Examining the association between delay discounting,delay aversion and physical activity in Chinese adults with type-2 diabetes mellitus

BACKGROUND The role of physical activity in diabetes is critical,influencing this disease's development,man-agement,and overall outcomes.In China,22.3%of adults do not meet the minimum level of physical activity recommended by the World Health Organization.Therefore,it is imperative to identify the factors that contributing to lack of physical activity must be identified.AIM To investigate the relationship among delay discounting,delay aversion,glycated hemoglobin(HbA1c),and various levels of physical activity in Chinese adults diagnosed with type 2 diabetes mellitus(T2DM).METHODS In 2023,400 adults with T2DM were recruited from the People's Hospital of Linxia Hui Autonomous Prefecture of Gansu Province.A face-to-face questionnaire was used to gather demographic data and details on physical activity,delay discounting,and delay aversion.In addition,HbA1c levels were measured in all 400 participants.The primary independent variables considered were delay discounting and delay aversion.The outcome variables included HbA1c levels and different intensity levels of physical activity,including walking,moderate physical activity,and vigorous physical activity.Multiple linear regression models were utilized to assess the relationship between delay discounting,delay aversion,and HbA1c levels,along with the intensity of different physical activity measured in met-hours per week.RESULTS After controlling for the sample characteristics,delay discounting was negatively associated with moderate physical activity(β=-2.386,95%CI:-4.370 to-0.401).Meanwhile,delay aversion was negatively associated with the level of moderate physical activity(β=-3.527,95%CI:-5.578 to-1.476)in the multiple linear regression model,with statistically significant differences.CONCLUSION Elevated delay discounting and increased delay aversion correlated with reduced levels of moderate physical activity.Result suggests that delay discounting and aversion may influence engagement in moderate physical activity.This study recommends that health administration and government consider delay discounting and delay aversion when formulating behavioral intervention strategies and treatment guidelines involving physical activity for patients with T2DM,which may increase participation in physical activity.This study contributes a novel perspective to the research on physical activity in adults with T2DM by examining the significance of future health considerations and the role of emotional responses to delays.

Conditioned Taste Aversion Diminishes Sugar Intake

Animals learn to avoid particular food when some of its sensory properties are associated with gastrointestinal discomfort. Twenty rats were exposed to free access to food and a sugar solution for ten days in first phase. During second phase, experimental group received a dose of LiCl. Control group received an injection without LiCl. Both groups had free access to a sugar solution and food restriction for three days. In the final phase, both groups returned to the conditions of first phase. Results showed a significant decrease in sugar intake after aversive conditioning regarding the intake registered in the initial phase in experimental group. Control group did not show any differences in its sugar intake before and after the experimental manipulation. The procedure carried out is discussed as a means to decrease sugar intake.

Applications of the Aversion Order of Risks in Reinsurance

The aversion order is a way of ordering of risks. Is there the optimal in aversion order in reinsurance contracts of reinsurance？ This paper discusses these objects and gives some optimal reinsurance contracts in certain sets of feasible reinsurance contracts.

Value-at-risk under ambiguity aversion

This study explored the effects of ambiguity on the calculation of Value-at-Risk(VaR)using a mathematical model based on the theory of Choquet-Brownian processes.It was found that while a moderate degree of ambiguity aversion yields a higher value for VaR and Expected Shortfall(ES),the result can be reversed in a deeply ambiguous environment.Additionally,some sufficient conditions are provided for the preservation of this effect under various forms of risk aggregation.This study offers a new perspective to full awareness on capital requirement calculation as requested by international regulation.

Uncertainty aversion and farmers' innovative seed adoption:Evidence from a field experiment in rural China

Based on the microdata of 705 wheat farmers in the Loess Plateau, this study empirically analyzes the impact of uncertainty on farmers' adoption of innovative seeds using a field experiment. The results indicate that farmers are generally ambiguity-averse and risk-averse. In addition, farmers with higher ambiguity aversion and risk aversion are less likely to adopt innovative wheat seeds, where their risk aversion plays a dominant role. Enhancing information access will alleviate the negative influence of ambiguity aversion on farmers' adoption of innovative seeds, and interlinked insurance and credit contracts will be beneficial to ease the adverse effect of risk aversion on the adoption of innovative wheat seeds. Meanwhile, heterogeneity analysis reveals that the inhibitory effects of ambiguity aversion and risk aversion on innovative seed adoption are more significant among farmers with lower education and household income.The government can establish both ex-ante and ex-post relevant guarantee mechanisms to help farmers preferably cope with various uncertainties in the production process, remitting farmers' ambiguity aversion and risk aversion to enhance new agricultural technology adoption rates.

The GABA Antagonist Picrotoxin Attenuates an Ethanol-Induced Taste Aversion in Taste Aversion-Prone Rats

The aversive properties of alcohol can be examined by using ethanol as a conditioning agent in a taste aversion (TA) paradigm. However, there is often variability in how organisms respond to the aversive properties of alcohol. Using a selectively bred line of TA-prone (TAP) rats, the present study sought to determine if antagonizing the GABA receptor complex with picrotoxin could block the acquisition of an ethanol-based conditioned aversion to a normally preferred fluid. Fifty TAP rats were randomly divided into 5 groups. In the two experimental groups, rats were pretreated with i.p. injections of low or high doses of the GABA Aantagonist picrotoxin prior to undergoing taste aversion conditioning —wherein consumption of a novel saccharin solution (0.1%) was followed by an i.p. injection of ethanol (1.5 mg/kg). In the primary control group, rats were treated identically, except that isotonic saline was substituted for picrotoxin. In the non-conditioning and pseudo-conditioning control groups, rats did not receive an ethanol-saccharin pairing but did receive a picrotoxin injection. Repeated measures ANOVA revealed that animals in the picrotoxin groups displayed significantly weaker TAs than the primary control group (p 0.05) as measured by post-conditioning, two-bottle saccharin preference scores. Picrotoxin hinders the acquisition of an ethanol-induced TA, thereby supporting the hypothesis that the GABA system plays a central role in ethanol’s motivational effects. Possible mechanisms include 1) picrotoxin attenuates negative effects of ethanol, 2) picrotoxin interferes with the central associative processes that promote TA conditioning or 3) some combination of 1 and 2.

An Examination of the Validity of the Differentiation-of-Self Hypothesis and Its Mechanism Related to Negative Life Event Aversion among Japanese University Students

This study examined the validity of the differentiation-of-self hypothesis for Japanese university students, and its mechanism in relation to negative life event aversion. Although the differentiation-of-self hypothesis is accepted as one of the basic hypotheses in the clinical field of family therapy in Japan, empirical studies on the subject are scarce. Further, there are few studies, internationally, on its mechanism. A questionnaire survey was conducted with university students (n = 250) to measure their differentiation of self, maladaptive states, and negative life event aversion. Compared to the better-differentiated group, the less-differentiated group had higher scores both for maladaptive states—somatic symptoms (t(223) = -2.70, p = 0.008), social dysfunction (t(211.00) = -3.30, p = 0.001), and severe depression (t(208.78) = -4.08, p < 0.001)—and negative life event aversion—interpersonal domain (t(223) = -3.96, p < 0.001) and achievement domain (t(223) = -3.83, p < 0.001). The results supported the validity of the differentiation-of-self hypothesis for Japanese university students, and that cognitive tendencies toward negative life events may be part of the mechanism for less-differentiated individuals’ subsequent vulnerability. This suggests the effectiveness of cognitive interventions.

Maximum Group Perceived Utility Consensus Models Considering Regret Aversion

In the consensus-reaching process(CRP),the actual utility of decision-makers(DMs)is often influenced by the psychological behavior of regret aversion.However,the influence of regret aversion on DMs’utilities is rarely taken into account in the existing consensus models.The consensus-reaching problem of DMs with regret aversion is explored to maximize their perceived utilities under a limited budget.Firstly,three basic types of perceived utility functions are constructed based on the regret theory to describe the perceived utility of DMs with various preferences.Then,considering the limited budget and individual regret aversion,the maximum perceived utility consensus models based on types of left-skewed,right-skewed,middle-skewed,and heterogeneous utility preferences are proposed to achieve the consensus that maximizes the group perceived utility.After that,an example of land-transfer price negotiation in China is given to illustrate the validity of the proposed models.Finally,the model comparison and the sensitivity analysis are presented to reveal the influence of DMs’regret aversion on the CRP.The results suggest that the DMs’regret aversion will not affect left-skewed and right-skewed groups,but will affect the consensus results of middle-skewed and heterogeneous groups.

Some Likelihood Based Properties in Large Samples: Utility and Risk Aversion, Second Order Prior Selection and Posterior Density Stability

The likelihood function plays a central role in statistical analysis in relation to information, from both frequentist and Bayesian perspectives. In large samples several new properties of the likelihood in relation to information are developed here. The Arrow-Pratt absolute risk aversion measure is shown to be related to the Cramer-Rao Information bound. The derivative of the log-likelihood function is seen to provide a measure of information related stability for the Bayesian posterior density. As well, information similar prior densities can be defined reflecting the central role of likelihood in the Bayes learning paradigm.

Pain-related mediators underlie incision-induced mechanical nociception in the dorsal root ganglia

Approximately 50-70% of patients experience incision-induced mechanical nociception after sur- gery. However, the mechanism underlying incision-induced mechanical nociception is still unclear. Interleukin-10 and brain-derived neurotrophic factor are important pain mediators, but whether in- terleukin-10 and brain-derived neurotrophic factor are involved in incision-induced mechanical no- ciception remains uncertain. In this study, forty rats were divided randomly into the incision surgery （n = 32） and sham surgery （n = 8） groups. Plantar incision on the central part of left hind paw was performed under anesthesia in rats from the surgery group. Rats in the sham surgery group re- ceived anesthesia, but not an incision. Yon Frey test results showed that, compared with the sham surgery group, incision surgery decreased the withdrawal threshold of rats at 0.5, 3, 6 and 24 hours after incision. Immunofluorescence staining in the dorsal root ganglia of the spinal cord （L3-5） showed that interleukin-10 and brain-derived neurotrophic factor were expressed mainly on small- and medium-sized neurons （diameter 〈 20 pm and 20-40 pm） and satellite cells in the dorsal root ganglia of the spinal cord （L3-5） in the sham surgery group. By contrast, in the surgery group, high expression of interleukin-10 and brain-derived neurotrophic factor appeared in large-sized neurons （diameter 〉 40 pm） at 6 and 24 hours after incision surgery, which corresponded to the decreased mechanical withdrawal threshold of rats in the surgery group. These experimental findings suggest that expression pattern shift of interleukin-10 and brain-derived neurotrophic factor induced by inci- sion surgery in dorsal root ganglia of rats was closely involved in lowering the threshold to me- chanical stimulus in the hind paw following incision surgery. Pain-related mediators induced by in- cision surgery in dorsal root ganglia of rats possibly underlie mechanical nociception in ipsilateral hind paws.

The risk aversion measures in Architectural Engineering Project Management

With the continuous development of the construction industry, the scale and volume of the construction project is expanding. And the project management of the construction project still has the big risk problem which influenced by many factors. These risks will not only bring unnecessary interference to the construction of the project, but also may jeopardize the safety of people＇s life and property. It is the focus of this article to do a good job in risk aversion in the management of construction projects.

Systematic Reform and Risk Aversion in the Interregional Flow of Chinese Rural Labor Force --Wuhan Case Study

Based on Wuhan city investigation, this paper makes a positive analysis to the uncertainty of shifting rural labors to urban areas, and put forward thoughts and countermeasures to avert the risk of the interregional flow of rural labors.

Increased CXCL13 and CXCR5 in Anterior Cingulate Cortex Contributes to Neuropathic Pain-Related Conditioned Place Aversion

Pain consists of sensory-discriminative and emotional-affective components.The anterior cingulate cortex(ACC)is a critical brain area in mediating the affective pain.However,the molecular mechanisms involved remain largely unknown.Our recent study indicated that C-X-C motif chemokine 13(CXCL13)and its sole receptor CXCR5 are involved in sensory sensitization in the spinal cord after spinal nerve ligation(SNL).Whether CXCL13/CXCR5 signaling in the ACC contributes to the pathogenesis of pain-related aversion remains unknown.Here,we showed that SNL increased the CXCL13 level and CXCR5 expression in the ACC after SNL.Knockdown of CXCR5 by microinjection of Cxcr5 shRNA into the ACC did not affect SNL-induced mechanical allodynia but effectively alleviated neuropathic painrelated place avoidance behavior.Furthermore,electrophysiological recording from layer Ⅱ-Ⅲ neurons in the ACC showed that SNL increased the frequency and amplitude of spontaneous excitatory postsynaptic currents(sEPSCs),decreased the EPSC paired-pulse ratio,and increased the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor/N-methyl-D-aspartate receptor ratio,indicating enhanced glutamatergic synaptic transmission.Finally,superfusion of CXCL13 onto ACC slices increased the frequency and amplitude of spontaneous EPSCs.Pre-injection of Cxcr5 shRNA into the ACC reduced the increase in glutamatergic synaptic transmis sion induced by SNL.Collectively,these results suggest that CXCL13/CXCR5 signaling in the ACC is involved in neuropathic pain-related aversion via synaptic potentiation.

Lycium barbarum polysaccharide-glycoprotein preventative treatment ameliorates aversive stimuli-induced depression

Previous studies have shown that Lycium barbarum polysaccharide,the main active component of Lycium barbarum,exhibits antiinflammatory and antioxidant effects in treating neurological diseases.However,the therapeutic action of Lycium barbarum polysaccharide on depression has not been studied.In this investigation,we established mouse models of depression using aversive stimuli including exposure to fox urine,air puff and foot shock and physical restraint.Concurrently,we administered 5 mg/kg per day Lycium barbarum polysaccharide-glycoprotein to each mouse intragastrically for the 28 days.Our results showed that long-term exposure to aversive stimuli significantly enhanced depressive-like behavior evaluated by the sucrose preference test and the forced swimming test and increased anxietylike behaviors evaluated using the open field test.In addition,aversive stimuli-induced depressed mice exhibited aberrant neuronal activity in the lateral habenula.Importantly,concurrent Lycium barbarum polysaccharide-glycoprotein treatment significantly reduced these changes.These findings suggest that Lycium barbarum polysaccharide-glycoprotein is a potential preventative intervention for depression and may act by preventing aberrant neuronal activity and microglial activation in the lateral habenula.The study was approved by the Jinan University Institutional Animal Care and Use Committee(approval No.20170301003)on March 1,2017.

loss-averse测度的低碳闭环供应链最优减排研究

以低碳产品销售为不确定市场环境为背景,以Stackelberg博弈理论为方法,以loss-averse为工具,构建了双第三方回收低碳风险再制造闭环供应链模型,研究了制造商低碳减排能力、碳排放征税政策、销售商风险厌恶程度和废旧低碳产品回收市场竞争特性等因素的影响作用机理;揭示非合作博弈和协调运作下,订单数量、交易价格、低碳废旧产品回收价格等重要变量和节点企业收益、期望效用及整个链条收益的变化规律及隐含的经济意义与管理理念。设计正向渠道收益共享、逆向渠道风险共担契约,克服风险规避效应和双重边际效应的不利影响,实现低碳再制造闭环供应链的协调;通过数值仿真研究和灵敏度分析,验证了低碳风险再制造闭环供应链模型的有效性及实用性,为供应链上下游企业开展低碳减排合作提供了理论依据和政策建议。

Contributions of aversive environmental stress to migraine chronification:Research update of migraine pathophysiology

Clinical studies have suggested that internal and/or external aversive cues may produce a negative affective-motivational component whereby maladaptive responses(plasticity)of dural afferent neurons are initiated contributing to migraine chronification.However,pathophysiological processes and neural circuitry involved in aversion(unpleasantness)-producing migraine chronification are still evolving.An interdisciplinary team conducted this narrative review aimed at reviewing neuronal plasticity for developing migraine chronicity and its relevant neurocircuits and providing the most cutting-edge information on neuronal mechanisms involved in the processing of affective aspects of pain and the role of unpleasantness evoked by internal and/or external cues in facilitating the chronification process of migraine headache.Thus,information presented in this review promotes the understanding of the pathophysiology of chronic migraine and contribution of unpleasantness(aversion)to migraine chronification.We hope that it will bring clinicians’attention to how the maladaptive neuroplasticity of the emotion brain in the aversive environment produces a significant impact on the chronification of migraine headache,which will in turn lead to new therapeutic strategies for this type of pain.

Optimal Portfolio Selection of Wind Power Plants Using a Stochastic Risk-Averse Optimization Model, Considering the Wind Complementarity of the Sites and a Budget Constraint

This work focuses on the best financial resources allocation to define a wind power plant portfolio, considering a set of feasible sites. To accomplish the problem formulation and solution, the first step was to establish a long-term wind series reconstruction methodology for generating scenarios of wind energy, applying it to study five different locations of the Brazilian territory. Secondly, a risk-averse stochastic optimization model was implemented and used to define the optimal wind power plant selection that maximizes the portfolio financial results, considering an investment budget constraint. In a sequence, a case study was developed to illustrate a practical situation of applying the methodology to the portfolio selection problem, considering five wind power plants options. The case study was supported by the proposed optimization model, using the scenarios of generation created by the reconstruction methodology. The obtained results show the model performance in terms of defining the best financial resources allocation considering the effect of the complementarity between sites, making it feasible to select the optimal set of wind power plants, characterizing a wind plant optimal portfolio that takes into account the budget constraint. The adopted methodology makes it possible to realize that the diversification of the portfolio depends on the investor risk aversion. Although applied to the Brazilian case, this model can be customized to solve a similar problem worldwide.

Decision-Making of a Single Supplier and Multiple Loss-Averse Retailers under Partial Trade Credit

Under partial trade credit,suppliers usually require retailers to pay a fraction of the purchase cost immediately when ordering and the remaining payment is deferred at the end of the sales period.Considering a supply chain consisting of a risk-neutral supplier and multiple loss-averse retailers,we develop models under partial trade credit.We analyze the optimal decisions of a supplier and retailers under decentralized decision-making.The study shows that there is a unique Nash equilibrium among the retailers,and the optimal total order quantity of retailers increases as the delayed payment ratio increases and as the degree of retailers'competition increases,but decreases with an increase in the loss aversion.Numerical studies are conducted to demonstrate the solution procedures and the effects of the parameters on decisions and profits.

Multi-Objective Low Carbon Vehicle Routing for Cold Chain Distribution with Customer Time Loss Aversion

The elevated refrigeration expenses linked to cold chain distribution contribute to increased overall logistics costs and carbon emissions.Concurrently,the sensitivity of consumers to delivery delays also impacts the design of cold chain distribution operations.This paper considers the logistics costs of cold chain,consumer time loss aversion,and the efficiency of low-carbon distribution to construct a multi-objective cold chain vehicle routing problem.It combines a decomposition-based multi-objective solution algorithm and fruit fly optimization algorithm to solve the proposed model,and validates the algorithm and model through a large number of numerical experiments.Firstly,our computations of the C-metric,IGD value,Hypervolumn,and CPU time demonstrate that the algorithm employed in this study has yielded notable advantages in terms of convergence and the overall performance of the non-dominated solutions.Secondly,we find that increasing logistics satisfaction requires a significant investment in logistics costs,thus requiring a delicate balance between logistics expenditure and service advantages.Finally,we used a typical example to analyze the size of different cost modules in cold chain distribution and find that vehicles can optimize their routes without needing to make extensive diversions to reach distant customers,ultimately leading to reduced fuel consumption and carbon emissions.Besides,the traditional assumption that a higher utilization of logistics vehicles results in increased carbon emissions and fuel usage is not universally valid.Our research contributes to the current balance between cold chain costs and consumer satisfaction in cold chain distribution.Additionally,leveraging multi-objective algorithm design,we provide feasible solutions for current cold chain delivery operations.Further,by incorporating consumer time loss aversion model,we aid in understanding the impact of consumer behavior on the design of cold chain delivery solutions.