AIM:To evaluate the effects of estrogen(E2) on systemic and splanchnic hyperdynamic circulation in portal hypertensive rats.METHODS:Fifty castrated female Sprague-Dawley rats were divided into five groups:sham operati...AIM:To evaluate the effects of estrogen(E2) on systemic and splanchnic hyperdynamic circulation in portal hypertensive rats.METHODS:Fifty castrated female Sprague-Dawley rats were divided into five groups:sham operation(SO),partial portal vein ligation(PPVL) + placebo(PLAC),PPVL + E2,PPVL + ICI and PPVL + E2 + ICI. Hemodynamic measurements were performed using ultrasonography. Mesenteric arteriole contractility in response to norepinephrine was determined using a vessel perfusion system. Oxidative stress in the mesenteric artery was investigated by in situ detection of the superoxide anion(O2) and hydrogen peroxide(H2O2) concentrations.RESULTS:Treatment with E2 resulted in a significant decrease of portal pressure(P < 0.01) and portal venous inflow(P < 0.05),and higher systemic vascular resistance(P < 0.05) and splanchnic arteriolar resistance(P < 0.01) in PPVL + E2 rats compared to PPVL+ PLAC rats. In the mesenteric arterioles of PPVL +E2 rats,the dose-response curve was shifted left,and the EC50was decreased(P < 0.01). E2 reduced O2 production and H2O2concentration in the mesenteric artery. However,ICI182,780 reversed the beneficial effects of E2,therefore,the systemic and splanchnic hyperdynamic circulation were more deteriorated in ICI182,780-treated rats.CONCLUSION:Treatment with estrogen improved the systemic and splanchnic hyperdynamic circulation in PPVL rats,in part due to the alleviation of oxidative stress.展开更多
The recovery stress characteristics of a TiNi shape memory alloy wire under different constraint conditions were studied. The results show that the recovery stress rate (dσ/dT) in the second heating cycle increases s...The recovery stress characteristics of a TiNi shape memory alloy wire under different constraint conditions were studied. The results show that the recovery stress rate (dσ/dT) in the second heating cycle increases significantly with the increasing constraining-spring coefficient in the first heating cycle. As a result, a distinct discontinuity appears on the recovery stress curves of the TiNi alloy wires in the second heating process. Also, the results of differential scanning calorimeter(DSC) measurements show that after the thermomechanical process, the heating curve of the TiNi alloy wire consists of two independent endothermic peaks.展开更多
Under Type-Ⅱ progressively hybrid censoring, this paper discusses statistical inference and optimal design on stepstress partially accelerated life test for hybrid system in presence of masked data. It is assumed tha...Under Type-Ⅱ progressively hybrid censoring, this paper discusses statistical inference and optimal design on stepstress partially accelerated life test for hybrid system in presence of masked data. It is assumed that the lifetime of the component in hybrid systems follows independent and identical modified Weibull distributions. The maximum likelihood estimations(MLEs)of the unknown parameters, acceleration factor and reliability indexes are derived by using the Newton-Raphson algorithm. The asymptotic variance-covariance matrix and the approximate confidence intervals are obtained based on normal approximation to the asymptotic distribution of MLEs of model parameters. Moreover,two bootstrap confidence intervals are constructed by using the parametric bootstrap method. The optimal time of changing stress levels is determined under D-optimality and A-optimality criteria.Finally, the Monte Carlo simulation study is carried out to illustrate the proposed procedures.展开更多
Partially stabilized zirconia ceramics were sintered using fine powder of ZrO 2 3mol%Y 2O 3 prepared by the chemical co precipitation method.The tetragonal to monoclinic phase transformation in ZrO 2 ceramics ...Partially stabilized zirconia ceramics were sintered using fine powder of ZrO 2 3mol%Y 2O 3 prepared by the chemical co precipitation method.The tetragonal to monoclinic phase transformation in ZrO 2 ceramics during the aging in boiling water and the effect of an applied stress of 100MPa were mainly investigated.The degradation of ZrO 2 ceramics is considered to be caused by the reaction between Y 2O 3 and H 2O,which leads to a decreasing in the stability of tetragonal phase of ZrO 2.It is found that the tensile stress improves the driving force of the phase transformation and accelerates the degradation while the compressive stress has no obvious effect on the degradation.展开更多
文摘AIM:To evaluate the effects of estrogen(E2) on systemic and splanchnic hyperdynamic circulation in portal hypertensive rats.METHODS:Fifty castrated female Sprague-Dawley rats were divided into five groups:sham operation(SO),partial portal vein ligation(PPVL) + placebo(PLAC),PPVL + E2,PPVL + ICI and PPVL + E2 + ICI. Hemodynamic measurements were performed using ultrasonography. Mesenteric arteriole contractility in response to norepinephrine was determined using a vessel perfusion system. Oxidative stress in the mesenteric artery was investigated by in situ detection of the superoxide anion(O2) and hydrogen peroxide(H2O2) concentrations.RESULTS:Treatment with E2 resulted in a significant decrease of portal pressure(P < 0.01) and portal venous inflow(P < 0.05),and higher systemic vascular resistance(P < 0.05) and splanchnic arteriolar resistance(P < 0.01) in PPVL + E2 rats compared to PPVL+ PLAC rats. In the mesenteric arterioles of PPVL +E2 rats,the dose-response curve was shifted left,and the EC50was decreased(P < 0.01). E2 reduced O2 production and H2O2concentration in the mesenteric artery. However,ICI182,780 reversed the beneficial effects of E2,therefore,the systemic and splanchnic hyperdynamic circulation were more deteriorated in ICI182,780-treated rats.CONCLUSION:Treatment with estrogen improved the systemic and splanchnic hyperdynamic circulation in PPVL rats,in part due to the alleviation of oxidative stress.
基金Project(50071037) supported by the National Natural Science Foundation of China Project supported by the ScientificResearch Foundation for the Returned Overseas Chinese Scholars Education Ministry of China
文摘The recovery stress characteristics of a TiNi shape memory alloy wire under different constraint conditions were studied. The results show that the recovery stress rate (dσ/dT) in the second heating cycle increases significantly with the increasing constraining-spring coefficient in the first heating cycle. As a result, a distinct discontinuity appears on the recovery stress curves of the TiNi alloy wires in the second heating process. Also, the results of differential scanning calorimeter(DSC) measurements show that after the thermomechanical process, the heating curve of the TiNi alloy wire consists of two independent endothermic peaks.
基金supported by the National Natural Science Foundation of China(71401134 71571144+1 种基金 71171164)the Program of International Cooperation and Exchanges in Science and Technology Funded by Shaanxi Province(2016KW-033)
文摘Under Type-Ⅱ progressively hybrid censoring, this paper discusses statistical inference and optimal design on stepstress partially accelerated life test for hybrid system in presence of masked data. It is assumed that the lifetime of the component in hybrid systems follows independent and identical modified Weibull distributions. The maximum likelihood estimations(MLEs)of the unknown parameters, acceleration factor and reliability indexes are derived by using the Newton-Raphson algorithm. The asymptotic variance-covariance matrix and the approximate confidence intervals are obtained based on normal approximation to the asymptotic distribution of MLEs of model parameters. Moreover,two bootstrap confidence intervals are constructed by using the parametric bootstrap method. The optimal time of changing stress levels is determined under D-optimality and A-optimality criteria.Finally, the Monte Carlo simulation study is carried out to illustrate the proposed procedures.
文摘Partially stabilized zirconia ceramics were sintered using fine powder of ZrO 2 3mol%Y 2O 3 prepared by the chemical co precipitation method.The tetragonal to monoclinic phase transformation in ZrO 2 ceramics during the aging in boiling water and the effect of an applied stress of 100MPa were mainly investigated.The degradation of ZrO 2 ceramics is considered to be caused by the reaction between Y 2O 3 and H 2O,which leads to a decreasing in the stability of tetragonal phase of ZrO 2.It is found that the tensile stress improves the driving force of the phase transformation and accelerates the degradation while the compressive stress has no obvious effect on the degradation.
