Background: Breast-conserving surgery (BCS) followed by whole breast irradiation (WBI) has become the standard of care for treating patients with early-stage breast cancer. Recently, various radiation techniques follo...Background: Breast-conserving surgery (BCS) followed by whole breast irradiation (WBI) has become the standard of care for treating patients with early-stage breast cancer. Recently, various radiation techniques followed by BCS have been reported. We have been investigating “personalized radiotherapy after BCS” ranging from accelerated partial breast irradiation (APBI) to WBI with regional nodal irradiation (RNI) based on the axillary node status. In this study, we compared different cohorts that received personalized radiotherapy. Method: Of 317 consecutive patients who underwent BCS followed by radiotherapy since November 2007, 187 who received APBI and 122 who received WBI were analyzed. Results: The local-only recurrence rate was 1.1% in the APBI group and 3.3% in the WBI group, and the regional-only recurrence rate was 1.1% for APBI and 0.8% for WBI. Conclusions: The clinical efficacy of APBI for local control after BCS was comparable to that of WBI ± RNI. Although this study was based on a small number of patients with a short follow-up period, the feasibility of breast-conserving therapy using multicatheter brachytherapy to achieve acceptable clinical outcomes was demonstrated.展开更多
In the conventional differential quadrature （DQ） method the functional values along a mesh line are used to approximate derivatives and its application is limited to regular regions. In this paper, a local different...In the conventional differential quadrature （DQ） method the functional values along a mesh line are used to approximate derivatives and its application is limited to regular regions. In this paper, a local differential quadrature （LDQ） method was developed by using irregular distributed nodes, where any spatial derivative at a nodal point is approximated by a linear weighted sum of the functional values of nodes in the local physical domain. The weighting coefficients in the new approach are determined by the quadrature rule with the aid of nodal interpolation. Since the proposed method directly approximates the derivative, it can be consistently well applied to linear and nonlinear problems and the mesh-free feature is still kept. Numerical examples are provided to validate the LDQ method.展开更多
文摘Background: Breast-conserving surgery (BCS) followed by whole breast irradiation (WBI) has become the standard of care for treating patients with early-stage breast cancer. Recently, various radiation techniques followed by BCS have been reported. We have been investigating “personalized radiotherapy after BCS” ranging from accelerated partial breast irradiation (APBI) to WBI with regional nodal irradiation (RNI) based on the axillary node status. In this study, we compared different cohorts that received personalized radiotherapy. Method: Of 317 consecutive patients who underwent BCS followed by radiotherapy since November 2007, 187 who received APBI and 122 who received WBI were analyzed. Results: The local-only recurrence rate was 1.1% in the APBI group and 3.3% in the WBI group, and the regional-only recurrence rate was 1.1% for APBI and 0.8% for WBI. Conclusions: The clinical efficacy of APBI for local control after BCS was comparable to that of WBI ± RNI. Although this study was based on a small number of patients with a short follow-up period, the feasibility of breast-conserving therapy using multicatheter brachytherapy to achieve acceptable clinical outcomes was demonstrated.
文摘In the conventional differential quadrature （DQ） method the functional values along a mesh line are used to approximate derivatives and its application is limited to regular regions. In this paper, a local differential quadrature （LDQ） method was developed by using irregular distributed nodes, where any spatial derivative at a nodal point is approximated by a linear weighted sum of the functional values of nodes in the local physical domain. The weighting coefficients in the new approach are determined by the quadrature rule with the aid of nodal interpolation. Since the proposed method directly approximates the derivative, it can be consistently well applied to linear and nonlinear problems and the mesh-free feature is still kept. Numerical examples are provided to validate the LDQ method.
基金国家自然科学基金重点资助项目(the Key Project of National Natural Science Foundation of China under Grant No.60634030)国家自然科学基金(the National Natural Science Foundation of China under Grant No.60702066)教育部新世纪优秀人才支持计划资助项目(the Program for New Century Excellent Talents in University)
