Background: A Randomized Controlled Trial (RCT) has been elaborated where goal directed fluid and hemodynamic therapy (GDFHT) will be realized with trans-thoracic echocardiographic aortic blood flow peak velocity vari...Background: A Randomized Controlled Trial (RCT) has been elaborated where goal directed fluid and hemodynamic therapy (GDFHT) will be realized with trans-thoracic echocardiographic aortic blood flow peak velocity variation (ΔVpeak) and distance minute (DM) to guide fluid therapy and hemodynamics in high risk pediatric surgical patients. This RCT will clarify the impact of GDFHT with ΔVpeak and DM on postoperative outcome in terms of morbidity, length of stay in the intensive care unit (LOSICU), length of mechanical ventilation (LMV) and length of hospital stay (LOS) in children. To determine values of ΔVpeak, DM and VTI predictive of these postoperative outcomes, an observational pilot study will be realized. This pilot study is described here. The primary objective of this study is to determine values of ΔVpeak, DM and ITV predictive of postoperative outcome in children in terms of morbidity. The secondary objectives are to determine values of ΔVpeak, DM and ITV predictive of LOSICU, LMV, LOS, intraoperative, postoperative fluid administration and vasoactive-inotropic therapy. Methods: 500 - 1000 children aged less than 18 years will be included prospectively. Statistic analysis will be realized with XLSTAT 2019.4.2 software or plus. Results and Conclusions: This trial protocol will determine values of ΔVpeak, DM and ITV with echocardiography predictive of postoperative outcome in children.展开更多
Accurate flood prediction is an important tool for risk management and hydraulic works design on a watershed scale. The objective of this study was to calibrate and validate 24 linear and non-linear regression models,...Accurate flood prediction is an important tool for risk management and hydraulic works design on a watershed scale. The objective of this study was to calibrate and validate 24 linear and non-linear regression models, using only upstream data to estimate real-time downstream flooding. Four critical downstream estimation points in the Mataquito and Maule river basins located in central Chile were selected to estimate peak flows using data from one, two, or three upstream stations. More than one thousand paper-based storm hydrographs were manually analyzed for rainfall events that occurred between 1999 and 2006, in order to determine the best models for predicting downstream peak flow. The Peak Flow Index (IQP) (defined as the quotient between upstream and downstream data) and the Transit Times (TT) between upstream and downstream points were also obtained and analyzed for each river basin. The Coefficients of Determination (R2), the Standard Error of the Estimate (SEE), and the Bland-Altman test (ACBA) were used to calibrate and validate the best selected model at each basin. Despite the high variability observed in peak flow data, the developed models were able to accurately estimate downstream peak flows using only upstream flow data.展开更多
文摘Background: A Randomized Controlled Trial (RCT) has been elaborated where goal directed fluid and hemodynamic therapy (GDFHT) will be realized with trans-thoracic echocardiographic aortic blood flow peak velocity variation (ΔVpeak) and distance minute (DM) to guide fluid therapy and hemodynamics in high risk pediatric surgical patients. This RCT will clarify the impact of GDFHT with ΔVpeak and DM on postoperative outcome in terms of morbidity, length of stay in the intensive care unit (LOSICU), length of mechanical ventilation (LMV) and length of hospital stay (LOS) in children. To determine values of ΔVpeak, DM and VTI predictive of these postoperative outcomes, an observational pilot study will be realized. This pilot study is described here. The primary objective of this study is to determine values of ΔVpeak, DM and ITV predictive of postoperative outcome in children in terms of morbidity. The secondary objectives are to determine values of ΔVpeak, DM and ITV predictive of LOSICU, LMV, LOS, intraoperative, postoperative fluid administration and vasoactive-inotropic therapy. Methods: 500 - 1000 children aged less than 18 years will be included prospectively. Statistic analysis will be realized with XLSTAT 2019.4.2 software or plus. Results and Conclusions: This trial protocol will determine values of ΔVpeak, DM and ITV with echocardiography predictive of postoperative outcome in children.
文摘Accurate flood prediction is an important tool for risk management and hydraulic works design on a watershed scale. The objective of this study was to calibrate and validate 24 linear and non-linear regression models, using only upstream data to estimate real-time downstream flooding. Four critical downstream estimation points in the Mataquito and Maule river basins located in central Chile were selected to estimate peak flows using data from one, two, or three upstream stations. More than one thousand paper-based storm hydrographs were manually analyzed for rainfall events that occurred between 1999 and 2006, in order to determine the best models for predicting downstream peak flow. The Peak Flow Index (IQP) (defined as the quotient between upstream and downstream data) and the Transit Times (TT) between upstream and downstream points were also obtained and analyzed for each river basin. The Coefficients of Determination (R2), the Standard Error of the Estimate (SEE), and the Bland-Altman test (ACBA) were used to calibrate and validate the best selected model at each basin. Despite the high variability observed in peak flow data, the developed models were able to accurately estimate downstream peak flows using only upstream flow data.
