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Comparative efficacy and safety of Chinese patent medicines of iron deficiency anemia during pregnancy:A network meta-analysis
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作者 Jia-Chen Zou Xian-Ling Jia +2 位作者 Hai-Xia Wang Ying-Jie Su Jing-Yu Zhu 《World Journal of Clinical Cases》 SCIE 2024年第18期3515-3528,共14页
BACKGROUND Iron deficiency anemia(IDA)is a prevalent nutritional disorder during pregnancy.Clinical studies indicate that incorporating Chinese patent medicines(CPMs)with oral iron(OI)in treating IDA in pregnancy can ... BACKGROUND Iron deficiency anemia(IDA)is a prevalent nutritional disorder during pregnancy.Clinical studies indicate that incorporating Chinese patent medicines(CPMs)with oral iron(OI)in treating IDA in pregnancy can reduce adverse effects and improve clinical outcomes.Nonetheless,the comparative efficacy of different CPMs remains unclear.AIM To assess the safety and effectiveness of different CPMs for treating IDA during pregnancy using network meta-analysis.METHODS We conducted a search for randomized controlled trials(RCTs)that combined CPM and OI for IDA treatment in pregnancy,spanning from 2013 to the present.Data analysis was performed using Rev Man 5.3 and Stata 14.0 on literature that satisfied the quality criteria.RESULTS The analysis included 45 RCTs,encompassing 4422 pregnant patients with IDA.Six CPMs were examined,including Shengxuebao Mixture,Shengxuening Tablets(SXN),Yiqi Weixue CPMs(YQWX),Jianpi Shengxue CPMs(JPSX),Yiqi Buxue Tablets,and Compound Hongyi Buxue Oral Liquid(FFHY).Findings indicated that FFHY+OI significantly improved the clinical effective rate.SXN+OI was most effective in boosting red blood cells counts and hemoglobin levels.YQWX+OI showed superior results in improving serum ferritin,and SXN+OI was most effective in increasing serum iron levels.JPSX+OI was optimal in reducing adverse pregnancy outcomes,while YQBX+OI effectively minimized adverse events.A cluster analysis suggested that SXN+OI could be the potentially optimal therapeutic regimen for IDA in pregnancy.CONCLUSION This study demonstrates that the combination of OI with CPMs offers better outcomes than OI alone.Based on clinical efficacy and other measured outcomes,SXN+OI emerges as the most effective treatment modality for improving the health of pregnant patients with IDA. 展开更多
关键词 Chinese patent medicine network meta-analysis Shengxuebao Mixture Shengxuening Tablets Yiqi Weixue Chinese patent medicines Jianpi Shengxue Chinese patent medicines Yiqi Buxue Tablets Compound Hongyi Buxue Oral Liquid
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Effectiveness and safety of seven oral Chinese patent medicines as adjuvant therapy for cancer-related anemia: A systematic review and network meta-analysis of randomized controlled trials
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作者 Jing Xu Kang Wu +4 位作者 Xiao Li Chiah Shean Teo Guangda Li Yiming Pan Li Hou 《Journal of Traditional Chinese Medical Sciences》 CAS 2023年第2期150-160,共11页
Objective:To evaluate the effectiveness and safety of seven oral Chinese patent medicines(CPMs)as adjuvant therapy for cancer-related anemia(CRA)by network meta-analysis(NMA).Methods:A literature search to obtain rand... Objective:To evaluate the effectiveness and safety of seven oral Chinese patent medicines(CPMs)as adjuvant therapy for cancer-related anemia(CRA)by network meta-analysis(NMA).Methods:A literature search to obtain randomized controlled trials(RCTs)of seven oral CPMs in the adjuvant treatment of CRA was conducted in multiple databases from the inception to April 2022.The RevMan5.3 and R 4.1.1 software were used for NMA.Results:We ultimately included 29 RCTs with 2140 patients.Traditional meta-analysis showed that Fufang E'jiao syrup(FFEJS),Shengxuebao mixture(SXBM),Shengxuening tablets(SXNT),Jianpi Shengxue granules(JPSXG),and Yixuesheng capsule(YXSC)combined with basic Western treatment(BWT)could improve the hemoglobin(HGB)level.JPSXG combined with BWT could improve the red blood cell(RBC).FFEJS combined with BWT improved the Karnofsky performance status(KPS).NMA showed that FFEJS,JPSXG,SXBM,and SXNT plus BWT improved HGB better than Shengxue tablets(SXT)plus BWT,with top three ranking results being JPSXG plus BWT>SXNT plus BWT>FFEJS plus BWT.FFEJS plus BWT,JPSXG plus BWT,SXBM plus BWT,SXNT plus BWT,and SXT plus BWT improved RBC better than BWT,with top three ranking results being SXNT plus BWT>JPSXG plus BWT>FFEJS plus BWT.In terms of the KPS score,compared with SXT plus BWT,FFEJS,JPSXG,SXBM,SXNT,and Yizhong Shengxue capsule(YZSXC)plus BWT had higher KPS,with top three ranking results being SXBM plus BWT>JPSXG plus BWT>FFEJS plus BWT.Conclusions:Our NMA demonstrated that seven oral CPMs used as adjuvant treatment of CRA had a definite clinical effect.JPSXG not only increases the levels of HGB and RBC to enhance the clinical effect but also improves patients'quality of life.More accurate conclusions need to be verified by more high-quality RCTs. 展开更多
关键词 Cancer-related anemia Chinese patent medicine network meta-analysis EFFECTIVENESS SAFETY
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Research on overlapping structures and evolution properties of co-citation network 被引量:2
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作者 Shiji CHEN Xiaolin ZHANG 《Chinese Journal of Library and Information Science》 2013年第1期1-13,共13页
Purpose: This paper intends to explore methodologies and indicators for the analysis of overlapping structures and evolution properties in a co-citation network, and provide reference for overlapping structure analysi... Purpose: This paper intends to explore methodologies and indicators for the analysis of overlapping structures and evolution properties in a co-citation network, and provide reference for overlapping structure analysis of other scientific networks.Design/methodology/approach: The Q-value variance is defined to achieve overlapping structures of different levels in the scientific networks. At the same time, analyses for time correlation variance and subject correlation variance are used to present the formation of overlapping structures in scientific networks. As a test, a co-citation network of highly cited papers on Molecular Biology & Genetics from Essential Science Indicator(ESI) is taken as an example for an empirical analysis.Findings: Our research showed that the Q-value variance is effective for achieving the desired overlapping structures. Meanwhile, the time correlation variance and subject correlation variance are equally useful for uncovering the evolution progress of scientific research, and the properties of overlapping structures in the research of co-citation network as well.Research limitations: In this paper, the theoretical analysis and verification of time and subject correlation variances are still at its initial stage. Further studies in this regard need to take actual evolution of research areas into consideration.Practical implications: Evolution properties of overlapping structures pave the way for overlapping and evolution analysis of disciplines or areas, this study is of practical value for the planning of scientific and technical innovation.Originality/value: This paper proposes an analytical method of time correlation variance and subject correlation variance based on the evolution properties of overlapping structures, which would provide the foundation for the evolution analysis of disciplines and interdisciplinary research. 展开更多
关键词 Overlapping structure co-citation network Q-value variance Time correlation variance Subject correlation variance
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Evolution Characteristics of Government-Industry-University-Research Cooperative Innovation Network for China's Agriculture and Influ- encing Factors: Illustrated According to Agricultural Patent Case 被引量:14
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作者 LI Erling YAO Fei +1 位作者 XI Jiaxin GUO Chunyang 《Chinese Geographical Science》 SCIE CSCD 2018年第1期137-152,共16页
Under the special background of China, the cooperative innovation between different government-industry-university-research institutes plays an increasingly important role in the agricultural field. However, the exist... Under the special background of China, the cooperative innovation between different government-industry-university-research institutes plays an increasingly important role in the agricultural field. However, the existing literature has paid little attention to it. Considering the cooperation patents, published in the agriculture field stemming from the Full-text Database of China Patents as the study object, the spatial and institutional attribute of the authors as the data source, and by combining the social network and spatial econometrics analysis, this paper analyzes the structure evolution characteristics of cooperative innovation networks of agricultural government-industry-university-research institute in the city level of China in 1985–2014, based on the triple helix theory, with the influence factors discussed. This shows that, 1) since 1985, China's agricultural innovation level has been substantially increased, but the development degree of the cooperative innovation network is low, and the patent cooperation mainly relies on authors in the same unit; 2) enterprises play a leading role in the agricultural cooperative innovation. The effect of the government and hybrid organizations driven by the government is not obvious; 3) the cooperative innovation in the province and city dominates, and a multi-pole pattern has been formed. The cooperative innovation network structure evolves from a single helix empty core and double helix multi core to a double helix hierarchical network; 4) the city's science, education funding and personnel investment are key factors determining the agricultural cooperative innovation, while the agricultural development of the city presents slight negative impacts on it. The spatial mismatch of supply and demand is present in the technical cooperative innovation of China's agriculture. Therefore, the science enhancement and education investment to big agricultural provinces should be promptly implemented. 展开更多
关键词 cooperation innovation networks government-industry-university-research institute China's agricultural patent Socialnetwork Analysis (SNA)
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Feature and Tendency of Technology Transfer in Z-Park Patent Cooperation Network:From the Perspective of Global Optimal Path 被引量:1
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作者 Jun Guan Jingying Xu +2 位作者 Yu Han Dawei Wang Lizhi Xing 《Journal of Data and Information Science》 CSCD 2021年第4期111-138,共28页
Purpose:This study aims to provide a new framework for analyzing the path of technology diffusion in the innovation network at the regional level and industrial level respectively,which is conducive to the integration... Purpose:This study aims to provide a new framework for analyzing the path of technology diffusion in the innovation network at the regional level and industrial level respectively,which is conducive to the integration of innovation resources,the coordinated development of innovative subjects,and the improvement of innovation abilities.Design/methodology/approach:Based on the Z-Park patent cooperation data,we establish Inter-Enterprise Technology Transfer Network model and apply the concept of Pivotability to describe the key links of technology diffusion and quantify the importance of innovative partnerships.By measuring the topologically structural characteristics in the levels of branch park and the technosphere,this paper demonstrates how technology spreads and promotes overall innovation activities within the innovation network.Findings:The results indicate that:(1)Patent cooperation network of the Z-Park displays heterogeneity and the connections between the innovative subjects distribute extremely uneven.(2)Haidian park owns the highest pivotability in the IETTN model,yet the related inter-enterprise patent cooperation is mainly concentrated in its internal,failing to facilitate the technology diffusion across multiple branch parks.(3)Such fields as“electronics and information”and“advanced manufacturing”are prominent in the cross-technosphere cooperation,while fields such as“new energy”and“environmental protection technology”can better promote industrial integration.Research limitations:Only the part of the joint patent application is taken into account while establishing the patent cooperation network.The other factors that influence the mechanism of technology diffusion in the innovation network need to be further studied,such as financial capital,market competition,and personnel mobility,etc.Practical implications:The findings of this paper will provide useful information and suggestions for the administration and policy-making of high-tech parks.Originality/value:The value of this paper is to build a bridge between the massive amount of patent data and the nature of technology diffusion,and to develop a set of tools to analyze the nonlinear relations between innovative subjects. 展开更多
关键词 patent Cooperation Innovation network Industrial Integration Z-Park
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Evolution of the Socio-cognitive Structure of Knowledge Management(1986–2015): An Author Co-citation Analysis
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作者 Carlos Luis González-Valiente Magda León Santos Ricardo Arencibia-Jorge 《Journal of Data and Information Science》 CSCD 2019年第2期36-55,共20页
Purpose: The evolution of the socio-cognitive structure of the field of knowledge management(KM) during the period 1986–2015 is described. Design/methodology/approach: Records retrieved from Web of Science were submi... Purpose: The evolution of the socio-cognitive structure of the field of knowledge management(KM) during the period 1986–2015 is described. Design/methodology/approach: Records retrieved from Web of Science were submitted to author co-citation analysis(ACA) following a longitudinal perspective as of the following time slices: 1986–1996, 1997–2006, and 2007–2015. The top 10% of most cited first authors by sub-periods were mapped in bibliometric networks in order to interpret the communities formed and their relationships.Findings: KM is a homogeneous field as indicated by networks results. Nine classical authors are identified since they are highly co-cited in each sub-period, highlighting Ikujiro Nonaka as the most influential authors in the field. The most significant communities in KM are devoted to strategic management, KM foundations, organisational learning and behaviour, and organisational theories. Major trends in the evolution of the intellectual structure of KM evidence a technological influence in 1986–1996, a strategic influence in 1997–2006, and finally a sociological influence in 2007–2015.Research limitations: Describing a field from a single database can offer biases in terms of output coverage. Likewise, the conference proceedings and books were not used and the analysis was only based on first authors. However, the results obtained can be very useful to understand the evolution of KM research.Practical implications: These results might be useful for managers and academicians to understand the evolution of KM field and to(re)define research activities and organisational projects.Originality/value: The novelty of this paper lies in considering ACA as a bibliometric technique to study KM research. In addition, our investigation has a wider time coverage than earlier articles. 展开更多
关键词 KNOWLEDGE management BIBLIOMETRICS AUTHOR co-citation ANALYSIS KNOWLEDGE domain visualization Social network ANALYSIS INTELLECTUAL structure
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A Study on Forecasting System of Patent Registration Based on Bayesian Network
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作者 Gabjo Kim Sangsung Park +3 位作者 Sunghae Jun Yosup Kim Dongjin Kang Dongsik Jang 《Intelligent Information Management》 2012年第5期284-290,共7页
Recently the importance of intellectual property has been increased. There has been various ways of research on analy- sis of companies, forecast of technology and so on through patents and many investments of money a... Recently the importance of intellectual property has been increased. There has been various ways of research on analy- sis of companies, forecast of technology and so on through patents and many investments of money and time. Unlike traditional method of patent analysis such as company analysis, forecasting technologies, this research is to suggest the ways to forecast registration and rejection of patents which help minimize the efforts to register patents. To do so, in- formation such as inventors, applicants, application date, and IPC codes were extracted to be used as input variables for analyzing Bayesian network. Especially, among various forms of Bayesian network, we used Tree Augmented NBN (TAN) to forecast registration and rejection of patent. This is because, TAN was assumed to have dependence between variables. As a result of this Bayesian network, it was shown that there are nearly more than 80% of accuracy to fore- cast registration and rejection of patents. Therefore, we expect the minimization of time and cost of registration by forecasting registration and rejection of R&D patent through this research. 展开更多
关键词 Bayesian network patent REGISTRATION Tree AUGMENTED NBN FORECAST
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National patent Chinese herbal compound for parkinson's disease based on data mining and network pharmacology analysis
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作者 PAN Yu WANG Liang +1 位作者 WANG Peng YANG Ming-hui 《Journal of Hainan Medical University》 2022年第24期54-61,共8页
Objective:To analyze the dosing pattern and mechanism of herbal compound patents for the treatment of Parkinson's disease using data mining and network pharmacology methods,and to provide ideas for the clinical us... Objective:To analyze the dosing pattern and mechanism of herbal compound patents for the treatment of Parkinson's disease using data mining and network pharmacology methods,and to provide ideas for the clinical use of Parkinson's disease and new drug development.Methods:The Chinese herbal medicine compound prescriptions for Parkinson's disease built up to May 31,2022 by searching the official website of patent publication notice.An Excel table was built,and after term normalization of the included compound prescriptions,Excel and IBM SPSS Modeler 18.0 were used for data mining such as frequency statistics.We also applied network pharmacology methods to study HF drugs,using TCMSP and TCM database@Taiwan to obtain drug components and using TCMSP platform and Swiss ADME screening,collecting targets through UniProt and Swiss Target Prediction platform;obtaining PD disease from databases such as GeneCards The targets were obtained from GeneCards and other databases,drug-disease target intersections were obtained,and"drug-disease-target"networks were created using Cytoscape 3.8 software,and GO and KEGG enrichment analyses were performed using the Metascapep platform.Results:A total of 113 patented Chinese medicine recipes were included,involving 394 drugs,among which Tianma,Angelica and Bai Shao were the most commonly used drugs.A total of 442 drug targets,4884 disease targets and 324 drug-disease common targets were obtained.Conclusion:The study found that the medicinal properties of the patented compound Chinese medicine for Parkinson's disease are mainly warm and cold,the taste of the medicine is mainly sweet and bitter,the normalizing meridian is mainly liver,heart and spleen meridians,and the treatment method is mainly to strengthen the liver and kidney,nourish the qi and blood,and extinguish the wind and dredge the luo.The core ingredients include 4-ethoxymethylphenyl-4'-hydroxyl,palmitic acid,lignan,etc.;the main action targets are PTGS2,PTGS1,SCN5A,etc.;involved in PI3K-Akt,cAMP and other signaling pathways.The development of relevant compound can be based on clinical symptoms,appropriate tailoring,and flexible use of such drugs,in order to obtain the best therapeutic effect. 展开更多
关键词 Parkinson's disease patents Data mining network pharmacology Medication regimen
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Chinese patent medicine for stable angina pectoris:protocol for a systematic review and network meta-analysis
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作者 Wei Mu Deng-Feng Kong +7 位作者 Qiang Xu Xu-Fang Gu Jie Li Bao-He Wang Ge Li Jin-Hua Si Rui-Hua Wang Yu-Hong Huang 《TMR Integrative Medicine》 2022年第1期1-9,共9页
Stable angina pectoris is a common condition that affects a wide group of patients with coronary artery diseases.A number of Chinese patent drugs based on classic herbal formulations are available for angina managemen... Stable angina pectoris is a common condition that affects a wide group of patients with coronary artery diseases.A number of Chinese patent drugs based on classic herbal formulations are available for angina management.A network meta-analysis is proposed to assess the relative efficacy and safety of commonly used drugs for stable angina and generate a clinically meaningful ranking for each important outcome.We composed a list of 24 widely-used oral blood-quickening Chinese patent drugs from literature review and expert consultation.Three English and five Chinese electronic databases will be searched up to July 2021 for randomised clinical trials comparing between drugs on the list or with nitrates or placebo for stable angina.Unpublished data or grey literature will be sought through trial registries and correspondence to the report authors.Two reviewers independently screen literature,extract data and assess clinical and methodological features of included studies.The WinBUGS software will be used to perform network meta-analysis and the Stata 13.0 software to generate graphic demonstrations of the results.Primary outcomes are the incidence of cardiovascular events and changes in angina frequency,duration and intensity.We will use the surface under the cumulative ranking curve and the mean value for the numeric presentation of efficacy and safety ranking probabilities of multiple treatments.Heterogeneity and inconsistency will be assessed using appropriate statistical tests,and subgroup analysis and network meta-regression will be resorted when necessary.The quality of evidence for each outcome will be graded with the web-based GRADEpro GDT. 展开更多
关键词 Stable angina Blood-quickening Chinese patent medicine network meta-analysis Systematic review
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基于网络效应与行动者效应的专利转让及受让行为研究 被引量:1
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作者 刘晓燕 孙丽娜 +1 位作者 单晓红 杨娟 《科技进步与对策》 CSSCI 北大核心 2024年第2期35-45,共11页
专利交易是技术创新扩散的主要渠道,是实现科技成果转化的有效途径。研究专利转让与受让行为可以识别影响专利交易的主要因素,为政府制定技术交易政策提供科学依据。以2002—2019年中国集成电路产业专利转让记录作为数据源,利用Siena模... 专利交易是技术创新扩散的主要渠道,是实现科技成果转化的有效途径。研究专利转让与受让行为可以识别影响专利交易的主要因素,为政府制定技术交易政策提供科学依据。以2002—2019年中国集成电路产业专利转让记录作为数据源,利用Siena模型,结合网络效应和行动者效应,对专利转让与受让行为影响因素进行实证检验。研究发现:①专利技术交易以单向交易为主,随着集成电路产业从萌芽阶段步入成长阶段,产业内技术交易主体增加,网络规模扩大,网络信息传输效率有所提升,但仍处于较低水平;②网络初期产生的锁定效应明显得以缓解,技术交易网络内组织社团化特征明显,技术交易社团规模呈扩张态势且社团内紧密程度不断提高;③网络效应方面,转让者更倾向于与技术交易伙伴进行交易,频繁发生受让行为的企业会吸引更多新的交易伙伴,企业间不存在明显的互惠交易;④行动者效应方面,随着产业进入成长阶段,成熟企业更倾向于专利转让行为,初创企业更倾向于专利受让行为,占据高结构洞位置的企业更倾向于专利转让行为。企业间技术创新能力差距越小越容易发生技术交易,企业倾向于选择同一国别或同一企业集团内伙伴进行交易。 展开更多
关键词 网络效应 行动者效应 专利转让 专利受让 技术交易 科技成果转化
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“一带一路”共建国家间的技术扩散——基于技术内容与网络结构的分析 被引量:2
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作者 李林 彭方雪 +1 位作者 何建洪 朱浩 《重庆邮电大学学报(社会科学版)》 2024年第2期135-145,共11页
技术扩散是强化国际经济与创新联系的有效途径,是构建高质量开放创新体系的重要方式。国际技术扩散作为两个主体间的技术扩散活动具有方向性,不同国家的创新政策和技术发展战略侧重点不同,在技术扩散能力和技术吸收能力上均有差异。因... 技术扩散是强化国际经济与创新联系的有效途径,是构建高质量开放创新体系的重要方式。国际技术扩散作为两个主体间的技术扩散活动具有方向性,不同国家的创新政策和技术发展战略侧重点不同,在技术扩散能力和技术吸收能力上均有差异。因而国家间需要构建高效、稳定的技术扩散网络,充分发挥自身的技术优势、补齐技术短板,进一步加大技术流动和增强创新能力。本研究基于技术扩散理论,运用专利引证数据构建“一带一路”共建国家间技术扩散网络,分时段纵向分析共建国家技术扩散网络的演化,分技术领域横向分析共建国家间技术扩散的特征,探索中国与共建国家间技术扩散的内容和路径。研究认为:中国在共建国家技术扩散网络中的核心地位逐步确立,且在“一带一路”倡议提出后中国的核心位置更加明显、技术扩散范围更加广泛;但整体技术扩散网络密度低,除中国外的其他国家间技术扩散关系构建较少;不同技术领域的技术扩散网络形态各有不同,其中化学技术领域的技术扩散最活跃、网络复杂度最高;俄罗斯在化学、机械工程、仪器、其他技术领域具有一定技术优势,并且对中国的技术扩散强度很大,而中国在电气工程技术领域更有技术扩散优势。 展开更多
关键词 “一带一路” 技术扩散 社会网络分析 专利引证
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专利非实施主体的价值评判与法律规制——以网络化开放创新范式为视角 被引量:1
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作者 宁立志 龚涛 《知识产权》 CSSCI 北大核心 2024年第4期92-108,共17页
在传统视角下,专利非实施主体(NPE)主要产生于知识产权制度的漏洞,它们通过滥诉和滥用禁令救济等方式攫取了不合理的高额利润,会产生阻碍创新、损害消费者利益、破坏市场秩序等消极效果。但实际上,NPE的产生与网络化开放创新密切相关。... 在传统视角下,专利非实施主体(NPE)主要产生于知识产权制度的漏洞,它们通过滥诉和滥用禁令救济等方式攫取了不合理的高额利润,会产生阻碍创新、损害消费者利益、破坏市场秩序等消极效果。但实际上,NPE的产生与网络化开放创新密切相关。NPE是知识产权二级市场发展和专业化分工的产物,它在许可谈判中的优势地位很大程度上来自于专利许可模式由事前许可向事后许可的转变。同时,NPE也反过来促进了网络化开放创新。它可以促进技术流动,降低企业获取技术的搜寻成本,提高小企业和个体发明人的创新激励。因此,NPE并没有“原罪”,而是一个中性的市场主体。对NPE的规制思路,应当从基于主体身份的规制路径转变为基于滥用行为及其权利源头的规制路径。 展开更多
关键词 网络化开放创新 非实施主体 专利主张实体 标准必要专利 禁令
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中国专利奖视角下的颠覆性技术识别分析 被引量:1
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作者 施国良 吴静 +1 位作者 陈挺 张笑笑 《科技管理研究》 CSSCI 2024年第9期10-19,共10页
为充分利用专利结构化数据和文本数据,实现准确有效的颠覆性技术识别,以中国专利奖为切入点,提出基于图神经网络的颠覆性技术识别框架。首先以获得中国专利奖的授权发明专利定义颠覆性技术,解决技术定义难的问题;接着使用Neo4j图数据库... 为充分利用专利结构化数据和文本数据,实现准确有效的颠覆性技术识别,以中国专利奖为切入点,提出基于图神经网络的颠覆性技术识别框架。首先以获得中国专利奖的授权发明专利定义颠覆性技术,解决技术定义难的问题;接着使用Neo4j图数据库构建异质有向图,存储专利多重关系数据和方向信息,解决关系数据利用率低的问题;最后使用关系图卷积神经网络(R-GCN)模型进行训练,实现颠覆性技术识别,解决识别效果不佳的问题。研究表明以获得中国专利奖的专利技术直接定义颠覆性技术是合理且可靠的;提出的颠覆性技术识别框架能充分利用专利数据信息和专利异质有向图中空间信息,识别出绝大部分的颠覆性技术,丰富了图神经网络在颠覆性技术识别方面的研究。 展开更多
关键词 颠覆性技术 中国专利奖 Neo4j图数据库 关系图卷积神经网络
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自我中心网络关系嵌入对企业创新的影响研究——基于生物医药领域核心企业数据 被引量:1
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作者 曾莉 栗倩 周璇 《科技创业月刊》 2024年第8期65-72,共8页
基于生物医药领域核心企业专利合作申请数据构建企业自我中心网络,结合关系嵌入理论,将网络关系嵌入强度、嵌入广度的静态特征及关系稳定性的动态特征纳入到同一研究框架,采用标准负二项模型研究生物医药领域核心企业自我中心网络关系... 基于生物医药领域核心企业专利合作申请数据构建企业自我中心网络,结合关系嵌入理论,将网络关系嵌入强度、嵌入广度的静态特征及关系稳定性的动态特征纳入到同一研究框架,采用标准负二项模型研究生物医药领域核心企业自我中心网络关系嵌入特征对其创新的影响。研究结果表明:企业自我中心网络关系嵌入强度对企业创新呈现倒U型影响;网络关系嵌入广度、关系稳定性均对企业创新有显著正向影响;企业知识积累在网络关系嵌入影响企业创新中起中介作用。研究结论丰富了企业自我中心网络的相关理论研究,并为生物医药领域创新高质量发展提供了理论依据。 展开更多
关键词 专利合作 自我中心网络 生物医药 关系嵌入 企业创新
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创新联合体潜在合作伙伴选择研究
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作者 吴洁 谢小东 +1 位作者 盛永祥 桂亮 《复杂系统与复杂性科学》 CAS CSCD 北大核心 2024年第2期104-111,共8页
为研究创新联合体构建过程中如何合理有效地挑选潜在合作伙伴,充分发挥创新联合体在实现高水平科技自立自强中的战略作用,构建了基于专利异构网络和SimRank算法的创新主体技术背景相似度计算方法,借助可视化方法展现潜在合作关系网络,... 为研究创新联合体构建过程中如何合理有效地挑选潜在合作伙伴,充分发挥创新联合体在实现高水平科技自立自强中的战略作用,构建了基于专利异构网络和SimRank算法的创新主体技术背景相似度计算方法,借助可视化方法展现潜在合作关系网络,结合谱聚类算法划分创新联合体潜在合作伙伴。在高分子材料领域进行实证分析,实证结果较好地展示了该领域创新主体的潜在合作关系和技术背景高度相似的创新主体聚类结果,证实了研究理论和方法的有效性,为创新联合体伙伴选择提供参考。 展开更多
关键词 创新联合体 专利信息 异构网络 技术背景相似度 潜在合作伙伴
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专利中药处方治疗放射性肺损伤的用药规律及作用机制研究
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作者 李梅 李建华 +4 位作者 刘欢 王志鹏 高洁 袁慧 孙鸽 《癌变.畸变.突变》 CAS 2024年第4期275-280,共6页
目的:搜集国家专利中治疗放射性肺损伤的中药处方,探索其用药规律及作用机制。方法:检索国家知识产权局中国专利公布网站中治疗放射性肺损伤的中药处方,利用古今医案云平台进行统计分析、关联分析、聚类分析及网络构建分析等;通过网络... 目的:搜集国家专利中治疗放射性肺损伤的中药处方,探索其用药规律及作用机制。方法:检索国家知识产权局中国专利公布网站中治疗放射性肺损伤的中药处方,利用古今医案云平台进行统计分析、关联分析、聚类分析及网络构建分析等;通过网络药理学方法探讨治疗放射性肺损伤核心处方的作用靶点及相关通路。结果:纳入从专利数据库建立至2022年8月治疗放射性肺损伤的中药处方专利17项,共包含153味中药,药物出现频次较高的有甘草、生地黄;常用的药对为玄参-生地黄、苦杏仁-甘草、鱼腥草-甘草、生地黄-玄参;核心处方组成包括甘草、生地黄、苦杏仁、玄参和鱼腥草;核心处方治疗放射性肺损伤的主要靶点可能为JUN、IL-6、PTGS2、FOS、IL-8、IL-10等,相关的作用通路有脂质与动脉粥样硬化、化学致癌-受体激活、化学致癌-活性氧物种、PI3K-Akt信号通路、MAPK信号通路等。结论:专利中药处方主要可能通过抑制炎症反应从而发挥减轻放射性引起的肺损伤作用。 展开更多
关键词 放射性肺损伤 专利中药处方 用药规律 网络药理学
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已上市治疗产后缺乳中成药的核心处方多维度分析
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作者 李兰兰 曹婧 +4 位作者 虎亚光 张睿 代伟 杨涛 谭建伟 《临床医学研究与实践》 2024年第25期6-9,共4页
目的分析已上市治疗产后缺乳中成药组方规律、核心处方及其作用机制。方法收集中成药价值评估信息数据库中治疗产后缺乳的中成药,运用频数统计与关联规则分析用药特点及组方规律;利用网络模块划分法挖掘核心处方,从成分-靶点-生物通路... 目的分析已上市治疗产后缺乳中成药组方规律、核心处方及其作用机制。方法收集中成药价值评估信息数据库中治疗产后缺乳的中成药,运用频数统计与关联规则分析用药特点及组方规律;利用网络模块划分法挖掘核心处方,从成分-靶点-生物通路角度分析其作用机制。结果共收集到23种中成药处方,含69味中药,涉及8种剂型、2种药品类别。使用频次最高的为当归、王不留行,支持度最高的药对为王不留行-当归。核心处方组成为王不留行、川芎、当归、白芍及甘草,均可调节催乳素及其下游信号通路。结论关联规则与网络模块划分相结合能够多维度分析治疗产后缺乳用药规律,为中药治疗产后缺乳的临床应用提供参考。 展开更多
关键词 产后缺乳 中成药 核心处方 网络模块划分
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基于图神经网络的专利文本分类研究
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作者 魏雯婕 张更平 《竞争情报》 2024年第2期24-34,共11页
传统专利分类由专家逐件审阅,随着大数据、人工智能和自然语言处理技术的快速发展,专利文本自动分类正在成为学界、业界的重要研究方向之一。文本分类技术可以用于判断专利申请是否获得授权,帮助审查员自动化处理和分析专利申请文件,从... 传统专利分类由专家逐件审阅,随着大数据、人工智能和自然语言处理技术的快速发展,专利文本自动分类正在成为学界、业界的重要研究方向之一。文本分类技术可以用于判断专利申请是否获得授权,帮助审查员自动化处理和分析专利申请文件,从而提高工作效率。针对海量专利的英文文本,提出一种基于图神经网络模型的专利文本自动分类方法,用于测度专利申请是否可获得授权。使用深度学习算法TextGCN对专利摘要语料进行学习和训练,利用图结构数据的邻居信息和节点特征,通过神经网络产生专利文本的表示向量,进而实现专利授权与否的预测。实验结果表明,本文采用的深度学习算法能够得到较好的分类效果,并且与Doc2vec和TFIDF表示方法相比,该模型在精确度、召回率、准确率及F1方面均有所提高,可为专利授权与否的自动预测提供可靠的研究依据。 展开更多
关键词 专利分类 图卷积神经网络 Doc2vec TFIDF 表示学习
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口服中成药联合常规西药治疗稳定型心绞痛的网状Meta分析
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作者 王薇 曹璐 +3 位作者 任鹏 赵会林 朱贝贝 刘凯 《中医临床研究》 2024年第2期50-61,共12页
目的:运用网状Meta分析方法系统评价中成药联合常规西药治疗稳定型心绞痛的有效性及安全性。方法:计算机检索PubMed、The Cochrane Library、Embase、Web of Science、万方、维普、知网和中国生物医学文献数据库,搜集中成药联合常规西... 目的:运用网状Meta分析方法系统评价中成药联合常规西药治疗稳定型心绞痛的有效性及安全性。方法:计算机检索PubMed、The Cochrane Library、Embase、Web of Science、万方、维普、知网和中国生物医学文献数据库,搜集中成药联合常规西药治疗稳定型心绞痛的随机对照试验,检索时限均为建库至2022年2月10日。采用RevMan5.3、STATA15.1软件进行数据统计分析。结果:共纳入70项随机对照试验,包括6 973例患者,涉及7种中成药。网状Meta分析结果显示:(1)在提高心绞痛疗效方面,排序依次为养心氏片+常规西药>麝香保心丸+常规西药>冠心舒通胶囊+常规西药>芪参益气滴丸+常规西药>丹蒌片+常规西药>心可舒片+常规西药>益心舒胶囊+常规西药>常规西药;(2)在提高心电图疗效方面,排序依次为芪参益气滴丸+常规西药>养心氏片+常规西药>麝香保心丸+常规西药>冠心舒通胶囊+常规西药>心可舒片+常规西药>益心舒胶囊+常规西药>丹蒌片+常规西药>常规西药;(3)在升高高密度脂蛋白胆固醇方面,排序依次为冠心舒通胶囊+常规西药>益心舒胶囊+常规西药>麝香保心丸+常规西药>心可舒片+常规西药>常规西药;(4)在降低低密度脂蛋白胆固醇方面,排序依次为养心氏片+常规西药>益心舒胶囊+常规西药>冠心舒通胶囊+常规西药>丹蒌片+常规西药>心可舒片+常规西药>麝香保心丸+常规西药>常规西药;(5)在安全性方面,中成药联合常规西药的不良反应整体少于对照组。结论:本研究表明,中成药联合常规西药治疗稳定型心绞痛可显著提高其心绞痛及心电图疗效,同时具有调脂作用且安全性更好。但部分纳入研究的方法学质量不佳,故此结论需进一步在更多高质量研究中予以验证。 展开更多
关键词 中成药 稳定型心绞痛 网状Meta分析
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基于海洋产业的城市创新网络特征及邻近性分析
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作者 郭建科 田冬翠 《地域研究与开发》 CSSCI 北大核心 2024年第1期46-52,60,共8页
基于2000—2020年海洋产业合作申请专利数据,运用社会网络分析法和地理探测器,分析城市创新网络的拓扑结构、空间格局和邻近性机理。结果表明:①拓扑结构方面,2000年和2001年城市创新网络不具备无标度网络特征;2002—2020年,网络规模逐... 基于2000—2020年海洋产业合作申请专利数据,运用社会网络分析法和地理探测器,分析城市创新网络的拓扑结构、空间格局和邻近性机理。结果表明:①拓扑结构方面,2000年和2001年城市创新网络不具备无标度网络特征;2002—2020年,网络规模逐渐扩大,城市间合作增加,网络以2011年为分界点由松散转为集聚阶段。网络的无标度特性和小世界性逐渐明显,并由“双核心”结构逐渐发育为以北京为单核心的“核心-边缘”结构。②空间格局方面,核心城市和中介城市均表现出区域性特征,主要集聚在京津地区、长三角、珠三角和山东半岛,城市创新网络形成了以三角结构为支撑的四边形空间格局。③城市专利合作由沿海城市向内陆城市扩展,但海洋产业的科技创新主要依靠深圳、青岛、上海、天津、广州等沿海城市和北京、武汉等少部分内陆城市。④社会邻近性对城市创新网络的解释力最高,地理距离对城市合作的限制作用逐渐减弱,不同邻近因子间均存在非线性增强的两两交互作用。 展开更多
关键词 海洋产业 合作专利 社会网络分析 地理探测器 多维邻近性 城市创新网络
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