Objective: To assess the efficacy of artesunate on falciparum malaria. Methods: A randomizedand controlled study on the treatment of 90 uncomplicated falciparum malaria patients was carried out respectively with 400 m...Objective: To assess the efficacy of artesunate on falciparum malaria. Methods: A randomizedand controlled study on the treatment of 90 uncomplicated falciparum malaria patients was carried out respectively with 400 mg of artesunate tablet as the total dose in 3 days, 600 mg in 5 days and 800 mg in 7 days. Results:All patients were cured. Fever clearance time (FCT) and parasite clearance time (PCT) among the three groupswere similar. Parasite recrudescence rates within 28 days were 39. 3 % (11/28 ) in the 3-day group, 6. 9 % (2/29) in the 5-day group and 3. 4% (1/29) in the 7-day group (comparing the 5-day group with the 3-daygroup, P＜0. 005, comparing 7-day group with the 3-day group, P＜0. 005). Conclusion: Parasite recrudescence rate may be effectively decreased by prolonging the treatment course.展开更多
文摘Objective: To assess the efficacy of artesunate on falciparum malaria. Methods: A randomizedand controlled study on the treatment of 90 uncomplicated falciparum malaria patients was carried out respectively with 400 mg of artesunate tablet as the total dose in 3 days, 600 mg in 5 days and 800 mg in 7 days. Results:All patients were cured. Fever clearance time (FCT) and parasite clearance time (PCT) among the three groupswere similar. Parasite recrudescence rates within 28 days were 39. 3 % (11/28 ) in the 3-day group, 6. 9 % (2/29) in the 5-day group and 3. 4% (1/29) in the 7-day group (comparing the 5-day group with the 3-daygroup, P＜0. 005, comparing 7-day group with the 3-day group, P＜0. 005). Conclusion: Parasite recrudescence rate may be effectively decreased by prolonging the treatment course.
