变化特点。方法入选144例右心室心尖部植入永久起搏电极患者,分为被动电极组及主动电极组。测定电极固定后0、5和10 min的COI及常规起搏参数,分析COI变化...目的探讨不同永久起搏电极植入右心室心尖部后损伤电流(current of injury,COI)的变化特点。方法入选144例右心室心尖部植入永久起搏电极患者,分为被动电极组及主动电极组。测定电极固定后0、5和10 min的COI及常规起搏参数,分析COI变化特点。结果被动电极固定后0、5和10 min分别测定COI值均明显小于主动电极固定后测定的COI值(P<0.01)。两种电极固定后COI随时间均显著逐步下降(P<0.01),被动电极固定后COI值下降幅度明显大于主动电极(P<0.01)。被动电极固定后10 min内后5 min COI下降幅度大于前5 min下降幅度(P<0.01),主动电极固定10 min内COI值前后5 min下降幅度未见差异。术后3例患者电极脱位,其COI均<5.0 m V。结论右心室心尖部植入被动电极产生的COI明显小于主动电极,两种电极产生的COI均随时间逐步减小,被动电极产生的COI下降速度较快。展开更多
Phrenic nerve stimulation is a technique whereby a nerve stimulator provides electrical stimulation of the phrenic nerve to cause diaphragmatic contraction in patients with respiratory failure due to cervical spinal c...Phrenic nerve stimulation is a technique whereby a nerve stimulator provides electrical stimulation of the phrenic nerve to cause diaphragmatic contraction in patients with respiratory failure due to cervical spinal cord injury. This paper presents an eigth-channel stimulator circuit with an output stage (electrode driving circuit) that doesn’t need off-chip blocking-capacitors and is used for phrenic nerve stimulation. This stimulator circuit utilizes only 1 output stage for 8 channels. The proposed current generator circuit in this stimulator reducing to a single step the translation of the digital input bits into the stimulus current, thus minimizing silicon area and power consumption. An 8 bit implementation is utilized for this current generator circuit. The average pulse width for this eight- channel stimulator with 1 mA current, 20 Hz frequency and 8 bits resolution, is 150 - 300 μs. The average power consumption for a single-channel stimulation is 38 mW from a 1.2 V power supply. This implantable stimulator system was simulated in HSPICE using 90 nm CMOS technology.展开更多
文摘目的探讨不同永久起搏电极植入右心室心尖部后损伤电流(current of injury,COI)的变化特点。方法入选144例右心室心尖部植入永久起搏电极患者,分为被动电极组及主动电极组。测定电极固定后0、5和10 min的COI及常规起搏参数,分析COI变化特点。结果被动电极固定后0、5和10 min分别测定COI值均明显小于主动电极固定后测定的COI值(P<0.01)。两种电极固定后COI随时间均显著逐步下降(P<0.01),被动电极固定后COI值下降幅度明显大于主动电极(P<0.01)。被动电极固定后10 min内后5 min COI下降幅度大于前5 min下降幅度(P<0.01),主动电极固定10 min内COI值前后5 min下降幅度未见差异。术后3例患者电极脱位,其COI均<5.0 m V。结论右心室心尖部植入被动电极产生的COI明显小于主动电极,两种电极产生的COI均随时间逐步减小,被动电极产生的COI下降速度较快。
文摘Phrenic nerve stimulation is a technique whereby a nerve stimulator provides electrical stimulation of the phrenic nerve to cause diaphragmatic contraction in patients with respiratory failure due to cervical spinal cord injury. This paper presents an eigth-channel stimulator circuit with an output stage (electrode driving circuit) that doesn’t need off-chip blocking-capacitors and is used for phrenic nerve stimulation. This stimulator circuit utilizes only 1 output stage for 8 channels. The proposed current generator circuit in this stimulator reducing to a single step the translation of the digital input bits into the stimulus current, thus minimizing silicon area and power consumption. An 8 bit implementation is utilized for this current generator circuit. The average pulse width for this eight- channel stimulator with 1 mA current, 20 Hz frequency and 8 bits resolution, is 150 - 300 μs. The average power consumption for a single-channel stimulation is 38 mW from a 1.2 V power supply. This implantable stimulator system was simulated in HSPICE using 90 nm CMOS technology.
