Here two cases of renal failure occurring in pregnancy were reported,with biopsy-proven pauci-immune crescentic glomerulonephritis at postpartum.It is most rare that pauci-immune crescentic glomerulonephritis as the c...Here two cases of renal failure occurring in pregnancy were reported,with biopsy-proven pauci-immune crescentic glomerulonephritis at postpartum.It is most rare that pauci-immune crescentic glomerulonephritis as the cause of renal failure in pregnancy.Their renal function could remain stable for some time due to timely and appropriate treatment.Therefore,the pregnant and maternal who have the performance of renal impairment should be closely tracked their blood pressure,urinary protein and renal function,if necessary,execute renal biopsy,for a clear and accurate pathological diagnosis is of great significance to grasp the opportunity of treatment.But the long-term prognosis is still poor.展开更多
Objective To evaluate the significance of serum anti neutrophil cytoplasmic antibodies (ANCAs) and the effects of immune suppressive treatments on its activity in patients with pauci immune crescentic glomeruloneph...Objective To evaluate the significance of serum anti neutrophil cytoplasmic antibodies (ANCAs) and the effects of immune suppressive treatments on its activity in patients with pauci immune crescentic glomerulonephritis (PICGN) Methods Serum ANCAs and myeloperoxidase (MPO) ANCA were detected by indirect immunofluorescence and enzyme linked immuno^sorbent assay (ELISA) methods respectively, and the renal tissues infiltrating cells including CD4 +, CD8 +, CD68 + and PCNA + cells were determined by four layer peroxidase antiperoxidase (PAP) method The clinical manifestations, pathologic features and immune pathologic changes in patients with positive ANCAs were compared with that in patients with negative ANCAs The effects of immune suppressive therapy on clinic and pathologic changes as well as ANCAs activity were also investigated in ANCAs positive and ANCAs negative patients Results Both of clinic active manifestations such as the degree of hematuria, rapidly progressive renal failure and pathologic active features including segmental capillary necrosis and vasculitis were much common in patients with positive ANCAs as compared with that in patients with negative ANCAs The number of infiltrating cells in renal tissue, especially CD4 + cells, was markedly higher in ANCAs positive patients than that in ANCAs negative patients The effects of immune suppressive therapy were also much better in patients with positive ANCAs than that in patients with negative ANCAs Conclusion Serum ANCAs is not only a marker for diagnosis of systemic vasculitis, but also a sensitive predictor for evaluation of diseases' activity and treatment in patients with PICGN The good effect of immune suppressive treatments on patients with PICGN is partially associated with the degree of ANCAs activity展开更多
目的:探讨抗中性粒细胞胞浆抗体(ANCA)阴性少免疫沉积型新月体性肾炎患者血清抗内皮细胞抗体(AECA)表达情况,及其与临床表现的关系。方法:选取2010年至2015年在我院治疗的少免疫沉积型新月体性肾小球肾炎患者,其中ANCA阴性患者45例(观察...目的:探讨抗中性粒细胞胞浆抗体(ANCA)阴性少免疫沉积型新月体性肾炎患者血清抗内皮细胞抗体(AECA)表达情况,及其与临床表现的关系。方法:选取2010年至2015年在我院治疗的少免疫沉积型新月体性肾小球肾炎患者,其中ANCA阴性患者45例(观察组),ANCA阳性患者49例(对照组),采用Western blot检测各组患者血清AECA水平。结果:观察组平均年龄和伯明翰血管炎活动性评分(BVAS)分别为(41.08±9.43)岁和(15.03±3.82)分,明显低于对照组(P<0.05);观察组出现发热、关节痛的比例分别为26.67%和13.33%,明显低于对照组(P<0.05);观察组出现肾病综合征比例为48.89%,高于对照组(P<0.05);观察组血清AECA阳性率为46.67%,明显低于对照组的81.63%(P<0.05);观察组Ig G-AECA共识别7种蛋白,而对照组共识别11种蛋白,其中观察组抗90 k D抗体阳性率为13.33%(6/45),明显低于对照组的51.02%(25/49)(P<0.05);观察组抗76 k D抗体阳性患者出现皮疹的比例为100%,明显高于阴性患者(P<0.05),抗200 k D抗体阳性患者BVAS评分为(18.02±2.51)分,明显高于阴性患者(P<0.05)。结论:ANCA阴性少免疫沉积型新月体性肾炎患者血清存在不同的AECA,可能与某些临床表现有关;ANCA阴性和阳性患者AECA有所不同,两者临床表现的差异可能与AECA的不同有关,需待进一步研究。展开更多
Single- and a few-chain aggregates of isotactic polystyrene（i-PS） were prepared by the freeze-drying procedure from dilute solutions with the concentration from 1×10-3 to 2×10-5 g/mL.It was found that the ...Single- and a few-chain aggregates of isotactic polystyrene（i-PS） were prepared by the freeze-drying procedure from dilute solutions with the concentration from 1×10-3 to 2×10-5 g/mL.It was found that the melting point of crystals was gradually shifted to lower temperatures as the solution concentration decreased by the differential scanning calorimetry（DSC）.As a result, the thickness of the lamellas of bulk samples and the samples prepared by the freeze-drying procedure from 2×10-5 g/mL solution decreased from 19.3 nm to 12.6 nm,respectively.The half crystallization time（t1/2） of samples by freezing-dried from 1×10-4 g/mL solution was about 36 s,it was merely a tenth of the period of the bulk sample annealed at 468.3 K.In addition,the growth rate of spherulite（dr/dt） of the samples prepared from 2×10-5 g/mL solution was more faster than ones of the bulk samples annealed at 478.3 K.All these should be attributed to the samples with less entanglement prepared by freeze-drying procedure from dilute solution.A preliminary study on the crystallization of the samples indicates that entanglements has a pronounced effect on crystallization behavior of polymer.展开更多
文摘Here two cases of renal failure occurring in pregnancy were reported,with biopsy-proven pauci-immune crescentic glomerulonephritis at postpartum.It is most rare that pauci-immune crescentic glomerulonephritis as the cause of renal failure in pregnancy.Their renal function could remain stable for some time due to timely and appropriate treatment.Therefore,the pregnant and maternal who have the performance of renal impairment should be closely tracked their blood pressure,urinary protein and renal function,if necessary,execute renal biopsy,for a clear and accurate pathological diagnosis is of great significance to grasp the opportunity of treatment.But the long-term prognosis is still poor.
文摘Objective To evaluate the significance of serum anti neutrophil cytoplasmic antibodies (ANCAs) and the effects of immune suppressive treatments on its activity in patients with pauci immune crescentic glomerulonephritis (PICGN) Methods Serum ANCAs and myeloperoxidase (MPO) ANCA were detected by indirect immunofluorescence and enzyme linked immuno^sorbent assay (ELISA) methods respectively, and the renal tissues infiltrating cells including CD4 +, CD8 +, CD68 + and PCNA + cells were determined by four layer peroxidase antiperoxidase (PAP) method The clinical manifestations, pathologic features and immune pathologic changes in patients with positive ANCAs were compared with that in patients with negative ANCAs The effects of immune suppressive therapy on clinic and pathologic changes as well as ANCAs activity were also investigated in ANCAs positive and ANCAs negative patients Results Both of clinic active manifestations such as the degree of hematuria, rapidly progressive renal failure and pathologic active features including segmental capillary necrosis and vasculitis were much common in patients with positive ANCAs as compared with that in patients with negative ANCAs The number of infiltrating cells in renal tissue, especially CD4 + cells, was markedly higher in ANCAs positive patients than that in ANCAs negative patients The effects of immune suppressive therapy were also much better in patients with positive ANCAs than that in patients with negative ANCAs Conclusion Serum ANCAs is not only a marker for diagnosis of systemic vasculitis, but also a sensitive predictor for evaluation of diseases' activity and treatment in patients with PICGN The good effect of immune suppressive treatments on patients with PICGN is partially associated with the degree of ANCAs activity
文摘目的:探讨抗中性粒细胞胞浆抗体(ANCA)阴性少免疫沉积型新月体性肾炎患者血清抗内皮细胞抗体(AECA)表达情况,及其与临床表现的关系。方法:选取2010年至2015年在我院治疗的少免疫沉积型新月体性肾小球肾炎患者,其中ANCA阴性患者45例(观察组),ANCA阳性患者49例(对照组),采用Western blot检测各组患者血清AECA水平。结果:观察组平均年龄和伯明翰血管炎活动性评分(BVAS)分别为(41.08±9.43)岁和(15.03±3.82)分,明显低于对照组(P<0.05);观察组出现发热、关节痛的比例分别为26.67%和13.33%,明显低于对照组(P<0.05);观察组出现肾病综合征比例为48.89%,高于对照组(P<0.05);观察组血清AECA阳性率为46.67%,明显低于对照组的81.63%(P<0.05);观察组Ig G-AECA共识别7种蛋白,而对照组共识别11种蛋白,其中观察组抗90 k D抗体阳性率为13.33%(6/45),明显低于对照组的51.02%(25/49)(P<0.05);观察组抗76 k D抗体阳性患者出现皮疹的比例为100%,明显高于阴性患者(P<0.05),抗200 k D抗体阳性患者BVAS评分为(18.02±2.51)分,明显高于阴性患者(P<0.05)。结论:ANCA阴性少免疫沉积型新月体性肾炎患者血清存在不同的AECA,可能与某些临床表现有关;ANCA阴性和阳性患者AECA有所不同,两者临床表现的差异可能与AECA的不同有关,需待进一步研究。
文摘Single- and a few-chain aggregates of isotactic polystyrene（i-PS） were prepared by the freeze-drying procedure from dilute solutions with the concentration from 1×10-3 to 2×10-5 g/mL.It was found that the melting point of crystals was gradually shifted to lower temperatures as the solution concentration decreased by the differential scanning calorimetry（DSC）.As a result, the thickness of the lamellas of bulk samples and the samples prepared by the freeze-drying procedure from 2×10-5 g/mL solution decreased from 19.3 nm to 12.6 nm,respectively.The half crystallization time（t1/2） of samples by freezing-dried from 1×10-4 g/mL solution was about 36 s,it was merely a tenth of the period of the bulk sample annealed at 468.3 K.In addition,the growth rate of spherulite（dr/dt） of the samples prepared from 2×10-5 g/mL solution was more faster than ones of the bulk samples annealed at 478.3 K.All these should be attributed to the samples with less entanglement prepared by freeze-drying procedure from dilute solution.A preliminary study on the crystallization of the samples indicates that entanglements has a pronounced effect on crystallization behavior of polymer.
