Experiments were performed on 25 rats. Putative serotonergic antagonist, Cyproheptadine(Cyp), was applied microiontophoretically on the nucleus parafascicularis of the thalamus (Pf) andthe effect of Cyp on Pf nocicept...Experiments were performed on 25 rats. Putative serotonergic antagonist, Cyproheptadine(Cyp), was applied microiontophoretically on the nucleus parafascicularis of the thalamus (Pf) andthe effect of Cyp on Pf nociceptive neuronal discharge was observed. The result suggested that Cypcan increase the spontaneous and evoked discharge rates of Pf nociceptive neuron, and that Cypmay antagonize the inhibitory effect of endogenous serotonin on the spontaneous and evokeddischarges of Pf nociceptive neurons.展开更多
文摘Experiments were performed on 25 rats. Putative serotonergic antagonist, Cyproheptadine(Cyp), was applied microiontophoretically on the nucleus parafascicularis of the thalamus (Pf) andthe effect of Cyp on Pf nociceptive neuronal discharge was observed. The result suggested that Cypcan increase the spontaneous and evoked discharge rates of Pf nociceptive neuron, and that Cypmay antagonize the inhibitory effect of endogenous serotonin on the spontaneous and evokeddischarges of Pf nociceptive neurons.
