When examining the file transfer performance in a peer-to-peer file sharing system, a fundamental problem is how to describe the service rate for a file transfer. In this paper, the problem is examined by analyzing th...When examining the file transfer performance in a peer-to-peer file sharing system, a fundamental problem is how to describe the service rate for a file transfer. In this paper, the problem is examined by analyzing the distribution of server-like nodes' upstream-bandwidth among their concurrent transfers. A sufficient condition for the service rate, what a receiver obtains for downloading a file, to asymptotically be uniform is presented. On the aggregate service rate for transferring a file in a system, a sufficient condition for it to asymptotically follow a Zipf distribution is presented. These asymptotic equalities are both in the mean square sense. These analyses and the sufficient conditions provide a mathematic base for modeling file transfer processes in peer-to-peer file sharing systems.展开更多
In radiology,magnetic resonance imaging(MRI)is an essential diagnostic tool that provides detailed images of a patient’s anatomical and physiological structures.MRI is particularly effective for detecting soft tissue...In radiology,magnetic resonance imaging(MRI)is an essential diagnostic tool that provides detailed images of a patient’s anatomical and physiological structures.MRI is particularly effective for detecting soft tissue anomalies.Traditionally,radiologists manually interpret these images,which can be labor-intensive and time-consuming due to the vast amount of data.To address this challenge,machine learning,and deep learning approaches can be utilized to improve the accuracy and efficiency of anomaly detection in MRI scans.This manuscript presents the use of the Deep AlexNet50 model for MRI classification with discriminative learning methods.There are three stages for learning;in the first stage,the whole dataset is used to learn the features.In the second stage,some layers of AlexNet50 are frozen with an augmented dataset,and in the third stage,AlexNet50 with an augmented dataset with the augmented dataset.This method used three publicly available MRI classification datasets:Harvard whole brain atlas(HWBA-dataset),the School of Biomedical Engineering of Southern Medical University(SMU-dataset),and The National Institute of Neuroscience and Hospitals brain MRI dataset(NINS-dataset)for analysis.Various hyperparameter optimizers like Adam,stochastic gradient descent(SGD),Root mean square propagation(RMS prop),Adamax,and AdamW have been used to compare the performance of the learning process.HWBA-dataset registers maximum classification performance.We evaluated the performance of the proposed classification model using several quantitative metrics,achieving an average accuracy of 98%.展开更多
Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational levels.tsRNAs are not on...Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational levels.tsRNAs are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell death.tsRNA dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases annually.AP development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ferroptosis.Notably,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote AP.We show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.展开更多
BACKGROUND Thumb replantation following complete traumatic avulsion requires complex techniques to restore function,especially in cases of avulsion at the level of the metacarpophalangeal joint(MCP I)and avulsion of t...BACKGROUND Thumb replantation following complete traumatic avulsion requires complex techniques to restore function,especially in cases of avulsion at the level of the metacarpophalangeal joint(MCP I)and avulsion of the flexor pollicis longus(FPL)at the musculotendinous junction.Possible treatments include direct tendon suture or tendon transfer,most commonly from the ring finger.To optimize function and avoid donor finger complications,we performed thumb replantation with flexion restoration using brachioradialis(BR)tendon transfer with palmaris longus(PL)tendon graft.CASE SUMMARY A 20-year-old left-handed male was admitted for a complete traumatic left thumb amputation following an accident while sliding from the top of a handrail.The patient presented with skin and bone avulsion at the MCP I,avulsion of the FPL tendon at the musculotendinous junction(zone 5),avulsion of the extensor pollicis longus tendon(zone T3),and avulsion of the thumb’s collateral arteries and nerves.The patient was treated with two stage thumb repair.The first intervention consisted of thumb replantation with MCP I arthrodesis,resection of avulsed FPL tendon and implantation of a silicone tendon prosthesis.The second intervention consisted of PL tendon graft and BR tendon transfer.Follow-up at 10 months showed good outcomes with active interphalangeal flexion of 70°,grip strength of 45 kg,key pinch strength of 15 kg and two-point discrimination threshold of 4 mm.CONCLUSION Flexion restoration after complete thumb amputation with FPL avulsion at the musculotendinous junction can be achieved using BR tendon transfer with PL tendon graft.展开更多
Peer to Peer网络(简称p2p)作为一种新型的覆盖网络引起了越来越多研究者的兴趣。本文介绍了在我国进行的骨干互联网上p2p网络流量测量。与现有国外研究不同,本文的数据来源于核心路由器,因此克服了它们的缺陷。其研究集中在汇聚流中的...Peer to Peer网络(简称p2p)作为一种新型的覆盖网络引起了越来越多研究者的兴趣。本文介绍了在我国进行的骨干互联网上p2p网络流量测量。与现有国外研究不同,本文的数据来源于核心路由器,因此克服了它们的缺陷。其研究集中在汇聚流中的3个周期性尖峰群、不同主机发送或接收流量的重尾分布、p2p流量的长相关特性以及提出了ADTE的估计方法来区分信令和数据流量。本文的研究也显示出Napster在p2p流中占大部分,这暗示着超级节点和阶层式拓扑较纯p2p结构潜在的优势。同时,观察到在我国p2p的流量仅占Internet总流量的1%弱,这个值跟国外的数据有很大区别。我们分析了其中的原因并希望该结论为我国p2p软件的发展提供参考。展开更多
以小世界模型为理论基础,以 Region 为基本逻辑管理单位,按用户需求和共享目的组织 Region。提出了基于 Region 的多层结构 Peer-to-Peer 网络模型和构造规则,给出了 Region 的划分策略和数学模型,证明了模型的正确和合理性;对模型中的...以小世界模型为理论基础,以 Region 为基本逻辑管理单位,按用户需求和共享目的组织 Region。提出了基于 Region 的多层结构 Peer-to-Peer 网络模型和构造规则,给出了 Region 的划分策略和数学模型,证明了模型的正确和合理性;对模型中的层和域、中心节点、普通节点和汇聚点进行了明确的定义,给出了节点加入、离开、中心节点选取策略和算法描述;使定位某种服务的工作量和查询范围从网络中的所有结点数降低到 Region 的节点数,有效地防止了恶意请求引发的洪,网络系统开销为常数。模拟分析表明,该模型可有效解决可扩展性、性能与效率不高问题,且网络规模越大,其综合性能的优越性越明显,因此,模型是合理有效的。展开更多
提出并实现了一种建立在Peer-to-Peer 搜索策略上的自组织、自适应、高效和可靠的文件系统DISPFS(Double ID Space basedPeer-to-peer File System)。它在双层ID 空间中构造虚拟存储节点,不仅有效地取得了文件系统内的负载均衡、提高系...提出并实现了一种建立在Peer-to-Peer 搜索策略上的自组织、自适应、高效和可靠的文件系统DISPFS(Double ID Space basedPeer-to-peer File System)。它在双层ID 空间中构造虚拟存储节点,不仅有效地取得了文件系统内的负载均衡、提高系统利用率,而且保证了动态环境中文件的可靠、快速获取。试验数据表明,DISPFS 在系统接近满负荷运行和文件插入/删除操作频繁的双重压力下依然保持优良的性能。展开更多
The design and evaluation of accelerated transmission (AT) systems in peer-to-peer networks for data transmission are introduced. Based on transfer control protocol (TCP) and peer-to-peer (P2P) substrate network...The design and evaluation of accelerated transmission (AT) systems in peer-to-peer networks for data transmission are introduced. Based on transfer control protocol (TCP) and peer-to-peer (P2P) substrate networks, AT can select peers of high performance quality, monitor the transfer status of each peer, dynamically adjust the transmission velocity and react to connection degradation with high accuracy and low overhead. The system performance is evaluated by simulations, and the interrelationship between network flow, bandwidth utilities and network throughput is analyzed. Owing to the collaborative operation of neighboring peers, AT accelerates the process of data transmission and the collective network performance is much more satisfactory.展开更多
基金National High Technology Research and Development Program of China (No.2007AA01Z457)Shanghai Science and Technology Development Fundation,China(No.07QA14033)
文摘When examining the file transfer performance in a peer-to-peer file sharing system, a fundamental problem is how to describe the service rate for a file transfer. In this paper, the problem is examined by analyzing the distribution of server-like nodes' upstream-bandwidth among their concurrent transfers. A sufficient condition for the service rate, what a receiver obtains for downloading a file, to asymptotically be uniform is presented. On the aggregate service rate for transferring a file in a system, a sufficient condition for it to asymptotically follow a Zipf distribution is presented. These asymptotic equalities are both in the mean square sense. These analyses and the sufficient conditions provide a mathematic base for modeling file transfer processes in peer-to-peer file sharing systems.
文摘In radiology,magnetic resonance imaging(MRI)is an essential diagnostic tool that provides detailed images of a patient’s anatomical and physiological structures.MRI is particularly effective for detecting soft tissue anomalies.Traditionally,radiologists manually interpret these images,which can be labor-intensive and time-consuming due to the vast amount of data.To address this challenge,machine learning,and deep learning approaches can be utilized to improve the accuracy and efficiency of anomaly detection in MRI scans.This manuscript presents the use of the Deep AlexNet50 model for MRI classification with discriminative learning methods.There are three stages for learning;in the first stage,the whole dataset is used to learn the features.In the second stage,some layers of AlexNet50 are frozen with an augmented dataset,and in the third stage,AlexNet50 with an augmented dataset with the augmented dataset.This method used three publicly available MRI classification datasets:Harvard whole brain atlas(HWBA-dataset),the School of Biomedical Engineering of Southern Medical University(SMU-dataset),and The National Institute of Neuroscience and Hospitals brain MRI dataset(NINS-dataset)for analysis.Various hyperparameter optimizers like Adam,stochastic gradient descent(SGD),Root mean square propagation(RMS prop),Adamax,and AdamW have been used to compare the performance of the learning process.HWBA-dataset registers maximum classification performance.We evaluated the performance of the proposed classification model using several quantitative metrics,achieving an average accuracy of 98%.
基金Supported by the Central South University Innovation-Driven Research Programme,No.2023CXQD075。
文摘Transfer RNA(tRNA)-derived fragments,a new type of tRNA-derived small RNA(tsRNA),can be cleaved from tRNA by enzymes to regulate target gene expression at the transcriptional and translational levels.tsRNAs are not only degradation fragments but also have biological functions,including those in immune inflammation,metabolic disorders,and cell death.tsRNA dysregulation is closely associated with multiple diseases,including various cancers and acute pancreatitis(AP).AP is a common gastrointestinal disease,and its incidence increases annually.AP development is associated with tsRNAs,which regulate cell injury and induce inflammation,especially pyroptosis and ferroptosis.Notably,serum tRF36 has the potential to serve as a non-invasive diagnostic biomarker and leads to pancreatic acinar cell ferroptosis causing inflammation to promote AP.We show the characteristics of tsRNAs and their diagnostic value and function in AP,and discuss the potential opportunities and challenges of using tsRNAs in clinical applications and research.
文摘BACKGROUND Thumb replantation following complete traumatic avulsion requires complex techniques to restore function,especially in cases of avulsion at the level of the metacarpophalangeal joint(MCP I)and avulsion of the flexor pollicis longus(FPL)at the musculotendinous junction.Possible treatments include direct tendon suture or tendon transfer,most commonly from the ring finger.To optimize function and avoid donor finger complications,we performed thumb replantation with flexion restoration using brachioradialis(BR)tendon transfer with palmaris longus(PL)tendon graft.CASE SUMMARY A 20-year-old left-handed male was admitted for a complete traumatic left thumb amputation following an accident while sliding from the top of a handrail.The patient presented with skin and bone avulsion at the MCP I,avulsion of the FPL tendon at the musculotendinous junction(zone 5),avulsion of the extensor pollicis longus tendon(zone T3),and avulsion of the thumb’s collateral arteries and nerves.The patient was treated with two stage thumb repair.The first intervention consisted of thumb replantation with MCP I arthrodesis,resection of avulsed FPL tendon and implantation of a silicone tendon prosthesis.The second intervention consisted of PL tendon graft and BR tendon transfer.Follow-up at 10 months showed good outcomes with active interphalangeal flexion of 70°,grip strength of 45 kg,key pinch strength of 15 kg and two-point discrimination threshold of 4 mm.CONCLUSION Flexion restoration after complete thumb amputation with FPL avulsion at the musculotendinous junction can be achieved using BR tendon transfer with PL tendon graft.
文摘Peer to Peer网络(简称p2p)作为一种新型的覆盖网络引起了越来越多研究者的兴趣。本文介绍了在我国进行的骨干互联网上p2p网络流量测量。与现有国外研究不同,本文的数据来源于核心路由器,因此克服了它们的缺陷。其研究集中在汇聚流中的3个周期性尖峰群、不同主机发送或接收流量的重尾分布、p2p流量的长相关特性以及提出了ADTE的估计方法来区分信令和数据流量。本文的研究也显示出Napster在p2p流中占大部分,这暗示着超级节点和阶层式拓扑较纯p2p结构潜在的优势。同时,观察到在我国p2p的流量仅占Internet总流量的1%弱,这个值跟国外的数据有很大区别。我们分析了其中的原因并希望该结论为我国p2p软件的发展提供参考。
文摘以小世界模型为理论基础,以 Region 为基本逻辑管理单位,按用户需求和共享目的组织 Region。提出了基于 Region 的多层结构 Peer-to-Peer 网络模型和构造规则,给出了 Region 的划分策略和数学模型,证明了模型的正确和合理性;对模型中的层和域、中心节点、普通节点和汇聚点进行了明确的定义,给出了节点加入、离开、中心节点选取策略和算法描述;使定位某种服务的工作量和查询范围从网络中的所有结点数降低到 Region 的节点数,有效地防止了恶意请求引发的洪,网络系统开销为常数。模拟分析表明,该模型可有效解决可扩展性、性能与效率不高问题,且网络规模越大,其综合性能的优越性越明显,因此,模型是合理有效的。
文摘提出并实现了一种建立在Peer-to-Peer 搜索策略上的自组织、自适应、高效和可靠的文件系统DISPFS(Double ID Space basedPeer-to-peer File System)。它在双层ID 空间中构造虚拟存储节点,不仅有效地取得了文件系统内的负载均衡、提高系统利用率,而且保证了动态环境中文件的可靠、快速获取。试验数据表明,DISPFS 在系统接近满负荷运行和文件插入/删除操作频繁的双重压力下依然保持优良的性能。
基金The National Natural Science Foundation of China(No60573133)the National Basic Research Program of China (973Program) (No2003CB314801)
文摘The design and evaluation of accelerated transmission (AT) systems in peer-to-peer networks for data transmission are introduced. Based on transfer control protocol (TCP) and peer-to-peer (P2P) substrate networks, AT can select peers of high performance quality, monitor the transfer status of each peer, dynamically adjust the transmission velocity and react to connection degradation with high accuracy and low overhead. The system performance is evaluated by simulations, and the interrelationship between network flow, bandwidth utilities and network throughput is analyzed. Owing to the collaborative operation of neighboring peers, AT accelerates the process of data transmission and the collective network performance is much more satisfactory.