Biological markers that evaluate physical healing as well as psychological impact of a burn are essential for effective treatment of paediatric burns.The objective of this review is to summarize the evidence supportin...Biological markers that evaluate physical healing as well as psychological impact of a burn are essential for effective treatment of paediatric burns.The objective of this review is to summarize the evidence supporting the use of biomarkers in children with burns.An extensive review of the literature was performed using PubMed.A total of 59 biomarkers were identified relating to burn presence,specifically relating to processes involved in inflammation,wound healing,growth and metabolism.In addition,biomarkers involved in the stress response cascade following a burn trauma were also identified.Although many biomarkers have been identified that are potentially associated with burn-related physical and psychological trauma,an understanding of burn biology is still lacking in children.We propose that future research in the field of children’s burns should be conducted using broad screening methods for identifying potential biomarkers,examine the biological interactions of different biomarkers,utilize child-appropriate biological fluids such as urine or saliva,and include a range of different severity burns.Through further research,the biological response to burn injury may be fully realized and clinically relevant diagnostic tests and treatment therapies utilizing these biomarkers could be developed,for the improvement of healing outcomes in paediatric burn patients.展开更多
Background:Nail adhesives are widely available beauty products that are used in the cosmetic industry and households to attach false nails.Nail adhesive burns are uncommon,and it is crucial that healthcare providers a...Background:Nail adhesives are widely available beauty products that are used in the cosmetic industry and households to attach false nails.Nail adhesive burns are uncommon,and it is crucial that healthcare providers and the public are aware of its potential to cause chemical burn.Case Presentation:Case series of accidental burns secondary to cyanoacrylate nail glue treated at the Welsh Centre for Burns and Plastic Surgery(WCBPS)in Swansea,United Kingdom.Conclusion:All of the burns were observed in children and occurred due to accidental spillage.Therefore,it is important for the public to be aware that nail glue is a chemical agent which should be stored safely away from the reaches of young children.The case series highlights the importance of first aid in reducing the severity of chemical burns secondary to the nail adhesives,and its early recognition and treatment are emphasised.展开更多
基金M.C.is supported by the Australian Government Research Training Program(RTP)Stipend.C.P.is funded by the National Institute of Health(NIH),Cancer Australia(APP1145657)the Garnett Passéand Rodney Williams Foundation.L.C.is the recipient of a National Health and Medical Research Council Fellowship(APP1130862),funded by the Australian Government.
文摘Biological markers that evaluate physical healing as well as psychological impact of a burn are essential for effective treatment of paediatric burns.The objective of this review is to summarize the evidence supporting the use of biomarkers in children with burns.An extensive review of the literature was performed using PubMed.A total of 59 biomarkers were identified relating to burn presence,specifically relating to processes involved in inflammation,wound healing,growth and metabolism.In addition,biomarkers involved in the stress response cascade following a burn trauma were also identified.Although many biomarkers have been identified that are potentially associated with burn-related physical and psychological trauma,an understanding of burn biology is still lacking in children.We propose that future research in the field of children’s burns should be conducted using broad screening methods for identifying potential biomarkers,examine the biological interactions of different biomarkers,utilize child-appropriate biological fluids such as urine or saliva,and include a range of different severity burns.Through further research,the biological response to burn injury may be fully realized and clinically relevant diagnostic tests and treatment therapies utilizing these biomarkers could be developed,for the improvement of healing outcomes in paediatric burn patients.
文摘Background:Nail adhesives are widely available beauty products that are used in the cosmetic industry and households to attach false nails.Nail adhesive burns are uncommon,and it is crucial that healthcare providers and the public are aware of its potential to cause chemical burn.Case Presentation:Case series of accidental burns secondary to cyanoacrylate nail glue treated at the Welsh Centre for Burns and Plastic Surgery(WCBPS)in Swansea,United Kingdom.Conclusion:All of the burns were observed in children and occurred due to accidental spillage.Therefore,it is important for the public to be aware that nail glue is a chemical agent which should be stored safely away from the reaches of young children.The case series highlights the importance of first aid in reducing the severity of chemical burns secondary to the nail adhesives,and its early recognition and treatment are emphasised.
