Spatio-temporal distribution of net primary productivity along the northeast China transect and its response to climatic change

An improved Carnegie Ames Stanford Approach model （CASA model） was used to estimate the net primary productivity （NPP） of the Northeast China Transect （NECT） every month from 1982 to 2000. The spatial-temporal distribution of NPP along NECT and its response to climatic change were also analyzed. Results showed that the change tendency of NPP spatial distribution in NECT is quite similar to that of precipitation and their spatial correlation coefficient is up to 0.84 （P 〈 0.01）. The inter-annual variation of NPP in NECT is mainly affected by the change of the aestival NPP every year, which accounts for 67.6% of the inter-annual increase in NPP and their spatial correlation coefficient is 0.95 （P 〈 0.01）. The NPP in NECT is mainly cumulated between May and September, which accounts for 89.8% of the annual NPP. The NPP in summer （June to August） accounts for 65.9% of the annual NPP and is the lowest in winter. Recent climate changes have enhanced plant growth in NECT. The mean NPP increased 14.3% from 1980s to 1990s. The inter-annual linear trend of NPP is 4.6 gC·m^-2·a^-1, and the relative trend is 1.17%, which owns mainly to the increasing temperature.

Analysis on Spatio-temporal Distribution of Lightning in Dalian Area of China between 2007 and 2008

The cloud-to-ground lightning data between 2007 and 2008 were collected by lightning detection and location system,which was composed of four lightning detectors in four different sites of Dalian area.The spatio-temporal distribution of cloud-to-ground lightning in surrounding areas of Dalian was analyzed from several aspects of polarity distribution,diurnal variation,lightning intensity and lightning density.The results showed that the number of negative lightning accounted for 93.9% of the total number of lightning,and its average lightning intensity was 27.99 kA.The number of positive lightning accounted for 6.1% of the total number of lightning,and its average lightning intensity was 35.56 kA.The diurnal variation of lightning frequency showed an obvious structure of two peaks (17:00-18:00 and 04:00-05:00) and two valleys (09:00-10:00 and 00:00-01:00).The number of lightning between May and September was 91.5% of the annual number,and the lightning occurred the most frequently between June and August.Most of positive and negative lightning was at the intensity of 15-35 kA,80.0% lower than 40 kA,and 99.3% lower than 100 kA.The lightning density had obvious regional differences in distribution,high in the Liaodong Bay and the Dalian Bay and low in inland areas.Therefore,coastal areas should attract more attention in lightning disaster defense in the surrounding areas of Dalian.

Response of Spatio-temporal Distribution of Fishery Resources to Mairne Environment in the Northern South China Sea

[Objective] The paper was to investigate the spatio-temporal distribution of fishery resources in the northern South China Sea and to provide reference for scientific evaluation and effective protection of fishery resources in the northern South China Sea. [Methods] Based on monitoring data and satellite remote sensing data [including Sea Surface Temperature(SST), Chlorophyll a concentration(Chl a) and Sea Surface Wind(SSW)] in winter(January to February) and summer(August to September) in the northern South China Sea, the relationship between spatio-temporal distribution of fishery resources and marine environment was investigated by using Generalized Linear Models(GLM), fishing ground gravity and correlation analysis. [Results] The suitable SST and Chl a of light falling-net fishing ground in winter were 17-23°C and 0.2-0.6 mg/m3, respectively. The suitable SST and Chl a in summer were approximately 28°C and 0.2-1.0 mg/m3. Standardized Catch Per Unit Effort(SCPUE) was higher in summer(2-4) and lower in winter(1-3). From winter to summer, the fishing ground gravity migrated to the east about 1 °E. [Conclusion] The spatio-temporal distribution of fishery resources is related to eastern Hainan-western Guangdong upwelling and the coastal flow, caused by the monsoon in the northern South China Sea, and the major catch species of light falling-net.

Spatio-Temporal Distribution of Agricultural Non-Point Source Pollution in Binzhou City Based on Large Computer Data

Based on the relevant statistics on the agricultural non-point source pollution in Binzhou City,we studied the spatio-temporal variation in agricultural non-point source nitrogen pollution and phosphorus pollution in Binzhou City during 2008-2015. The results showed that the agricultural non-point source nitrogen pollution and phosphorus pollution in Binzhou City changed from 114400 t and 28800 t in 2008 to110600 t and 24400 t in 2015,respectively; for the non-point source nitrogen pollution sources,the proportion of chemical fertilizer,manure and domestic sewage changed from 80. 41%,10. 47% and 9. 13% in 2008 to 82. 94%,4. 77% and 12. 29% in 2015,respectively; for the non-point source phosphorus pollution sources,the proportion of chemical fertilizer,manure and domestic sewage changed from 89. 29%,8. 32% and 2. 39% in 2008 to 91. 6%,4. 78% and 3. 62% in 2015,respectively; in 2015,the non-point source nitrogen pollution was most serious in Wudi County and Huimin County and least serious in Zhanhua County; the non-point source phosphorus pollution was most serious in Zouping County and least serious in Wudi County.

Implementing geostatistical analysis to study spatio-temporal distribution patterns of swimming crabs(Portunus trituberculatus)

This study attempted to compare the performance of local polynomial interpolation,inverse distance weighted interpolation,and ordinary kriging in studying distribution patterns of swimming crabs.Cross-validation was used to select the optimum method to get distribution results,and kriging was used for making spatial variability analysis.Data were collected from 87 sampling stations in November of 2015(autumn)and February(winter),May(spring)and August(summer)of 2016.Results indicate that swimming crabs widely distributed in autumn and summer:in the summer,they were more spatially independent,and resources in each sampling station varied a lot;in the winter and spring,the abundance of crabs was much lower,but the individual crab size was bigger,and they showed the patchy and more concentrative distribution pattern,which means they were more spatially dependent.Distribution patterns were in accordance with ecological migration features of swimming crabs,which were affected by the changing marine environment.This study could infer that it is applicable to study crab fishery or even other crustacean species using geostatistical analysis.It not only helps practitioners have a better understanding of how swimming crabs migrate from season to season,but also assists researchers in carrying out a more comprehensive assessment of the fishery.Therefore,it may facilitate advancing the implementation in the pilot quota management program of swimming crabs in northern Zhejiang fishing grounds.

Spatio-temporal distribution of malaria vectors(Diptera:Culicidae) across different climatic zones of Iran

Malaria is a main vector-borne public health problem in Iran.The last studies on Iranian mosquitoes show 31 Anopheles species including different sibling species and genotypes,eight of them are reported to play role in malaria transmission.The objective of this study is to provide a reference for malaria vectors of Iran and to map their spatial and temporal distribution in different climatic zones.Shape files of administrative boundaries and climates of Iran were provided by National Cartographic Center.Data on distribution and seasonal activity of malaria vectors were obtained from different sources and a databank in district level was created in Excel 2003, inserted to the shape files and analyzed by ArcGIS 9.2 to provide the maps.Anopheles culicifacies Giles s.l.,Anopheles dthali Patton,Anopheles fluviatilis James s.L,Anopheles maculipennis Meigen s.L,Anopheles sacharovi Favre,Anopheles stephensi IJston,and Anopheles superpictus Grassi have been introduced as primary and secondary malaria vectors and Anopheles puicherrimus Theobald as a suspected vector in Iran.Temporal distribution of anopheline mosquitoes is restricted to April_December in northern Iran,however mosquitoes can be found during the year in southern region.Spatial distribution of malaria vectors is different based on species,thus six of them(except for Anopheles maculipennis s.l.and Anopheles sacharovi) are reported from endemic malarious area in southern and southeastern areas of Iran.The climate of this part is usually warm and humid,which makes it favorable for mosquito rearing and malaria transmission.Correlation between climate conditions and vector distribution can help to predict the potential range of activity for each species and preparedness for malaria epidemics.

Root growth and spatio-temporal distribution of three common annual halophytes in a saline desert, northern Xinjiang

Root growth and spatial and temporal distribution in the 0-100 cm soil profiles of three common annual halophytes Salsola subcrassa, Suaeda acuminate and Petrosimonia sibirica distributed in a saline desert in north- ern Xinjiang, China were studied in 2009 and 2010. The results showed that the root systems of the three halo- phytes were of the taproot type, vertically distributed in the 90-cm soil profile, and were deepest in late July. Their taproots reached maximum depth rapidly, early in the growth period, but with rare lateral roots. They were then dug out in an orderly way, from bottom to top, exhibiting vertical development first and then horizontal development. The distribution of specific root length, which reflects the characteristics of the feeder root, was gradually increased from top to bottom, whereas root weight displayed an opposite distribution pattern. The root length distribution of the three halophytes was concentrated （62% to 76%） in the middle soil profile （20-60 cm）, with less distribution in the surface （0-20 cm） and bottom （60-90 cm） soil profiles. The results indicated that the roots of the three annual halophytes grew rapidly into the deeper soil layer after germination, which ensured the plant survival and uptake of water and nutrition, and thus built up a strong tolerance to an arid, high-salt environment.

Spatio-temporal distribution of Konosirus punctatus spawning and nursing ground in the South Yellow Sea

In recent years,Konosirus punctatus has accounted for a large portion in catch composition and become important economic species in the South Yellow Sea.However,the distribution of K.punctatus early life stages is still poorly understood.In this study,generalized additive models with Tweedie distribution were used to analyze the relationships between K.punctatus ichthyoplankton and environmental factors(longitude and latitude,sea surface temperature(SST),sea surface salinity(SSS)and depth),and predict distribution K.punctatus spawning ground and nursing ground,based on samplings collected in 6 months during 2014–2017.The results showed that K.punctatus’spawning ground were mainly distributed in central and north study area(from 33.0°N to 37.0°N).By comparison,the nursing ground shifted southward,which were approximately located along central and south coast of study area(from 31.7°N to 35.5°N).The optimal models identified that suitable SST,SSS and depth for eggs were 19–26℃,25–30 and 9–23 m,respectively.The suitable SSS for larvae were 29–31.The K.punctatus spawning habit might have changed in the past decades,which was a response to increasing SST and fishing pressure.That needs to be proved in further study.The study provides references of conservation and exploitation for K.punctatus.

Diversity and Influence of Environmental Factors on the Spatio-Temporal Distribution of the Ichthyofauna of Malonda Lagoon (Congo Brazzaville)

This study was initiated with the aim of studying the diversity and spatio-temporal distribution of fish in the Malonda lagoon, one of the coastal ecosystems of the Base Guinea in the Republic of Congo. The fish were sampled over a period of two years in three zones each including three stations known as: Mangrove, Grass and Full water. One station upstream towards the freshwater zone, one station downstream towards the mouth and one station in the containment zone. The catches were made using monofilament gillnets of 8, 10, 20 and 30 mm mesh size. During the rainy season, 1516 specimens belonging to 29 species, 17 families and 12 orders were collected. In the dry season, 768 specimens belonging to 20 species, 11 families and 8 orders were collected. For both seasons, the family Cichlidae is the most diversified. The marine forms are the most represented compared to the continental forms. Redundancy Analysis with forward selection coupled with Monte Carlo permutation tests showed that in the rainy season four variables influenced the distribution of species (Depth: 48%, Vase: 16%, Nitrogen: 10% and Transparency: 10%);in the dry season three variables influenced the distribution of species (Vase: 38%, Nitrogen: 14% and Oxygen: 11%). Ecological indices showed that the Malonda lagoon is already undergoing either anthropic or natural impacts, its state of ecological integrity is disturbed, the values of Shannon diversity and Equitability indices are not close to maximum values. The results of this study will serve as an ecological database for the proper management of these ecosystems.

The Influence of Climate Change and Variability on Spatio-Temporal Rainfall and Temperature Distribution in Zanzibar

Climate change has resulted in serious social-economic ramifications and extremely catastrophic weather events in the world, Tanzania and Zanzibar in particular, with adaptation being the only option to reduce impacts. The study focuses on the influence of climate change and variability on spatio-temporal rainfall and temperature variability and distribution in Zanzibar. The station observation datasets of rainfall, Tmax and Tmin acquired from Tanzania Meteorological Authority (TMA) and the Coordinated Regional Climate Downscaling Experiment program (CORDEX) projected datasets from the Regional climate model HIRHAM5 under driving model ICHEC-EC-EARH, for the three periods of 1991-2020 used as baseline (HS), 2021-2050 as near future (NF) and 2051-2080 far future (FF), under two representative concentration pathways (RCP) of 4.5 and 8.5, were used. The long-term observed Tmax and Tmin were used to produce time series for observing the nature and trends, while the observed rainfall data was used for understanding wet and dry periods, trends and slope (at p ≤ 0.05) using the Standardized Precipitation Index (SPI) and the Mann Kendall test (MK). Moreover, the Quantum Geographic Information System (QGIS) under the Inverse Distance Weighting (IDW) interpolation techniques were used for mapping the three decades of 1991-2000 (hereafter D1), 2001-2010 (hereafter D2) and 2011-2020 (hereafter D3) to analyze periodical spatial rainfall distribution in Zanzibar. As for the projected datasets the Climate Data Operator Commands (CDO), python scripts and Grid analysis and Display System (GrADS) soft-wares were used to process and display the results of the projected datasets of rainfall, Tmax and Tmin for the HS, NF and FF, respectively. The results show that the observed Tmax increased by the rates of 0.035℃ yr-1 and 0.0169℃ yr-1, while the Tmin was increased by a rate of 0.064℃ yr-1 and 0.104℃ yr-1 for Unguja and Pemba, respectively. The temporal distribution of wetness and dryness indices showed a climate shift from near normal to moderate wet during 2005 at Zanzibar Airport, while normal to moderately dry conditions, were observed in Pemba at Matangatuani. The decadal rainfall variability and distributions revealed higher rainfall intensity with an increasing trend and good spatial distribution in D3 from March to May (MAM) and October to December (OND). The projected results for Tmax during MAM and OND depicted higher values ranging from 1.7℃ - 1.8℃ to 1.9℃ - 2.0℃ and 1.5℃ to 2.0℃ in FF compared to NF under both RCPs. Also, higher Tmin values of 1.12℃ - 1.16℃ was projected in FF for MAM and OND under both RCPs. Besides, the rainfall projection generally revealed increased rainfall intensity in the range of 0 - 25 mm for Pemba and declined rainfall in the range of 25 - 50 mm in Unguja under both RCPs in perspectives of both NF and FF. Conclusively the study has shown that the undergoing climate change has posed a significant impact on both rainfall and temperature spatial and temporal distributions in Zanzibar (Unguja and Pemba), with Unguja being projected to have higher rainfall deficits while increasing rainfall strengths in Pemba. Thus, the study calls for more studies and formulation of effective adaptation, strategies and resilience mechanisms to combat the projected climate change impacts especially in the agricultural sector, water and food security.

Simulation of the spatio-temporal evolution of the electron energy distribution function in a pulsed hollow-cathode discharge

This article presents the 2D simulation results of a nanosecond pulsed hollow cathode discharge obtained through a combination of fluid and kinetic models.The spatio-temporal evolution of the electron energy distribution function(EEDF)of the plasma column and electrical characteristics of the nanosecond pulsed hollow cathode discharge at a gas pressure of 5 Torr are studied.The results show that the discharge development starts with the formation of an ionization front at the anode surface.The ionization front splits into two parts in the cathode cavity while propagating along its lateral surfaces.The ionization front formation leads to an increase in the fast isotropic EEDF component at its front,as well as in the anisotropic EEDF component.The accelerated electrons enter the cathode cavity,which significantly contributes to the formation of the highenergy EEDF component and EEDF anisotropy.

Epidemic Characteristics and Spatio-Temporal Patterns of HFRS in Qingdao City,China,2010-2022

Objective This study investigated the epidemic characteristics and spatio-temporal dynamics of hemorrhagic fever with renal syndrome(HFRS)in Qingdao City,China.Methods Information was collected on HFRS cases in Qingdao City from 2010 to 2022.Descriptive epidemiologic,seasonal decomposition,spatial autocorrelation,and spatio-temporal cluster analyses were performed.Results A total of 2,220 patients with HFRS were reported over the study period,with an average annual incidence of 1.89/100,000 and a case fatality rate of 2.52%.The male:female ratio was 2.8:1.75.3%of patients were aged between 16 and 60 years old,75.3%of patients were farmers,and 11.6%had both“three red”and“three pain”symptoms.The HFRS epidemic showed two-peak seasonality:the primary fall-winter peak and the minor spring peak.The HFRS epidemic presented highly spatially heterogeneous,street/township-level hot spots that were mostly distributed in Huangdao,Pingdu,and Jiaozhou.The spatio-temporal cluster analysis revealed three cluster areas in Qingdao City that were located in the south of Huangdao District during the fall-winter peak.Conclusion The distribution of HFRS in Qingdao exhibited periodic,seasonal,and regional characteristics,with high spatial clustering heterogeneity.The typical symptoms of“three red”and“three pain”in patients with HFRS were not obvious.

Federated Learning Model for Auto Insurance Rate Setting Based on Tweedie Distribution

In the assessment of car insurance claims,the claim rate for car insurance presents a highly skewed probability distribution,which is typically modeled using Tweedie distribution.The traditional approach to obtaining the Tweedie regression model involves training on a centralized dataset,when the data is provided by multiple parties,training a privacy-preserving Tweedie regression model without exchanging raw data becomes a challenge.To address this issue,this study introduces a novel vertical federated learning-based Tweedie regression algorithm for multi-party auto insurance rate setting in data silos.The algorithm can keep sensitive data locally and uses privacy-preserving techniques to achieve intersection operations between the two parties holding the data.After determining which entities are shared,the participants train the model locally using the shared entity data to obtain the local generalized linear model intermediate parameters.The homomorphic encryption algorithms are introduced to interact with and update the model intermediate parameters to collaboratively complete the joint training of the car insurance rate-setting model.Performance tests on two publicly available datasets show that the proposed federated Tweedie regression algorithm can effectively generate Tweedie regression models that leverage the value of data fromboth partieswithout exchanging data.The assessment results of the scheme approach those of the Tweedie regressionmodel learned fromcentralized data,and outperformthe Tweedie regressionmodel learned independently by a single party.

Coseismic deformation and fault slip distribution of the 2023 M_(W)7.8 and M_(W)7.6 earthquakes in Türkiye

On February 6,2023,a devastating earthquake with a moment magnitude of M_(W)7.8 struck the town of Pazarcik in south-central Türkiye,followed by another powerful earthquake with a moment magnitude of M_(W)7.6 that struck the nearby city of Elbistan 9 h later.To study the characteristics of surface deformation caused by this event and the influence of fault rupture,this study calculated the static coseismic deformation of 56 stations and dynamic displacement waveforms of 15 stations using data from the Turkish national fixed global navigation satellite system(GNSS)network.A maximum static coseismic displacement of 0.38 m for the M_(W)7.8 Kahramanmaras earthquake was observed at station ANTE,36 km from the epicenter,and a maximum dynamic coseismic displacement of 4.4 m for the M_(W)7.6 Elbistan earthquake was observed at station EKZ1,5 km from the epicenter.The rupture-slip distributions of the two earthquakes were inverted using GNSS coseismic deformation as a constraint.The results showed that the Kahramanmaras earthquake rupture segment was distinct and exposed on the ground,resulting in significant rupture slip along the Amanos and Pazarcik fault segments of the East Anatolian Fault.The maximum slip in the Pazarcik fault segment was 10.7 m,and rupture occurred at depths of 0–15 km.In the Cardak fault region,the Elbistan earthquake caused significant ruptures at depths of 0–12 km,with the largest amount of slip reaching 11.6 m.The Coulomb stress change caused by the Kahramanmaras earthquake rupture along the Cardak fault segment was approximately 2 bars,and the area of increased Coulomb stress corresponded to the subsequent rupture region of the M_(W)7.6 earthquake.Thus,it is likely that the M_(W)7.8 earthquake triggered or promoted the M_(W)7.6 earthquake.Based on the cumulative stress impact of the M_(W)7.8 and M_(W)7.6 events,the southwestern segment of the East Anatolian Fault,specifically the Amanos fault segment,experienced a Coulomb rupture stress change exceeding 2 bars,warranting further attention to assess its future seismic hazard risk.

Extended wet sieving method for determination of complete particle size distribution of general soils

The traditional standard wet sieving method uses steel sieves with aperture?0.063 mm and can only determine the particle size distribution(PSD)of gravel and sand in general soil.This paper extends the traditional method and presents an extended wet sieving method.The extended method uses both the steel sieves and the nylon filter cloth sieves.The apertures of the cloth sieves are smaller than 0.063 mm and equal 0.048 mm,0.038 mm,0.014 mm,0.012 mm,0.0063 mm,0.004 mm,0.003 mm,0.002 mm,and 0.001 mm,respectively.The extended method uses five steps to separate the general soil into many material sub-groups of gravel,sand,silt and clay with known particle size ranges.The complete PSD of the general soil is then calculated from the dry masses of the individual material sub-groups.The extended method is demonstrated with a general soil of completely decomposed granite(CDG)in Hong Kong,China.The silt and clay materials with different particle size ranges are further examined,checked and verified using stereomicroscopic observation,physical and chemical property tests.The results further confirm the correctness of the extended wet sieving method.

Integrative biogeography: Validating hypotheses of species distribution

DEAR EDITOR,Biogeography is a scientific field dedicated to the investigation of the origins and distribution patterns of organisms,as well as predicting future alterations in their geographical distributions(Cox&Moore,2005).However,the majority of conclusions drawn within the field of biogeography are hypothetical.Rigorous testing of these biogeographic hypotheses remains a considerable challenge.This paper presents the concept of“integrative biogeography”,which emphasizes the experimental testing of biogeographic hypotheses through studies on geological history,as well as biotic and abiotic factors(Figure 1).

Variation of spatio-temporal distribution of on-road vehicle emissions based on real-time RFID data

High-resolution vehicular emissions inventories are important for managing vehicular pollution and improving urban air quality. This study developed a vehicular emission inventory with high spatio-temporal resolution in the main urban area of Chongqing, based on realtime traffic data from 820 RFID detectors covering 454 roads, and the differences in spatiotemporal emission characteristics between inner and outer districts were analysed. The result showed that the daily vehicular emission intensities of CO, hydrocarbons, PM2.5, PM10,and NO_(x) were 30.24, 3.83, 0.18, 0.20, and 8.65 kg/km per day, respectively, in the study area during 2018. The pollutants emission intensities in inner district were higher than those in outer district. Light passenger cars(LPCs) were the main contributors of all-day CO emissions in the inner and outer districts, from which the contributors of NO_(x) emissions were different. Diesel and natural gas buses were major contributors of daytime NO_(x) emissions in inner districts, accounting for 40.40%, but buses and heavy duty trucks(HDTs) were major contributors in outer districts. At nighttime, due to the lifting of truck restrictions and suspension of buses, HDTs become the main NO_(x) contributor in both inner and outer districts,and its three NO_(x) emission peak hours were found, which are different to the peak hours of total NO_(x) emission by all vehicles. Unlike most other cities, bridges and connecting channels are always emission hotspots due to long-time traffic congestion. This knowledge will help fully understand vehicular emissions characteristics and is useful for policymakers to design precise prevention and control measures.

Influence of Topography on the Distribution and Structure of Woody Plants in the Senegalese Sahel (Sandy Ferlo)

This study describes the floristic composition and structure of a woody stand in the Senegalese Sahel, paying particular attention to the edaphic factors of its floristic composition. A stratified inventory considering the different relief units was adopted. Woody vegetation was surveyed using a dendrometric approach. The results obtained show that the flora is dominated by a few species adapted to drought, such as Balanites aegyptiaca (L.) Del., Calotropis procera Ait. and Boscia senegalensis (Pers.). The distribution of this flora and the structure of the ligneous plants are linked to the topography. In the lowlands, the flora is more diversified and the ligneous plants reach their optimum level of development compared with the higher relief areas. In the lowlands, there are a few woody species which, in the past, were indicative of better climatic conditions. These are Anogeissus leiocarpus (DC.), Commiphora africana (A. Rich.), Feretia apodanthera Del., Loeseneriella africana (A. Smith), Mitragyna inermis (Willd.) and Sclerocarya birrea (A. Rich). It is important that their reintroduction into reforestation projects takes account of their edaphic preference.

Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease

Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a whole.Here,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial distribution.Additionally,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse model.Our findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-βproduction.Thus,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial biogenesis.In addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis.

Diversity of Orchids in Terms of Their Distribution, Uses and Conservation in Annapurna Conservation Area of Nepal

The Annapurna Conservation Area (ACA), the first conservation area and the largest protected area (PA) in Nepal, is incredibly rich in biodiversity. Notwithstanding this, orchids in the ACA have not been explored enough yet thus making the need for ambitious research to be carried out. Previous study only included 81 species of orchids within ACA. This study aims to update the record of species and genera richness in the ACA. In total 198 species of orchids, belonging to 67 genera (40% and 62% of the total recorded orchid species and genera in Nepal) has been recorded in ACA. This represents an increase of 144% in species and 56% in genera over the previous data. Out of the 198 species, 99 were epiphytes, 6 were holomycotrophic and 93 were terrestrial. Among the 67 genera, Bulbophyllum (17) species were dominant, followed by Dendrobium (16), Herminium (10), Coelogyne, Plantanthera (9 each), Eria, Habenaria, Oberonia (8 each), Calanthe (7), and Liparis (6). Fifty-six species were found to be ornamentally significant and 85 species medicinally significant.