The use of mathematical models can aid in optimizing therapy settings in ventilated patients to achieve certain therapy goals. Especially when multiple goals have to be met, the use of individualized models can be of ...The use of mathematical models can aid in optimizing therapy settings in ventilated patients to achieve certain therapy goals. Especially when multiple goals have to be met, the use of individualized models can be of great help. The presented work shows the potential of using models of respiratory mechanics and gas exchange to optimize minute ventilation and oxygen supply to achieve a defined oxygenation and carbon dioxide removal in a patient while guaranteeing lung protective ventilation. The venti-lator settings are optimized using respiratory mechanics models to compute a respira-tion rate and tidal volume that keeps the maximum airway pressure below the critical limit of 30 cm H2O while ensuring a sufficient expiration. A three-parameter gas ex-change model is then used to optimize both minute ventilation and oxygen supply to achieve defined arterial partial pressures of oxygen and carbon dioxide in the patient. The presented approach was tested using a JAVA based patient simulator that uses various model combinations to compute patient reactions to changes in the ventilator settings. The simulated patient reaction to the optimized ventilator settings showed good agreement with the desired goals.展开更多
目的构建适合新型冠状病毒感染康复患者集生理、心理和社会功能康复于一体的知信行模式,评估以该模式为框架的系统作为支持性干预模式的有效性和实用性并验证其远期成效。方法选取100例符合新型冠状病毒感染的患者为研究对象,随机分为...目的构建适合新型冠状病毒感染康复患者集生理、心理和社会功能康复于一体的知信行模式,评估以该模式为框架的系统作为支持性干预模式的有效性和实用性并验证其远期成效。方法选取100例符合新型冠状病毒感染的患者为研究对象,随机分为干预组和对照组各50例,对照组进行常规治疗及健康教育,干预组在此基础上实施支持性干预方案。比较两组患者在干预前、干预后1个月、干预后3个月的心理及社会功能结局状况。结果干预组患者焦虑自评量表(Self-Rating Anxiety Scale,SAS)[1]和抑郁自评量表[2](Self-Rating Depression Scale,SDS)的得分均低于对照组干预后1个月、干预后3个月的得分,领悟社会支持量表(Perceived Social Support Scale,PSSS)、生活质量量表(Quality of Life Scale,QOL)评分均显著高于对照组干预后1个月、干预后3个月的得分,差异均有统计学意义(P<0.05)。结论知信行理论模式可缓解新型冠状病毒感染康复患者的焦虑及抑郁情绪,提高患者的生活质量和社会支持能力。展开更多
文摘The use of mathematical models can aid in optimizing therapy settings in ventilated patients to achieve certain therapy goals. Especially when multiple goals have to be met, the use of individualized models can be of great help. The presented work shows the potential of using models of respiratory mechanics and gas exchange to optimize minute ventilation and oxygen supply to achieve a defined oxygenation and carbon dioxide removal in a patient while guaranteeing lung protective ventilation. The venti-lator settings are optimized using respiratory mechanics models to compute a respira-tion rate and tidal volume that keeps the maximum airway pressure below the critical limit of 30 cm H2O while ensuring a sufficient expiration. A three-parameter gas ex-change model is then used to optimize both minute ventilation and oxygen supply to achieve defined arterial partial pressures of oxygen and carbon dioxide in the patient. The presented approach was tested using a JAVA based patient simulator that uses various model combinations to compute patient reactions to changes in the ventilator settings. The simulated patient reaction to the optimized ventilator settings showed good agreement with the desired goals.
文摘目的构建适合新型冠状病毒感染康复患者集生理、心理和社会功能康复于一体的知信行模式,评估以该模式为框架的系统作为支持性干预模式的有效性和实用性并验证其远期成效。方法选取100例符合新型冠状病毒感染的患者为研究对象,随机分为干预组和对照组各50例,对照组进行常规治疗及健康教育,干预组在此基础上实施支持性干预方案。比较两组患者在干预前、干预后1个月、干预后3个月的心理及社会功能结局状况。结果干预组患者焦虑自评量表(Self-Rating Anxiety Scale,SAS)[1]和抑郁自评量表[2](Self-Rating Depression Scale,SDS)的得分均低于对照组干预后1个月、干预后3个月的得分,领悟社会支持量表(Perceived Social Support Scale,PSSS)、生活质量量表(Quality of Life Scale,QOL)评分均显著高于对照组干预后1个月、干预后3个月的得分,差异均有统计学意义(P<0.05)。结论知信行理论模式可缓解新型冠状病毒感染康复患者的焦虑及抑郁情绪,提高患者的生活质量和社会支持能力。
