It is of vital significance to investigate mass transfer enhancements for chemical engineering processes.This work focuses on investigating the coupling influence of embedding wire mesh and adding solid particles on b...It is of vital significance to investigate mass transfer enhancements for chemical engineering processes.This work focuses on investigating the coupling influence of embedding wire mesh and adding solid particles on bubble motion and gas-liquid mass transfer process in a bubble column.Particle image velocimetry(PIV)technology was employed to analyze the flow field and bubble motion behavior,and dynamic oxygen absorption technology was used to measure the gas-liquid volumetric mass transfer coefficient(kLa).The effect of embedding wire mesh,adding solid particles,and wire mesh coupling solid particles on the flow characteristic and kLa were analyzed and compared.The results show that the gas-liquid interface area increases by 33%-72%when using the wire mesh coupling solid particles strategy compared to the gas-liquid two-phase flow,which is superior to the other two strengthening methods.Compared with the system without reinforcement,kLa in the bubble column increased by 0.5-1.8 times with wire mesh coupling solid particles method,which is higher than the sum of kLa increases with inserting wire mesh and adding particles,and the coupling reinforcement mechanism for affecting gas-liquid mass transfer process was discussed to provide a new idea for enhancing gas-liquid mass transfer.展开更多
High-voltage transmission lines play a crucial role in facilitating the utilization of renewable energy in regions prone to desertification. The accumulation of atmospheric particles on the surface of these lines can ...High-voltage transmission lines play a crucial role in facilitating the utilization of renewable energy in regions prone to desertification. The accumulation of atmospheric particles on the surface of these lines can significantly impact corona discharge and wind-induced conductor displacement. Accurately quantifying the force exerted by particles adhering to conductor surfaces is essential for evaluating fouling conditions and making informed decisions. Therefore, this study investigates the changes in electric field intensity along branched conductors caused by various fouling layers and their resulting influence on the adhesion of dust particles. The findings indicate that as individual particle size increases, the field strength at the top of the particle gradually decreases and eventually stabilizes at approximately 49.22 k V/cm, which corresponds to a field strength approximately 1.96 times higher than that of an unpolluted transmission line. Furthermore,when particle spacing exceeds 15 times the particle size, the field strength around the transmission line gradually decreases and approaches the level observed on non-adhering surface. The electric field remains relatively stable. In a triangular arrangement of three particles, the maximum field strength at the tip of the fouling layer is approximately 1.44 times higher than that of double particles and 1.5 times higher compared to single particles. These results suggest that particles adhering to the transmission line have a greater affinity for adsorbing charged particles. Additionally, relevant numerical calculations demonstrate that in dry environments, the primary adhesion forces between particles and transmission lines follow an order of electrostatic force and van der Waals force. Specifically, at the minimum field strength, these forces are approximately74.73 times and 19.43 times stronger than the gravitational force acting on the particles.展开更多
The homogeneous/particulate fluidization flow regime is particularly suitable for handling the various gas–solid contact processes encountered in the chemical and energy industry.This work aimed to extend such a regi...The homogeneous/particulate fluidization flow regime is particularly suitable for handling the various gas–solid contact processes encountered in the chemical and energy industry.This work aimed to extend such a regime of Geldart-A particles by exerting the axial uniform and steady magnetic field.Under the action of the magnetic field,the overall homogeneous fluidization regime of Geldart-A magnetizable particles became composed of two parts:inherent homogeneous fluidization and newly-created magnetic stabilization.Since the former remained almost unchanged whereas the latter became broader as the magnetic field intensity increased,the overall homogeneous fluidization regime could be extended remarkably.As for Geldart-A nonmagnetizable particles,certain amount of magnetizable particles had to be premixed to transmit the magnetic stabilization.Among others,the mere addition of magnetizable particles could broaden the homogeneous fluidization regime.The added content of magnetizable particles had an optimal value with smaller/lighter ones working better.The added magnetizable particles might raise the ratio between the interparticle force and the particle gravity.After the magnetic field was exerted,the homogeneous fluidization regime was further expanded due to the formation of magnetic stabilization flow regime.The more the added magnetizable particles,the better the magnetic performance and the broader the overall homogeneous fluidization regime.Smaller/lighter magnetizable particles were preferred to maximize the magnetic performance and extend the overall homogeneous fluidization regime.This phenomenon could be ascribed to that the added magnetizable particles themselves became more Geldart-A than-B type as their density or size decreased.展开更多
In paper[Chin.Phys.B 32070308(2023)],Xing et al.proposed a semi-quantum secret sharing protocol by using single particles.We study the security of the proposed protocol and find that it is not secure,that is,the three...In paper[Chin.Phys.B 32070308(2023)],Xing et al.proposed a semi-quantum secret sharing protocol by using single particles.We study the security of the proposed protocol and find that it is not secure,that is,the three dishonest agents,Bob,Charlie and Emily can collude to obtain Alice's secret without the help of David.展开更多
All eukaryotic cells can secrete extracellular vesicles, which have a double-membrane structure and are important players in the intercellular communication involved in a variety of important biological processes. Pla...All eukaryotic cells can secrete extracellular vesicles, which have a double-membrane structure and are important players in the intercellular communication involved in a variety of important biological processes. Platelets form platelet-derived microparticles (PMPs) in response to activation, injury, or apoptosis. This review introduces the origin, pathway, and biological functions of PMPs and their importance in physiological and pathological processes. In addition, we review the potential applications of PMPs in cancer, vascular homeostasis, thrombosis, inflammation, neural regeneration, biomarkers, and drug carriers to achieve targeted drug delivery. In addition, we comprehensively report on the origin, biological functions, and applications of PMPs. The clinical transformation, high heterogeneity, future development direction, and limitations of the current research on PMPs are also discussed in depth. Evidence has revealed that PMPs play an important role in cell-cell communication, providing clues for the development of PMPs as carriers for relevant cell-targeted drugs. The development history and prospects of PMPs and their cargos are explored in this guidebook.展开更多
This work focuses on numerically studying hydrodynamic interaction between a passive particle and a self-propelled particle,termed a squirmer,by using a two-dimensional lattice Boltzmann method(LBM).It is found that t...This work focuses on numerically studying hydrodynamic interaction between a passive particle and a self-propelled particle,termed a squirmer,by using a two-dimensional lattice Boltzmann method(LBM).It is found that the squirmer can capture a passive particle and propel it simultaneously,provided the passive particle is situated within the squirmer's wake.Our research shows that the critical capture distance,which determines whether the particle is captured,primarily depends on the intensity of the squirmer's dipolarity.The stronger dipolarity of squirmer results in an increased critical capture distance.Conversely,the Reynolds number is found to have minimal influence on this interaction.Interestingly,the passive particle,when driven by the squirmer's wake,contributes to a reduction in the squirmer's drag.This results in a mutual acceleration for both particles.Our findings can provide valuable perspectives for formulating the principles of reducing the drag of micro-swimmers and help to achieve the goal of using micro-swimmers to transport goods without physical tethers.展开更多
The Dirac equation γ<sub>μ</sub>(δ<sub>μ</sub>-eA<sub>μ</sub>)Ψ=mc<sup>2</sup>Ψ describes the bound states of the electron under the action of external potentials...The Dirac equation γ<sub>μ</sub>(δ<sub>μ</sub>-eA<sub>μ</sub>)Ψ=mc<sup>2</sup>Ψ describes the bound states of the electron under the action of external potentials, A<sub>μ</sub>. We assumed that the fundamental form of the Dirac equation γ<sub>μ</sub>(δ<sub>μ</sub>-S<sub>μ</sub>)Ψ=0 should describe the stable particles (the electron, the proton and the dark-matter-particle (dmp)) bound to themselves under the action of their own potentials S<sub>μ</sub>. The new equation reveals that self energy is consequence of self action, it also reveals that the spin angular momentum is consequence of the dynamic structure of the stable particles. The quantitative results are the determination of their relative masses as well as the determination of the electromagnetic coupling constant.展开更多
A dark matter mechanism within the framework of the standard model (SM) of particle physics is proposed in this article that the essence of dark matter may be the excited virtual particle field by the gravitational fi...A dark matter mechanism within the framework of the standard model (SM) of particle physics is proposed in this article that the essence of dark matter may be the excited virtual particle field by the gravitational field of ordinary matter, which contains virtual photons, virtual positive and negative electron pairs, virtual gluons, virtual positive and negative quark pairs, virtual neutrinos etc. In this mechanism, there are two basic assumptions: 1) the stronger the gravitational field of ordinary matter, the greater the excited energy (mass) density of virtual particle field;2) The excited virtual particle field is generally very weak in self-interaction. The virtual particle field excited by gravity can exhibit the properties of dark matter and may become a dark matter candidate. Based on this new dark matter mechanism, the hydrodynamic equations and cosmic perturbation equations describing cosmic matter are improved, and this may be meaningful for solving the challenges faced by the standard cosmological model (Lambda-CDM or LCDM) and developing and perfecting LCDM model.展开更多
Present studies in physics assume that elementary particles are the building blocks of all matter, and that they are zero-dimensional objects which do not occupy space. The new I-Theory predicts that elementary partic...Present studies in physics assume that elementary particles are the building blocks of all matter, and that they are zero-dimensional objects which do not occupy space. The new I-Theory predicts that elementary particles do indeed have a substructure, three dimensions, and occupy space, being composed of fundamental particles called I-particles. In this article we identify the substructural pattern of elementary particles and define the quanta of energy that form each elementary particle. We demonstrate that the substructure comprises two classes of quanta which we call “attraction quanta” and “repulsion quanta”. We create a model that defines the rest-mass energy of each elementary particle and can predict new particles. Lastly, in order to incorporate this knowledge into the contemporary models of science, a revised periodic table is proposed.展开更多
The Southern Ocean is an important carbon sink pool and plays a critical role in the global carbon cycling.The Amundsen Sea was reported to be highly productive in inshore area in the Southern Ocean.In order to invest...The Southern Ocean is an important carbon sink pool and plays a critical role in the global carbon cycling.The Amundsen Sea was reported to be highly productive in inshore area in the Southern Ocean.In order to investigate the influence of transparent exopolymer particles(TEP)on the behavior of dissolved organic carbon(DOC)in this region,a comprehensive study was conducted,encompassing both open water areas and highly productive polynyas.It was found that microbial heterotrophic metabolism is the primary process responsible for the production of humic-like fluorescent components in the open ocean.The relationship between apparent oxygen utilization and the two humic-like components can be accurately described by a power-law function,with a conversion rate consistent with that observed globally.The presence of TEP was found to have little impact on this process.Additionally,the study revealed the accumulation of DOC at the sea surface in the Amundsen Sea Polynya,suggesting that TEP may play a critical role in this phenomenon.These findings contribute to a deeper understanding of the dynamics and surface accumulation of DOC in the Amundsen Sea Polynya,and provide valuable insights into the carbon cycle in this region.展开更多
As one of the main application directions of quantum technology,underwater quantum communication is of great research significance.In order to study the influence of marine planktonic algal particles on the communicat...As one of the main application directions of quantum technology,underwater quantum communication is of great research significance.In order to study the influence of marine planktonic algal particles on the communication performance of underwater quantum links,based on the extinction characteristics of marine planktonic algal particles,the influence of changes in the chlorophyll concentration and particle number density of planktonic algal particles on the attenuation of underwater links is explored respectively,the influence of marine planktonic algal particles on the fidelity of underwater quantum links,the generation rate of the security key,and the utilization rate of the channel is analyzed,and simulation experiments are carried out.The results show that with the increase in chlorophyll concentration and particle density of aquatic planktonic algal particles,quantum communication channel link attenuation shows a gradually increasing trend.In addition,the security key generation rate,channel fidelity and utilization rate are gradually decreasing.Therefore,the performance of underwater quantum communication channel will be interfered by marine planktonic algal particles,and it is necessary to adjust the relevant parameter values in the quantum communication system according to different marine planktonic algal particle number density and chlorophyll concentration to improve the performance of quantum communication.展开更多
The effects of ionic emulsifier, sodium dodecylbenzene sulfate (SDBS), on the formation of the multihollow structures in sub-micron sized polymer particles produced by alkali/acid posttreatment were investigated. The ...The effects of ionic emulsifier, sodium dodecylbenzene sulfate (SDBS), on the formation of the multihollow structures in sub-micron sized polymer particles produced by alkali/acid posttreatment were investigated. The original latex particles with narrow size distribution were synthesized by a new sequence emulsifier-free/emulsifier emulsion copolymerization of styrene (St) and methacrylic acid (MAA). Results indicated that the pore size decreased and the pore number increased with the increase of SDBS amount, and the morphology of the posttreated latex particles was also significantly influenced by the introducing time of SDBS in the preparation of the original latex particles, and a suitable introducing time was 3 h of polymerization. (c) 2007 Cheng You Kan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
The presence of diatoms is accompanied by the production of a large amount of extracellular polymeric substances,which are mainly composed of carbohydrates.Transparent exopolymer particles(TEP)are a large class of ext...The presence of diatoms is accompanied by the production of a large amount of extracellular polymeric substances,which are mainly composed of carbohydrates.Transparent exopolymer particles(TEP)are a large class of extracellular polymeric substances with high stickiness that promotes the formation of aggregates and marine snow,which affects marine bio-carbon pump efficiency.The purpose of this research was to determine how temperature increases affect the allocation of cellular carbohydrates and the formation and aggregation of TEP.The results showed that the responses of two different diatom species(Thalassiosira weissflogii and Skeletonema marinoi)differed according to temperature.The cell density and chlorophyll a concentration of the former were not significantly correlated with temperature,while those of the latter were significantly decreased with increasing temperature.This indicates that the two species of diatom may have different heat tolerance ranges.A temperature increase will promote significant formation of TEP by both types of diatoms,including aggregation of S.marinoi as the temperature rises,meaning that the high temperature will produce an aggregate with a larger particle size and thus may increase the sedimentation rate of organic carbon.Moreover,the TEP aggregation of T.weissflogii did not increase;therefore,its particle size was smaller,and so it may remain on the sea surface at high temperatures for longer periods.These influences have a profound impact on the biogeochemical cycling of carbon.展开更多
Transparent exopolymer particles(TEPs)are ubiquitous throughout the oceans,and their sedimentation is considered an efficient biological carbon sink pathway.To investigate the role of coastal TEPs in sinking carbon fr...Transparent exopolymer particles(TEPs)are ubiquitous throughout the oceans,and their sedimentation is considered an efficient biological carbon sink pathway.To investigate the role of coastal TEPs in sinking carbon from the upper layer,samples were collected in the spring and summer of 2011 in the Changjiang River(Yangtze River)Estuary,a typical coastal water.The concentrations and sinking rates of TEPs were measured,and potential sedimentation flux of TEPs was estimated.TEPs concentrations ranged from 40.00μg/L to 1040.00μg/L(mean=(209.70±240.93)μg/L)in spring and 56.67μg/L to 1423.33μg/L(mean=(433.33±393.02)μg/L)in summer,and they were higher at bloom stations than at non-bloom stations during both cruises.A significant positive correlation between TEPs concentration and chlorophyll a(Chl a)concentration was detected,suggesting that phytoplankton was the primary source of TEPs in this area.TEPs sinking rates ranged from 0.08 m/d to 0.57 m/d with a mean of(0.28±0.14)m/d in spring and 0.10 m/d to 1.08 m/d with a mean of(0.34±0.31)m/d in summer.The potential sedimentation flux of TEP-C ranged from 4.95 mg/(m2·d)to 29.40 mg/(m2·d)with a mean of(14.66±8.83)mg/(m2·d)in spring and 6.80 mg/(m2·d)to 30.45 mg/(m2·d)with a mean of(15.71±8.73)mg/(m2·d)in summer,which was^17.81%to 138.27%(mean=65.15%±31.75%)of sedimentation flux of phytoplankton cells in the study area.Due to the increase of TEPs concentrations and their sinking rates,sedimentation fluxes of TEPs at the bloom station were obviously higher than at the non-bloom station during both cruises.This study indicates that TEPs serve as a carbon sink in the Changjiang River Estuary,especially during bloom events,and their sedimentation should be taken into account when we study the carbon sedimentation in the coastal sea.展开更多
A simple two-step method was developed to prepare silver nanoshells coated on silica paticles. The method involves two steps: concentration of reaction precursor (AgNO3) on particle surfaces and subsequent reduction b...A simple two-step method was developed to prepare silver nanoshells coated on silica paticles. The method involves two steps: concentration of reaction precursor (AgNO3) on particle surfaces and subsequent reduction by formaldehyde. The obtained composite particles were characterized by TEM, ED, and SEM-EDS measurements. The results show that the silver nanoshell is coated on silica particle surface in the form of a polycrystalline (cubic structure) layer with average thickness of 20 nm and weight percentage of 19%.展开更多
This study explored the potential of polysaccharides from Actium lappa(ALPs)as natural wall materials for producing ALP-based nanoparticles to deliver poorly water-soluble oleanolic acid(OA)and ursolic acid(UA).Encaps...This study explored the potential of polysaccharides from Actium lappa(ALPs)as natural wall materials for producing ALP-based nanoparticles to deliver poorly water-soluble oleanolic acid(OA)and ursolic acid(UA).Encapsulating OA+UA with ALPs(ALP:OA+UA,50:1;OA:UA,1:1)changed the crystalline nature to a more amorphous state through hydrogen bonding and involving O-H/C-O/O-C-O groups.ALP-OA/UA nanoparticles had a particle size and zeta potential(in water)of 199.1 nm/-7.15 mV,with a narrow unimodal size distribution,and excellent pH,salt solution,temperature and storage stability.Compared with ALPs,ALPOA/UA nanoparticles showed enhanced anti-inflammatory activity(especially at a dose of 100μg/mL)in a CuSO-induced zebrafish inflammation model via down-regulating the NF-κB signalling pathway and gene expression of associated transcription factors and cytokines(TNF-α,IL-1βand IL-8).Therefore,ALP-based nanoparticles are natural and anti-inflammatory carriers for hydrophobic bioactive molecules.展开更多
The properties of dry-coated paracetamol particles(fast-dissolving model drug)with carnauba wax particles as the coating agent(dissolution retardant)were investigated.Raman mapping technique was used to non-destructiv...The properties of dry-coated paracetamol particles(fast-dissolving model drug)with carnauba wax particles as the coating agent(dissolution retardant)were investigated.Raman mapping technique was used to non-destructively examine the thickness and homogeneity of coated particles.The results showed that the wax existed in two forms on the surface of the paracetamol particles,forming a porous coating layer:i)whole wax particles on the surface of paracetamol and glued together with other wax surface particles,and ii)deformed wax particles spread on the surface.Regardless of the final particle size fraction(between 100 and 800 mm),the coating thickness had high variability,with average thickness of 5.9±4.2 mm.The ability of carnauba wax to decrease the dissolution rate of paracetamol was confirmed by dissolution of powder and tablet formulations.The dissolution was slower for larger coated particles.Tableting further reduced the dissolution rate,clearly indicating the impact of subsequent formulation processes on the final quality of the product.展开更多
基金supported by the Key Research and Development Plan of Shandong Province(the Major Scientific and Technological Innovation Projects,2021ZDSYS13)the Natural Science Foundation of Shandong Province(ZR2021MB135)Natural Science Foundation of Shandong Province(ZR2021ME224).
文摘It is of vital significance to investigate mass transfer enhancements for chemical engineering processes.This work focuses on investigating the coupling influence of embedding wire mesh and adding solid particles on bubble motion and gas-liquid mass transfer process in a bubble column.Particle image velocimetry(PIV)technology was employed to analyze the flow field and bubble motion behavior,and dynamic oxygen absorption technology was used to measure the gas-liquid volumetric mass transfer coefficient(kLa).The effect of embedding wire mesh,adding solid particles,and wire mesh coupling solid particles on the flow characteristic and kLa were analyzed and compared.The results show that the gas-liquid interface area increases by 33%-72%when using the wire mesh coupling solid particles strategy compared to the gas-liquid two-phase flow,which is superior to the other two strengthening methods.Compared with the system without reinforcement,kLa in the bubble column increased by 0.5-1.8 times with wire mesh coupling solid particles method,which is higher than the sum of kLa increases with inserting wire mesh and adding particles,and the coupling reinforcement mechanism for affecting gas-liquid mass transfer process was discussed to provide a new idea for enhancing gas-liquid mass transfer.
基金Project supported by the National Natural Science Foundation of China (Grant No.12064034)the Leading Talents Program of Science and Technology Innovation in Ningxia Hui Autonomous Region,China (Grant No.2020GKLRLX08)+2 种基金the Natural Science Foundation of Ningxia Hui Auatonomous Region,China (Grant Nos.2022AAC03643,2022AAC03117,and 2018AAC03029)the Major Science and Technology Project of Ningxia Hui Autonomous Region,China (Grant No.2022BDE03006)the Natural Science Project of the Higher Education Institutions of Ningxia Hui Autonomous Region,China (Grant No.13-1069)。
文摘High-voltage transmission lines play a crucial role in facilitating the utilization of renewable energy in regions prone to desertification. The accumulation of atmospheric particles on the surface of these lines can significantly impact corona discharge and wind-induced conductor displacement. Accurately quantifying the force exerted by particles adhering to conductor surfaces is essential for evaluating fouling conditions and making informed decisions. Therefore, this study investigates the changes in electric field intensity along branched conductors caused by various fouling layers and their resulting influence on the adhesion of dust particles. The findings indicate that as individual particle size increases, the field strength at the top of the particle gradually decreases and eventually stabilizes at approximately 49.22 k V/cm, which corresponds to a field strength approximately 1.96 times higher than that of an unpolluted transmission line. Furthermore,when particle spacing exceeds 15 times the particle size, the field strength around the transmission line gradually decreases and approaches the level observed on non-adhering surface. The electric field remains relatively stable. In a triangular arrangement of three particles, the maximum field strength at the tip of the fouling layer is approximately 1.44 times higher than that of double particles and 1.5 times higher compared to single particles. These results suggest that particles adhering to the transmission line have a greater affinity for adsorbing charged particles. Additionally, relevant numerical calculations demonstrate that in dry environments, the primary adhesion forces between particles and transmission lines follow an order of electrostatic force and van der Waals force. Specifically, at the minimum field strength, these forces are approximately74.73 times and 19.43 times stronger than the gravitational force acting on the particles.
基金supported by Shandong Provincial Natural Science Foundation (ZR2023MB038)National Natural Science Foundation of China (21808232 and 21978143)Financial support from the Qingdao University of Science and Technology
文摘The homogeneous/particulate fluidization flow regime is particularly suitable for handling the various gas–solid contact processes encountered in the chemical and energy industry.This work aimed to extend such a regime of Geldart-A particles by exerting the axial uniform and steady magnetic field.Under the action of the magnetic field,the overall homogeneous fluidization regime of Geldart-A magnetizable particles became composed of two parts:inherent homogeneous fluidization and newly-created magnetic stabilization.Since the former remained almost unchanged whereas the latter became broader as the magnetic field intensity increased,the overall homogeneous fluidization regime could be extended remarkably.As for Geldart-A nonmagnetizable particles,certain amount of magnetizable particles had to be premixed to transmit the magnetic stabilization.Among others,the mere addition of magnetizable particles could broaden the homogeneous fluidization regime.The added content of magnetizable particles had an optimal value with smaller/lighter ones working better.The added magnetizable particles might raise the ratio between the interparticle force and the particle gravity.After the magnetic field was exerted,the homogeneous fluidization regime was further expanded due to the formation of magnetic stabilization flow regime.The more the added magnetizable particles,the better the magnetic performance and the broader the overall homogeneous fluidization regime.Smaller/lighter magnetizable particles were preferred to maximize the magnetic performance and extend the overall homogeneous fluidization regime.This phenomenon could be ascribed to that the added magnetizable particles themselves became more Geldart-A than-B type as their density or size decreased.
基金Project supported by the Offline Course Program of“Experiment of College Physics”in the 2022-year Anhui Provincial Quality Engineering Program (Grant No.2022xxkc134)the Program for Academic Leader Reserve Candidates in Tongling University (Grant Nos.2020tlxyxs43 and 2014tlxyxs30)+1 种基金the Talent Scientific Research Foundation of Tongling University (Grant No.2015tlxyrc01)the 2014 year Program for Excellent Youth Talents in University of Anhui Province。
文摘In paper[Chin.Phys.B 32070308(2023)],Xing et al.proposed a semi-quantum secret sharing protocol by using single particles.We study the security of the proposed protocol and find that it is not secure,that is,the three dishonest agents,Bob,Charlie and Emily can collude to obtain Alice's secret without the help of David.
基金supported by the National Science Fund for Distinguished Young Scholars(No:81901099 and 81703427)the 64th batch of China Postdoctoral Science Foundation(No:2018M641731).
文摘All eukaryotic cells can secrete extracellular vesicles, which have a double-membrane structure and are important players in the intercellular communication involved in a variety of important biological processes. Platelets form platelet-derived microparticles (PMPs) in response to activation, injury, or apoptosis. This review introduces the origin, pathway, and biological functions of PMPs and their importance in physiological and pathological processes. In addition, we review the potential applications of PMPs in cancer, vascular homeostasis, thrombosis, inflammation, neural regeneration, biomarkers, and drug carriers to achieve targeted drug delivery. In addition, we comprehensively report on the origin, biological functions, and applications of PMPs. The clinical transformation, high heterogeneity, future development direction, and limitations of the current research on PMPs are also discussed in depth. Evidence has revealed that PMPs play an important role in cell-cell communication, providing clues for the development of PMPs as carriers for relevant cell-targeted drugs. The development history and prospects of PMPs and their cargos are explored in this guidebook.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.12132015 and 11972336)。
文摘This work focuses on numerically studying hydrodynamic interaction between a passive particle and a self-propelled particle,termed a squirmer,by using a two-dimensional lattice Boltzmann method(LBM).It is found that the squirmer can capture a passive particle and propel it simultaneously,provided the passive particle is situated within the squirmer's wake.Our research shows that the critical capture distance,which determines whether the particle is captured,primarily depends on the intensity of the squirmer's dipolarity.The stronger dipolarity of squirmer results in an increased critical capture distance.Conversely,the Reynolds number is found to have minimal influence on this interaction.Interestingly,the passive particle,when driven by the squirmer's wake,contributes to a reduction in the squirmer's drag.This results in a mutual acceleration for both particles.Our findings can provide valuable perspectives for formulating the principles of reducing the drag of micro-swimmers and help to achieve the goal of using micro-swimmers to transport goods without physical tethers.
文摘The Dirac equation γ<sub>μ</sub>(δ<sub>μ</sub>-eA<sub>μ</sub>)Ψ=mc<sup>2</sup>Ψ describes the bound states of the electron under the action of external potentials, A<sub>μ</sub>. We assumed that the fundamental form of the Dirac equation γ<sub>μ</sub>(δ<sub>μ</sub>-S<sub>μ</sub>)Ψ=0 should describe the stable particles (the electron, the proton and the dark-matter-particle (dmp)) bound to themselves under the action of their own potentials S<sub>μ</sub>. The new equation reveals that self energy is consequence of self action, it also reveals that the spin angular momentum is consequence of the dynamic structure of the stable particles. The quantitative results are the determination of their relative masses as well as the determination of the electromagnetic coupling constant.
文摘A dark matter mechanism within the framework of the standard model (SM) of particle physics is proposed in this article that the essence of dark matter may be the excited virtual particle field by the gravitational field of ordinary matter, which contains virtual photons, virtual positive and negative electron pairs, virtual gluons, virtual positive and negative quark pairs, virtual neutrinos etc. In this mechanism, there are two basic assumptions: 1) the stronger the gravitational field of ordinary matter, the greater the excited energy (mass) density of virtual particle field;2) The excited virtual particle field is generally very weak in self-interaction. The virtual particle field excited by gravity can exhibit the properties of dark matter and may become a dark matter candidate. Based on this new dark matter mechanism, the hydrodynamic equations and cosmic perturbation equations describing cosmic matter are improved, and this may be meaningful for solving the challenges faced by the standard cosmological model (Lambda-CDM or LCDM) and developing and perfecting LCDM model.
文摘Present studies in physics assume that elementary particles are the building blocks of all matter, and that they are zero-dimensional objects which do not occupy space. The new I-Theory predicts that elementary particles do indeed have a substructure, three dimensions, and occupy space, being composed of fundamental particles called I-particles. In this article we identify the substructural pattern of elementary particles and define the quanta of energy that form each elementary particle. We demonstrate that the substructure comprises two classes of quanta which we call “attraction quanta” and “repulsion quanta”. We create a model that defines the rest-mass energy of each elementary particle and can predict new particles. Lastly, in order to incorporate this knowledge into the contemporary models of science, a revised periodic table is proposed.
基金funded by the National Natural Science Foundation of China(Grant nos.42276255 and 41976227)project“Impact and Response of Antarctic Seas to Climate Change,IRASCC 2020-2022”(Grant nos.01-01-02A and 02-02-05).
文摘The Southern Ocean is an important carbon sink pool and plays a critical role in the global carbon cycling.The Amundsen Sea was reported to be highly productive in inshore area in the Southern Ocean.In order to investigate the influence of transparent exopolymer particles(TEP)on the behavior of dissolved organic carbon(DOC)in this region,a comprehensive study was conducted,encompassing both open water areas and highly productive polynyas.It was found that microbial heterotrophic metabolism is the primary process responsible for the production of humic-like fluorescent components in the open ocean.The relationship between apparent oxygen utilization and the two humic-like components can be accurately described by a power-law function,with a conversion rate consistent with that observed globally.The presence of TEP was found to have little impact on this process.Additionally,the study revealed the accumulation of DOC at the sea surface in the Amundsen Sea Polynya,suggesting that TEP may play a critical role in this phenomenon.These findings contribute to a deeper understanding of the dynamics and surface accumulation of DOC in the Amundsen Sea Polynya,and provide valuable insights into the carbon cycle in this region.
基金funded by Youth Fund of the National Natural Science Foundation of China,grant number 11504176,61601230.
文摘As one of the main application directions of quantum technology,underwater quantum communication is of great research significance.In order to study the influence of marine planktonic algal particles on the communication performance of underwater quantum links,based on the extinction characteristics of marine planktonic algal particles,the influence of changes in the chlorophyll concentration and particle number density of planktonic algal particles on the attenuation of underwater links is explored respectively,the influence of marine planktonic algal particles on the fidelity of underwater quantum links,the generation rate of the security key,and the utilization rate of the channel is analyzed,and simulation experiments are carried out.The results show that with the increase in chlorophyll concentration and particle density of aquatic planktonic algal particles,quantum communication channel link attenuation shows a gradually increasing trend.In addition,the security key generation rate,channel fidelity and utilization rate are gradually decreasing.Therefore,the performance of underwater quantum communication channel will be interfered by marine planktonic algal particles,and it is necessary to adjust the relevant parameter values in the quantum communication system according to different marine planktonic algal particle number density and chlorophyll concentration to improve the performance of quantum communication.
文摘The effects of ionic emulsifier, sodium dodecylbenzene sulfate (SDBS), on the formation of the multihollow structures in sub-micron sized polymer particles produced by alkali/acid posttreatment were investigated. The original latex particles with narrow size distribution were synthesized by a new sequence emulsifier-free/emulsifier emulsion copolymerization of styrene (St) and methacrylic acid (MAA). Results indicated that the pore size decreased and the pore number increased with the increase of SDBS amount, and the morphology of the posttreated latex particles was also significantly influenced by the introducing time of SDBS in the preparation of the original latex particles, and a suitable introducing time was 3 h of polymerization. (c) 2007 Cheng You Kan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
基金supported by the National Natural Science Foundation of China(No.31500411)the Guangxi Zhuang Autonomous Region International Platform Project(No.2019AC17008)+4 种基金the Guangxi Beihai Science and Technology Research Focus(Nos.201995048202082021 and 2019D05)the U.S.National Science Foundation(No.OCE 0726369)the Special Fund for Asian Regional Cooperation‘2019 China-ASEAN Marine Science and Technology Cooperation Seminar Project’the China Asia-Pacific Economic Cooperation(APEC)Cooperation Fund Project‘APEC Typical Regional Coral Reef Ecosystem Comprehensive Assessment Technology and Management Cooperation Research’the‘Bilateral and Multilateral International Cooperation’Project of the Central Financial Allocation Program in 2019 and 2020。
文摘The presence of diatoms is accompanied by the production of a large amount of extracellular polymeric substances,which are mainly composed of carbohydrates.Transparent exopolymer particles(TEP)are a large class of extracellular polymeric substances with high stickiness that promotes the formation of aggregates and marine snow,which affects marine bio-carbon pump efficiency.The purpose of this research was to determine how temperature increases affect the allocation of cellular carbohydrates and the formation and aggregation of TEP.The results showed that the responses of two different diatom species(Thalassiosira weissflogii and Skeletonema marinoi)differed according to temperature.The cell density and chlorophyll a concentration of the former were not significantly correlated with temperature,while those of the latter were significantly decreased with increasing temperature.This indicates that the two species of diatom may have different heat tolerance ranges.A temperature increase will promote significant formation of TEP by both types of diatoms,including aggregation of S.marinoi as the temperature rises,meaning that the high temperature will produce an aggregate with a larger particle size and thus may increase the sedimentation rate of organic carbon.Moreover,the TEP aggregation of T.weissflogii did not increase;therefore,its particle size was smaller,and so it may remain on the sea surface at high temperatures for longer periods.These influences have a profound impact on the biogeochemical cycling of carbon.
基金Foundation item:The National Key Research and Development Project of China under contract No.2019YFC1407805the National Natural Science Foundation of China under contract Nos 41876134,91751202,31700425,41676112 and 41276124+1 种基金the Tianjin 131 Innovation Team Program under contract No.20180314the Changjiang Scholar Program of Chinese Ministry of Education(T2014253)to Jun Sun.
文摘Transparent exopolymer particles(TEPs)are ubiquitous throughout the oceans,and their sedimentation is considered an efficient biological carbon sink pathway.To investigate the role of coastal TEPs in sinking carbon from the upper layer,samples were collected in the spring and summer of 2011 in the Changjiang River(Yangtze River)Estuary,a typical coastal water.The concentrations and sinking rates of TEPs were measured,and potential sedimentation flux of TEPs was estimated.TEPs concentrations ranged from 40.00μg/L to 1040.00μg/L(mean=(209.70±240.93)μg/L)in spring and 56.67μg/L to 1423.33μg/L(mean=(433.33±393.02)μg/L)in summer,and they were higher at bloom stations than at non-bloom stations during both cruises.A significant positive correlation between TEPs concentration and chlorophyll a(Chl a)concentration was detected,suggesting that phytoplankton was the primary source of TEPs in this area.TEPs sinking rates ranged from 0.08 m/d to 0.57 m/d with a mean of(0.28±0.14)m/d in spring and 0.10 m/d to 1.08 m/d with a mean of(0.34±0.31)m/d in summer.The potential sedimentation flux of TEP-C ranged from 4.95 mg/(m2·d)to 29.40 mg/(m2·d)with a mean of(14.66±8.83)mg/(m2·d)in spring and 6.80 mg/(m2·d)to 30.45 mg/(m2·d)with a mean of(15.71±8.73)mg/(m2·d)in summer,which was^17.81%to 138.27%(mean=65.15%±31.75%)of sedimentation flux of phytoplankton cells in the study area.Due to the increase of TEPs concentrations and their sinking rates,sedimentation fluxes of TEPs at the bloom station were obviously higher than at the non-bloom station during both cruises.This study indicates that TEPs serve as a carbon sink in the Changjiang River Estuary,especially during bloom events,and their sedimentation should be taken into account when we study the carbon sedimentation in the coastal sea.
文摘A simple two-step method was developed to prepare silver nanoshells coated on silica paticles. The method involves two steps: concentration of reaction precursor (AgNO3) on particle surfaces and subsequent reduction by formaldehyde. The obtained composite particles were characterized by TEM, ED, and SEM-EDS measurements. The results show that the silver nanoshell is coated on silica particle surface in the form of a polycrystalline (cubic structure) layer with average thickness of 20 nm and weight percentage of 19%.
基金supported by the Shandong Provincial Natural Science Foundation of China(ZR2019BC100)Science,Education and Industry Integration Innovation Pilot Project of Qilu University of Technology(Shandong Academy of Sciences)(2020KJC-ZD10)Incubation Program of Youth Innovation in Shandong Province。
文摘This study explored the potential of polysaccharides from Actium lappa(ALPs)as natural wall materials for producing ALP-based nanoparticles to deliver poorly water-soluble oleanolic acid(OA)and ursolic acid(UA).Encapsulating OA+UA with ALPs(ALP:OA+UA,50:1;OA:UA,1:1)changed the crystalline nature to a more amorphous state through hydrogen bonding and involving O-H/C-O/O-C-O groups.ALP-OA/UA nanoparticles had a particle size and zeta potential(in water)of 199.1 nm/-7.15 mV,with a narrow unimodal size distribution,and excellent pH,salt solution,temperature and storage stability.Compared with ALPs,ALPOA/UA nanoparticles showed enhanced anti-inflammatory activity(especially at a dose of 100μg/mL)in a CuSO-induced zebrafish inflammation model via down-regulating the NF-κB signalling pathway and gene expression of associated transcription factors and cytokines(TNF-α,IL-1βand IL-8).Therefore,ALP-based nanoparticles are natural and anti-inflammatory carriers for hydrophobic bioactive molecules.
基金supported by specific university research(Grant No.:A1_FCHI_2022_006).
文摘The properties of dry-coated paracetamol particles(fast-dissolving model drug)with carnauba wax particles as the coating agent(dissolution retardant)were investigated.Raman mapping technique was used to non-destructively examine the thickness and homogeneity of coated particles.The results showed that the wax existed in two forms on the surface of the paracetamol particles,forming a porous coating layer:i)whole wax particles on the surface of paracetamol and glued together with other wax surface particles,and ii)deformed wax particles spread on the surface.Regardless of the final particle size fraction(between 100 and 800 mm),the coating thickness had high variability,with average thickness of 5.9±4.2 mm.The ability of carnauba wax to decrease the dissolution rate of paracetamol was confirmed by dissolution of powder and tablet formulations.The dissolution was slower for larger coated particles.Tableting further reduced the dissolution rate,clearly indicating the impact of subsequent formulation processes on the final quality of the product.