Transcranial Hall-effect stimulation(THS) is a new stimulation method in which an ultrasonic wave in a static magnetic field generates an electric field in an area of interest such as in the brain to modulate neuron...Transcranial Hall-effect stimulation(THS) is a new stimulation method in which an ultrasonic wave in a static magnetic field generates an electric field in an area of interest such as in the brain to modulate neuronal activities. However, the biophysical basis of simulating the neurons remains unknown. To address this problem, we perform a theoretical analysis based on a passive cable model to investigate the THS mechanism of neurons. Nerve tissues are conductive; an ultrasonic wave can move ions embedded in the tissue in a static magnetic field to generate an electric field(due to Lorentz force).In this study, a simulation model for an ultrasonically induced electric field in a static magnetic field is derived. Then,based on the passive cable model, the analytical solution for the voltage distribution in a nerve tissue is determined. The simulation results showthat THS can generate a voltage to stimulate neurons. Because the THS method possesses a higher spatial resolution and a deeper penetration depth, it shows promise as a tool for treating or rehabilitating neuropsychiatric disorders.展开更多
Traumatic brain injury(TBI) is a leading cause of death and disability in individuals worldwide.Producing a clinically relevant TBI model in small-sized animals remains fairly challenging.For good screening of poten...Traumatic brain injury(TBI) is a leading cause of death and disability in individuals worldwide.Producing a clinically relevant TBI model in small-sized animals remains fairly challenging.For good screening of potential therapeutics,which are effective in the treatment of TBI,animal models of TBI should be established and standardized.In this study,we established mouse models of closed head injury using the Shohami weight-drop method with some modifications concerning cognitive deficiency assessment and provided a detailed description of the severe TBI animal model.We found that 250 g falling weight from 2 cm height produced severe closed head injury in C57BL/6 male mice.Cognitive disorders in mice with severe closed head injury could be detected using passive avoidance test on day 7 after injury.Findings from this study indicate that weight-drop injury animal models are suitable for further screening of brain neuroprotectants and potentially are similar to those seen in human TBI.展开更多
Analysis of a gravity-induced film flow of a fluid containing both nanoparticles and gyrotactic microorganisms along a convectively heated vertical surface is presented.The Buongiorno model is applied. Two kinds of bo...Analysis of a gravity-induced film flow of a fluid containing both nanoparticles and gyrotactic microorganisms along a convectively heated vertical surface is presented.The Buongiorno model is applied. Two kinds of boundary conditions, the passive and the active boundary conditions, are considered to investigate this film flow phenomenon.Through a set of similarity variables, the ordinary differential equations that describe the conservation of the momentum, the thermal energy, the nanoparticles, and the microorganisms are derived and then solved numerically by an efficient finite difference technique.The effects of various physical parameters on the profiles of momentum, thermal energy,nanoparticles, microorganisms, local skin friction, local Nusselt number, local wall mass flux, and local wall motile microorganisms flux are investigated. It is expected that the passively controlled nanofluid model can be much more easily achieved and applied in real circumstances than the actively controlled model.展开更多
Micromechanics aims mainly at establishing the quantitative relation between the macroscopic mechanical behavior and the microstructure of heterogeneous materials.
The theory of passive localization for underwater sources based on acoustic ray channel modeling is discussed. The principles of channel modeling in Ray-theory, determination of eigenrays which connect source and rece...The theory of passive localization for underwater sources based on acoustic ray channel modeling is discussed. The principles of channel modeling in Ray-theory, determination of eigenrays which connect source and receiver, analysis of DOA arriving structure and time delay spectrum arriving structure, their relationship to source location are given in the paper. Source location is estimated by matching measured DOA and TDS to their calculated counterparts. The method of Ray-theory based passive localization features its simplicity, less calculation, short array aperture and robust performance to environment parameters, as compared with those methods based on Normal Mode theory.展开更多
It is thought that there are many unregulated anthropogenic chemicals in the environment.For risk assessment of chemicals, it is essential to estimate the predicted environmental concentrations. As an effort of identi...It is thought that there are many unregulated anthropogenic chemicals in the environment.For risk assessment of chemicals, it is essential to estimate the predicted environmental concentrations. As an effort of identifying residual organic contaminants in air and water in Korea, nontarget screening using two-dimensional gas chromatography time-of-flight mass spectrometry(GC × GC-TOFMS) was conducted at 10 sites using polyurethane foam passive air sampler and at 6 sites using polydimethyl siloxane(PDMS) passive water sampler in three different seasons in 2014. More than 600 chemical peaks were identified satisfying the identification criteria in air and water samples, respectively, providing a list for further investigation. Chemical substances with reported national emission rates in2014(n = 149) were also screened for potential existence in the environment using a level Ⅱ fugacity model. Most of chemical substances classified as not detectable were not identified with detection frequency greater than 20% by nontarget screening, indicating that a simple equilibrium model has a strong potential to be used to exclude chemicals that are not likely to remain in the environment after emissions from targeted monitoring.展开更多
For the performance issues of satellite transceivers suffering passive intermodulation interference,a novel and effective digital suppression algorithm is presented in this paper.In contrast to analog approaches,digit...For the performance issues of satellite transceivers suffering passive intermodulation interference,a novel and effective digital suppression algorithm is presented in this paper.In contrast to analog approaches,digital passive intermodulation(PIM) suppression approaches can be easily reconfigured and therefore are highly attractive for future satellite communication systems.A simplified model of nonlinear distortion from passive microwave devices is established in consideration of the memory effect.The multiple high-order PIM products falling into the receiving band can be described as a bilinear predictor function.A suppression algorithm based on a bilinear polynomial decorrelated adaptive filter is proposed for baseband digital signal processing.In consideration of the time-varying characteristics of passive intermodulation,this algorithm can achieve the rapidness of online interference estimation and low complexity with less consumption of resources.Numerical simulation results show that the algorithm can effectively compensate the passive intermodulation interference,and achieve a high signal-to-interference ratio gain.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61273063 and 61503321)the China Postdoctoral Science Foundation(Grant No.2013M540215)+1 种基金the Natural Science Foundation of Hebei Province,China(Grant No.F2014203161)the Youth Research Program of Yanshan University,China(Grant No.02000134)
文摘Transcranial Hall-effect stimulation(THS) is a new stimulation method in which an ultrasonic wave in a static magnetic field generates an electric field in an area of interest such as in the brain to modulate neuronal activities. However, the biophysical basis of simulating the neurons remains unknown. To address this problem, we perform a theoretical analysis based on a passive cable model to investigate the THS mechanism of neurons. Nerve tissues are conductive; an ultrasonic wave can move ions embedded in the tissue in a static magnetic field to generate an electric field(due to Lorentz force).In this study, a simulation model for an ultrasonically induced electric field in a static magnetic field is derived. Then,based on the passive cable model, the analytical solution for the voltage distribution in a nerve tissue is determined. The simulation results showthat THS can generate a voltage to stimulate neurons. Because the THS method possesses a higher spatial resolution and a deeper penetration depth, it shows promise as a tool for treating or rehabilitating neuropsychiatric disorders.
基金supported by a grant from the Ministry of Higher Education of Malaysia,No.RAGS/2013/UPNM/SKK/01/2
文摘Traumatic brain injury(TBI) is a leading cause of death and disability in individuals worldwide.Producing a clinically relevant TBI model in small-sized animals remains fairly challenging.For good screening of potential therapeutics,which are effective in the treatment of TBI,animal models of TBI should be established and standardized.In this study,we established mouse models of closed head injury using the Shohami weight-drop method with some modifications concerning cognitive deficiency assessment and provided a detailed description of the severe TBI animal model.We found that 250 g falling weight from 2 cm height produced severe closed head injury in C57BL/6 male mice.Cognitive disorders in mice with severe closed head injury could be detected using passive avoidance test on day 7 after injury.Findings from this study indicate that weight-drop injury animal models are suitable for further screening of brain neuroprotectants and potentially are similar to those seen in human TBI.
基金Project supported by the Program for New Century Excellent Talents in University(No.NCET-12-0347)
文摘Analysis of a gravity-induced film flow of a fluid containing both nanoparticles and gyrotactic microorganisms along a convectively heated vertical surface is presented.The Buongiorno model is applied. Two kinds of boundary conditions, the passive and the active boundary conditions, are considered to investigate this film flow phenomenon.Through a set of similarity variables, the ordinary differential equations that describe the conservation of the momentum, the thermal energy, the nanoparticles, and the microorganisms are derived and then solved numerically by an efficient finite difference technique.The effects of various physical parameters on the profiles of momentum, thermal energy,nanoparticles, microorganisms, local skin friction, local Nusselt number, local wall mass flux, and local wall motile microorganisms flux are investigated. It is expected that the passively controlled nanofluid model can be much more easily achieved and applied in real circumstances than the actively controlled model.
文摘Micromechanics aims mainly at establishing the quantitative relation between the macroscopic mechanical behavior and the microstructure of heterogeneous materials.
文摘The theory of passive localization for underwater sources based on acoustic ray channel modeling is discussed. The principles of channel modeling in Ray-theory, determination of eigenrays which connect source and receiver, analysis of DOA arriving structure and time delay spectrum arriving structure, their relationship to source location are given in the paper. Source location is estimated by matching measured DOA and TDS to their calculated counterparts. The method of Ray-theory based passive localization features its simplicity, less calculation, short array aperture and robust performance to environment parameters, as compared with those methods based on Normal Mode theory.
基金supported by the National Institute of Environmental Research(No.NIER-RP-2014-335)
文摘It is thought that there are many unregulated anthropogenic chemicals in the environment.For risk assessment of chemicals, it is essential to estimate the predicted environmental concentrations. As an effort of identifying residual organic contaminants in air and water in Korea, nontarget screening using two-dimensional gas chromatography time-of-flight mass spectrometry(GC × GC-TOFMS) was conducted at 10 sites using polyurethane foam passive air sampler and at 6 sites using polydimethyl siloxane(PDMS) passive water sampler in three different seasons in 2014. More than 600 chemical peaks were identified satisfying the identification criteria in air and water samples, respectively, providing a list for further investigation. Chemical substances with reported national emission rates in2014(n = 149) were also screened for potential existence in the environment using a level Ⅱ fugacity model. Most of chemical substances classified as not detectable were not identified with detection frequency greater than 20% by nontarget screening, indicating that a simple equilibrium model has a strong potential to be used to exclude chemicals that are not likely to remain in the environment after emissions from targeted monitoring.
基金supported by the National Natural SciencFoundation of China(Nos.U1636125,61601027)
文摘For the performance issues of satellite transceivers suffering passive intermodulation interference,a novel and effective digital suppression algorithm is presented in this paper.In contrast to analog approaches,digital passive intermodulation(PIM) suppression approaches can be easily reconfigured and therefore are highly attractive for future satellite communication systems.A simplified model of nonlinear distortion from passive microwave devices is established in consideration of the memory effect.The multiple high-order PIM products falling into the receiving band can be described as a bilinear predictor function.A suppression algorithm based on a bilinear polynomial decorrelated adaptive filter is proposed for baseband digital signal processing.In consideration of the time-varying characteristics of passive intermodulation,this algorithm can achieve the rapidness of online interference estimation and low complexity with less consumption of resources.Numerical simulation results show that the algorithm can effectively compensate the passive intermodulation interference,and achieve a high signal-to-interference ratio gain.