When the human society steps into a new epoch, we, in cooperation with the World Intellectual Property Organization (WIPO), hold the Sino-African Intellectual Property Forum, on which we may exchange experiences in de...When the human society steps into a new epoch, we, in cooperation with the World Intellectual Property Organization (WIPO), hold the Sino-African Intellectual Property Forum, on which we may exchange experiences in developing intellectual property systems and discuss issues of common concern. The themes listed in the agenda not only mirror the emerging issues of the development of the international intellectual property system, but also carry significant weight to展开更多
Objective Herbal medicines containing toxic herbs or minerals such as Compound Danshen Tablet （CDT）, Angong Niuhuang Pill （ANP）, and Lidan Paishi Tablet （LPT） are avoided or used with caution for pregnant women ...Objective Herbal medicines containing toxic herbs or minerals such as Compound Danshen Tablet （CDT）, Angong Niuhuang Pill （ANP）, and Lidan Paishi Tablet （LPT） are avoided or used with caution for pregnant women because of potential teratogenicity. To understand their mechanism, they were chosen as model subjects for the research. Methods Zebrafish embryos were used to evaluate their potential teratogenic risk in vitro. Results All of them showed teratogenic and lethal effects in zebrafish embryos, with the ECs0 values at 351,793, and 220 μg/mL, and LC50 values at 41 7, 596, and 380 μg/mL, respectively. CDT and LPT, displaying week potential teratogenicity as their teratogenicity indexes were greater than 1, induced tail malformation and cardiac edema mainly in zebrafish embryos, respectively. Conclusion The results provide the significant guidance of clinical safety of medication.展开更多
文摘When the human society steps into a new epoch, we, in cooperation with the World Intellectual Property Organization (WIPO), hold the Sino-African Intellectual Property Forum, on which we may exchange experiences in developing intellectual property systems and discuss issues of common concern. The themes listed in the agenda not only mirror the emerging issues of the development of the international intellectual property system, but also carry significant weight to
基金Guangzhou Science and Technology Program(No.2014J4100171)
文摘Objective Herbal medicines containing toxic herbs or minerals such as Compound Danshen Tablet （CDT）, Angong Niuhuang Pill （ANP）, and Lidan Paishi Tablet （LPT） are avoided or used with caution for pregnant women because of potential teratogenicity. To understand their mechanism, they were chosen as model subjects for the research. Methods Zebrafish embryos were used to evaluate their potential teratogenic risk in vitro. Results All of them showed teratogenic and lethal effects in zebrafish embryos, with the ECs0 values at 351,793, and 220 μg/mL, and LC50 values at 41 7, 596, and 380 μg/mL, respectively. CDT and LPT, displaying week potential teratogenicity as their teratogenicity indexes were greater than 1, induced tail malformation and cardiac edema mainly in zebrafish embryos, respectively. Conclusion The results provide the significant guidance of clinical safety of medication.
