This paper investigates the fundamental data detection problem with burst interference in massive multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM) systems. In particular, burst inte...This paper investigates the fundamental data detection problem with burst interference in massive multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM) systems. In particular, burst interference may occur only on data symbols but not on pilot symbols, which means that interference information cannot be premeasured. To cancel the burst interference, we first revisit the uplink multi-user system and develop a matrixform system model, where the covariance pattern and the low-rank property of the interference matrix is discussed. Then, we propose a turbo message passing based burst interference cancellation(TMP-BIC) algorithm to solve the data detection problem, where the constellation information of target data is fully exploited to refine its estimate. Furthermore, in the TMP-BIC algorithm, we design one module to cope with the interference matrix by exploiting its lowrank property. Numerical results demonstrate that the proposed algorithm can effectively mitigate the adverse effects of burst interference and approach the interference-free bound.展开更多
During the war between Liao Dynasty(907-1125)and Northern Song Dynasty(960-1127),there was a classic battle that happened in Yanmen Pass(located in today’s Dai County,Xinzhou,Shanxi Province,China).It was a well know...During the war between Liao Dynasty(907-1125)and Northern Song Dynasty(960-1127),there was a classic battle that happened in Yanmen Pass(located in today’s Dai County,Xinzhou,Shanxi Province,China).It was a well known battle of ancient China because a commander of the Song army named Yang Ye(?-986)was really famous in both classical Chinese fictions and Chinese war history.He is the early protagonist of a famous Chinese classic fiction named The Romance of the Yang family’s generals(written in the 16th century,Ming Dynasty of China).The story of his family also appears in other novels.Besides,in history,he was a general who was active in the early stages of the war between Liao Dynasty and Northern Song Dynasty.The battle of Yanmen Pass(980)was one of the most important battles of Yang’s military career.His combat style especially his cavalry tactic can be summarized through researching this battle.展开更多
Objective:To explore the application effect of the blended education strategy based on the Learning Pass platform in the phase III cardiac rehabilitation of patients with coronary artery disease.Methods:90 patients di...Objective:To explore the application effect of the blended education strategy based on the Learning Pass platform in the phase III cardiac rehabilitation of patients with coronary artery disease.Methods:90 patients diagnosed with coronary artery disease in the Department of Cardiology of our hospital from January 2019 to January 2021 were selected and divided into the control group and the experimental group according to the method of randomized numerical table,with 45 cases in each group.Both the experimental group and the control group received pre-discharge cardiac rehabilitation education by conventional means.The control group received education and supervision information via WeChat after discharge,while the experimental group joined the Learning Pass platform to receive online and offline hybrid education and supervision,with online as the mainstay and offline as a supplement.The disease cognitive level,self-management skills,quality of life,medication adherence,and emotional status of the two groups were compared.Results:The disease cognitive levels in the experimental group were significantly higher than those of the control group(P<0.05);the scores of the experimental group in terms of quality of life,self-management skills,and medication adherence were significantly higher than those of the control group(P<0.05);and the scores of anxiety and depression in the experimental group were significantly lower than those of the control group(P<0.05).Conclusion:The blended education strategy based on the Learning Pass platform has a significant application effect in phase III cardiac rehabilitation of patients with coronary artery disease.It can improve patients’disease cognitive level,self-management skills,and quality of life,and provide a basis for improving patients’prognosis.展开更多
The high-resolution DEM-IMB-LBM model can accurately describe pore-scale fluid-solid interactions,but its potential for use in geotechnical engineering analysis has not been fully unleashed due to its prohibitive comp...The high-resolution DEM-IMB-LBM model can accurately describe pore-scale fluid-solid interactions,but its potential for use in geotechnical engineering analysis has not been fully unleashed due to its prohibitive computational costs.To overcome this limitation,a message passing interface(MPI)parallel DEM-IMB-LBM framework is proposed aimed at enhancing computation efficiency.This framework utilises a static domain decomposition scheme,with the entire computation domain being decomposed into multiple subdomains according to predefined processors.A detailed parallel strategy is employed for both contact detection and hydrodynamic force calculation.In particular,a particle ID re-numbering scheme is proposed to handle particle transitions across sub-domain interfaces.Two benchmarks are conducted to validate the accuracy and overall performance of the proposed framework.Subsequently,the framework is applied to simulate scenarios involving multi-particle sedimentation and submarine landslides.The numerical examples effectively demonstrate the robustness and applicability of the MPI parallel DEM-IMB-LBM framework.展开更多
High-order harmonics q(ψ_(s))=1 energetic particle modes(EPMs)have been observed in toroidal plasmas experiments with neutral beam injection.To investigate these phenomena,linear properties and nonlinear dynamics of ...High-order harmonics q(ψ_(s))=1 energetic particle modes(EPMs)have been observed in toroidal plasmas experiments with neutral beam injection.To investigate these phenomena,linear properties and nonlinear dynamics of these EPMs driven by passing energetic particles(EPs)are studied via the global hybrid kinetic-magnetohydrodynamic code M3D-K.Simulation results demonstrate that passing EPs'effects on high mode-number harmonics(q(ψ_(s))=m/n=2/2,3/3,4/4)instability are more obvious than the q(ψ_(s))=1/1 mode,especially when q-profile is sufficiently flat in the core region.Furthermore,the effects of the pitch angleΛ_0 and beam ion pressure P_(hot)/P_(total)on the features of high n components are also analyzed specifically.It is found that there exists only one resonant condition for these EPMs.In the nonlinear phase,these high mode-number harmonics can induce significant energetic ions redistribution and chirping up phenomena,which differs from the classical fishbone excited by passing EPs.These discoveries are conducive to better apprehend the underlying physical mechanisms of the highorder harmonics driven by passing EPs.展开更多
Background Genotype-by-sequencing has been proposed as an alternative to SNP genotyping arrays in genomic selection to obtain a high density of markers along the genome.It requires a low sequencing depth to be cost ef...Background Genotype-by-sequencing has been proposed as an alternative to SNP genotyping arrays in genomic selection to obtain a high density of markers along the genome.It requires a low sequencing depth to be cost effective,which may increase the error at the genotype assigment.Third generation nanopore sequencing technology offers low cost sequencing and the possibility to detect genome methylation,which provides added value to genotype-by-sequencing.The aim of this study was to evaluate the performance of genotype-by-low pass nanopore sequencing for estimating the direct genomic value in dairy cattle,and the possibility to obtain methylation marks simultaneously.Results Latest nanopore chemistry(LSK14 and Q20)achieved a modal base calling accuracy of 99.55%,whereas previous kit(LSK109)achieved slightly lower accuracy(99.1%).The direct genomic value accuracy from genotype-by-low pass sequencing ranged between 0.79 and 0.99,depending on the trait(milk,fat or protein yield),with a sequencing depth as low as 2×and using the latest chemistry(LSK114).Lower sequencing depth led to biased estimates,yet with high rank correlations.The LSK109 and Q20 achieved lower accuracies(0.57-0.93).More than one million high reliable methylated sites were obtained,even at low sequencing depth,located mainly in distal intergenic(87%)and promoter(5%)regions.Conclusions This study showed that the latest nanopore technology in useful in a LowPass sequencing framework to estimate direct genomic values with high reliability.It may provide advantages in populations with no available SNP chip,or when a large density of markers with a wide range of allele frequencies is needed.In addition,low pass sequencing provided nucleotide methylation status of>1 million nucleotides at≥10×,which is an added value for epigenetic studies.展开更多
Background: In linear accelerators, the treatment field’s uniform intensity is achieved by including a flattening filter in the beam. However, to produce more conformal dose distributions, contemporary radiotherapy p...Background: In linear accelerators, the treatment field’s uniform intensity is achieved by including a flattening filter in the beam. However, to produce more conformal dose distributions, contemporary radiotherapy practice now frequently uses fluence and aperture modifying techniques, such as volumetric modulated arc therapy. In these circumstances, the flattening filter in the beam manufacturing process is no longer required. It is therefore necessary to compare the monitor units of 6 MV and flattening filter free plans and how it influences the gamma pass rates to determine which is best for treating cervical cancer with pelvic lymph node metastasis. Methods: VMAT plans for fifteen patients with cervical cancer with pathological pelvic lymph node metastasis were included in this study. Each patient had two VMAT plans using conventional 6 MV beam with flattening filter and one with flattening filter free beam (FFF). The VMAT plans were made using two arcs, and then recalculated to give the planned dose distribution to the detectors in a Delta4 phantom. The VMAT plans were irradiated on the Delta4 phantom using an Elekta linear accelerator (6 MV). Results: The mean monitor unit for the 6 MV plans was 506.3 MU and a standard deviation of 48.6 while that of the FFF plans had a mean MU of 701.5 with a standard deviation of 87.6. The total monitor units (MUs) for the FFF plans were significantly greater than the 6 MV plans (p = 6.1 × 10<sup>-5</sup>). Conclusion: Flattening filter free (FFF) plans require more numbers of monitor units in comparison to conventional 6 MV filtered beams for external radiation of cervical cancer with pelvic lymph nodes involvement.展开更多
Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs worldwide.Due to the aging population,it is expected that the number of peopl...Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs worldwide.Due to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more prevalent.Glaucoma primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.展开更多
Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells c...Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be changed.An exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.展开更多
Objective:To evaluate the application value of a refined quality control management model for a sterilization supply center.Methods:A retrospective analysis was conducted on the work situation of the sterilization sup...Objective:To evaluate the application value of a refined quality control management model for a sterilization supply center.Methods:A retrospective analysis was conducted on the work situation of the sterilization supply center from January 2021 to January 2023.The work situation before January 31,2022,was classified as the control group;a routine quality control management model was implemented,and the work situation after January 31,2022,was classified as the observation group.The quality of medical device management and department satisfaction between the two groups were compared.Results:The timely recovery and supply rate,classification and cleaning pass rate,disinfection pass rate,packaging pass rate,sterilization pass rate,and department satisfaction score in the observation group were all higher than those of the control group(P<0.05).Conclusion:Implementing a refined quality control management model in the sterilization supply center can improve the quality management level of medical devices and department satisfaction and is worthy of promotion.展开更多
Objective:To explore the application effect of the blended education strategy based on the Learning Pass platform in the phase III cardiac rehabilitation of patients with coronary artery disease.Methods:90 patients di...Objective:To explore the application effect of the blended education strategy based on the Learning Pass platform in the phase III cardiac rehabilitation of patients with coronary artery disease.Methods:90 patients diagnosed with coronary artery disease in the Department of Cardiology of our hospital from January 2019 to January 2021 were selected and divided into the control group and the experimental group according to the method of randomized numerical table,with 45 cases in each group.Both the experimental group and the control group received pre-discharge cardiac rehabilitation education by conventional means.The control group received education and supervision information via WeChat after discharge,while the experimental group joined the Learning Pass platform to receive online and offline hybrid education and supervision,with online as the mainstay and offline as a supplement.The disease cognitive level,self-management skills,quality of life,medication adherence,and emotional status of the two groups were compared.Results:The disease cognitive levels in the experimental group were significantly higher than those of the control group(P<0.05);the scores of the experimental group in terms of quality of life,self-management skills,and medication adherence were significantly higher than those of the control group(P<0.05);and the scores of anxiety and depression in the experimental group were significantly lower than those of the control group(P<0.05).Conclusion:The blended education strategy based on the Learning Pass platform has a significant application effect in phase III cardiac rehabilitation of patients with coronary artery disease.It can improve patients’disease cognitive level,self-management skills,and quality of life,and provide a basis for improving patients’prognosis.展开更多
We study non-equilibrium behaviors of a particle subjected to a high-frequency cutoff noise in terms of generalized Langevin equation, where the spectrum of internal noise is considered to be of the generalized Debye ...We study non-equilibrium behaviors of a particle subjected to a high-frequency cutoff noise in terms of generalized Langevin equation, where the spectrum of internal noise is considered to be of the generalized Debye form. A closed solution is impossible even if the equation is linear, because the Laplace transform of the memory kernel is a multi-value function. We use a numerical method to calculate the velocity correlation function of a force-free particle and the probability of a particle passing over the top of an inverse harmonic potential. We indicate the nonergodicity of the second type, i.e., the auto-correlation function of the velocity approaches to non-stationary at large times. Applied to the barrier passage problem, we find and analyse a resonant phenomenon that the dependence of the cutoff frequency is nonmonotonic when the initial directional velocity of the particle is less than the critical value, the latter is determined by the passing probability equal to 0.5.展开更多
Graph Convolutional Neural Networks(GCNs)have been widely used in various fields due to their powerful capabilities in processing graph-structured data.However,GCNs encounter significant challenges when applied to sca...Graph Convolutional Neural Networks(GCNs)have been widely used in various fields due to their powerful capabilities in processing graph-structured data.However,GCNs encounter significant challenges when applied to scale-free graphs with power-law distributions,resulting in substantial distortions.Moreover,most of the existing GCN models are shallow structures,which restricts their ability to capture dependencies among distant nodes and more refined high-order node features in scale-free graphs with hierarchical structures.To more broadly and precisely apply GCNs to real-world graphs exhibiting scale-free or hierarchical structures and utilize multi-level aggregation of GCNs for capturing high-level information in local representations,we propose the Hyperbolic Deep Graph Convolutional Neural Network(HDGCNN),an end-to-end deep graph representation learning framework that can map scale-free graphs from Euclidean space to hyperbolic space.In HDGCNN,we define the fundamental operations of deep graph convolutional neural networks in hyperbolic space.Additionally,we introduce a hyperbolic feature transformation method based on identity mapping and a dense connection scheme based on a novel non-local message passing framework.In addition,we present a neighborhood aggregation method that combines initial structural featureswith hyperbolic attention coefficients.Through the above methods,HDGCNN effectively leverages both the structural features and node features of graph data,enabling enhanced exploration of non-local structural features and more refined node features in scale-free or hierarchical graphs.Experimental results demonstrate that HDGCNN achieves remarkable performance improvements over state-ofthe-art GCNs in node classification and link prediction tasks,even when utilizing low-dimensional embedding representations.Furthermore,when compared to shallow hyperbolic graph convolutional neural network models,HDGCNN exhibits notable advantages and performance enhancements.展开更多
In this paper,efficient signal detectors are designed for Orthogonal Time Frequency Space(OTFS)modulation with Index Modulation(IM)systems.Firstly,the Minimum Mean Squared Error(MMSE)based linear equalizer and its cor...In this paper,efficient signal detectors are designed for Orthogonal Time Frequency Space(OTFS)modulation with Index Modulation(IM)systems.Firstly,the Minimum Mean Squared Error(MMSE)based linear equalizer and its corresponding soft-aided decision are studied for OTFS-IM.To further improve the performance,a Vectorby-Vector-aided Message Passing(VV-MP)detector and its associated soft-decision are proposed,where each IM symbol is considered an entire vector utilized for message calculation and passing.Simulation results are shown that the OTFS-IM system relying on the proposed detectors is capable of providing considerable Bit Error Rate(BER)performance gains over the OTFS and Orthogonal Frequency Division Multiplex(OFDM)with IM systems.展开更多
Orthogonal time frequency space(OTFS)technique, which modulates data symbols in the delayDoppler(DD) domain, presents a potential solution for supporting reliable information transmission in highmobility vehicular net...Orthogonal time frequency space(OTFS)technique, which modulates data symbols in the delayDoppler(DD) domain, presents a potential solution for supporting reliable information transmission in highmobility vehicular networks. In this paper, we study the issues of DD channel estimation for OTFS in the presence of fractional Doppler. We first propose a channel estimation algorithm with both low complexity and high accuracy based on the unitary approximate message passing(UAMP), which exploits the structured sparsity of the effective DD domain channel using hidden Markov model(HMM). The empirical state evolution(SE) analysis is then leveraged to predict the performance of our proposed algorithm. To refine the hyperparameters in the proposed algorithm,we derive the update criterion for the hyperparameters through the expectation-maximization(EM) algorithm. Finally, Our simulation results demonstrate that our proposed algorithm can achieve a significant gain over various baseline schemes.展开更多
China is home to the world’s largest aging population.According to data of the seventh national census,the number of people aged 60 and above is 264.02 million,accounting for 18.70 percent of Chinese population.The M...China is home to the world’s largest aging population.According to data of the seventh national census,the number of people aged 60 and above is 264.02 million,accounting for 18.70 percent of Chinese population.The Ministry of Civil Affairs forecasts that China's senior population will exceed 300 million during the 14th Five-Year Plan period(2021-2025),passing from a mildly aging society to a moderately aging society.展开更多
With its GDP surpassing RMB 126 trillion,per capita disposable income increasing by 6.1 percent,and 12.44 million urban jobs created,China saw brisk economic recovery last year.These achievements reflect the sound fun...With its GDP surpassing RMB 126 trillion,per capita disposable income increasing by 6.1 percent,and 12.44 million urban jobs created,China saw brisk economic recovery last year.These achievements reflect the sound fundamentals of its economy,particularly given the shrinking global trade and increasing geopolitical frictions.展开更多
基金supported by the National Key Laboratory of Wireless Communications Foundation,China (IFN20230204)。
文摘This paper investigates the fundamental data detection problem with burst interference in massive multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM) systems. In particular, burst interference may occur only on data symbols but not on pilot symbols, which means that interference information cannot be premeasured. To cancel the burst interference, we first revisit the uplink multi-user system and develop a matrixform system model, where the covariance pattern and the low-rank property of the interference matrix is discussed. Then, we propose a turbo message passing based burst interference cancellation(TMP-BIC) algorithm to solve the data detection problem, where the constellation information of target data is fully exploited to refine its estimate. Furthermore, in the TMP-BIC algorithm, we design one module to cope with the interference matrix by exploiting its lowrank property. Numerical results demonstrate that the proposed algorithm can effectively mitigate the adverse effects of burst interference and approach the interference-free bound.
文摘During the war between Liao Dynasty(907-1125)and Northern Song Dynasty(960-1127),there was a classic battle that happened in Yanmen Pass(located in today’s Dai County,Xinzhou,Shanxi Province,China).It was a well known battle of ancient China because a commander of the Song army named Yang Ye(?-986)was really famous in both classical Chinese fictions and Chinese war history.He is the early protagonist of a famous Chinese classic fiction named The Romance of the Yang family’s generals(written in the 16th century,Ming Dynasty of China).The story of his family also appears in other novels.Besides,in history,he was a general who was active in the early stages of the war between Liao Dynasty and Northern Song Dynasty.The battle of Yanmen Pass(980)was one of the most important battles of Yang’s military career.His combat style especially his cavalry tactic can be summarized through researching this battle.
文摘Objective:To explore the application effect of the blended education strategy based on the Learning Pass platform in the phase III cardiac rehabilitation of patients with coronary artery disease.Methods:90 patients diagnosed with coronary artery disease in the Department of Cardiology of our hospital from January 2019 to January 2021 were selected and divided into the control group and the experimental group according to the method of randomized numerical table,with 45 cases in each group.Both the experimental group and the control group received pre-discharge cardiac rehabilitation education by conventional means.The control group received education and supervision information via WeChat after discharge,while the experimental group joined the Learning Pass platform to receive online and offline hybrid education and supervision,with online as the mainstay and offline as a supplement.The disease cognitive level,self-management skills,quality of life,medication adherence,and emotional status of the two groups were compared.Results:The disease cognitive levels in the experimental group were significantly higher than those of the control group(P<0.05);the scores of the experimental group in terms of quality of life,self-management skills,and medication adherence were significantly higher than those of the control group(P<0.05);and the scores of anxiety and depression in the experimental group were significantly lower than those of the control group(P<0.05).Conclusion:The blended education strategy based on the Learning Pass platform has a significant application effect in phase III cardiac rehabilitation of patients with coronary artery disease.It can improve patients’disease cognitive level,self-management skills,and quality of life,and provide a basis for improving patients’prognosis.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.12072217 and 42077254)the Natural Science Foundation of Hunan Province,China(Grant No.2022JJ30567).
文摘The high-resolution DEM-IMB-LBM model can accurately describe pore-scale fluid-solid interactions,but its potential for use in geotechnical engineering analysis has not been fully unleashed due to its prohibitive computational costs.To overcome this limitation,a message passing interface(MPI)parallel DEM-IMB-LBM framework is proposed aimed at enhancing computation efficiency.This framework utilises a static domain decomposition scheme,with the entire computation domain being decomposed into multiple subdomains according to predefined processors.A detailed parallel strategy is employed for both contact detection and hydrodynamic force calculation.In particular,a particle ID re-numbering scheme is proposed to handle particle transitions across sub-domain interfaces.Two benchmarks are conducted to validate the accuracy and overall performance of the proposed framework.Subsequently,the framework is applied to simulate scenarios involving multi-particle sedimentation and submarine landslides.The numerical examples effectively demonstrate the robustness and applicability of the MPI parallel DEM-IMB-LBM framework.
基金supported by National Key R&D Program of China(Nos.2019YFE03050002,2018YFE0310400,and 2022YFE03040002)National Natural Science Foundation of China(Nos.12005003 and 11975270)Science Foundation of Institute of Plasma Physics,Chinese Academy of Sciences(No.DSJJ-2022-04)。
文摘High-order harmonics q(ψ_(s))=1 energetic particle modes(EPMs)have been observed in toroidal plasmas experiments with neutral beam injection.To investigate these phenomena,linear properties and nonlinear dynamics of these EPMs driven by passing energetic particles(EPs)are studied via the global hybrid kinetic-magnetohydrodynamic code M3D-K.Simulation results demonstrate that passing EPs'effects on high mode-number harmonics(q(ψ_(s))=m/n=2/2,3/3,4/4)instability are more obvious than the q(ψ_(s))=1/1 mode,especially when q-profile is sufficiently flat in the core region.Furthermore,the effects of the pitch angleΛ_0 and beam ion pressure P_(hot)/P_(total)on the features of high n components are also analyzed specifically.It is found that there exists only one resonant condition for these EPMs.In the nonlinear phase,these high mode-number harmonics can induce significant energetic ions redistribution and chirping up phenomena,which differs from the classical fishbone excited by passing EPs.These discoveries are conducive to better apprehend the underlying physical mechanisms of the highorder harmonics driven by passing EPs.
文摘Background Genotype-by-sequencing has been proposed as an alternative to SNP genotyping arrays in genomic selection to obtain a high density of markers along the genome.It requires a low sequencing depth to be cost effective,which may increase the error at the genotype assigment.Third generation nanopore sequencing technology offers low cost sequencing and the possibility to detect genome methylation,which provides added value to genotype-by-sequencing.The aim of this study was to evaluate the performance of genotype-by-low pass nanopore sequencing for estimating the direct genomic value in dairy cattle,and the possibility to obtain methylation marks simultaneously.Results Latest nanopore chemistry(LSK14 and Q20)achieved a modal base calling accuracy of 99.55%,whereas previous kit(LSK109)achieved slightly lower accuracy(99.1%).The direct genomic value accuracy from genotype-by-low pass sequencing ranged between 0.79 and 0.99,depending on the trait(milk,fat or protein yield),with a sequencing depth as low as 2×and using the latest chemistry(LSK114).Lower sequencing depth led to biased estimates,yet with high rank correlations.The LSK109 and Q20 achieved lower accuracies(0.57-0.93).More than one million high reliable methylated sites were obtained,even at low sequencing depth,located mainly in distal intergenic(87%)and promoter(5%)regions.Conclusions This study showed that the latest nanopore technology in useful in a LowPass sequencing framework to estimate direct genomic values with high reliability.It may provide advantages in populations with no available SNP chip,or when a large density of markers with a wide range of allele frequencies is needed.In addition,low pass sequencing provided nucleotide methylation status of>1 million nucleotides at≥10×,which is an added value for epigenetic studies.
文摘Background: In linear accelerators, the treatment field’s uniform intensity is achieved by including a flattening filter in the beam. However, to produce more conformal dose distributions, contemporary radiotherapy practice now frequently uses fluence and aperture modifying techniques, such as volumetric modulated arc therapy. In these circumstances, the flattening filter in the beam manufacturing process is no longer required. It is therefore necessary to compare the monitor units of 6 MV and flattening filter free plans and how it influences the gamma pass rates to determine which is best for treating cervical cancer with pelvic lymph node metastasis. Methods: VMAT plans for fifteen patients with cervical cancer with pathological pelvic lymph node metastasis were included in this study. Each patient had two VMAT plans using conventional 6 MV beam with flattening filter and one with flattening filter free beam (FFF). The VMAT plans were made using two arcs, and then recalculated to give the planned dose distribution to the detectors in a Delta4 phantom. The VMAT plans were irradiated on the Delta4 phantom using an Elekta linear accelerator (6 MV). Results: The mean monitor unit for the 6 MV plans was 506.3 MU and a standard deviation of 48.6 while that of the FFF plans had a mean MU of 701.5 with a standard deviation of 87.6. The total monitor units (MUs) for the FFF plans were significantly greater than the 6 MV plans (p = 6.1 × 10<sup>-5</sup>). Conclusion: Flattening filter free (FFF) plans require more numbers of monitor units in comparison to conventional 6 MV filtered beams for external radiation of cervical cancer with pelvic lymph nodes involvement.
基金supported by the National Institutes of Health grants EY034116 (to WKJ, KYK, and SHC) and AG081037 (to YIM and WKJ)。
文摘Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs worldwide.Due to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more prevalent.Glaucoma primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.
基金supported by Canada First Research Excellence Fund,Medicine by Design(to CMM)。
文摘Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative medicine.The brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be changed.An exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.
文摘Objective:To evaluate the application value of a refined quality control management model for a sterilization supply center.Methods:A retrospective analysis was conducted on the work situation of the sterilization supply center from January 2021 to January 2023.The work situation before January 31,2022,was classified as the control group;a routine quality control management model was implemented,and the work situation after January 31,2022,was classified as the observation group.The quality of medical device management and department satisfaction between the two groups were compared.Results:The timely recovery and supply rate,classification and cleaning pass rate,disinfection pass rate,packaging pass rate,sterilization pass rate,and department satisfaction score in the observation group were all higher than those of the control group(P<0.05).Conclusion:Implementing a refined quality control management model in the sterilization supply center can improve the quality management level of medical devices and department satisfaction and is worthy of promotion.
文摘Objective:To explore the application effect of the blended education strategy based on the Learning Pass platform in the phase III cardiac rehabilitation of patients with coronary artery disease.Methods:90 patients diagnosed with coronary artery disease in the Department of Cardiology of our hospital from January 2019 to January 2021 were selected and divided into the control group and the experimental group according to the method of randomized numerical table,with 45 cases in each group.Both the experimental group and the control group received pre-discharge cardiac rehabilitation education by conventional means.The control group received education and supervision information via WeChat after discharge,while the experimental group joined the Learning Pass platform to receive online and offline hybrid education and supervision,with online as the mainstay and offline as a supplement.The disease cognitive level,self-management skills,quality of life,medication adherence,and emotional status of the two groups were compared.Results:The disease cognitive levels in the experimental group were significantly higher than those of the control group(P<0.05);the scores of the experimental group in terms of quality of life,self-management skills,and medication adherence were significantly higher than those of the control group(P<0.05);and the scores of anxiety and depression in the experimental group were significantly lower than those of the control group(P<0.05).Conclusion:The blended education strategy based on the Learning Pass platform has a significant application effect in phase III cardiac rehabilitation of patients with coronary artery disease.It can improve patients’disease cognitive level,self-management skills,and quality of life,and provide a basis for improving patients’prognosis.
文摘We study non-equilibrium behaviors of a particle subjected to a high-frequency cutoff noise in terms of generalized Langevin equation, where the spectrum of internal noise is considered to be of the generalized Debye form. A closed solution is impossible even if the equation is linear, because the Laplace transform of the memory kernel is a multi-value function. We use a numerical method to calculate the velocity correlation function of a force-free particle and the probability of a particle passing over the top of an inverse harmonic potential. We indicate the nonergodicity of the second type, i.e., the auto-correlation function of the velocity approaches to non-stationary at large times. Applied to the barrier passage problem, we find and analyse a resonant phenomenon that the dependence of the cutoff frequency is nonmonotonic when the initial directional velocity of the particle is less than the critical value, the latter is determined by the passing probability equal to 0.5.
基金supported by the National Natural Science Foundation of China-China State Railway Group Co.,Ltd.Railway Basic Research Joint Fund (Grant No.U2268217)the Scientific Funding for China Academy of Railway Sciences Corporation Limited (No.2021YJ183).
文摘Graph Convolutional Neural Networks(GCNs)have been widely used in various fields due to their powerful capabilities in processing graph-structured data.However,GCNs encounter significant challenges when applied to scale-free graphs with power-law distributions,resulting in substantial distortions.Moreover,most of the existing GCN models are shallow structures,which restricts their ability to capture dependencies among distant nodes and more refined high-order node features in scale-free graphs with hierarchical structures.To more broadly and precisely apply GCNs to real-world graphs exhibiting scale-free or hierarchical structures and utilize multi-level aggregation of GCNs for capturing high-level information in local representations,we propose the Hyperbolic Deep Graph Convolutional Neural Network(HDGCNN),an end-to-end deep graph representation learning framework that can map scale-free graphs from Euclidean space to hyperbolic space.In HDGCNN,we define the fundamental operations of deep graph convolutional neural networks in hyperbolic space.Additionally,we introduce a hyperbolic feature transformation method based on identity mapping and a dense connection scheme based on a novel non-local message passing framework.In addition,we present a neighborhood aggregation method that combines initial structural featureswith hyperbolic attention coefficients.Through the above methods,HDGCNN effectively leverages both the structural features and node features of graph data,enabling enhanced exploration of non-local structural features and more refined node features in scale-free or hierarchical graphs.Experimental results demonstrate that HDGCNN achieves remarkable performance improvements over state-ofthe-art GCNs in node classification and link prediction tasks,even when utilizing low-dimensional embedding representations.Furthermore,when compared to shallow hyperbolic graph convolutional neural network models,HDGCNN exhibits notable advantages and performance enhancements.
基金supported in part by the National Key Research and Development Program of China under Grant 2020YFB1807100in part by the National Natural Science Foundation of China under Grant 62001179in part by the Fundamental Research Funds for the Central Universities under Grant 2020kfyXJJS111.
文摘In this paper,efficient signal detectors are designed for Orthogonal Time Frequency Space(OTFS)modulation with Index Modulation(IM)systems.Firstly,the Minimum Mean Squared Error(MMSE)based linear equalizer and its corresponding soft-aided decision are studied for OTFS-IM.To further improve the performance,a Vectorby-Vector-aided Message Passing(VV-MP)detector and its associated soft-decision are proposed,where each IM symbol is considered an entire vector utilized for message calculation and passing.Simulation results are shown that the OTFS-IM system relying on the proposed detectors is capable of providing considerable Bit Error Rate(BER)performance gains over the OTFS and Orthogonal Frequency Division Multiplex(OFDM)with IM systems.
基金supported by the Key Scientific Research Project in Colleges and Universities of Henan Province of China(Grant Nos.21A510003)Science and the Key Science and Technology Research Project of Henan Province of China(Grant Nos.222102210053)。
文摘Orthogonal time frequency space(OTFS)technique, which modulates data symbols in the delayDoppler(DD) domain, presents a potential solution for supporting reliable information transmission in highmobility vehicular networks. In this paper, we study the issues of DD channel estimation for OTFS in the presence of fractional Doppler. We first propose a channel estimation algorithm with both low complexity and high accuracy based on the unitary approximate message passing(UAMP), which exploits the structured sparsity of the effective DD domain channel using hidden Markov model(HMM). The empirical state evolution(SE) analysis is then leveraged to predict the performance of our proposed algorithm. To refine the hyperparameters in the proposed algorithm,we derive the update criterion for the hyperparameters through the expectation-maximization(EM) algorithm. Finally, Our simulation results demonstrate that our proposed algorithm can achieve a significant gain over various baseline schemes.
文摘China is home to the world’s largest aging population.According to data of the seventh national census,the number of people aged 60 and above is 264.02 million,accounting for 18.70 percent of Chinese population.The Ministry of Civil Affairs forecasts that China's senior population will exceed 300 million during the 14th Five-Year Plan period(2021-2025),passing from a mildly aging society to a moderately aging society.
文摘With its GDP surpassing RMB 126 trillion,per capita disposable income increasing by 6.1 percent,and 12.44 million urban jobs created,China saw brisk economic recovery last year.These achievements reflect the sound fundamentals of its economy,particularly given the shrinking global trade and increasing geopolitical frictions.